Nuclear SREBP-1a causes loss of pancreatic β-cells and impaired insulin secretion

Biochemical and Biophysical Research Communications

Volumn 378, Issue 3, 2009, Pages 545-550

  Iwasaki, Yuko ^a   Iwasaki, Hitoshi ^a   Yatoh, Shigeru ^a   Ishikawa, Mayumi ^a   Kato, Toyonori ^a   Matsuzaka, Takashi ^a   Nakagawa, Yoshimi ^a   Yahagi, Naoya ^a   Kobayashi, Kazuto ^a   Takahashi, Akimitsu ^a   Suzuki, Hiroaki ^a   Yamada, Nobuhiro ^a   Shimano, Hitoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Cholesterol; Lipotoxicity; Sterol regulatory element binding protein; Transcription factors; Triglycerides

Indexed keywords

CHOLESTEROL; GLUCAGON; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 2; NUCLEAR PROTEIN; POTASSIUM; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL GROWTH; CELL LOSS; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; FATTY ACID SYNTHESIS; GENE CONTROL; GENE EXPRESSION; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; CELL NUCLEUS; CHOLESTEROL; GENE EXPRESSION PROFILING; GLUCOSE TOLERANCE TEST; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; MAF TRANSCRIPTION FACTORS, LARGE; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANS-ACTIVATORS; TRIGLYCERIDES;

MUS MUSCULUS;

EID: 57749204769     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.11.105     Document Type: Article

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