Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: Discovery of L-786,392

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 5, 1999, Pages 679-684

  Ratcliffe, R W ^a   Wilkening, R R ^a   Wildonger, K J ^a   Waddell, S T ^a   Santorelli, G M ^a   Parker Jr , D L ^b   Morgan, J D ^a   Blizzard, T A ^a   Hammond, M L ^a   Heck, J V ^a   Huber, J ^a   Kohler, J ^a   Dorso, K L ^a   St Rose, E ^a   Sundelof, J G ^a   May, W J ^a   Hammond, G G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1BETA METHYL 2 (NAPHTHOSULTAMYL)METHYLCARBAPENEM DERIVATIVE; CARBAPENEM DERIVATIVE; L 786392; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; DOSE RESPONSE; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN;

ANIMALS; CARBAPENEMS; DRUG RESISTANCE, MICROBIAL; GRAM-POSITIVE BACTERIA; HUMANS; LACTAMS; MICE; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

ANIMALIA; BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 0033535386     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00071-2     Document Type: Article

References (25)

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