Corynebacterium diphtheriae: Genome diversity, population structure and genotyping perspectives

Infection, Genetics and Evolution

Volumn 9, Issue 1, 2009, Pages 1-15

  Mokrousov, Igor ^a  

^a ST PETERSBURG PASTEUR INSTITUTE   (Russian Federation)

Author keywords

CRISPR; Diphtheria toxin; DtxR; Epidemic clone; Non toxigenic strains; VNTR

Indexed keywords

ADHESIN; DIPHTHERIA TOXIN; DIPHTHERIA VACCINE; FIMBRIA PROTEIN;

AMPLIFIED FRAGMENT LENGTH POLYMORPHISM; BACTERIAL GENETICS; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIOPHAGE; BACTERIUM IDENTIFICATION; CORYNEBACTERIUM DIPHTHERIAE; DIPHTHERIA; EPIDEMIC; GENE STRUCTURE; GENETIC HETEROGENEITY; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; HORIZONTAL GENE TRANSFER; HOST PATHOGEN INTERACTION; HUMAN; INFECTION CONTROL; IRON TRANSPORT; MOLECULAR CLONING; MOLECULAR GENETICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PERIODICITY; PHYLOGEOGRAPHY; POLYMERASE CHAIN REACTION; POPULATION STRUCTURE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVIEW; RUSSIAN FEDERATION; SOCIOECONOMICS; STRAIN DIFFERENCE; TOXIN SYNTHESIS; VACCINATION;

CORYNEBACTERIUM DIPHTHERIAE; DIPHTHERIA; DISEASE OUTBREAKS; ENDEMIC DISEASES; GENETIC TECHNIQUES; GENETIC VARIATION; GENOME, BACTERIAL; GENOTYPE; HUMANS; PERIODICITY; POLYMERASE CHAIN REACTION; RIBOTYPING; RISK FACTORS; RUSSIA; USSR;

CORYNEBACTERIUM DIPHTHERIAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 57549098966     PISSN: 15671348     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meegid.2008.09.011     Document Type: Review

References (112)

1. Alland D., Whittam T.S., Murray M.B., Cave M.D., Hazbon M.H., Dix K., Kokoris M., Duesterhoeft A., Eisen J.A., Fraser C.M., and Fleischmann R.D. Modeling bacterial evolution with comparative-genome-based marker systems: application to Mycobacterium tuberculosis evolution and pathogenesis. J. Bacteriol. 185 (2003) 3392-3399
2. Anderson J.S., Cooper K.E., Happold F.C., and McLeod J.W. Incidence and correlation with clinical severity of gravis, mitis and intermediate types of diphtheria bacillus in a series of 500 cases at Leeds. J. Pathol. Bacteriol. 36 (1933) 169-182
3. Bobkova M.R., Kombarova S.Iu., Lipis S.V., Bobkov A.F., and Mazurova I.K. The use of DNA fingerprint analysis for the differentiation of populations of toxigenic Corynebacterium diphtheriae. Zh. Mikrobiol. Epidemiol. Immunobiol. 7 (1989) 28-30 in Russian
4. Bolotin A., Quinquis B., Sorokin A., and Ehrlich S.D. Clustered regularly interspaced short palindrome repeats CRISPRs have spacers of extrachromosomal origin. Microbiology 151 (2005) 2551-2561
5. Borisova O., Kombarova S., Berens T., Narvskaya O., Vyazovaya A., and Mazurova I. Proceedings of Eighth International Meeting of the European Laboratory Working Group on Diphtheria and Diphtheria Surveillance Network DIPNET. Copenhagen, Denmark, 16-18 June 2004 (2004)
6. Boyd E.F., and Brussow H. Common themes among bacteriophage-encoded virulence factors and diversity among the bacteriophages involved. Trends Microbiol. 10 (2002) 521-529
7. Brooks G.F., Bennett J.V., and Feldman R.A. Diphtheria in the United States, 1959-1970. J. Infect. Dis. 129 (1974) 172-178
8. Brudey K., Driscoll J.R., Rigouts L., Prodinger W.M., Gori A., Al-Hajoj S.A., Allix C., Aristimuño L., Arora J., Baumanis V., Binder L., Cafrune P., Cataldi A., Cheong S., Diel R., Ellermeier C., Evans J.T., Fauville-Dufaux M., Ferdinand S., Garcia de Viedma D., Garzelli C., Gazzola L., Gomes H.M., Guttierez M.C., Hawkey P.M., van Helden P.D., Kadival G.V., Kreiswirth B.N., Kremer K., Kubin M., Kulkarni S.P., Liens B., Lillebaek T., Ho M.L., Martin C., Mokrousov I., Narvskaïa O., Ngeow Y.F., Naumann L., Niemann S., Parwati I., Rahim Z., Rasolofo-Razanamparany V., Rasolonavalona T., Rossetti M.L., Rüsch-Gerdes S., Sajduda A., Samper S., Shemyakin I.G., Singh U.B., Somoskovi A., Skuce R.A., van Soolingen D., Streicher E.M., Suffys P.N., Tortoli E., Tracevska T., Vincent V., Victor T.C., Warren R.M., Yap S.F., Zaman K., Portaels F., Rastogi N., and Sola C. Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology. BMC Microbiol. 6 (2006) 23
9. Bulat S.A., and Mironenko N.V. Species identity of the phytopathogenic fungi Pyrenophora teres Dreschler and P. graminea Ito et Kuribayashi. Mikol. Fitopatol. 24 (1990) 435-441 In Russian
10. Canchaya C., Fournous G., and Brussow H. The impact of prophages on bacterial chromosomes. Mol. Microbiol. 53 (2004) 9-18
11. Cerdeño-Tarraga A.M., Efstratiou A., Dover L.G., Holden M.T., Pallen M., Bentley S.D., Besra G.S., Churcher C., James K.D., De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K., Moule S., Quail M.A., Rabbinowitsch E., Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G., and Parkhill J. The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129. Nucleic Acids Res. 31 (2003) 6516-6523
12. Chen R.T., Broome C.V., Einstein R.A., Weaver R., and Tsai T.F. Diphtheria in the United States, 1971-81. Am. J. Public Health 75 (1985) 1393-1397
13. Cockroft W., Boyko W., and Allen D. Cutaneous infections due to Corynebacterium diphtheriae. Can. Med. Assoc. J. 108 (1973) 329-331
14. Cox M.M. A broadening view of recombinational DNA repair in bacteria. Genes Cells 3 (1998) 65-78
15. Coyle M.B., Groman N.B., Russell J.Q., Harnishc J.P., Rabin M., and Holmes K.K. The molecular epidemiology of three biotypes of Corynebacterium diphtheriae in the Seattle outbreak 1972-1982. J. Infect. Dis. 159 (1989) 670-679
16. Dale J.W., Brittain D., Cataldi A.A., Cousins D., Crawford J.T., Driscoll J., Heersma H., Lillebaek T., Quitugua T., Rastogi N., Skuce R.A., Sola C., Van Soolingen D., and Vincent V. Spacer oligonucleotide typing of bacteria of the Mycobacterium tuberculosis complex: recommendations for standardised nomenclature. Int. J. Tuberc. Lung Dis. 5 (2001) 216-219
17. Dallman T., Neal S., Green J., and Efstratiou A. Development of an online database for diphtheria molecular epidemiology under the remit of the DIPNET project. Euro Surveill. 13 (2008) 18865
18. Damian M., Grimont F., Narvskaya O., Straut M., Surdeanu M., Cojocaru R., Mokrousov I., Diaconescu A., Andronescu C., Melnic A., Mutoi L., and Grimont P.A.D. Study of Corynebacterium diphtheriae strains isolated in Romania, northwestern Russia and the Republic of Moldova. Res. Microbiol. 153 (2002) 99-106
19. De Zoysa A.S., and Efstratiou A. PCR typing of Corynebacterium diphtheriae by random amplification of polymorphic DNA. J. Med. Microbiol. 48 (1999) 335-340
20. De Zoysa A., and Efstratiou A. Use of amplified fragment length polymorphisms for typing Corynebacterium diphtheriae. J. Clin. Microbiol. 38 (2000) 3843-3845
21. De Zoysa A., and Efstratiou A. Eighth International Meeting of the European Laboratory Working Group on Diphtheria and the Diphtheria Surveillance Network - June 2004: progress is needed to sustain control of diphtheria in European Region. Euro Surveill. 9 (2004) 47-50
22. De Zoysa A., Efstratiou A., George R.C., Jahkola M., Vuopio-Varkila J., Deshevoi S., Tseneva G., and Rikushin Y. Molecular epidemiology of Corynebacterium diphtheriae from northwestern Russia and surrounding countries studied by using ribotyping and pulsed-field gel electrophoresis. J. Clin. Microbiol. 33 (1995) 1080-1083
23. De Zoysa A., Efstratiou A., and Hawkey P.M. Molecular characterisation of diphtheria toxin repressor (dtxR) genes present in non-toxigenic Corynebacterium diphtheriae isolated in the UK. J. Clin. Microbiol. 43 (2005) 223-228
24. De Zoysa A., Hawkey P., Charlett A., and Efstratiou A. Comparison of four molecular typing methods for characterization of Corynebacterium diphtheriae and determination of transcontinental spread of C. diphtheriae based on BstEII rRNA gene profiles. J. Clin. Microbiol. 46 (2008) 3626-3635
25. Dittman S., Wharton M., Vitek C., Ciotti M., Galazka A., Guichard S., et al. Successful control of epidemic diphtheria in the states of the former union of Soviet Socialist Republics: lessons learned. J. Infect. Dis. 181 (2000) S10-S22
26. Efstratiou A. Report: first international meeting of the European Laboratory Working Group in diphtheria. PHLS Microbiol. Dig. 12 (1995) 83-92
27. Efstratiou A., and George R.C. Laboratory guidelines for the diagnosis of infections caused by Corynebacterium diphtheriae and C. ulcerans. Commun. Dis. Public Health 2 (1999) 250-257
28. Efstratiou A., and Roure C. The European Laboratory Working Group on Diphtheria: a global microbiologic network. J. Infect. Dis. 181 (2000) S146-S151
29. Efstratiou A., Tiley S.M., Sangrador A., Greenacre E., Cookson B.D., Chen S.C., Mallon R., and Gilbert G.L. Invasive disease caused by multiple clones of Corynebacterium diphtheriae. Clin. Infect. Dis. 17 (1993) 136
30. Efstratiou A., Engler K.H., and De Zoysa A. Diagnosis and epidemiology of diphtheria. Methods Mol. Med. 15 (1998) 191-212
31. Eskola J., Lumio J., and Vuopio-Varkila J. Resurgent diphtheria-are we safe?. Br. Med. Bull. 54 (1998) 635-645
32. Ferretti J.J., McShan W.M., Ajdic D., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., et al. Complete genome sequence of an M1 strain of Streptococcus pyogenes. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 4658-4663
33. Galazka A. Implications of the diphtheria epidemic in the Former Soviet Union for immunization programs. J. Infect. Dis. 181 (2000) S244-S248
34. Galazka A.M., and Robertson S.E. Diphtheria: changing patterns in the developing world and the industrialized world. Eur. J. Epidemiol. 11 (1995) 107-117
35. Galazka A., Robertson S., and Oblapenko G. Resurgence of diphtheria. Eur. J. Epidemiol. 11 (1995) 95-105
36. Golaz A., Hardy I.R., Strebel P., Bisgard K.M., Vitek C., Popovic T., and Wharton M. Epidemic diphtheria in the Newly Independent States of the Former Soviet Union: implications for diphtheria control in the United States. J. Infect. Dis. 181 (2000) S237-S243
37. Grimont P.A.D. Taxotron Package (2002), Taxolab, Institut Pasteur, Paris
38. Grimont F., and Grimont P.A. Ribosomal ribonucleic acid gene restriction patterns as potential taxonomic tools. Ann. Inst. Pasteur Microbiol. 137B (1986) 165-175
39. Grimont P.A., Grimont F., Efstratiou A., De Zoysa A., Mazurova I., Ruckly C., Lejay-Collin M., Martin-Delautre S., and Regnault B. European Laboratory Working Group on Diphtheria. International nomenclature for Corynebacterium diphtheriae ribotypes. Res. Microbiol. 155 (2004) 162-166
40. Grissa I., Vergnaud G., and Pourcel C. CRISPRcompar: a website to compare clustered regularly interspaced short palindromic repeats. Nucleic Acids Res. 36 (2008) W145-W148
41. Hadfield T.L., McEvoy P., Polotsky Y., Tzinserling V.A., and Yakovlev A.A. The pathology of diphtheria. J. Infect. Dis. 181 (2000) S116-S120
42. Hentschel U., and Hacker J. Pathogenicity islands: the tip of the iceberg. Microbes Infect. 3 (2001) 545-548
43. Hermans P.W.M., van Soolingen D., Bik E.M., de Haas P.E.W., Dale J.W., and van Embden J.D.A. The insertion element IS987 from Mycobacterium bovis BCG is located in a hot spot integration region for insertion elements in Mycobacterium tuberculosis complex strains. Infect. Immun. 59 (1991) 2695-2705
44. Hogg G.G., Strachan J.E., Huayi L., Beaton S.A., Robinson P.M., and Taylor K. Non-toxigenic Corynebacterium diphtheriae biovar gravis: evidence for an invasive clone in a south-eastern Australian community. Med. J. Aust. 164 (1996) 72-75
45. Jang J., Becq J., Gicquel B., Deschavanne P., and Neyrolles O. Horizontally acquired genomic islands in the tubercle bacilli. Trends Microbiol. 16 (2008) 303-308
46. Jansen R., van Embden J.D.A., Gaastra W., and Schouls L.M. Identification of genes that are associated with DNA repeats in prokaryotes. Mol. Microbiol. 43 (2002) 1565-1575
47. Kamerbeek J., Schouls L., Kolk A., van Agterveld M., van Soolingen D., Kuijper S., Bunschoten A., Molhuizen H., Shaw R., Goyal M., and van Embden J. Rapid detection and simultaneous strain differentiation of Mycobacterium tuberculosis for diagnosis and tuberculosis control. J. Clin. Microbiol. 35 (1997) 907-914
48. Kolodkina V., Titov L., Sharapa T., Grimont F., Grimont P.A., and Efstratiou A. Molecular epidemiology of C. diphtheriae strains during different phases of the diphtheria epidemic in Belarus. BMC Infect Dis. 6 (2006) 129
49. Kombarova S., Kim C., Melnikov V., Reeves M., Borisova O., Mazurova I., and Popovic T. Rapid identification of Corynebacterium diphtheriae clonal group associated with diphtheria epidemic, Russian Federation. Emerg. Infect. Dis. 7 (2001) 133-136
50. Kombarova S.Iu., Mazurova I.K., Mel'nikov V.G., Kostiukova N.N., Volkovoi K.I., Borisova O.Iu., Platonova T.V., and Efstratiou A. Genetic structure of Corynebacterium diphtheriae strains isolated in Russia during epidemics of various intensity. Zh. Mikrobiol. Epidemiol. Immunobiol. 3 (2001) 3-8 In Russian
51. Kombarova S.Yu., Melnikov V.G., Borisova O.Yu., Platonova T.V., and Mazurova I.K. Genotype characteristics of Corynebacterium diphtheriae strains in a period of low diphtheria incidence in Russia: 1997 to 2001. Proceedings of Seventh International Meeting of the European Laboratory Working Group on Diphtheria and Diphtheria Surveillance Network DIPNET. Vienna, Austria, 12-14 June 2002 (2002)
52. Kombarova S., Zotina A., Borisova O., Narvskaya O., Limeschenko E., and Mazurova I. Circulation of toxigenic and non-toxigenic Corynebacterium diphtheriae in the period of decreasing morbidity of diphtheria in Russia. Proceedings of Eighth International Meeting of the European Laboratory Working Group on Diphtheria and Diphtheria Surveillance Network DIPNET. Copenhagen, Denmark, 16-18 June 2004 (2004)
53. Krech T., de Chastonay J., and Falsen E. Epidemiology of diphtheria: polypeptide and restriction enzyme analysis in comparison with conventional phage typing. Eur. J. Clin. Microbiol. Infect. Dis. 7 (1988) 232-237
54. Liebl W. The genus corynebacterium-nonmedical. In: Balows A., Truper H.G., Dworkin M., Harder W., and Schleicer K.H. (Eds). The Prokaryotes. 2nd ed. vol. 2 (1991), Springer-Verlag, New York 1157-1171
55. MacQueen S. Diphtheria: a changing pattern. Nurs. Times 93 (1997) 57-62
56. Markina S.A., Maksimova N.M., Vitec C.R., Bogatyreva E.Y., and Monisov A.A. Diphtheria in the Russian Federation in the 1990s. J. Infect. Dis. 181 (2000) S27-S34
57. Marston C.K., Jamieson F., Cahoon F., Lesiak G., Golaz A., Reeves M., and Popovic T. Persistence of a distinct Corynebacterium diphtheriae clonal group within two communities in the United States and Canada where diphtheria is endemic. J. Clin. Microbiol. 39 (2001) 1586-1590
58. Mattos-Guaraldi A.L., Moreira L.O., Damasco P.V., and Hirata Junior R. Diphtheria remains a threat to health in the developing world - an overview. Mem. Inst. Oswaldo Cruz 98 (2003) 987-993
59. McLeod J.W. Nomenclature in diphtheria. Br. Med. J. 1 (1945) 606-607
60. Melnikov V.G., Kombarova S.Iu., Borisova O.Iu., Volozhantsev N.V., Verevkin V.V., Volkovoi K.I., and Mazurova I.K. Corynebacterium diphtheriae nontoxigenic strain carrying the gene of diphtheria toxin. Zh. Mikrobiol. Epidemiol. Immunobiol. 1 (2004) 3-7 In Russian
61. Mojica F.J., Diez-Villasenor C., Garcia-Martinez J., and Soria E. Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J. Mol. Evol. 60 (2005) 174-182
62. Mokrousov I. Arbitrary PCR typing of Corynebacterium diphtheriae strains. PHLS Microbiol. Digest 12 (1995) 89
63. Mokrousov I. CRISPR loci in Corynebacterium diphtheriae: in silico analysis and insights into their origin, evolution and function. In: Yoshida K., and Aoki M. (Eds). DNA Transposable Elements Research (2008), Nova Science Publishers, Inc., New York 167-179
64. Mokrousov I., Grimont F., and Gimont P. PCR-ribotyping and species identification of corynebacteria. Roum. Arch. Microbiol. Immunol. 55 (1996) 38
65. Mokrousov I., Narvskaya O., Tseneva G., Mihailov N., and Popel I. Genetic typing of Corynebacterium diphtheriae strains by PCR with universal primers. Zh. Mikrobiol. Epidemiol. Immunobiol. 5 (1996) 73-76 (In Russian)
66. Mokrousov I., Narvskaya O., Limeschenko E., and Vyazovaya A. Efficient discrimination within Corynebacterium diphtheriae epidemic clone by the novel macroarray-based method. J. Clin. Microbiol. 43 (2005) 1662-1668
67. Mokrousov I., Limeschenko E., Vyazovaya A., and Narvskaya O. Corynebacterium diphtheriae spoligotyping based on combined use of two CRISPR loci. Biotechnol. J. 2 (2007) 901-906
68. Moreira L.O., Andrade A.F., Vale M.D., Souza S.M., Hirata Jr. R., Asad L.M., Asad N.R., Monteiro-Leal L.H., Previato J.O., and Mattos-Guaraldi A.L. Effects of iron limitation on adherence and cell surface carbohydrates of Corynebacterium diphtheriae strains. Appl. Environ. Microbiol. 69 (2003) 5907-5913
69. Nakamura J., Nishio Y., Ikeo K., and Gojobori T. The genome stability in Corynebacterium diphtheriae species due to lack of the recombinational repair system. Gene 317 (2003) 149-155
70. Nakao H., and Popovic T. Development of a rapid ribotyping method for Corynebacterium diphtheriae by using PCR single-strand conformation polymorphism: comparison with standard ribotyping. J. Microbiol. Methods 31 (1998) 127-134
71. Nakao H., and Popovic T. Use of random amplified polymorphic DNA for rapid molecular subtyping of Corynebacterium diphtheriae. Diagn. Microbiol. Infect. Dis. 30 (1998) 167-172
72. Nakao H., Pruckler J.M., Mazurova I.K., Narvskaia O.V., Glushkevich T., Marijevski V.F., Kravetz A.N., Fields B.S., Wachsmuth I.K., and Popovic T. Heterogeneity of diphtheria toxin gene, tox, and its regulatory element, dtxR, in Corynebacterium diphtheriae strains causing epidemic diphtheria in Russia and Ukraine. J. Clin. Microbiol. 34 (1996) 1711-1716
73. Nakao H., Mazurova I.K., Glushkevich T., and Popovic T. Analysis of heterogeneity of Corynebacterium diphtheriae toxin gene, tox, and its regulatory element, dtxR, by direct sequencing. Res. Microbiol. 148 (1997) 45-54
74. Narkevich M.I., Onishchenko G.G., Bolotovskii W.M., Pichushkov A.V., Lazikova G.F., Boiko L.S., and Sadovnikova V.N. Status of immunoprophylaxis in the USSR and ways of its improvement. Zh. Mikrobiol. Epidemiol. Immunobiol. 12 (1990) 44-50 In Russian
75. Narvskaya O., Mokrousov I., Abakumova N., Avsyukevich N., Timofeeva E., Loseva L., Kvetnaya A., and Bicenko D. Molecular epidemiology of Corynebacterium diphtheriae infection in St. Petersburg: a six-year study. Proceedings of Sixth International Meeting of the European Laboratory Working Group on Diphtheria. European Commission, Brussels (2000) 58-59
76. Narvskaya O., Timofeeva E., Limeschenko E., Loseva L., and Mokrousov I. Current situation with diphtheria in St. Petersburg, Russia. Proceedings of Seventh International Meeting of the European Laboratory Working Group on Diphtheria and Diphtheria Surveillance Network DIPNET. Vienna, Austria, 12-14 June 2002 (2002)
77. Narvskaya O., Timofeeva E., Mokrousov I., Limeschenko E., and Vyazovaya A. Molecular epidemiological surveillance of Corynebacterium diphtheriae in St. Petersburg. Proceedings of Eighth International Meeting of the European Laboratory Working Group on Diphtheria and Diphtheria Surveillance Network DIPNET. Copenhagen, Denmark, 16-18 June 2004 (2004)
78. Neal S., and Efstratiou A. DIPNET-establishment of a dedicated surveillance network for diphtheria in Europe. Euro Surveill. 12 (2007) E9-E10
79. Nishio Y., Nakamura Y., Kawarabayasi Y., Usada Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., and Gojobori T. Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens. Genome Res. 13 (2003) 1572-1579
80. Orita M., Iwahana H., Kanazawa H., Hayashi K., and Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 2766-2770
81. Pappenheimer A.M., and Murphy J.R. Studies on the molecular epidemiology of diphtheria. Lancet 2 (1983) 923-924
82. Patey O., Bimet F., Riegel P., Halioua B., Emond J.P., Dellion S., Andronescu C., Grimont P.A., and Kiredjian M. Apport des methodes de typage dans l'etude des souches de Corynebacterium diphtheriae Med. Mal. Infect. 26 (1996) 386-388
83. Popovic T., Kombarova S.Y., Reeves M.W., Nakao H., Mazurova I.K., Wharton M., Wachsmuth I.K., and Wenger J.D. Molecular epidemiology of diphtheria in Russia, 1985-1994. J. Infect. Dis. 174 (1996) 1064-1072
84. Popovic T., Kim C., Reiss J., Reeves M., Nakao H., and Golaz A. Use of molecular subtyping to document long-term persistence of Corynebacterium diphtheriae in South Dakota. J. Clin. Microbiol. 37 (1999) 1092-1099
85. Popovic T., Mazurova I.K., Efstratiou A., Vuopio-Varkila J., Reeves M.W., De Zoysa A., Glushkevich T., and Grimont P. Molecular epidemiology of diphtheria. J. Infect. Dis. 181 (2000) S168-S177
86. Pourcel C., Salvignol G., and Vergnaud G. CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Microbiology 151 (2005) 653-663
87. Rappuoli R., Perugini M., and Falsen E. Molecular epidemiology of the 1984-1986 outbreak of diphtheria in Sweden. N. Engl. J. Med. 318 (1988) 12-14
88. Reacher M., Ramsay M., White J., De Zoysa A., Efstratiou A., Mann G., Mackay A., and George R.C. Nontoxigenic Corynebacterium diphtheriae: an emerging pathogen in England and Wales?. Emerg. Infect. Dis. 6 (2000) 640-645
89. Reeves M.W., Evins G.M., Heiba A.A., Plikaytis B.D., and Farmer III J.J. Clonal nature of Salmonella typhi and its genetic relatedness to other salmonellae as shown by multilocus enzyme electrophoresis, and proposal of Salmonella bongori comb. nov. J. Clin. Microbiol. 27 (1989) 313-320
90. Regnault B., Grimont F., and Grimont P.A. Universal ribotyping method using a chemically labelled oligonucleotide probe mixture. Res. Microbiol. 148 (1997) 649-659
91. Reyes, J.F., Francis, A.R., Tanaka, M.M., submitted for publication. Models of deletion for visualizing bacterial variation: an application to tuberculosis spoligotypes.
92. Riegel P., Freitas F.I., Prevost G., Andronescu C., Bimet F., Kiredjian M., Estrangin E., Emond J.P., Dellion S., Halioua B., Monteil H., and Patey O. Comparison of traditional and molecular methods for typing nontoxigenic strains of Corynebacterium diphtheriae. Eur. J. Clin. Microbiol. Infect. Dis. 16 (1997) 610-614
93. Romney M.G., Roscoe D.L., Bernard K., Lai S., Efstratiou A., and Clarke A.M. Emergence of an invasive clone of nontoxigenic Corynebacterium diphtheriae in the urban poor population of Vancouver, Canada. J. Clin. Microbiol. 44 (2006) 1625-1629
94. Sharma N.C., Banavaliker J.N., Ranjan R., and Kumar R. Bacteriological and epidemiological characteristics of diphtheria cases in and around Delhi-a retrospective study. Indian J. Med. Res. 126 (2007) 545-552
95. Skogen V., Cherkasova V.V., Maksimova N., Marston C.K., Sjursen H., Reeves M.W., Olsvik Ø., and Popovic T. Molecular characterization of Corynebacterium diphtheriae isolates, Russia, 1957-1987. Emerg. Infect. Dis. 8 (2002) 516-518
96. Sorek R., Kunin V., and Hugenholtz P. CRISPR-a widespread system that provides acquired resistance against phages in bacteria and archaea. Nat. Rev. Microbiol. 6 (2008) 181-186
97. Sulakvelidze A., Kekelidze M., Gomelauri T., Deng Y., Khetsuriani N., Kobaidze K., De Zoysa A., Efstratiou A., Morris Jr. J.G., and Imnadze P. Diphtheria in the Republic of Georgia: use of molecular typing techniques for characterization of Corynebacterium diphtheriae strains. J. Clin. Microbiol. 37 (1999) 3265-3270
98. Tang C., Reyes J.F., Luciani F., Francis A.R., and Tanaka M.M. spolTools: online utilities for analyzing spoligotypes of the Mycobacterium tuberculosis complex. Bioinformatics 24 (2008) 2414-2415
99. Tharmaphornpilas P., Yoocharoan P., Prempree P., Youngpairoj S., Sriprasert P., and Vitek C.R. Diphtheria in Thailand in the 1990s. J. Infect. Dis. 184 (2001) 1035-1040
100. Titov L., Kolodkina V., Dronina A., Grimont F., Grimont P.A., Lejay-Collin M., de Zoysa A., Andronescu C., Diaconescu A., Marin B., and Efstratiou A. Genotypic and phenotypic characteristics of Corynebacterium diphtheriae strains isolated from patients in Belarus during an epidemic period. J. Clin. Microbiol. 41 (2003) 1285-1288
101. van Embden J.D., van Gorkom T., Kremer K., Jansen R., van Der Zeijst B.A., and Schouls L.M. Genetic variation and evolutionary origin of the direct repeat locus of Mycobacterium tuberculosis complex bacteria. J. Bacteriol. 182 (2000) 2393-2401
102. Vitek C.R., and Wharton M. Diphtheria in the former Soviet Union: reemergence of a pandemic disease. Emerg. Infect. Dis. 4 (1998) 539-550
103. Vitek C.R., Bogatyreva E.Y., and Wharton M. Diphtheria surveillance and control in the Former Soviet Union and the Newly Independent States. J. Infect. Dis. 181 (2000) S23-S26
104. Volozhantsev N.V., Bannov V.A., Krasilnikova V.M., and Efstratiou A. Mechanism of blockage of tox gene expression in NTTB Corynebacterium diphtheriae strains and reactivation of the 'silent' tox gene. Proceedings of Eighth International Meeting of the European Laboratory Working Group on Diphtheria and Diphtheria Surveillance Network DIPNET. Copenhagen, Denmark, 16-18 June 2004 (2004)
105. von Hunolstein C., Alfarone G., Scopetti F., Pataracchia M., La Valle R., Franchi F., Pacciani L., Manera A., Giammanco A., Farinelli S., Engler K., De Zoysa A., and Efstratiou A. Molecular epidemiology and characteristics of Corynebacterium diphtheriae and Corynebacterium ulcerans isolated in Italy during the 1990s. J. Med. Microbiol. 52 (2003) 181-188
106. Vos P., Hogers R., Bleeker M., Reijans M., van de Lee T., Hornes M., Frijters A., Pot J., Peleman J., Kuiper M., and Zabeau M. AFLP: a new technique for DNA fingerprinting. Nucleic Acids Res. 23 (1995) 4407-4414
107. Welsh J., and McClelland M. Fingerprinting genomes using PCR with arbitrary primers. Nucleic Acids Res. 18 (1990) 7213-7218
108. Wheeler S.M., and Morton A.R. Epidemiological observations in the Halifax epidemic. Am. J. Public Health Nations Health 32 (1942) 947-956
109. World Health Organization. Expanded programme on immunization: diphtheria outbreak in the Newly Independent States of the former USSR, 1990-94. Wkly. Epidemiol. Rec. 70 (1995) 141-144
110. World Health Organization. WHO vaccine preventable diseases monitoring system. Global Summary, November 1999 (1999), World Health Organization, Geneva, Switzerland WHO/V&B/99.17
111. Willlams J.G., Kubelik A.R., Livak K.J., Rafalski J.A., and Tingey S.V. DNA polymorphisms amplified by arbitrary primers are useful as genetic markers. Nucleic Acids Res. 18 (1990) 6531-6535
112. Zasada A.A., Zaleska M., Podlasin R.B., and Seferynska I. The first case of septicemia due to nontoxigenic Corynebacterium diphtheriae in Poland: case report. Ann. Clin. Microbiol. Antimicrob. 4 (2005) 8