Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-Position. Part I: Synthesis and biological activities of 3-(benzothiazol-2-yl)thiocephalosporin derivatives, CP0467 and related compounds

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 7, 1998, Pages 1009-1017

  Tsushima, Masaki ^a   Iwamatsu, Katsuyoshi ^a   Tamura, Atsushi ^a   Shibahara, Seiji ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

Cephalosporin; CP0467; Long acting pharmacokinetic profiles; MRSA

Indexed keywords

CEPHALOSPORIN DERIVATIVE; CILASTATIN; CILASTATIN PLUS IMIPENEM; CP 0467; CP 04677; FLOMOXEF; HETEROCYCLIC COMPOUND; IMIPENEM; PENICILLIN BINDING PROTEIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; SUBCUTANEOUS DRUG ADMINISTRATION;

ACETAMIDES; ANIMALS; BACTERIAL PROTEINS; CARRIER PROTEINS; CEPHALOSPORINS; COLONY COUNT, MICROBIAL; DRUG EVALUATION, PRECLINICAL; GRAM-POSITIVE BACTERIA; HEXOSYLTRANSFERASES; MALE; METHICILLIN RESISTANCE; MICE; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PENICILLIN-BINDING PROTEINS; PENICILLINS; PEPTIDYL TRANSFERASES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0031713328     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00050-9     Document Type: Article

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