Synthesis of novel di- and tricationic carbapenems with potent anti-MRSA activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 2, 2009, Pages 447-450

  Maruyama, Takahisa ^a   Yamamoto, Yasuo ^a   Kano, Yuko ^a   Kurazono, Mizuyo ^a   Shitara, Eiki ^a   Iwamatsu, Katsuyoshi ^a   Atsumi, Kunio ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

Beta lactam; Carbapenem; Cationic charge; Imidazo 5,1 b thiazol; MRSA

Indexed keywords

1BETA METHYL CARBAPENEM; CARBAPENEM DERIVATIVE; CP 5068; IMIDAZO[5,1 B]THIAZOL 2 YL; IMIDAZO[5,1 B]THIAZOLE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DEPROTECTION REACTION; DRUG DESIGN; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STILLE REACTION; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CARBAPENEMS; CATIONS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; SOLUBILITY;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 57749096097     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.039     Document Type: Article

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