Improvement of a stereoselective biocatalytic synthesis by substrate and enzyme engineering: 2-hydroxy-(4×-oxocyclohexyl)acetonitrile as the model

Chemistry - A European Journal

Volumn 14, Issue 36, 2008, Pages 11415-11422

  Avi, Manuela ^a   Wiedner, Romana M ^a   Griengl, Herfried ^a,b   Schwab, Helmut ^a,b  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b RESEARCH CENTRE APPLIED BIOCATALYSIS   (Austria)

Author keywords

Cyanohydrins; Enzyme catalysis; Enzyme engineering; Hydroxynitrile lyase; Substrate engineering

Indexed keywords

ACETONITRILE; CATALYSIS; ENGINEERING; ENZYMES; ETHERS; KETONES; ORGANIC COMPOUNDS;

CYANOHYDRINS; ENZYME CATALYSIS; ENZYME ENGINEERING; HYDROXYNITRILE LYASE; SUBSTRATE ENGINEERING;

SUBSTRATES;

2 HYDROXY (4' OXOCYCLOHEXYL)ACETONITRILE; 2-HYDROXY-(4'-OXOCYCLOHEXYL)ACETONITRILE; ACETONITRILE DERIVATIVE; LYASE; S HYDROXYNITRILE LYASE, HEVEA BRASILIENSIS; S-HYDROXYNITRILE LYASE, HEVEA BRASILIENSIS;

AMINO ACID SUBSTITUTION; ARTICLE; BIOCATALYSIS; CHEMISTRY; COMPUTER SIMULATION; ENZYME SPECIFICITY; ENZYMOLOGY; HEVEA; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETONITRILES; ALDEHYDE-LYASES; AMINO ACID SUBSTITUTION; BASE SEQUENCE; BIOCATALYSIS; COMPUTER SIMULATION; HEVEA; MUTATION; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 57649200475     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200800609     Document Type: Article

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