Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence

Biological Psychiatry

Volumn 65, Issue 2, 2009, Pages 175-180

  Martinez, Diana ^a   Slifstein, Mark ^a   Gil, Roberto ^a   Hwang, Dah Ren ^a   Huang, Yiyun ^a   Perez, Audrey ^a   Frankle, W Gordon ^a   Laruelle, Marc ^a   Krystal, John ^b   Abi Dargham, Anissa ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol dependence; human subjects; PET; serotonin 1A receptor; serotonin transporter

Indexed keywords

N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; TRACER;

ADULT; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; MALE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAPHE NUCLEUS;

ADULT; ALCOHOLISM; BRAIN; BRAIN MAPPING; CARBON RADIOISOTOPES; CASE-CONTROL STUDIES; DRUG USERS; FEMALE; HUMANS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RECEPTOR, SEROTONIN, 5-HT1A; REFERENCE VALUES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEVERITY OF ILLNESS INDEX;

EID: 57849110428     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2008.08.034     Document Type: Article

References (37)

1. Zhou F.C., Pu C.F., Murphy J., Lumeng L., and Li T.K. Serotonergic neurons in the alcohol preferring rats. Alcohol 11 (1994) 397-403
2. 1A receptors in the hippocampus and cerebral cortex of alcohol-preferring P rats. Life Sci 46 (1990) 231-235
3. Buydens-Branchey L., Branchey M.H., Noumair D., and Lieber C.S. Age of alcoholism onset. II. Relationship to susceptibility to serotonin precursor availability. Arch Gen Psychiatry 46 (1989) 231-236
4. von Knorring A.L., Bohman M., von Knorring L., and Oreland L. Platelet MAO activity as a biological marker in subgroups of alcoholism. Acta Psychiatr Scand 72 (1985) 51-58
5. Limson R., Goldman D., Roy A., Lamparski D., Ravitz B., Adinoff B., and Linnoila M. Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Arch Gen Psychiatry 48 (1991) 437-441
6. Virkkunen M., and Linnoila M. Brain serotonin, type II alcoholism and impulsive violence. J Studies Alcohol Suppl 11 (1993) 163-169
7. Fils-Aime M.L., Eckardt M.J., George D.T., Brown G.L., Mefford I., and Linnoila M. Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics. Arch Gen Psychiatry 53 (1996) 211-216
8. Chen H.T., Casanova M.F., Kleinman J.E., Zito M., Goldman D., and Linnoila M. 3H-paroxetine binding in brains of alcoholics. Psychiatry Res 38 (1991) 293-299
9. Heinz A., Ragan P., Jones D.W., Hommer D., Williams W., Knable M.B., et al. Reduced central serotonin transporters in alcoholism. Am J Psychiatry 155 (1998) 1544-1549
10. Suehiro M., Scheffel U., Dannals R.F., Ravert H.T., Ricaurte G.A., and Wagner Jr. H.N. A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z. J Nucl Med 34 (1993) 120-127
11. Szabo Z., Kao P.F., Scheffel U., Suehiro M., Mathews W.B., Ravert H.T., et al. Positron emission tomography imaging of serotonin transporters in the human brain using [11C](+)McN5652. Synapse 20 (1995) 37-43
12. Szabo Z., Owonikoko T., Peyrot M., Varga J., Mathews W.B., Ravert H.T., et al. Positron emission tomography imaging of the serotonin transporter in subjects with a history of alcoholism. Biol Psychiatry 55 (2004) 766-771
13. Brown A.K., George D.T., Fujita M., Liow J.S., Ichise M., Hibbeln J., et al. PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. Alcohol Clin Exp Res 31 (2007) 28-32
14. 1A receptor parameters with [carbonyl-11C]WAY-100635 in humans: Comparison of arterial and reference tissue input functions. J Cereb Blood Flow Metab 20 (2000) 1111-1133
15. 1A receptors in the CNS of alcohol-preferring and -nonpreferring rats. Pharmacol Biochem Behav 49 (1994) 7-12
16. 1A receptor function in C57BL/6J mice. Int J Neuropsychopharmacol 10 (2007) 595-607
17. Cloninger C.R. Neurogenetic adaptive mechanisms in alcohol. Science 236 (1987) 410-416
18. Maisto S.A., Sobell L.C., Cooper A.M., and Sobell M.B. Comparison of two techniques to obtain retrospective reports of drinking behavior from alcohol abusers. Addict Behav 7 (1982) 33-38
19. Skinner H.A., and Allen B.A. Alcohol dependence syndrome: Measurement and validation. J Abnorm Psychol 91 (1982) 199-209
20. 1A receptor availability in patients with schizophrenia and schizo-affective disorder: A positron emission tomography imaging study with [11C]WAY 100635. Psychopharmacology (Berl) 189 2 (2006) 155-164
21. Frankle W.G., Slifstein M., Gunn R.N., Huang Y., Hwang D.R., Darr E.A., et al. Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: Reproducibility and comparison of methods. J Nucl Med 47 (2006) 815-826
22. Slifstein M., and Laruelle M. Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers. Nucl Med Biol 28 (2001) 595-608
23. Innis R.B., Cunningham V.J., Delforge J., Fujita M., Gjedde A., Gunn R.N., et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab 27 (2007) 1533-1539
24. Smith A.D., and Weiss F. Ethanol exposure differentially alters central monoamine neurotransmission in alcohol-preferring versus -nonpreferring rats. J Pharmacol Exp Ther 288 (1999) 1223-1228
25. Katner S.N., and Weiss F. Neurochemical characteristics associated with ethanol preference in selected alcohol-preferring and -nonpreferring rats: A quantitative microdialysis study. Alcohol Clin Exp Res 25 (2001) 198-205
26. Thielen R.J., Bare D.J., McBride W.J., Lumeng L., and Li T.K. Ethanol-stimulated serotonin release in the ventral hippocampus: An absence of rapid tolerance for the alcohol-preferring P rat and insensitivity in the alcohol-nonpreferring NP rat. Pharmacol Biochem Behav 71 (2002) 111-117
27. Mantere T., Tupala E., Hall H., Särkioja T., Räsänen P., Bergström K., et al. Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: A whole-hemisphere autoradiography study. Am J Psychiatry 159 (2002) 599-606
28. Storvik M., Tiihonen J., Haukijärvi T., and Tupala E. Lower serotonin transporter binding in caudate in alcoholics. Synapse 59 (2006) 144-151
29. Storvik M., Tiihonen J., Haukijärvi T., and Tupala E. Amygdala serotonin transporters in alcoholics measured by whole hemisphere autoradiography. Synapse 61 (2007) 629-636
30. Storvik M., Haukijärvi T., Tupala E., and Tiihonen J. Correlation between the SERT binding densities in hypothalamus and amygdala in Cloninger type 1 and 2 alcoholics. Alcohol Alcohol 43 (2008) 25-30
31. Heinz A., Jones D.W., Bissette G., Hommer D., Ragan P., Knable M., et al. Relationship between cortisol and serotonin metabolites and transporters in alcoholism [correction of alcolholism]. Pharmacopsychiatry 35 (2002) 127-134
32. Heinz A., Jones D.W., Mazzanti C., Goldman D., Ragan P., Hommer D., et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 47 (2000) 643-649
33. Wilson A.A., Ginovart N., Hussey D., Meyer J., and Houle S. In vitro and in vivo characterisation of [11C]-DASB: A probe for in vivo measurements of the serotonin transporter by positron emission tomography. Nucl Med Biol 29 (2002) 509-515
34. Reimold M., Smolka M.N., Schumann G., Zimmer A., Wrase J., Mann K., et al. Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype. J Neural Transm 114 (2007) 635-639
35. Praschak-Rieder N., Kennedy J., Wilson A.A., Hussey D., Boovariwala A., Willeit M., et al. Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: A [(11)C] DASB positron emission tomography study. Biol Psychiatry 62 (2007) 327-331
36. Talbot P.S., Frankle W.G., Hwang D.R., Huang Y., Suckow R.F., Slifstein M., et al. Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans. Synapse 55 (2005) 164-175
37. Milak M.S., Ogden R.T., Vinocur D.N., Van Heertum R.L., Cooper T.B., Mann J.J., and Parsey R.V. Effects of tryptophan depletion on the binding of [11C]-DASB to the serotonin transporter in baboons: Response to acute serotonin deficiency. Biol Psychiatry 57 (2005) 102-106