Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase

Human Gene Therapy

Volumn 19, Issue 12, 2008, Pages 1349-1357

  Li, Yi ^a   Shi, Chang Xin ^b   Mossman, Karen L ^a   Rosenfeld, Jack ^a   Boo, Yong Chool ^c   Schellhorn, Herb E ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MAYO CLINIC   (United States)

^c Kyungpook National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ASCORBIC ACID; GULONOLACTONE OXIDASE; RECOMBINANT HELPER DEPENDENT ADENOVIRUS MURINE CYTOMEGALOVIRUS VECTOR GULO; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCORBIC ACID DEFICIENCY; C57BL 6 MOUSE; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DOSE RESPONSE; DRUG MEGADOSE; GENE; GENE THERAPY; GULO GENE; HUMAN; HUMAN CELL; LIVER; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SCURVY; TRANSGENIC MOUSE; URINE; VITAMIN BLOOD LEVEL;

ADENOVIRIDAE; ANIMALS; ASCORBIC ACID; BASE SEQUENCE; CELL LINE; DNA PRIMERS; GENETIC VECTORS; HELPER VIRUSES; HUMANS; L-GULONOLACTONE OXIDASE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SUGAR ACIDS;

ADENOVIRIDAE; ANIMALIA; GULO; MAMMALIA; MURID HERPESVIRUS 1; MURINAE; MUS; MUS MUSCULUS;

EID: 57749195315     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2008.0106     Document Type: Article

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