Risk for bipolar disorder is associated with face-processing deficits across emotions

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 47, Issue 12, 2008, Pages 1455-1461

  Brotman, Melissa A ^a,b   Skup, Martha ^a   Rich, Brendan A ^a   Blair, Karina S ^a   Pine, Daniel S ^a   Blair, James R ^a   Leibenluft, Ellen ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NONE   (United States)

Author keywords

At risk; Bipolar disorder; Endophenotype; Face emotion labeling

Indexed keywords

ADOLESCENT; ADULT; ANGER; ARTICLE; BIPOLAR DISORDER; CHILD; CHILD DEVELOPMENT; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTION; FACIAL EXPRESSION; FEAR; FEMALE; HAPPINESS; HUMAN; LONELINESS; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; SCHOOL CHILD; TASK PERFORMANCE;

EID: 57749191017     PISSN: 08908567     EISSN: None     Source Type: Journal    
DOI: 10.1097/CHI.0b013e318188832e     Document Type: Article

References (36)

1. Dick DM, Foroud T, Flury L, et al. Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet. 2003;73:107-114.
2. Faraone SV, Su J, Tsuang MT. A genome-wide scan of symptom dimensions in bipolar disorder pedigrees of adult probands. J Affect Disord. 2004;82(suppl 1):S71-S78.
3. Kieseppa T, Partonen T, Haukka J, Kaprio J, Lonnqvist J. High concordance of bipolar I disorder in a nationwide sample of twins. Am J Psychiatry. 2004;161:1814-1821.
4. McGuffin P, Rijsdijk F, Andrew M, Sham P, Katz R, Cardno A. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry. 2003;60:497-502.
5. Smoller JW, Finn CT. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet. 2003;123C:48-58.
6. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic inrentions. Am J Psychiatry. 2003;160:636-645.
7. Gould TD, Gottesman II. Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav. 2006;5:113-119.
8. Hasler G, Drevers WC, Gould TD, Gottesman II, Manji HK. Toward constructing an endophenotype strategy for bipolar disorders. Biol Psychiatry. 2006;60:93-105.
9. Glahn DC, Bearden CE, Niendam TA, Escamilla MA. The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder. Bipolar Disord. 2004;6:171-182.
10. Lenox RH, Gould TD, Manji HK. Endophenotypes in bipolar disorder. Am J Med Genet. 2002;114:391-406.
11. McClure EB, Pope K, Hoberman AJ, Pine DS, Leibenluft E. Facial expression recognition in adolescents with mood and anxiety disorders. Am J Psychiatry. 2003;160:1-3.
12. McClure EB, Treland JE, Snow J, et al. Deficits in social cognition and response flexibility in pediatric bipolar disorder. Am J Psychiatry. 2005;162:1644-1651.
13. Schenkel LS, Pavuluri MN, Herbener ES, Harral EM, Sweeney JA. Facial emotion processing in acutely ill and euthymic patients with pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2007;46:1070-1079.
14. Rich BA, Grimley ME, Schmajuk M, Blair KS, Blair RJR, Leibenluft E. Face emotion labeling deficits in children with bipolar disorder and severe mood dysregulation. Dev Psychopathol. 2008;20:529-546.
15. Pine DS, Klein RG, Mannuzza S, et al. Face-emotion processing in offspring at risk for panic disorder. J Am Acad Child Adolesc Psychiatry. 2005;44:664-672.
16. Gur RE, Nimgaonkar VL, Almasy L, et al. Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia. Am J Psychiatry. 2007;164:813-819.
17. Guyer AE, McClure EB, Adler AD, et al. Specificity of facial expression labeling deficits in childhood psychopathology. J Child Psychol Psychiatry. 2007;48:863-871.
18. Brotman MA, Guyer AE, Lawson ES, et al. Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder. Am J Psychiatry. 2008;165:385-389.
19. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P). New York: New York State Psychiatric Institute, Biometrics Research; 2002.
20. Nurnberger JI, Blehar MC, Kaufmann CA, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry. 1994;51:849-859.
21. Kaufman J, Birmaher B, Brent D, et al. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997;36:980-988.
22. Leibenluft E, Charney DS, Towbin KE, Bhangoo RK, Pine DS. Defining clinical phenotypes of juvenile mania. Am J Psychiatry. 2003;160:430-437.
23. Wechsler D. Wechsler Abbreviated Scale of Intelligence. San Antonio: The Psychological Corporation; 1999.
24. Poznanski EO, Grossman JA, Buchsbaum Y, Banegas M, Freeman L, Gibbons R. Preliminary studies of the reliability and validity of the Children's Depression Rating Scale. J Am Acad Child Psychiatry. 1984;23:191-197.
25. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978;133:429-435.
26. Blair RJ, Colledge E, Murray L, Mitchell DG. A selective impairment in the processing of sad and fearful expressions in children with psychopathic tendencies. J Abnorm Child Psychol. 2001;29:491-498.
27. Ekman P, Friesen WV. Pictures of Facial Affect. Palo Alto: Consulting Psychologists Press. 1976.
28. Rich BA, Vinton DT, Roberson-Nay R, et al. Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proc Natl Acad Sci U S A. 2006;103:8900-8905.
29. Geller B, Bolhofner K, Craney JL, Williams M, DelBello MP, Gundersen K. Psychosocial functioning in a prepubertal and early adolescent bipolar disorder phenotype. J Am Acad Child Adolesc Psychiatry. 2000;39: 1543-1548.
30. Goldstein TR, Miklowitz DJ, Mullen KL. Social skills knowledge and performance among adolescents with bipolar disorder. Bipolar Disord. 2006;8:350-361.
31. Hecht H, Genzworker S, Helle M, van Calker D. Social functioning and personality of subjects at familial risk for affective disorder. J Affect Disord. 2005;84:33-42.
32. Axelson D, Birmaher B, Strober M, et al. Phenomenology of children and adolescenrs with bipolar spectrum disorders. Arch Gen Psychiatry. 2006;63:1139-1148.
33. DelBello MP, Geller B. Review of studies of child and adolescent offspring of bipolar parents. Bipolar Disord. 2001;3:325-334.
34. Chang KD, Steiner H, Ketter T. Psychiatric phenomenology of child and adolescent bipolar offspring. J Am Acad Child Adolesc Psychiatry. 2000;39:453-460.
35. Reichart CG, Wals M, Hillegers MHJ, Ormel J, Nolen WA, Verhulst FC. Psychopathology in the adolescent offspring of bipolar parents. J Affect Disord. 2004;78:67-71.
36. Henin A, Biederman J, Mick E, et al. Psychopathology in the offspring in parents with bipolar disorder: a controlled study. Biol Psychiatry. 2005;58:554-561.