t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma

Oral Oncology

Volumn 45, Issue 1, 2009, Pages 2-9

  O'Neill, Iain D ^a  

^a Centre d'Affaires Poincare   (France)

Author keywords

CRTC1; MAML2; Mucoepidermoid carcinoma; Oncogene; Prognosis; Review; Salivary gland tumours; t(11; 19); Translocation; Warthins tumour

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GAMMA SECRETASE INHIBITOR; IMATINIB; NOTCH RECEPTOR;

ADENOSQUAMOUS CARCINOMA; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 19; CHRONIC MYELOID LEUKEMIA; CLEAR CELL HIDRADENOMA; DRUG MECHANISM; HIDRADENOMA; HUMAN; ONCOGENE; ONCOGENE CRTC1 MAML2; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SALIVARY GLAND TUMOR; WARTHIN TUMOR;

ADENOLYMPHOMA; CARCINOMA, MUCOEPIDERMOID; CELL CYCLE; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 19; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MALE; NUCLEAR PROTEINS; ONCOGENE PROTEINS, FUSION; SALIVARY GLAND NEOPLASMS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 57649158952     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2008.03.012     Document Type: Review

References (77)

1. Speight P.M., and Barrett A.W. Salivary gland tumours. Oral Dis 8 5 (2002) 229-240
2. Jones A.V., Craig G.T., Speight P.M., and Franklin C.D. The range and demographics of salivary gland tumours diagnosed in a UK population. Oral Oncol 44 4 (2007) 407-417
3. Granata C., Battistini E., Toma P., Balducci T., Mattioli G., Fregonese B., et al. Mucoepidermoid carcinoma of the bronchus: a case report and review of the literature. Pediatr Pulmonol 23 3 (1997) 226-232
4. Heitmiller R.F., Mathisen D.J., Ferry J.A., Mark E.J., and Grillo H.C. Mucoepidermoid lung tumors. Ann Thorac Surg 47 3 (1989) 394-399
5. Yousem S.A., and Hochholzer L. Mucoepidermoid tumors of the lung. Cancer 60 6 (1987) 1346-1352
6. Baloch Z.W., Solomon A.C., and LiVolsi V.A. Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases. Mod Pathol 13 7 (2000) 802-807
7. Bhandarkar N.D., Chan J., and Strome M. A rare case of mucoepidermoid carcinoma of the thyroid. Am J Otolaryngol 26 2 (2005) 138-141
8. Di Tommaso L., Foschini M.P., Ragazzini T., Magrini E., Fornelli A., Ellis I.O., et al. Mucoepidermoid carcinoma of the breast. Virchows Arch 444 1 (2004) 13-19
9. Sofinski S.J., Brown B.J., Rao N., and Wan W.L. Mucoepidermoid carcinoma of the lacrimal gland. Case report and review of the literature. Ophthal Plast Reconstr Surg 2 3 (1986) 147-151
10. Robinson J.W., Brownstein S., Jordan D.R., and Hodge W.G. Conjunctival mucoepidermoid carcinoma in a patient with ocular cicatricial pemphigoid and a review of the literature. Surv Ophthalmol 51 5 (2006) 513-519
11. Pinkston J.A., and Cole P. Incidence rates of salivary gland tumors: results from a population-based study. Otolaryngol Head Neck Surg 120 6 (1999) 834-840
12. National Cancer Institute. SEER cancer statistics review 1975-2004. http.//seer.cancer.gov/csr/1975_2004/results_merged/sect_20_oral_cavity [accessed 23.11.2007].
13. Ostman J., Anneroth G., Gustafsson H., and Tavelin B. Malignant salivary gland tumours in Sweden 1960-1989 - an epidemiological study. Oral Oncol 33 3 (1997) 169-176
14. Bhattacharyya N., and Fried M.P. Determinants of survival in parotid gland carcinoma: a population-based study. Am J Otolaryngol 26 1 (2005) 39-44
15. Pires F.R., Pringle G.A., de Almeida O.P., and Chen S.Y. Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol 43 5 (2007) 463-470
16. Mendenhall W.M., Morris C.G., Amdur R.J., Werning J.W., and Villaret D.B. Radiotherapy alone or combined with surgery for salivary gland carcinoma. Cancer 103 12 (2005) 2544-2550
17. Saku T., Hayashi Y., Takahara O., Matsuura H., Tokunaga M., Tokunaga M., et al. Salivary gland tumors among atomic bomb survivors, 1950-1987. Cancer 79 8 (1997) 1465-1475
18. Modan B., Chetrit A., Alfandary E., Tamir A., Lusky A., Wolf M., et al. Increased risk of salivary gland tumors after low-dose irradiation. Laryngoscope 108 7 (1998) 1095-1097
19. Whatley W.S., Thompson J.W., and Rao B. Salivary gland tumors in survivors of childhood cancer. Otolaryngol Head Neck Surg 134 3 (2006) 385-388
20. Stenman G. Fusion oncogenes and tumor type specificity - insights from salivary gland tumors. Semin Cancer Biol 15 3 (2005) 224-235
21. Tonon G., Modi S., Wu L., Kubo A., Coxon A.B., Komiya T., et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 33 2 (2003) 208-213
22. Mitelman F., Johansson B., and Mertens F. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer 7 4 (2007) 233-245
23. Xia S.J., and Barr F.G. Chromosome translocations in sarcomas and the emergence of oncogenic transcription factors. Eur J Cancer 41 16 (2005) 2513-2527
24. Kumar-Sinha C., Tomlins S.A., and Chinnaiyan A.M. Evidence of recurrent gene fusions in common epithelial tumors. Trends Mol Med 12 11 (2006) 529-536
25. Hibbard M.K., Kozakewich H.P., Dal Cin P., Sciot R., Tan X., Xiao X., et al. PLAG fusion oncogenes in lipoblastoma. Cancer Res 60 17 (2000) 4869-4872
26. Enlund F., Behboudi A., Andren Y., Oberg C., Lendahl U., Mark J., et al. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res 292 1 (2004) 21-28
27. Martins C., Cavaco B., Tonon G., Kaye F.J., Soares J., and Fonseca I. A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands. J Mol Diagn 6 3 (2004) 205-210
28. Behboudi A., Enlund F., Winnes M., Andren Y., Nordkvist A., Leivo I., et al. Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer 45 5 (2006) 470-481
29. Okabe M., Miyabe S., Nagatsuka H., Terada A., Hanai N., Yokoi M., et al. MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res 12 13 (2006) 3902-3907
30. Tirado Y., Williams M.D., Hanna E.Y., Kaye F.J., Batsakis J.G., and El-Naggar A.K. CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. Genes Chromosomes Cancer 46 7 (2007) 708-715
31. Mayr B., and Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2 8 (2001) 599-609
32. Wu L., Liu J., Gao P., Nakamura M., Cao Y., Shen H., et al. Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J 24 13 (2005) 2391-2402
33. Miele L. Notch signaling. Clin Cancer Res 12 4 (2006) 1074-1079
34. Komiya T., Park Y., Modi S., Coxon A.B., Oh H., and Kaye F.J. Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation. Oncogene 25 45 (2005) 6128-6132
35. Conkright M.D., Canattieri G., Screaton R., Guzman E., Miraglia L., Hogenesch J.B., et al. TORCs: transducers of regulated CREB activity. Mol Cell 12 2 (2003) 413-423
36. Coxon A., Rozenblum E., Park Y.S., Joshi N., Tsurutani J., Dennis P.A., et al. Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. Cancer Res 65 16 (2005) 7137-7144
37. Nordkvist A., Gustafsson H., Juberg-Ode M., and Stenman G. Recurrent rearrangements of 11q14-22 in mucoepidermoid carcinoma. Cancer Genet Cytogenet 74 2 (1994) 77-83
38. Horsman D.E., Berean K., and Durham J.S. Translocation (11;19)(q21;p13 1) in mucoepidermoid carcinoma of salivary gland. Cancer Genet Cytogenet 80 2 (1995) 165-166
39. Dahlenfors R., Lindahl L., and Mark J. A fourth minor salivary gland mucoepidermoid carcinoma with 11q14-21 and 19p12 rearrangements. Hereditas 120 3 (1994) 287-288
40. El-Naggar A.K., Lovell M., Killary A.M., Clayman G.L., and Batsakis J.G. A mucoepidermoid carcinoma of minor salivary gland with t(11;19)(q21;p13 1) as the only karyotypic abnormality. Cancer Genet Cytogenet 87 1 (1996) 29-33
41. Dahlenfors R., Wedell B., Rundrantz H., and Mark J. Translocation(11;19)(q14-21;p12) in a parotid mucoepidermoid carcinoma of a child. Cancer Genet Cytogenet 79 2 (1995) 188
42. Johansson M., Mandahl N., Johansson L., Hambraeus G., Mitelman F., and Heim S. Translocation 11;19 in a mucoepidermoid tumor of the lung. Cancer Genet Cytogenet 80 1 (1995) 85-86
43. Stenman G., Petursdottir V., Mellgren G., and Mark J. A child with a t(11;19)(q14-21;p12) in a pulmonary mucoepidermoid carcinoma. Virchows Arch 433 6 (1998) 579-581
44. Roberts Jr. T.G., Barry M., and Skarin A.T. Mucoepidermoid carcinoma of the lung with t(11:19)(q21:p13): a link to new biology. Clin Adv Hematol Oncol 1 8 (2003) 486-487
45. Vogelberg C., Mohr B., Fitze G., Friedrich K., Hahn G., Roesner D., et al. Mucoepidermoid carcinoma as an unusual cause for recurrent respiratory infections in a child. J Pediatr Hematol Oncol 27 3 (2005) 162-165
46. Serra A., Schackert H.K., Mohr B., Weise A., Liehr T., and Fitze G. t(11;19)(q21;p12∼p1311) and MECT1-MAML2 fusion transcript expression as a prognostic marker in infantile lung mucoepidermoid carcinoma. J Pediatr Surg 42 7 (2007) E23-E29
47. Bullerdiek J., Haubrich J., Meyer K., and Bartnitzke S. Translocation t(11;19)(q21;p13 1) as the sole chromosome abnormality in a cystadenolymphoma (Warthin's tumor) of the parotid gland. Cancer Genet Cytogenet 35 1 (1988) 129-132
48. Mark J., Dahlenfors R., Stenman G., and Nordquist A. A human adenolymphoma showing the chromosomal aberrations del (7)(p12p14-15) and t(11;19)(q21;p12-13). Anticancer Res 9 6 (1989) 1565-1566
49. Winnes M., Enlund F., Mark J., and Stenman G. The MECT1-MAML2 gene fusion and benign Warthin's tumor: is the MECT1-MAML2 gene fusion specific to mucuepidermoid carcinoma?. J Mol Diagn 8 3 (2006) 394-395 [author reply 395-6]
50. Kaye F.J. Emerging biology of malignant salivary gland tumors offers new insights into the classification and treatment of mucoepidermoid cancer. Clin Cancer Res 12 13 (2006) 3878-3881
51. Fehr A., Röser K., Belge G., Löning T., and Bullerdiek J. A closer look at Warthin tumors and the t(11;19). Cancer Genet Cytogenet 180 2 (2008) 135-139
52. Bell D., Luna M.A., Weber R.S., Kaye F.J., and El-Naggar A.K. CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association. Genes Chromosomes Cancer 47 4 (2008) 309-314
53. Roser K., Fehr A., Belge G., Bullerdiek J., and Schumacher U. Subtyping of carcinoma ex pleomorphic adenoma in salivary glands as mucoepidermoid carcinoma ex pleomorphic adenoma by a t(11;19) translocation assay (abstract). Oral Oncol Suppl 2 1 (2007) 223
54. Obaidat N.A., Alsaad K.O., and Ghazarian D. Skin adnexal neoplasms - part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol 60 2 (2007) 145-159
55. Gorunova L., Mertens F., Mandahl N., Jonsson N., Persson B., Heim S., et al. Cytogenetic heterogeneity in a clear cell hidradenoma of the skin. Cancer Genet Cytogenet 77 1 (1994) 26-32
56. Behboudi A., Winnes M., Gorunova L., van den Oord J.J., Mertens F., Enlund F., et al. Clear cell hidradenoma of the skin - a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer 43 2 (2005) 202-205
57. Winnes M., Molne L., Suurkula M., Andren Y., Persson F., Enlund F., et al. Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. Genes Chromosomes Cancer 46 6 (2007) 559-563
58. Kazakov D.V., Vanecek T., Belousova I.E., Mukensnabl P., Kollertova D., and Michal M. Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast. Am J Dermatopathol 29 5 (2007) 457-461
59. Hughes J.H., Volk E.E., Wilbur D.C., Cytopathology Resource Committee, and College of American Pathologists. Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Arch Pathol Lab Med 129 1 (2005) 26-31
60. Klijanienko J., and Vielh P. Fine-needle sampling of salivary gland lesions IV. Review of 50 cases of mucoepidermoid carcinoma with histologic correlation. Diagn Cytopathol 17 2 (1997) 92-98
61. Brandwein M., Ivanov K., Wallace D., Hille J.J., Wang B., Fahmy A., et al. Salivary mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol 25 (2001) 835-845
62. Goode R.K., Auclair P.L., and Ellis G.L. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer 82 7 (1998) 1217-1224
63. Ellis GL, Auclair PL. Atlas of tumor pathology. Tumors of the salivary glands. Washington (DC): Armed Forces Institute of Pathology; 1996 [Series 3, Fascicle 17].
64. McGurk M. Management of salivary gland cancer: clinically or pathologically based? Overview. In: McGurk M., and Renehan A. (Eds). Controversies in the management of salivary gland disease (2001), Oxford University Press, Oxford 155-161
65. Spiro R.H. Management of malignant tumors of the salivary glands. Oncology (Williston Park) 12 5 (1998) 671-680 [discussion 683]
66. Chen A.M., Granchi P.J., Garcia J., Bucci M.K., Fu K.K., and Eisele D.W. Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: implications for adjuvant therapy. Int J Radiat Oncol Biol Phys 67 4 (2007) 982-987
67. Laurie S.A., and Licitra L. Systemic therapy in the palliative management of advanced salivary gland cancers. J Clin Oncol 24 17 (2006) 2673-2678
68. Deininger M., Buchdunger E., and Druker B.J. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 105 7 (2005) 2640-2653
69. Gold J.S., and Dematteo R.P. Combined surgical and molecular therapy: the gastrointestinal stromal tumor model. Ann Surg 244 2 (2006) 176-184
70. Sosman J.A., Sozzi G., and Pierotti M.A. Opportunities and obstacles to combination targeted therapy in renal cell cancer. Clin Cancer Res 13 2 Pt 2 (2007) 764s-769s
71. Bicknell R. The realisation of targeted antitumour therapy. Br J Cancer 92 Suppl. 1 (2005) S2-S5
72. Gasparini P., Sozzi G., and Pierotti M.A. The role of chromosomal alterations in human cancer development. J Cell Biochem 102 2 (2007) 320-331
73. Fehr A., Roser K., Heidorn K., et al. A new type of MAML2 fusion in mucoepidermoid carcinoma. Genes Chromosomes Cancer 47 3 (2008) 203-206
74. Lannon C.L., and Sprensen P.H. TV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol 15 3 (2005) 215-323
75. Argani P., and Ladanyi M. Translocation carcinomas of the kidney. Clin Lab Med 25 2 (2005) 363-378
76. Gatenby R.A., and Vincent T.L. An evolutionary model of carcinogenesis. Cancer Res 63 19 (2003) 6212-6220
77. Demichelis F., and Rubin M.A. TMPRSS2-ETS fusion prostate cancer: biological and clinical implications. J Clin Pathol 60 11 (2007) 1185-1186