Cell-based screening approach for antitumor drug leads which exploits sensitivity differences between normal and cancer cells: Identification of two novel cell-cycle inhibitors

Anti-Cancer Drug Design

Volumn 16, Issue 1, 2001, Pages 7-17

  Vassilev, L T ^a   Kazmer, S ^a   Marks, I M ^a   Pezzoni, G ^a   Sala, F ^a   Mischke, S G ^a   Foley, L ^a   Berthel, S J ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Antitumor; Cancer cells; Cell cycle; High throughput; Mitosis

Indexed keywords

2 BROMO 1 ETHOXYBENZENE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 5 ETHOXY 2 NITROBENZALDEHYDE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; BROMINE DERIVATIVE; RO 236538; RO 911311; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SPECIFICITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; METAPHASE; NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TUBULIN; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0035203298     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. p53 controls both G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
2. Complexity in the spindle checkpoint
3. A new aspect of the antiproliferative action of peripheral-type benzodiazepine receptor ligands
4. Cell cycle checkpoints: Preventing an identity crisis
5. Taxol induces bcl-2 phosphorylation and death in prostate cancer cells
6. Bcl2 is the guardian of microtubule integrity
7. Classification of human colorectal adenocarcinoma cell lines
8. Checking on the cell cycle
9. The NCI anti-cancer drug screen: A smart screen to identify effectors of novel targets
10. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
11. Sanwa Shoyaku Kk
12. Relaxed cell cycle arrest and propagation of unrepaired chromosomal damage in cancer cell lines with wild-type p53
13. Metastasis from human breast cancer cell lines
14. Anticancer drug screening with in vitro models
15. The effect of diazepam on mitosis and the microtubule cytoskeleton. I. Observations on the diatoms Hantzschia amphioxys and Surirella robusta
16. Clinical implications of p53 mutations
17. An information-intensive approach to the molecular pharmacology of cancer
18. Towards intelligent anticancer drug screening in the post-genome era