Tripeptide probes for tripeptidyl protease I production via gene transfer

Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2003, Pages 1603-1608

  Kim, MeeKyoung ^a   Mao, Qinwen ^b   Davidson, Beverly L ^b   Wiemer, David F ^a  

^a E11 SSH   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLOROANTHRAQUINONE HYDRAZIDE; ANTHRAQUINONE DERIVATIVE; ANTHRAQUINONE HYDRAZIDE; BRINASE; GLYCYLPROLYLALANYLCHLOROANTHRAQUINONE HYDRAZIDE; GLYCYLPROLYLSERINE ANTHRAQUINONE HYDRAZIDE; HYDRAZIDE; PYRAZOLOQUINONE; QUINONE DERIVATIVE; TRIPEPTIDE; TRIPEPTIDYL PROTEASE I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CNL2 GENE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME SUBSTRATE; GENE TRANSFER; KIDNEY PARENCHYMA; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; REACTION ANALYSIS;

ANIMALS; ANTHRAQUINONES; COLORING AGENTS; ENDOPEPTIDASES; FROZEN SECTIONS; GENE TRANSFER TECHNIQUES; HISTOCYTOCHEMISTRY; HYDRAZINES; KIDNEY; MICE; MICE, INBRED C57BL; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0344950510     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020525x     Document Type: Article

References (14)

1. Bennett, M. J.; Hofmann, S. L. The neuronal ceroid-lipofuscinoses (Batten disease): A new class of lysosomal storage diseases. J. Inherit. Metab. Dis. 1999, 22, 535-544.
2. Mole, S. E. Batten disease: Four genes and still counting. Neurobiol. Dis. 1998, 5, 287-303.
3. Sleat, D. E.; Donnelly, R. J.; Lackland, H.; Liu, C. G.; Sohar, I.; Pullarkat, R. K.; Lobel, P. Association of Mutations in a Lysosomal Protein with Classical Late Infantile Neuronal Ceroid Lipofuscinosis. Science 1997, 277, 1802-1805.
4. Palmer, D. N.; Bayliss, S. L.; Westlake, V. J. Batten Disease and the ATP Synthase Subunit-C Turnover Pathway - Raising Antibodies to Subunit-C. Am. J. Med. Genet. 1995, 57, 260-265.
5. Haskell, R. E.; Huges, S. M.; Chiorini, J. A.; Alisky, J. M.; Davidson, B. L. Gene Therapy 2002, in press.
6. Page, A. E.; Fuller, K.; Chambers, T. J.; Warburton, M. J. Purification and Characterization of a Tripeptidyl Peptidase I from Human Osteoclastomas: Evidence for Its Role in Bone Resorption. Arch. Biochem. Biophys. 1993, 306, 354-359.
7. Dikov, A.; Dimitrova, M.; Ivanov, I.; Krieg, R.; Halbhuber, K. J. Original Method for the Histochemical Demonstration of Tripeptidyl Aminopeptidase I. Cell. Mol. Biol. 2000, 46, 1219-1225.
8. Moehlau, R. Uber Anthrachinoyl-monohydrazine. Chem. Ber. 1912, 45, 2233-2247.
9. (a) Sheehan, J. C.; Cruickshank, P. A.; Boshart, G. L. A Convenient Synthesis of Water-soluble Carbodiimides. J. Org. Chem. 1961, 26, 2525-2528.
10. (b) Xu, Y.; Miller, M. J. Total Syntheses of Mycobactin Analogues as Potent Antimycobacterial Agents using a Minimal Protecting Group Strategy. J. Org. Chem. 1998, 63, 4314-4322.
11. Bradley, W.; Geddes, K. W. 1,9-Pyrazoloanthrone. I. Replacement of Halogens in derivatives of 1,9-pyrazoloanthrone. J. Chem. Soc. 1952, 1630-1635.
12. Zhang, L. H.; Meier, W. E.; Watson, E. J.; Gibson, E. P. Reversal of the Regioselectivity of Anthrapyrazole Formation - A New Synthesis of Losoxantrone (DUP941). Tetrahedron Lett. 1994, 35, 3675-3678.
13. Vines, D.; Warburton, M. J. Purification and characterization of a tripeptidyl aminopeptidase I from rat spleen. Biochim. Biophys. Acta 1998, 1384, 233-242.
14. Bodanszky, M.; Bodanszky, A. The Practice of Peptide Synthesis; Springer-Verlag: Berlin, New York, 1984; pp 145 and 165.