Selective type 5 phosphodiesterase inhibition alters pulmonary hemodynamics and lung liquid production in near-term fetal lambs

Journal of Applied Physiology

Volumn 99, Issue 6, 2005, Pages 2331-2336

  Dukarm, Robert C ^a   Steinhorn, Robin H ^a   Russell, James A ^a   Lakshminrusimha, Satyan ^a   Swartz, Daniel ^a   Cummings, James J ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b NONE   (United States)

Author keywords

Birth transition; Fetus; Guanosine 5 monophosphate; Phosphodiesterase; Pulmonary circulation

Indexed keywords

1 [6 CHLORO 4 (3,4 METHYLENEDIOXYBENZYLAMINO) 2 QUINAZOLINYL] 4 PIPERIDINECARBOXYLIC ACID; CYCLIC GMP; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; FETUS; FETUS LUNG; HEART RATE; HEMODYNAMIC PARAMETERS; LAMB; LUNG ARTERY; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; LUNG CIRCULATION; LUNG VASCULAR RESISTANCE; LUNG VEIN; NONHUMAN; PRIORITY JOURNAL; SHEEP;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; BLOOD FLOW VELOCITY; BRONCHOALVEOLAR LAVAGE FLUID; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRAVASCULAR LUNG WATER; LUNG; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERIDINES; PULMONARY CIRCULATION; QUINAZOLINES; SHEEP;

EID: 28044447610     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00120.2005     Document Type: Article

References (53)

1. Abman SH, Chatfield BA, Hall SL, and McMurtry IP. Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol Heart Circ Physiol 259: H1921-H1927, 1990.
2. Avery ME, Gatewood OB, and Brumley G. Transient tachypnea of the newborn. Am J Dis Child 111: 380-385, 1966.
3. Barker PM, Brown MJ, Ramsden CA, Strang LB, and Walters DV. The effect of thyroidectomy in the fetal sheep on lung liquid resorption induced by adrenaline or cyclic AMP. J Physiol 407: 373-383, 1988.
4. Beavo JA. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 75: 725-748, 1995.
5. Bland R, Hansen T, Haberkern C, Bressack M, Hazinski T, Raj J, and Goldberg R. Lung fluid balance in lambs before and after birth. J Appl Physiol 53: 992-1004, 1982.
6. Bland RD. Lung epithelial ion transport and fluid movement during the perinatal period. Am J Physiol Lung Cell Mol Physiol 259: L30-L37, 1990.
7. Boucher RC and Gatzy JT. Characteristics of sodium transport by excised rabbit trachea. J Appl Physiol 55: 1877-1883, 1983.
8. Braner DA, Fineman JR, Chang R, and Soifer SJ. M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs. Am J Physiol Heart Circ Physiol 264: H252-H258, 1993.
9. Cassin S. Effect of indomethacin on fetal lung liquid formation. Can J Physiol Pharmacol 62: 157-159, 1984.
10. Cassin S. Role of prostaglandins, thromboxanes, and leukotrienes in the control of the pulmonary circulation in the fetus and newborn. Semin Perinatal 11: 53-63, 1987.
11. Cassin S, DeMarco V, Perks A, Kuck H, and Ellis T. Regulation of lung liquid secretion in immature fetal sheep: hormonal interaction. J Appl Physiol 77: 1445-1450, 1994.
12. Cassin S and Perks A. Estimation of lung liquid production in fetal sheep with blue dye dextran and radioiodinated serum albumin. J Appl Physiol 92: 1531-1538, 2001.
13. Chapman DL, Carlton DP, Nielson DW, Cummings JJ, Poulain FR, and Bland RD. Changes in lung liquid during spontaneous labor in fetal sheep. J Appl Physiol 76: 523-530, 1994.
14. Cohen AH, Morris K, McMurtry IF, and Rodman DM. The cyclic guanylate monophosphate phosphodiesterase inhibitor E4021 is a pulmonary vasodilator in vitro and in vivo (Abstract). Am J Respir Crit Care Med 151: A626, 1995.
15. Cornfield DN, Chatfield BA, McQueston JA, McMurtry IF, and Abman SH. Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus. Am J Physiol Heart Circ Physiol 262: H1474-H1481, 1992.
16. Cott G, Sugahara K, and Mason R. Stimulation of net active ion transport across type II cell monolayers. Am J Physiol Cell Physiol 250: C222-C227, 1986.
17. Cummings JJ. Nitric oxide decreases lung liquid production in fetal lambs. J Appl Physiol 83: 1538-1544, 1997.
18. Cummings JJ. Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep. J Appl Physiol 79: 1212-1218, 1995.
19. Cummings JJ and Wang H. Nitric oxide decreases lung liquid production via guanosine 3′, 5′-cyclic monophosphate. Am J Physiol Lung Cell Mol Physiol 280: L929-L929, 2001.
20. Dukarm RC, Russell JA, Morin FC III, Perry BJ, and Steinhorn RH. The cGMP-specific phosphodiesterase inhibitor E4021 dilates the pulmonary circulation. Am J Respir Crit Care Med 160: 858-865, 1999.
21. Enhorning G, Chamberlain D, Contreras C, Burgoyne R, and Robertson B. Isoxsuprine-induced release of pulmonary surfactant in the rabbit fetus. Am J Obstet Gynecol 129: 197-202, 1977.
22. Fineman JR, Soifer SJ, and Heymann MA. The role of pulmonary vascular endothelium in perinatal pulmonary circulatory regulation. Semin Perinatal 15: 58-62, 1991.
23. Gao Y, Zhou H, and Raj JU. Heterogeneity in role of endothelium-derived NO in pulmonary arteries and veins of full-term fetal lambs. Am J Physiol Heart Circ Physiol 268: H1586-H1592, 1995.
24. Hanson K, Burns F, Rybalkin S, Miller J, Beavo J, and Clarke W. Developmental changes in lung cGMP phosphodiesterase-5 activity, protein, and message. Am J Respir Crit Care Med 158: 279-288, 1998.
25. Heymann MA. Control of the pulmonary circulation in the perinatal period. J Dev Physiol 6: 281-290, 1984.
26. Ichinose F, Adrie C, Hurford WE, and Zapol WM. Prolonged pulmonary vasodilator action of inhaled nitric oxide by zaprinast in awake lambs. J Appl Physiol 78: 1288-1295, 1995.
27. Kinsella JP, Torielli F, Ziegler JW, Ivy DD, and Abman SH. Dipyridamole augmentation of response to nitric oxide. Lancet 346: 647-648, 1995.
28. Kitterman JA. Fetal lung development. J Dev Physiol 6: 67-82, 1984.
29. Lakshminrusimha S, D'Angelis CA, Russell JA, Nielsen LC, Gugino SF, Nickerson PA, and Steinhorn RH. C-type natriuretic peptide system in fetal ovine pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol 281: L361-L368, 2001.
30. Lawson E, Brown E, Torday J, Madansky D, and Taeusch H. The effect of epinephrine on tracheal fluid flow and surfactant efflux in fetal sheep. Am Rev Respir Dis 118: 1023-1026, 1978.
31. Leffler CW, Hessler JR, and Green RS. The onset of breathing at birth stimulates pulmonary vascular prostacyclin synthesis. Pediatr Res 18: 938-942, 1984.
32. Morin FC III and Tiktinsky MH. Oxygenation increases fetal pulmonary blood flow via endothelium dependent vasodilation (Abstract). Pediatr Res 31: 1405A, 1992.
33. Perks AM and Cassin S. The effects of arginine vasopressin and other factors on the production of lung fluid in fetal goats. Chest 81: 63-65, 1982.
34. Pfister RE, Ramsden CA, Neil HL, Kyriakides MA, and Berger PJ. Errors in estimating lung liquid volume in fetal lambs when using radiolabeled serum albumin and blue dextran. J Appl Physiol 87: 2366-2374, 1999.
35. Rairigh RL, Cras TDL, Ivy DD, Kinsella JP, Richter G, Horan MP, Fan ID, and Abman SH. Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus. J Clin Invest 101: 15-21, 1998.
36. Rairigh RL, Storme L, Parker TA, Le Cras TD, Markham N, Jakkula M, and Abman SH. Role of neuronal nitric oxide synthase in regulation of vascular and ductus arteriosus tone in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 278: L105-L110, 2000.
37. Rudolph AM. Fetal and neonatal pulmonary circulation. Am Rev Respir Dis 115: 11-18, 1977.
38. Rudolph AM, Heymann MA, and Lewis AB. Physiology and pharmacology of the pulmonary circulation in the fetus and newborn. Development of the Lung, edited by Hodson WA. New York: Dekker, 1977, p. 497-523.
39. Rybalkin SD, Yan C, Bornfeldt KE, and Beavo JA. Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ Res 93: 280-291, 2003.
40. Sanchez L, de la Monte S, Filippov G, Jones R, Zapol W, and Bloch K. Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr Res 43: 163-168, 1998.
41. Skimming J, DeMarco V, Kadowitz P, and Cassin S. Effects of zaprinast and dissolved nitric oxide on the pulmonary circulation of fetal sheep. Pediatr Res 39: 223-228, 1996.
42. 2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension. J Pediatr 112: 774-777, 1988.
43. Steinhorn RH, Dukarm RC, Morin FC III, Gugino SF, and Russell JA. Dipyridamole enhances relaxations and cGMP generation to nitric oxide in lambs with persistent pulmonary hypertension (Abstract). Pediatr Res 39: 351A, 1996.
44. Steinhorn RH, Morin FC III, Gugino SF, Giese EC, and Russell JA. Developmental differences in endothelium-dependent responses in isolated ovine pulmonary arteries and veins. Am J Physiol Heart Circ Physiol 264: H2162-H2167, 1993.
45. Steinhorn RH, Russell JA, and Morin IIIF. Disruption of cyclic GMP production in pulmonary arteries isolated from fetal lambs with pulmonary hypertension. Am J Physiol Heart Circ Physiol 268: H1483-H1489, 1995.
46. Strang LB. Fetal lung liquid: secretion and reabsorption. Physiol Rev 71: 991-1016, 1991.
47. Teitel DF, Iwamoto HS, and Rudolph AM. Changes in the pulmonary circulation during birth-related events. Pediatr Res 27: 372-378, 1990.
48. Thusu KG, Morin FC, Russell JA, and Steinhorn RH. The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide. Am J Respir Crit Care Med 152: 1605-1610, 1995.
49. Walters DV and Olver RE. The role of catecholamines in lung liquid absorption at birth. Pediatr Res 12: 239-242, 1978.
50. Weibel ER. Design of airways and blood vessels considered as branching trees. The Lung: Scientific Foundations, edited by Crystal RG and West JB. New York: Raven, 1991, p. 711.
51. Woods B, Ng W, Thakorlal D, Liu A, and Perks A. Effects of acetylcholine on lung liquid production by in vitro lungs from fetal guinea pigs. Can J Physiol Pharmacol 74: 918-927, 1996.
52. Ziegler J, Ivy D, Fox J, Kinsella J, Clarke W, and Abman S. Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus. Am J Physiol Heart Circ Physiol 269: H473-H479, 1995.
53. Ziegler JW, Ivy DD, Kinsella JP, Clarke WR, and Abman SH. Dipyridamole, a cGMP phosphodiesterase inhibitor, augments inhaled nitric oxide-induce pulmonary vasodilation in the ovine transitional circulation (Abstract). Pediatr Res 35: 90A, 1994.