-
1
-
-
0032023777
-
Protein radicals in enzyme catalysis
-
Stubbe, J., and van der Donk, W. A. (1998) Protein radicals in enzyme catalysis. Chem. Rev. 98, 705-762.
-
(1998)
Chem. Rev
, vol.98
, pp. 705-762
-
-
Stubbe, J.1
van der Donk, W.A.2
-
3
-
-
35448984575
-
Enhanced subunit interactions with gemcitabine-5′-diphosphate inhibit ribonucleotide reductases
-
Wang, J., Lohman, G. J. S., and Stubbe, J. (2007) Enhanced subunit interactions with gemcitabine-5′-diphosphate inhibit ribonucleotide reductases. Proc. Natl. Acad. Sci. U.S.A. 104, 14324-14329.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A
, vol.104
, pp. 14324-14329
-
-
Wang, J.1
Lohman, G.J.S.2
Stubbe, J.3
-
4
-
-
0014694233
-
Ribonucleoside diphosphate reductase: Formation of active and inactive complexes of proteins B1 and B2
-
Brown, N. C., and Reichard, P. (1969) Ribonucleoside diphosphate reductase: Formation of active and inactive complexes of proteins B1 and B2. J. Mol. Biol. 46, 25-38.
-
(1969)
J. Mol. Biol
, vol.46
, pp. 25-38
-
-
Brown, N.C.1
Reichard, P.2
-
5
-
-
0015850211
-
Physicochemical characterization of ribonucleoside diphosphate reductase from Escherichia coli
-
Thelander, L. (1973) Physicochemical characterization of ribonucleoside diphosphate reductase from Escherichia coli. J. Biol. Chem. 248, 4591-4601.
-
(1973)
J. Biol. Chem
, vol.248
, pp. 4591-4601
-
-
Thelander, L.1
-
6
-
-
0017615856
-
Nature of free-radical in ribonucleotide reductase from Escherichia coli
-
Sjöberg, B. M., Reichard, P., Gräslund, A., and Ehrenberg, A. (1977) Nature of free-radical in ribonucleotide reductase from Escherichia coli. J. Biol. Chem. 252, 536-541.
-
(1977)
J. Biol. Chem
, vol.252
, pp. 536-541
-
-
Sjöberg, B.M.1
Reichard, P.2
Gräslund, A.3
Ehrenberg, A.4
-
7
-
-
0018135309
-
Tyrosine free-radical in ribonucleotide reductase from Escherichia coli
-
Sjöberg, B. M., Reichard, P., Gräslund, A., and Ehrenberg, A. (1978) Tyrosine free-radical in ribonucleotide reductase from Escherichia coli. J. Biol. Chem. 253, 6863-6865.
-
(1978)
J. Biol. Chem
, vol.253
, pp. 6863-6865
-
-
Sjöberg, B.M.1
Reichard, P.2
Gräslund, A.3
Ehrenberg, A.4
-
8
-
-
0028486194
-
Structure of ribonucleotide reductase protein R1
-
Uhlin, U., and Eklund, H. (1994) Structure of ribonucleotide reductase protein R1. Nature 370, 533-539.
-
(1994)
Nature
, vol.370
, pp. 533-539
-
-
Uhlin, U.1
Eklund, H.2
-
9
-
-
33646176383
-
The first holocomplex structure of ribonucleotide reductase gives new insight into its mechanism of action
-
Uppsten, M., Farnegardh, M., Domkin, V., and Uhlin, U. (2006) The first holocomplex structure of ribonucleotide reductase gives new insight into its mechanism of action. J. Mol. Biol. 359, 365-377.
-
(2006)
J. Mol. Biol
, vol.359
, pp. 365-377
-
-
Uppsten, M.1
Farnegardh, M.2
Domkin, V.3
Uhlin, U.4
-
10
-
-
0035544604
-
Structure and function of the radical enzyme ribonucleotide reductase
-
Eklund, H., Uhlin, U., Farnegardh, M., Logan, D. T., and Nordlund, P. (2001) Structure and function of the radical enzyme ribonucleotide reductase. Prog. Biophys. Mol. Biol. 77, 177-268.
-
(2001)
Prog. Biophys. Mol. Biol
, vol.77
, pp. 177-268
-
-
Eklund, H.1
Uhlin, U.2
Farnegardh, M.3
Logan, D.T.4
Nordlund, P.5
-
11
-
-
0027283896
-
Structure and function of the Escherichia coli ribonucleotide reductase protein R2
-
Nordlund, P., and Eklund, H. (1993) Structure and function of the Escherichia coli ribonucleotide reductase protein R2. J. Mol. Biol. 232, 123-164.
-
(1993)
J. Mol. Biol
, vol.232
, pp. 123-164
-
-
Nordlund, P.1
Eklund, H.2
-
12
-
-
0025293287
-
Three-dimensional structure of the free radical protein of ribonucleotide reductase
-
Nordlund, P., Sjöberg, B. M., and Eklund, H. (1990) Three-dimensional structure of the free radical protein of ribonucleotide reductase. Nature 345, 593-598.
-
(1990)
Nature
, vol.345
, pp. 593-598
-
-
Nordlund, P.1
Sjöberg, B.M.2
Eklund, H.3
-
13
-
-
0031571616
-
Binding of allosteric effectors to ribonucleotide reductase protein R1: Reduction of active-site cysteines promotes substrate binding
-
Eriksson, M., Uhlin, U., Ramaswamy, S., Ekberg, M., Regnstrom, K., Sjöberg, B. M., and Eklund, H. (1997) Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure 5, 1077-1092.
-
(1997)
Structure
, vol.5
, pp. 1077-1092
-
-
Eriksson, M.1
Uhlin, U.2
Ramaswamy, S.3
Ekberg, M.4
Regnstrom, K.5
Sjöberg, B.M.6
Eklund, H.7
-
14
-
-
27544491667
-
EPR distance measurements support a model for long-range radical initiation in Escherichia coli ribonucleotide reductase
-
Bennati, M., Robblee, J. H., Mugnaini, V., Stubbe, J., Freed, J. H., and Borbat, P. (2005) EPR distance measurements support a model for long-range radical initiation in Escherichia coli ribonucleotide reductase. J. Am. Chem. Soc. 127, 15014-15015.
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 15014-15015
-
-
Bennati, M.1
Robblee, J.H.2
Mugnaini, V.3
Stubbe, J.4
Freed, J.H.5
Borbat, P.6
-
15
-
-
37549042071
-
PELDOR spectroscopy with DOPA-β2 and NH2Y-α2s: Distance measurements between residues involved in the radical propagation pathway of Escherichia coli ribonucleotide reductase
-
Seyedsayamdost, M. R., Chan, C. T. Y., Mugnaini, V., Stubbe, J., and Bennati, M. (2007) PELDOR spectroscopy with DOPA-β2 and NH2Y-α2s: Distance measurements between residues involved in the radical propagation pathway of Escherichia coli ribonucleotide reductase. J. Am. Chem. Soc. 129, 15748-15749.
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 15748-15749
-
-
Seyedsayamdost, M.R.1
Chan, C.T.Y.2
Mugnaini, V.3
Stubbe, J.4
Bennati, M.5
-
16
-
-
0022455333
-
Specific-inhibition of herpesvirus ribonucleotide reductase by a nonapeptide derived from the carboxy terminus of subunit-2
-
Cohen, E. A., Gaudreau, P., Brazeau, P., and Langelier, Y. (1986) Specific-inhibition of herpesvirus ribonucleotide reductase by a nonapeptide derived from the carboxy terminus of subunit-2. Nature 321, 441-443.
-
(1986)
Nature
, vol.321
, pp. 441-443
-
-
Cohen, E.A.1
Gaudreau, P.2
Brazeau, P.3
Langelier, Y.4
-
17
-
-
0038796547
-
Oligopeptide inhibition of class I ribonucleotide reductases
-
Cooperman, B. S. (2003) Oligopeptide inhibition of class I ribonucleotide reductases. Biopolymers 71, 117-131.
-
(2003)
Biopolymers
, vol.71
, pp. 117-131
-
-
Cooperman, B.S.1
-
18
-
-
0025851264
-
Carboxyl-terminal peptides as probes for Escherichia coli ribonucleotide reductase subunit interaction - kinetic-analysis of inhibition studies
-
Climent, I., Sjöberg, B. M., and Huang, C. Y. (1991) Carboxyl-terminal peptides as probes for Escherichia coli ribonucleotide reductase subunit interaction - kinetic-analysis of inhibition studies. Biochemistry 30, 5164-5171.
-
(1991)
Biochemistry
, vol.30
, pp. 5164-5171
-
-
Climent, I.1
Sjöberg, B.M.2
Huang, C.Y.3
-
19
-
-
0029896950
-
A kinetic study on the influence of nucleoside triphosphate effectors on subunit interaction in mouse ribonucleotide reductase
-
Ingemarson, R., and Thelander, L. (1996) A kinetic study on the influence of nucleoside triphosphate effectors on subunit interaction in mouse ribonucleotide reductase. Biochemistry 35, 8603-8609.
-
(1996)
Biochemistry
, vol.35
, pp. 8603-8609
-
-
Ingemarson, R.1
Thelander, L.2
-
20
-
-
3843050352
-
Enhancement by effectors and substrate nucleotides of R1-R2 interactions in Escherichia coli class Ia ribonucleotide reductase
-
Kasrayan, A., Birgander, P. L., Pappalardo, L., Regnstrom, K., Westman, M., Slaby, A., Gordon, E., and Sjöberg, B. M. (2004) Enhancement by effectors and substrate nucleotides of R1-R2 interactions in Escherichia coli class Ia ribonucleotide reductase. J. Biol. Chem. 279, 31050-31057.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 31050-31057
-
-
Kasrayan, A.1
Birgander, P.L.2
Pappalardo, L.3
Regnstrom, K.4
Westman, M.5
Slaby, A.6
Gordon, E.7
Sjöberg, B.M.8
-
21
-
-
0026652152
-
Site-directed mutagenesis and deletion of the carboxyl terminus of Escherichia coli ribonucleotide reductase protein R2 - effects on catalytic activity and subunit interaction
-
Climent, I., Sjöberg, B. M., and Huang, C. Y. (1992) Site-directed mutagenesis and deletion of the carboxyl terminus of Escherichia coli ribonucleotide reductase protein R2 - effects on catalytic activity and subunit interaction. Biochemistry 31, 4801-4807.
-
(1992)
Biochemistry
, vol.31
, pp. 4801-4807
-
-
Climent, I.1
Sjöberg, B.M.2
Huang, C.Y.3
-
22
-
-
0021811719
-
Direct cloning of the trxB gene that encodes thioredoxin reductase
-
Russel, M., and Model, P. (1985) Direct cloning of the trxB gene that encodes thioredoxin reductase. J. Bacteriol. 163, 238-242.
-
(1985)
J. Bacteriol
, vol.163
, pp. 238-242
-
-
Russel, M.1
Model, P.2
-
23
-
-
0021256117
-
Amplification and purification of plasmid-encoded thioredoxin from Escherichia coli K12
-
Lunn, C. A., Kathju, S., Wallace, B. J., Kushner, S. R., and Pigiet, V. (1984) Amplification and purification of plasmid-encoded thioredoxin from Escherichia coli K12. J. Biol. Chem. 259, 10469-10474.
-
(1984)
J. Biol. Chem
, vol.259
, pp. 10469-10474
-
-
Lunn, C.A.1
Kathju, S.2
Wallace, B.J.3
Kushner, S.R.4
Pigiet, V.5
-
24
-
-
0348111211
-
Generation of the β2 subunit of ribonucleotide reductase by intein chemistry: Insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process
-
Yee, C. S., Seyedsayamdost, M. R., Chang, M. C. Y., Nocera, D. G., and Stubbe, J. (2003) Generation of the β2 subunit of ribonucleotide reductase by intein chemistry: Insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process. Biochemistry 42, 14541-14552.
-
(2003)
Biochemistry
, vol.42
, pp. 14541-14552
-
-
Yee, C.S.1
Seyedsayamdost, M.R.2
Chang, M.C.Y.3
Nocera, D.G.4
Stubbe, J.5
-
25
-
-
0034645606
-
Mechanism of rapid electron transfer during oxygen activation in the R2 subunit of Escherichia coli ribonucleotide reductase. 1. Evidence for a transient tryptophan radical
-
Baldwin, J., Krebs, C., Ley, B. A., Edmondson, D. E., Huynh, B. H., and Bollinger, J. M. J. (2000) Mechanism of rapid electron transfer during oxygen activation in the R2 subunit of Escherichia coli ribonucleotide reductase. 1. Evidence for a transient tryptophan radical. J. Am. Chem. Soc. 122, 12195-12206.
-
(2000)
J. Am. Chem. Soc
, vol.122
, pp. 12195-12206
-
-
Baldwin, J.1
Krebs, C.2
Ley, B.A.3
Edmondson, D.E.4
Huynh, B.H.5
Bollinger, J.M.J.6
-
26
-
-
0029157059
-
-
Bollinger, J. M., Tong, W. H., Ravi, N., Huynh, B. H., Edmondson, D. E., and Stubbe, J. (1995) Use of rapid kinetics methods to study the assembly of the diferric-tyrosyl radical cofactor of Escherichia coli ribonucleotide reductase, in. Methods Enzymol. 258, 278-303.
-
Bollinger, J. M., Tong, W. H., Ravi, N., Huynh, B. H., Edmondson, D. E., and Stubbe, J. (1995) Use of rapid kinetics methods to study the assembly of the diferric-tyrosyl radical cofactor of Escherichia coli ribonucleotide reductase, in. Methods Enzymol. 258, 278-303.
-
-
-
-
27
-
-
0026801085
-
A model for the role of multiple cysteine residues involved in ribonucleotide reduction - amazing and still confusing
-
Mao, S. S., Holler, T. P., Yu, G. X., Bollinger, J. M., Booker, S., Johnston, M. I., and Stubbe, J. (1992) A model for the role of multiple cysteine residues involved in ribonucleotide reduction - amazing and still confusing. Biochemistry 31, 9733-9743.
-
(1992)
Biochemistry
, vol.31
, pp. 9733-9743
-
-
Mao, S.S.1
Holler, T.P.2
Yu, G.X.3
Bollinger, J.M.4
Booker, S.5
Johnston, M.I.6
Stubbe, J.7
-
28
-
-
0014759788
-
A rapid assay for CDP reductase activity in mammalian cell extracts
-
Steeper, J. R., and Steuart, C. D. (1970) A rapid assay for CDP reductase activity in mammalian cell extracts. Anal. Biochem. 34, 123-130.
-
(1970)
Anal. Biochem
, vol.34
, pp. 123-130
-
-
Steeper, J.R.1
Steuart, C.D.2
-
29
-
-
0344493928
-
Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction
-
Kenny, C. H., Ding, W. D., Kelleher, K., Benard, S., Dushin, E. G., Sutherland, A. G., Mosyak, L., Kriz, R., and Ellestad, G. (2003) Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction. Anal. Biochem. 323, 224-233.
-
(2003)
Anal. Biochem
, vol.323
, pp. 224-233
-
-
Kenny, C.H.1
Ding, W.D.2
Kelleher, K.3
Benard, S.4
Dushin, E.G.5
Sutherland, A.G.6
Mosyak, L.7
Kriz, R.8
Ellestad, G.9
-
30
-
-
0030023342
-
Spectral properties of environmentally sensitive probes associated with horseradish peroxidase
-
Lasagna, M., Vargas, V., Jameson, D. M., and Brunet, J. E. (1996) Spectral properties of environmentally sensitive probes associated with horseradish peroxidase. Biochemistry 35, 973-979.
-
(1996)
Biochemistry
, vol.35
, pp. 973-979
-
-
Lasagna, M.1
Vargas, V.2
Jameson, D.M.3
Brunet, J.E.4
-
31
-
-
0023918636
-
An exact correction to the Cheng-Prusoff correction
-
Munson, P. J., and Rodbard, D. (1988) An exact correction to the Cheng-Prusoff correction. J. Recept. Res. 8, 533-546.
-
(1988)
J. Recept. Res
, vol.8
, pp. 533-546
-
-
Munson, P.J.1
Rodbard, D.2
-
32
-
-
0015861774
-
Relationship between inhibition constant (KI) and concentration of inhibitor which causes 50% inhibition (I50) of an enzymatic-reaction
-
Cheng, Y., and Prusoff, W. H. (1973) Relationship between inhibition constant (KI) and concentration of inhibitor which causes 50% inhibition (I50) of an enzymatic-reaction. Biochem. Pharmacol. 22, 3099-3108.
-
(1973)
Biochem. Pharmacol
, vol.22
, pp. 3099-3108
-
-
Cheng, Y.1
Prusoff, W.H.2
-
33
-
-
57449101887
-
Chemical tools for the study of complex biological systems
-
Imperiali, B., Shults, M. D., Vazquez, E., Rothman, D. M., Janes, K. A., Nguyen, A., Lauffenburger, D. A., and Yaffe, M. B. (2004) Chemical tools for the study of complex biological systems. Mol. Biol. Cell 15, 245A-245A.
-
(2004)
Mol. Biol. Cell
, vol.15
-
-
Imperiali, B.1
Shults, M.D.2
Vazquez, E.3
Rothman, D.M.4
Janes, K.A.5
Nguyen, A.6
Lauffenburger, D.A.7
Yaffe, M.B.8
-
34
-
-
0028235205
-
Benzophenone photophores in biochemistry
-
Dorman, G., and Prestwich, G. D. (1994) Benzophenone photophores in biochemistry. Biochemistry 33, 5661-5673.
-
(1994)
Biochemistry
, vol.33
, pp. 5661-5673
-
-
Dorman, G.1
Prestwich, G.D.2
-
35
-
-
0000736085
-
Preparation, crystalline-structure, and spectral properties of fluorescent-probe 4,4-bis-1-phenylamino-8-naphthalenesulfonate
-
Farris, F. J., Weber, G., Chiang, C. C., and Paul, I. C. (1978) Preparation, crystalline-structure, and spectral properties of fluorescent-probe 4,4-bis-1-phenylamino-8-naphthalenesulfonate. J. Am. Chem. Soc. 100, 4469-4474.
-
(1978)
J. Am. Chem. Soc
, vol.100
, pp. 4469-4474
-
-
Farris, F.J.1
Weber, G.2
Chiang, C.C.3
Paul, I.C.4
-
36
-
-
57449092546
-
-
Ph.D. Thesis, MIT, Cambridge, MA
-
Yee, C. S. (2004) Ph.D. Thesis, MIT, Cambridge, MA.
-
(2004)
-
-
Yee, C.S.1
-
37
-
-
0028176923
-
1H-NMR studies of mouse ribonucleotide reductase - the R2 protein carboxyl-terminal tail, essential for subunit interaction, is highly flexible but becomes rigid in the presence of protein R1
-
Lycksell, P. O., Ingemarson, R., Davis, R., Gräslund, A., and Thelander, L. (1994) 1H-NMR studies of mouse ribonucleotide reductase - the R2 protein carboxyl-terminal tail, essential for subunit interaction, is highly flexible but becomes rigid in the presence of protein R1. Biochemistry 33, 2838-2842.
-
(1994)
Biochemistry
, vol.33
, pp. 2838-2842
-
-
Lycksell, P.O.1
Ingemarson, R.2
Davis, R.3
Gräslund, A.4
Thelander, L.5
-
38
-
-
0029126928
-
Demonstration of segmental mobility in the functionally essential carboxyl-terminal part of ribonucleotide reductase protein R2 from Escherichia coli
-
Lycksell, P. O., and Sahlin, M. (1995) Demonstration of segmental mobility in the functionally essential carboxyl-terminal part of ribonucleotide reductase protein R2 from Escherichia coli. FEBS Lett. 368, 441-444.
-
(1995)
FEBS Lett
, vol.368
, pp. 441-444
-
-
Lycksell, P.O.1
Sahlin, M.2
-
39
-
-
33847666363
-
Forward and reverse electron transfer with the Y(356)DOPA-β2 heterodimer of Escherichia coli ribonucleotide reductase
-
Seyedsayamdost, M. R., and Stubbe, J. (2007) Forward and reverse electron transfer with the Y(356)DOPA-β2 heterodimer of Escherichia coli ribonucleotide reductase. J. Am. Chem. Soc. 129, 2226-2227.
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 2226-2227
-
-
Seyedsayamdost, M.R.1
Stubbe, J.2
-
40
-
-
0023655427
-
Half-site reactivity of the tyrosyl radical of ribonucleotide reductase from Escherichia coli
-
Sjöberg, B. M., Karlsson, M., and Jornvall, H. (1987) Half-site reactivity of the tyrosyl radical of ribonucleotide reductase from Escherichia coli. J. Biol. Chem. 262, 9736-9743.
-
(1987)
J. Biol. Chem
, vol.262
, pp. 9736-9743
-
-
Sjöberg, B.M.1
Karlsson, M.2
Jornvall, H.3
-
41
-
-
55249116734
-
Mapping the subunit interface of ribonucleotide reductase (RNR) using photo-cross-linking
-
in press
-
Hassan, A. Q., and Stubbe, J. (2008) Mapping the subunit interface of ribonucleotide reductase (RNR) using photo-cross-linking. Bioorg. Med. Chem. Lett., in press.
-
(2008)
Bioorg. Med. Chem. Lett
-
-
Hassan, A.Q.1
Stubbe, J.2
-
42
-
-
0018786922
-
Synthesis and spectral properties of a hydrophobic fluorescent-probe - 6-propionyl-2-(dimethylamino)Naphthalene
-
Weber, G., and Farris, F. J. (1979) Synthesis and spectral properties of a hydrophobic fluorescent-probe - 6-propionyl-2-(dimethylamino)Naphthalene. Biochemistry 18, 3075-3078.
-
(1979)
Biochemistry
, vol.18
, pp. 3075-3078
-
-
Weber, G.1
Farris, F.J.2
-
43
-
-
0028556688
-
A potent peptidomimetic inhibitor of Hsv ribonucleotide reductase with antiviral activity in-vivo
-
Liuzzi, M., Deziel, R., Moss, N., Beaulieu, P., Bonneau, A. M., Bousquet, C., Chafouleas, J. G., Garneau, M., Jaramillo, J., Krogsrud, R. L., Lagace, L., McCollum, R. S., Nawoot, S., and Guindon, Y. (1994) A potent peptidomimetic inhibitor of Hsv ribonucleotide reductase with antiviral activity in-vivo. Nature 372, 695-698.
-
(1994)
Nature
, vol.372
, pp. 695-698
-
-
Liuzzi, M.1
Deziel, R.2
Moss, N.3
Beaulieu, P.4
Bonneau, A.M.5
Bousquet, C.6
Chafouleas, J.G.7
Garneau, M.8
Jaramillo, J.9
Krogsrud, R.L.10
Lagace, L.11
McCollum, R.S.12
Nawoot, S.13
Guindon, Y.14
-
44
-
-
57449118316
-
New peptide inhibitors of mammalian ribonucleotide reductase. Mechanisms of action
-
Gao, Y., Tan, C., Kashlan, O. B., Kaur, J., and Cooperman, B. S. (2004) New peptide inhibitors of mammalian ribonucleotide reductase. Mechanisms of action. Regul. Pept. 122, 14-14.
-
(2004)
Regul. Pept
, vol.122
, pp. 14-14
-
-
Gao, Y.1
Tan, C.2
Kashlan, O.B.3
Kaur, J.4
Cooperman, B.S.5
|