Phasic hemodynamics and reverse blood flows in the aortic isthmus and pulmonary arteries of preterm lambs with pulmonary vascular dysfunction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 6, 2008, Pages

  Rolland, Pierre Henri ^a,d   De Lagausie, Pascal ^b   Stathopoulos, Euletheris ^b   Leprètre, Olivier ^b   Viudes, Gilles ^c   Gorincour, Guillaume ^a,b   Hery, Géraldine ^b   De Magnée, Catherine ^b   Paut, Olivier ^b   Guys, Jean Michel ^b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b TIMONE HOSPITAL   (France)

^c CEMAGREF   (France)

^d School of Medicine   (France)

Author keywords

Congenital diaphragmatic hernia; Endothelin receptor inhibitor; Fetal pulmonary circulation; Pulmonary reverse flows; Pulsatile impedance

Indexed keywords

ENDOTHELIN; ENDOTHELIN RECEPTOR; TEZOSENTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA FLOW; ARTERIOVENOUS SHUNT; ARTICLE; CONGENITAL DIAPHRAGM HERNIA; CONTROLLED STUDY; DRUG MECHANISM; FETUS; HEMODYNAMICS; LAMB; LUNG CIRCULATION; NONHUMAN; PRIORITY JOURNAL; PULMONARY VASCULAR DISEASE; VENOUS REFLUX;

ANIMALS; AORTA; BLOOD PRESSURE; CARDIAC OUTPUT; FETUS; GESTATIONAL AGE; HEMODYNAMICS; HERNIA, DIAPHRAGMATIC; LUNG; MICROSCOPY, ELECTRON, SCANNING; PULMONARY ARTERY; PULMONARY CIRCULATION; PULSATILE FLOW; PYRIDINES; RECEPTORS, ENDOTHELIN; REGIONAL BLOOD FLOW; SHEEP; TETRAZOLES; TIME FACTORS; VASOCONSTRICTION; VASODILATOR AGENTS;

EID: 57549083845     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00410.2008     Document Type: Article

References (63)

1. Anderson DF, Bissonnette JM, Faber JJ, Thornburg KL. Central shunt flows and pressures in the mature fetal lamb. Am J Physiol Heart Circ Physiol 241: H60-H66, 1981.
2. Balasubramaniam V, Maxey AM, Fouty BW, Abman SH. Nitric oxide augments fetal pulmonary artery endothelial cell angiogenesis in vitro. Am J Physiol Lung Cell Mol Physiol 290: L1111-L1116, 2006.
3. Bennett SH, Eldridge MW, Zaghi D, Zaghi SE, Milstein JM, Goetzman BW. Form and function of fetal and neonatal pulmonary arterial bifurcations. Am J Physiol Heart Circ Physiol 279: H3047-H3057, 2000.
4. Bennett SH, Goetzman BW, Milstein JM, Pannu JS. Role of arterial design on pulse wave reflection in a fractal pulmonary network. J Appl Physiol 80: 1033-1056, 1996.
5. Berry JL, Manoach E, Mekkaoui C, Rolland PH, Moore JE, Rachev A. Hemodynamics and wall mechanics of a compliance matching stent: in vitro and in vivo analysis. J Vasc Interv Radiol 13: 97-105, 2002.
6. Black SM, Kumar S, Wiseman D, Ravi K, Wedgwood S, Ryzhov V, Fineman JR. Pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide. Clin Hemorheol Microcircul 37: 111-120, 2007.
7. Bonnin P, Fouron JC, Teyssier G, Sonesson SE, Skoll A. Quantitative assessment of circulatory changes in the fetal aortic isthmus during progressive increase of resistance to umbilical blood flow. Circulation 88: 216-222, 1993.
8. Burrowes KS, Hunter PJ, Tawhai MH. Anatomically based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels. J Appl Physiol 99: 731-738, 2005.
9. Clozel M, Ramuz H, Clozel JP, Breu V, Hess P, Loffler BM, Coassolo P, Roux S. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther 290: 840-846, 1999.
10. Dawson CA, Krenz GS, Karau KL, Haworth ST, Hanger CC, Linehan JH. Structure-function relationships in the pulmonary arterial tree. J Appl Physiol 86: 569-583, 1999.
11. De Lagausie P, de Buys-Roessingh A, Ferkdadji L, Saada J, Aisenfisz S, Martinez-Vinson C, Fund X, Cayuela JM, Peuchmaur M, Mercier JC, Berrebi D. Endothelin receptor expression in human lungs of newborns with congenital diaphragmatic hernia. J Pathol 205: 112-118, 2005.
12. Dukarm RC, Steinhorn RH, Russell JA, Lakshminrusimha S, Swartz D, Cummings JJ. Selective type 5 phosphodiesterase inhibition alters pulmonary hemodynamics and lung liquid production in near-term fetal lambs. J Appl Physiol 99: 2331-2336, 2005.
13. Eldridge MW, Dempsey JA, Haverkamp HC, Lovering AT, Hokanson JS. Exercise-induced intrapulmonary arteriovenous shunting in healthy humans. J Appl Physiol 97: 797-805, 2004.
14. Fineman JR, Soifer SJ, Heymann MA. Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol 57: 115-134, 1995.
15. Folkesson HG, Chapin CJ, Beard LML, Ertsey R, Matthay MA, Kitterman JA. Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses. Am J Physiol Lung Cell Mol Physiol 290: L478-L484, 2006.
16. Fouron JC. The unrecognized physiological and clinical significance of the fetal aortic isthmus. Ultrasound Obstet Gynecol 22: 441-447, 2003.
17. Fouron JC, Gosselin J, miel-Tison C, Infante-Rivard C, Fouron C, Skoll A, Veilleux A. Correlation between prenatal velocity waveforms in the aortic isthmus and neurodevelopmental outcome between the ages of 2 and 4 years. Am J Obstet Gynecol 184: 630-636, 2001.
18. Fouron JC, Gosselin J, Raboisson MJ, Lamoureux J, Tison CA, Fouron C, Hudon L. The relationship between an aortic isthmus blood flow velocity index and the postnatal neurodevelopmental status of fetuses with placental circulatory insufficiency. Am J Obstet Gynecol 192: 497-503, 2005.
19. Fouron JC, Skoll A, Sonesson SE, Pfizenmaier M, Jaeggi E, Lessard M. Relationship between flow through the fetal aortic isthmus and cerebral oxygenation during acute placental circulatory insufficiency in ovine fetuses. Am J Obstet Gynecol 181: 1102-1107, 1999.
20. Fouron JC, Zarelli M, Drblik P, Lessard M. Flow velocity profile of the fetal aortic isthmus through normal gestation. Am J Cardiol 74: 483-486, 1994.
21. Gao YS, Raj JU. Role of veins in regulation of pulmonary circulation. Am J Physiol Lung Cell Mol Physiol 288: L213-L226, 2005.
22. Giraud GD, Faber JJ, Jonker SS, Davis L, Anderson DF. Effects of intravascular infusions of plasma on placental and systemic blood flow in fetal sheep. Am J Physiol Heart Circ Physiol 291: H2884-H2888, 2006.
23. Grant DA, Hollander E, Skuza EM, Fauchere JC. Interactions between the right ventricle and pulmonary vasculature in the fetus. J Appl Physiol 87: 1637-1643, 1999.
24. Graziano JN. Cardiac anomalies in patients with congenital diaphragmatic hernia and their prognosis: a report from the Congenital Diaphragmatic Hernia Study Group. J Pediatr Surg 40: 1045-1050, 2005.
25. Grover TR, Parker TA, Balasubramaniam V, Markham NE, Abman SH. Pulmonary hypertension impairs alveolarization and reduces lung growth in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 288: L648-L654, 2005.
26. Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS. The ex utero intrapartum therapy procedure for high-risk fetal lung lesions. J Pediatr Surg 40: 1038-1044, 2005.
27. Hislop AA. Airway and blood vessel interaction during lung development. J Anat 201: 325-334, 2002.
28. Hollander EH, Dobson GM, Wang JJ, Parker KH, Tyberg JV. Direct and series transmission of left atrial pressure perturbations to the pulmonary artery: a study using wave-intensity analysis. Am J Physiol Heart Circ Physiol 286: H267-H275, 2004.
29. Hollander EH, Wang JJ, Dobson GM, Parker KH, Tyberg JV. Negative wave reflections in pulmonary arteries. Am J Physiol Heart Circ Physiol 281: H895-H902, 2001.
30. Kenny JF, Plappert T, Doubilet P, Saltzman DH, Cartier M, Zollars L, Leatherman GF, St. John Sutton MG. Changes in intracardiac blood flow velocities and right and left ventricular stroke volumes with gestational age in the normal human fetus: a prospective Doppler echocardiographic study. Circulation 74: 1208-1216, 1986.
31. Laudy JA, Gaillard JL, vd Anker JN, Tibboel D, Wladimiroff JW. Doppler ultrasound imaging: a new technique to detect lung hypoplasia before birth? Ultrasound Obstet Gynecol 7: 386-392, 1996.
32. Laudy JA, Tibboel D, Robben SG, de Krijger RR, de Ridder MA, Wladimiroff JW. Prenatal prediction of pulmonary hypoplasia: clinical, biometric, and Doppler velocity correlates. Pediatrics 109: 250-258, 2002.
33. Lewis AB, Heymann MA, Rudolph AM. Gestational changes in pulmonary vascular responses in fetal lambs in utero. Circ Res 39: 536-541, 1976.
34. Lipsett J, Cool JC, Runciman SI, Ford WD, Kennedy JD, Martin AJ, Parsons DW. Morphometric analysis of preterm fetal pulmonary development in the sheep model of congenital diaphragmatic hernia. Pediatr Dev Pathol 3: 17-28, 2000.
35. Makikallio K, Erkinaro T, Niemi N, Kavasmaa T, Acharya G, Pakkila M, Rasanen J. Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model. Am J Obstet Gynecol 194: 542-550, 2006.
36. Makikallio K, Mcelhinney DB, Levine JC, Marx GR, Colan SD, Marshall AC, Lock JE, Marcus EN, Tworetzky W. Fetal aortic valve stenosis and the evolution of hypoplastic left heart syndrome: patient selection for fetal intervention. Circulation 113: 1401-1405, 2006.
37. McMullan DM, Hanley FL, Cohen GA, Portman MA, Riemer RK. Pulmonary arteriovenous shunting in the normal fetal lung. J Am Coll Cardiol 44: 1497-1500, 2004.
38. Mekkaoui C, Friggi A, Rolland PH, Bodard H, Piquet P, Bartoli JM, Mesana T. Simultaneous measurements of arterial diameter and blood pressure to determine the arterial compliance, wall mechanics and stresses in vivo. Eur J Vasc Endovasc Surg 21: 208-213, 2001.
39. Mekkaoui C, Rolland PH, Friggi A, Rasigni M, Mesana TG. Pressureflow loops and instantaneous input impedance in the thoracic aorta: another way to assess the effect of aortic bypass graft implantation on myocardial, brain, and subdiaphragmatic perfusion. J Thorac Cardiovasc Surg 125: 699-710, 2003.
40. Mitchell JR, Whitelaw WA, Sas R, Smith ER, Tyberg JV, Belenkie I. RV filling modulates LV function by direct ventricular interaction during mechanical ventilation. Am J Physiol Heart Circ Physiol 289: H549-H557, 2005.
41. Motte S, McEntee K, Naeije R. Endothelin receptor antagonists. Pharmacol Ther 110: 386-414, 2006.
42. Oishi P, Azakie A, Harmon C, Fitzgerald RK, Grobe A, Xu J, Hendricks-Munoz K, Black SM, Fineman JR. Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs. Am J Physiol Heart Circ Physiol 290: H1922-H1932, 2006.
43. Ovadia B, Reinhartz O, Fitzgerald R, Bekker JM, Johengen MJ, Azakie A, Thelitz S, Black SM, Fineman JR. Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol 284: H480-H490, 2003.
44. Piquet P, Rolland PH, Bartoli JM, Tranier P, Moulin G, Mercier C. Tantalum-Dacron coknit stent for endovascular treatment of aortic aneurysms: a preliminary experimental study. J Vasc Surg 19: 698-706, 1994.
45. Polglase GR, Morley CJ, Crossley KJ, Dargaville P, Harding R, Morgan DL, Hooper SB. Positive end-expiratory pressure differentially alters pulmonary hemodynamics and oxygenation in ventilated, very premature lambs. J Appl Physiol 99: 1453-1461, 2005.
46. Polglase GR, Wallace MJ, Morgan DL, Hooper SB. Increases in lung expansion alter pulmonary hemodynamics in fetal sheep. J Appl Physiol 101: 273-282, 2006.
47. Reddy VM, Meyrick B, Wong J, Khoor A, Liddicoat JR, Hanley FL, Fineman JR. In utero placement of aortopulmonary shunts. A model of postnatal pulmonary-hypertension with increased pulmonary blood-flow in lambs. Circulation 92: 606-613, 1995.
48. Rolland PH, Charifi AB, Verrier C, Bodard H, Friggi A, Piquet P, Moulin G, Bartoli JM. Hemodynamics and wall mechanics after stent placement in swine iliac arteries: comparative results from six stent designs. Radiology 213: 229-246, 1999.
49. Rolland PH, Friggi A, Barlatier A, Piquet P, Latrille V, Faye MM, Guillou J, Charpiot P, Bodard H, Ghiringhelli O, Calaf R, Luccioni R, GarçHyperhomocysteinemia-induced vascular damage in the minipig. Captopril-hydrochlorothiazide combination prevents elastic alterations. Circulation 91: 1161-1174, 1995.
50. Rolland PH, Mekkaoui C, Vidal V, Berry JL, Moore JE, Moreno M, Amabile P, Bartoli JM. Compliance matching stent placement in the carotid artery of the swine promotes optimal blood flow and attenuates restenosis. Eur J Vasc Endovasc Surg 28: 431-438, 2004.
51. Rudolph AM, Heymann MA. Circulatory changes during growth in the fetal lamb. Circ Res 26: 289-299, 1970.
52. Rudolph AM, Heymann MA. The circulation of the fetus in utero. Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 21: 163-184, 1967.
53. Said SI. Mediators and modulators of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 291: L547-L558, 2006.
54. Schmidt KG, Silverman NH, Rudolph AM. Phasic flow events at the aortic isthmus-ductus arteriosus junction and branch pulmonary artery evaluated by multimodal ultrasonography in fetal lambs. Am J Obstet Gynecol 179: 1338-1347, 1998.
55. Schwid HA. Frequency response evaluation of radial artery catheter-anometer systems: sinusoidal frequency analysis versus flush method. J Clin Monit 4: 181-185, 1988.
56. Shaw AM, Bunton DC, Fisher A, McGrath JC, Montgomery I, Daly C, MacDonald A. V-shaped cushion at the origin of bovine pulmonary supernumerary arteries: structure and putative function. J Appl Physiol 87: 2348-2356, 1999.
57. Sonesson SE, Fouron JC. Doppler velocimetry of the aortic isthmus in human fetuses with abnormal velocity waveforms in the umbilical artery. Ultrasound Obstet Gynecol 10: 107-111, 1997.
58. Stenmark KR, Abman SH. Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia. Annu Rev Physiol 67: 623-661, 2005.
59. Tchirikov M, Hecher K, Deprest J, Verbeken E, Roubliova X, Schroder HJ. Pulmonary circulation of fetal sheep with lung hyperplasia following tracheal occlusion. Ultrasound Obstet Gynecol 25: 277-281, 2005.
60. Thébaud B, Azancot A, de Lagausie P, Vuillard E, Ferkadji L, Benali K, Beaufils F. Congenital diaphragmatic hernia: antenatal prognostic factors. Does cardiac ventricular disproportion in utero predict outcome and pulmonary hypoplasia? Intensive Care Medicine 23: 1062-1069, 1997.
61. Thébaud B, de Lagausie P, Forgues D, Aigrain Y, Mercier JC, Tuan AD. ETA-receptor blockade and ETB-receptor stimulation in experimental congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol 278: L923-L932, 2000.
62. Thébaud B, Ladha F, Michelakis ED, Sawicka M, Thurston G, Eaton F, Hashimoto K, Harry G, Haromy A, Korbutt G, Archer SL. Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation 112: 2477-2486, 2005.
63. Tibboel D, Shehata SM, Guldemeester AH. The pulmonary vasculature in congenital diaphragmatic hernia. Fetal and neonatal pulmonary. Circulation 355-378, 2000.