A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis

Neoplasia

Volumn 10, Issue 12, 2008, Pages 1325-1334

  Triplett, Aleata A ^a   Montagna, Cristina ^b   Wagner, Kay Uwe ^a,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; PROTEIN P21; PROTEIN P53;

ANEUPLOIDY; ANIMAL TISSUE; ARTICLE; BREAST; BREAST ADENOCARCINOMA; BREAST CANCER; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER GROWTH; CANCER MODEL; CANCER SUSCEPTIBILITY; CHROMOSOME 11; CHROMOSOME DELETION; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DUPLICATION; GENE LOCUS; GENE SEQUENCE; GENETIC ENGINEERING; GENETIC MODEL; GENETIC TRANSCRIPTION; GENOMIC INSTABILITY; HAPLOTYPE; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; KARYOTYPE; MASTITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SEQUENCE ANALYSIS; SOMATIC MUTATION;

EID: 57349198210     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.08524     Document Type: Article

References (35)

1. Easton DF, Narod SA, Ford D, and Steel M (1994). The genetic epidemiology of BRCA1. Breast Cancer Linkage Consortium. Lancet 344, 761.
2. Struewing JP, Hartge P, Wacholder S, Baker SM, Berlin M, McAdams M, Timmerman MM, Brody LC, and Tucker MA (1997). The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med 336, 1401-1408.
3. Blackwood MA and Weber BL (1998). BRCA1 and BRCA2: from molecular genetics to clinical medicine. J Clin Oncol 16, 1969-1977.
4. Narod SA and Foulkes WD (2004). BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 4, 665-676.
5. Deng CX (2006). BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res 34, 1416-1426.
6. Evers B and Jonkers J (2006). Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects. Oncogene 25, 5885-5897.
7. Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, and Deng CX (1999). Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet 22, 37-43.
8. Magdinier F, Ribieras S, Lenoir GM, Frappart L, and Dante R (1998). Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region. Oncogene 17, 3169-3176.
9. Staff S, Isola J, and Tanner M (2003). Haplo-insufficiency of BRCA1 in sporadic breast cancer. Cancer Res 63, 4978-4983.
10. Osborne RJ and Hamshere MG (2000). A genome-wide map showing common regions of loss of heterozygosity/allelic imbalance in breast cancer. Cancer Res 60, 3706-3712.
11. Biggs PJ, Vogel H, Sage M, Martin LA, Donehower LA, and Bradley A (2003). Allelic phasing of a mouse chromosome 11 deficiency influences p53 tumorigenicity. Oncogene 22, 3288-3296.
12. Wagner KU, Wall RJ, St-Onge L, Gruss P, Wynshaw-Boris A, Garrett L, Li M, Furth PA, and Hennighausen L (1997). Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res 25, 4323-4330.
13. Triplett AA, Sakamoto K, Matulka LA, Shen L, Smith GH, and Wagner KU (2005). Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells. Genesis 43, 1-11.
14. Wagner KU, Young WS, Liu X, Ginns EI, Li M, Furth PA, and Hennighausen L (1997). Oxytocin and milk removal are required for post-partum mammary-gland development. Genes Funct 1, 233-244.
15. Wagner KU, Krempler A, Triplett AA, Qi Y, George NM, Zhu J, and Rui H (2004). Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. Mol Cell Biol 24, 5510-5520.
16. Medina D and Kittrell FS (2000). Establishment of mouse mammary cell lines. In Methods in Mammary Gland Biology and Breast Cancer. Chap 13, MM Ip, and BB Ash (Eds). Kluwer Academic/Plenum, New York, NY. pp. 137-145.
17. Montagna C, Lyu MS, Hunter K, Lukes L, Lowther W, Reppert T, Hissong B, Weaver Z, and Ried T (2003). The Septin 9 (MSF) gene is amplified and overexpressed in mouse mammary gland adenocarcinomas and human breast cancer cell lines. Cancer Res 63, 2179-2187.
18. 1/S and p53-independent cell death. J Biol Chem 277, 43216-43223.
19. Sakamoto K, Creamer BA, Triplett AA, and Wagner KU (2007). The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells. Mol Endocrinol 21, 1877-1892.
20. Wagner KU, McAllister K, Ward T, Davis B, Wiseman R, and Hennighausen L (2001). Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res 10, 545-553.
21. Chapman RS, Lourenco PC, Tonner E, Flint DJ, Selbert S, Takeda K, Akira S, Clarke AR, and Watson CJ (1999). Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev 13, 2604-2616.
22. Brodie SG, Xu X, Qiao W, Li WM, Cao L, and Deng CX (2001). Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice. Oncogene 20, 7514-7523.
23. Weaver Z, Montagna C, Xu X, Howard T, Gadina M, Brodie SG, Deng CX, and Ried T (2002). Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Oncogene 21, 5097-5107.
24. Liu P, Zhang H, McLellan A, Vogel H, and Bradley A (1998). Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics 150, 1155-1168.
25. Hentges KE, Nakamura H, Furuta Y, Yu Y, Thompson DM, O'Brien W, Bradley A, and Justice MJ (2006). Novel lethal mouse mutants produced in balancer chromosome screens. Gene Expr Patterns 6, 653-665.
26. Noguchi S, Kasugai T, Miki Y, Fukutomi T, Emi M, and Nomizu T (1999). Clinicopathologic analysis of BRCA1- or BRCA2-associated hereditary breast carcinoma in Japanese women. Cancer 85, 2200-2205.
27. Foulkes WD, Stefansson IM, Chappuis PO, Begin LR, Goffin JR, Wong N, Trudel M, and Akslen LA (2003). Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer. J Natl Cancer Inst 95, 1482-1485.
28. Lakhani SR, van de Vijver MJ, Jacquemier J, Anderson TJ, Osin PP, McGuffog L, and Easton DF (2002). The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. J Clin Oncol 20, 2310-2318.
29. Sgagias MK, Wagner KU, Hamik B, Stoeger S, Spieker R, Huber LJ, Chodosh LA, and Cowan KH (2004). Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS. Cell Cycle 3, 1451-1456.
30. Li W, Xiao C, Vonderhaar BK, and Deng CX (2007). A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation. Oncogene 26, 7204-7212.
31. Jones LP, Tilli MT, Assefnia S, Torre K, Halama ED, Parrish A, Rosen EM, and Furth PA (2008). Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer. Oncogene 27, 794-802.
32. Clarke RB, Howell A, Potten CS, and Anderson E (1997). Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res 57, 4987-4991.
33. Russo J, Ao X, Grill C, and Russo IH (1999). Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland. Breast Cancer Res Treat 53, 217-227.
34. Mallepell S, Krust A, Chambon P, and Brisken C (2006). Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci USA 103, 2196-2201.
35. McCarthy A, Savage K, Gabriel A, Naceur C, Reis-Filho JS, and Ashworth A (2007). A mouse model of basal-like breast carcinoma with metaplastic elements. J Pathol 211, 389-398.