Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense

Biological Chemistry

Volumn 389, Issue 12, 2008, Pages 1513-1522

  Shaw, Julie L V ^a,b   Petraki, Constantina ^c   Watson, Carole ^a   Bocking, Alan ^a   Diamandis, Eleftherios P ^a,b,d  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c EVANGELISMOS HOSPITAL   (Greece)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Cervical mucus; Cervico vaginal fluid; Desquamation; Fertility; Kallikrein; Mucin

Indexed keywords

DEFENSIN; DESMOCOLLIN; DESMOGLEIN; KALLIKREIN 12; KALLIKREIN 5; MUCIN 4; MUCIN 5B; SERINE PROTEINASE; TISSUE KALLIKREIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FEMALE; HORMONAL REGULATION; HOST RESISTANCE; HUMAN; HUMAN CELL; MENSTRUAL CYCLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SALIVA ANALYSIS; TISSUE DISTRIBUTION; UTERINE CERVIX MUCUS;

EID: 57649134974     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2008.171     Document Type: Article

References (35)

1. Barry, M.J. (2001). Clinical practice. Prostate-specific-antigen testing for early diagnosis of prostate cancer. N. Engl. J. Med. 344, 1373-1377.
2. Bhoola, K.D., Matthews, R.W., and Roberts, F. (1978). A survey of salivary kallikrein and amylase in a population of school-girls, throughout the menstrual cycle. Clin. Sci. Mol. Med. (Suppl.) 55, 561-566.
3. Bigelow, J.L., Dunson, D.B., Stanford, J.B., Ecochard, R., Gnoth, C., and Colombo, B. (2004). Mucus observations in the fertile window: a better predictor of conception than timing of intercourse. Hum. Reprod. 19, 889-892.
4. Borgono, C.A. and Diamandis, E.P. (2004). The emerging roles of human tissue kallikreins in cancer. Nat. Rev. Cancer 4, 876-890.
5. Borgono, C.A., Michael, I.P., and Diamandis, E.P. (2004). Human tissue kallikreins: physiologic roles and applications in cancer. Mol. Cancer Res. 2, 257-280.
6. Borgono, C.A., Michael, I.P., Komatsu, N., Jayakumar, A., Kapadia, R., Clayman, G.L., Sotiropoulou, G., and Diamandis, E.P. (2007). A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. J. Biol. Chem. 282, 3640-3652.
7. Brattsand, M. and Egelrud, T. (1999). Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J. Biol. Chem. 274, 30033-30040.
8. Brattsand, M., Stefansson, K., Lundh, C., Haasum, Y., and Egelrud, T. (2005). A proteolytic cascade of kallikreins in the stratum corneum. J. Invest. Dermatol. 124, 198-203.
9. Brunelli, R., Papi, M., Arcovito, G., Bompiani, A., Castagnola, M., Parasassi, T., Sampaolese, B., Vincenzoni, F., and De Spirito, M. (2007). Globular structure of human ovulatory cervical mucus. FASEB J. 21, 3872-3876.
10. Caubet, C., Jonca, N., Brattsand, M., Guerrin, M., Bernard, D., Schmidt, R., Egelrud, T., Simon, M., and Serre, G. (2004). Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J. Invest. Dermatol. 122, 1235-1244.
11. Cole, A.M. (2006). Innate host defense of human vaginal and cervical mucosae. Curr. Top. Microbiol. Immunol. 306, 199-230.
12. Ellison, P.T. (1993). Measurements of salivary progesterone. Ann. N.Y. Acad. Sci. 694, 161-176.
13. Emami, N. and Diamandis, E.P. (2007). Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade: possible function in seminal plasma and skin. J. Biol. Chem. 283, 3031-3041.
14. Faro, S. (2004). Vaginitis, Differential Diagnosis and Management (Boca Raton, USA: The Parthenon Publishing Group).
15. Fisher, W.A., and Black, A. (2007). Contraception in Canada: a review of method choices, characteristics, adherence and approaches to counselling. Can. Med. Assoc. J. 176, 953-961.
16. Gandara, B.K., Leresche, L., and Mancl, L. (2007). Patterns of salivary estradiol and progesterone across the menstrual cycle. Ann. N.Y. Acad. Sci. 1098, 446-450.
17. Ganz, T. (2003). Defensins: antimicrobial peptides of innate immunity. Nat. Rev. Immunol. 3, 710-720.
18. Gipson, I.K. (2001). Mucins of the human endocervix. Front. Biosci. 6, D1245-D1255.
19. Hofman, L.F. (2001). Human saliva as a diagnostic specimen. J. Nutr. 131, 1621S-1625S.
20. Huggins, G.R. and Preti, G. (1981). Vaginal odors and secretions. Clin. Obstet. Gynecol. 24, 355-377.
21. Kapadia, C., Chang, A., Sotiropoulou, G., Yousef, G.M., Grass, L., Soosaipillai, A., Xing, X., Howarth, D.H., and Diamandis, E.P. (2003). Human kallikrein 13: production and purification of recombinant protein and monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay. Clin. Chem. 49, 77-86.
22. Michael, I.P., Sotiropoulou, G., Pampalakis, G., Magklara, A., Ghosh, M., Wasney, G., and Diamandis, E.P. (2005). Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression. J. Biol. Chem. 280, 14628-14635.
23. Michael, I.P., Pampalakis, G., Mikolajczyk, S.D., Malm, J., Sotiropoulou, G., and Diamandis, E.P. (2006). Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression. J. Biol. Chem. 281, 12743-12750.
24. Moghissi, K.S. (1973). Sperm migration through the human cervix. In: The Biology of the Cervix, R.J. Blandau and K. Moghissi, eds. (Chicago, IL: The University of Chicago Press), pp. 305-323.
25. Moghissi, K.S. and Syner, F.N. (1970). The effect of seminal protease on sperm migration through cervical mucus. Int. J. Fertil. 15, 43-49.
26. Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I., Andrade-Gordon, P., Cottrell, G.S., Bunnett, N.W., et al. (2006). Proteinase-activated receptors, targets for kallikrein signaling. J. Biol. Chem. 281, 32095-32112.
27. Paliouras, M. and Diamandis, E.P. (2007). Coordinated steroid hormone-dependent and independent expression of multiple kallikreins in breast cancer cell lines. Breast Cancer Res. Treat. 102, 7-18.
28. Parker, C.R. Jr. (1998). The Endocrinology of Pregnancy. B.R. Carr and R.E. Blackwell, eds. (Stamford, CT, USA: Appleton and Lange), pp. 19-44.
29. Petraki, C.D., Papanastasiou, P.A., Karavana, V.N., and Diamandis, E.P. (2006). Cellular distribution of human tissue kallikreins: immunohistochemical localization. Biol. Chem. 387, 653-663.
30. Quayle, A.J., Porter, E.M., Nussbaum, A.A., Wang, Y.M., Brabec, C., Yip, K.P., and Mok, S.C. (1998). Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am. J. Pathol. 152, 1247-1258.
31. Shaw, J.L. and Diamandis, E.P. (2007). Distribution of 15 human kallikreins in tissues and biological fluids. Clin. Chem. 53, 1423-1432.
32. Shaw, J.L., Smith, C.R., and Diamandis, E.P. (2007). Proteomic analysis of human cervico-vaginal fluid. J. Proteome Res. 6, 2859-2865.
33. Yamasaki, K., Schauber, J., Coda, A., Lin, H., Dorschner, R.A., Schechter, N.M., Bonnart, C., Descargues, P., Hovnanian, A., and Gallo, R.L. (2006). Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. FASEB J. 20, 2068-2080.
34. Yousef, G.M., Kopolovic, A.D., Elliott, M.B., and Diamandis, E.P. (2003). Genomic overview of serine proteases. Biochem. Biophys. Res. Commun. 305, 28-36.
35. Zarghami, N., Grass, L., Sauter, E.R., and Diamandis, E.P. (1997). Prostate-specific antigen in serum during the menstrual cycle. Clin. Chem. 43, 1862-1867.