Design, Synthesis and Pharmacological Screening of Novel Antihypertensive Agents Using Hybrid Approach

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 1, 2009, Pages 390-400

  Bhandari, Shashikant V ^a   Bothara, Kailash G ^a   Patil, Ajit A ^a   Chitre, Trupti S ^a   Sarkate, Aniket P ^a   Gore, Suraj T ^a   Dangre, Sudarshan C ^a   Khachane, Chetan V ^a  

^a AISSMS COLLEGE OF PHARMACY   (India)

Author keywords

Antiarrhythmic; Antihypertensive; Hybrid; NO donor; Vasorelaxation

Indexed keywords

2 [2 [4 [2 HYDROXY 3 (4 OXO 2 (PHENYLIMINO) 5 (3,4,5 TRIMETHOXYBENZYLIDEN)THIAZOLIDIN 3 YL]PROPYLAMINO]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 2 [2 [4 [2 HYDROXY 3 [4 OXO 5 (3 PHENYLALLYLIDEN) 2 (PHENYLIMINO)THIAZOLIDIN 3 YL]PROPYLAMINO]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 2 [2 [4 [2 HYDROXY 3 [5 (2 HYDROXYBENZYLIDEN) 4 OXO 2 (PHENYLIMINO)THIAZOLIDIN 3 YL]PROPYLAMINO]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 2 [2 [4 [2 HYDROXY 3 [5 (3 NITROBENZYLIDEN) 4 OXO 2 (PHENYLIMINO)THIAZOLIDIN 3 YL] 2 HYDROXYPROPYLAMINO]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 2 [2 [4 [2 HYDROXY 3 [5 (4 HYDROXYBENZYLIDEN) 4 OXO 2 (PHENYLIMINO)THIAZOLIDIN 3 YL]PROPYLAMINO]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 2 [2 [4 [2 HYDROXY 3 [5 (4 METHYLBENZYLIDEN) 4 OXO 2 (PHENYLIMINO)THIAZOLIDIN 3 YL]PROPYLAMINO]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 2 [2 [4 [3 [5 (4 FLUOROBENZYLIDEN) 4 OXO 2 (PHENYLIMINO)THIAZOLIDIN 3 YL] 2 HYDROXYPROPYLAMINO]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; 2 [2 [4 [3 [5 BENZYLIDEN 4 OXO 2 (PHENYLIMINO)THIAZOLIDIN 3 YL] 2 HYDROXYPROPYLAMINO]BENZOYL]HYDRAZINYL] 2 OXOETHYLNITRATE; ANTIHYPERTENSIVE AGENT; ATENOLOL; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ARRHYTHMIA; NONHUMAN; PHARMACOPHORE; RAT; REACTION ANALYSIS;

ADRENERGIC ANTAGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTIHYPERTENSIVE AGENTS; AORTA; BLOOD PRESSURE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HEART RATE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57749172002     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.032     Document Type: Article

References (26)

1. Nieto R.M., and Coelho A. Chem. Pharm. Bull. 51 (2003) 1025
2. Christiaans J.A.M., and Timmerman H. Eur. J. Pharm. Sci. 4 (1996) 1
3. Nandakumar N., Singh R., Bansal S.K., Bodhankar S.L., Jindal D.P., Coumar M.S., and Bhardwaj S.H. Indian J. Pharmacol. 36 (2004) 381
4. Brizzi V., Francioli M., Brufani M., Filocamo L., Bruni G., and Massarelli P. IL Farmaco 54 (1999) 713
5. Bing R.J., Yamamoto T., Kim H., and Grubbs R.H. Biochem. Biophys. Res. Commun. 275 (2000) 350
6. Nguyen J., Velazquez C.A., and Knaus E.E. Bioorg. Med. Chem. 13 (2005) 1725
7. Martinez L., Abrego V., Balboa M.A., et al. Eur. J. Med. Chem. 43 (2008) 486
8. Stout D.M., Matier W.L., Barcelon-Yang C., Reynolds R.D., and Brown B.S. J. Med. Chem. 26 (1983) 808
9. Stout D.M., Matier W.L., Barcelon-Yang C., Reynolds R.D., and Brown B.S. J. Med. Chem. 27 (1984) 1347
10. Stout D.M., Matier W.L., Barcelon-Yang C., Reynolds R.D., and Brown B.S. J. Med. Chem. 28 (1985) 295
11. Glowka M.L., and Codding P.W. J. Med. Chem. 34 (1991) 2678
12. Zeng Y.L., Wang Y.F., Li J., Xu J.M., Wang M., and Qiu H. Eur. J. Pharmacol. 183 (1990) 1849
13. Dai D. J. Mol. Cell. Cardiol. 22 (1990) S74
14. Malawska B., Kulig K., Filipek B., et al. Eur. J. Med. Chem. 37 (2002) 183
15. Frank R.L., and Smith P.V. Org. Synth. 3 (1955) 735
16. Rout M.K., and Mahapatra G.N. Tetrahedron 77 (1955) 2427
17. Stallmann, O. U.S. Patent 1,977,253, 1934.
18. Furniss, B.; Hannaford, A.; Smith, P.; Tatchell, A. In Vogel's Textbook of Practical Organic Chemistry; ELBS Publication, 1994, pp 90, 908-973.
19. Abadi A.H., Hegazy G.H., and El-Zaher A.A. Bioorg. Med. Chem. 13 (2005) 5759
20. CPCSEA guidelines for laboratory animal facility. Indian J. Pharmacol. 2003, 35, 257. www.cpcsea.com.
21. Dylag T., Zygmunt M., Maciag D., Handzlik J., Bednarski M., Filipek B., and Kieć-Kononowicz K. Eur. J. Med. Chem. 39 (2004) 1013
22. Ferrarini P., Mori C., Calderone V., Calzolari L., Nieri P., Saccomanni G., and Martinotti E. Eur. J. Med. Chem. 34 (1999) 505
23. Calderone V., Martinotti E., Scatizzi R., Pellegrini A., and Breschi M. J. Pharmacol. Toxicol. Methods 35 (1996) 13l
24. Ferrarini P., Mori C., Calderone V., Calzolari L., Nieri P., Saccomanni G., and Martinotti E. Eur. J. Med. Chem. 33 (1998) 383
25. - Assay. Catalog Number DE1500B. info@RnDSystems.com.
26. Graph Pad Software Inc. 11452, E-1, Camino Real, #215, San Diego, CA 92130, USA. www.graphpad.com.