Rat tripeptidyl peptidase I: Molecular cloning, functional expression, tissue localization and enzymatic characterization

Biological Chemistry

Volumn 382, Issue 12, 2001, Pages 1715-1725

  Du, Pei Ge ^a   Kato, Shigeru ^a   Li, Yao Hua ^a   Maeda, Toshinaga ^a   Yamane, Takuya ^a   Yamamoto, Shigeto ^a   Fujiwara, Manabu ^a   Yamamoto, Yoshio ^a   Nishi, Katsuji ^a   Ohkubo, Iwao ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

cDNA structure; Classical late infantile neuronal ceroid lipofuscinosis (CLN2); Lysosomes; Rat kidney; Tripeptidyl peptidase I

Indexed keywords

ALANINE; AMINO ACID; ANTIGEN; ARGININE; ASPARAGINE; CHLOROMERCURIBENZENESULFONIC ACID; COMPLEMENTARY DNA; DODECYL SULFATE SODIUM; GLYCINE; LEUCINE; LYSOSOME ENZYME; NEUROKININ B; PEPTIDASE; PHENYLALANINE; SERINE; TRIPEPTIDE; TRIPEPTIDYL PEPTIDASE; TYROSINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBUNIT; GEL FILTRATION; HEART; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; LUNG; MICHAELIS CONSTANT; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKELETAL MUSCLE; SPLEEN; TESTIS; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANGIOTENSIN III; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; CHROMATOGRAPHY, AGAROSE; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; ENDOPEPTIDASES; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; KIDNEY; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NEUROKININ B; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 18244380131     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2001.207     Document Type: Article

References (24)

1. A lysosomal proteinase, the late-infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase
2. Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofusinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase
3. Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis
4. Increased brain lysosomal pepstatin-insensitive proteinase activity in patients with neurodegenerative diseases
5. Purification and characterization of bovine brain lysosomal pepstatin-in-sensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis
6. Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons
7. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
8. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
9. The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH
10. Structural organization and sequence of CLN2, the defective gene in classical late infantile neuronal ceroid lipofuscinosis
11. Partial purification and characterization of an ovarian tripeptidyl peptidase: A lysosomal exopeptidase that sequentially releases collagen-related (Gly-Pro-X) triplets
12. Batten's disease: Eight genes and still counting?
13. Molecular genetics of the neuronal ceroid lipofusinoses
14. Purification and characterization of a tripeptidyl peptidase I from human oseoclastomas: Evidence for its role in bone resorption
15. Mitochorndrial ATP synthase subunit c storage in the ceroid-lipofusinoses (Batten disease)
16. Tripeptidyl peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofusinosis
17. Aminopeptidase A, which generates one of the main effector peptides of the brain rennin-angiotensin system, angiotensin III has a key role in central control of atrial blood pressure
18. Angiotensin III: A central regulator of vasopressin release and blood pressure
19. Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis
20. Purification and characterization of a tripeptidyl aminopeptidase I from rat spleen
21. Classical late infantile neuronal ceroid lipofusionsisfibroblasts are deficient in lysosomal tripeptidyl peptidase I
22. Acidic tripeptidyl aminopeptidase in rat liver tritosomes: Partial purification and determination of its primary substrate specificity
23. Important role for angiotensin III in the brain renin-angiotensin system