Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 5, 2005, Pages 1725-1738

  Nguyen, Jeffrey Tri ^a   Velázquez, Carlos A ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

1,2 Diazen 1 ium 1,2 diolates; 1,4 Dihydropyridines; Calcium channel antagonists; Nitric oxide release

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CARBOXYLIC ACID DERIVATIVE; DIHYDROPYRIDINE DERIVATIVE; METHYL GROUP; NIFEDIPINE; NITRIC OXIDE DONOR; NITROGEN DERIVATIVE; PIPERAZINE DERIVATIVE; PRODRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EXPOSURE; DRUG POTENCY; DRUG POTENTIATION; DRUG RELEASE; GUINEA PIG; IC 50; IN SITU HYBRIDIZATION; IN VIVO CULTURE; ISOMERISM; NONHUMAN; REACTION ANALYSIS; SMOOTH MUSCLE; STRUCTURE ACTIVITY RELATION; VASODILATATION;

CAVIA PORCELLUS; SUS SCROFA;

EID: 13444270686     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.12.002     Document Type: Article

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