Varicella-zoster virus IE62 protein utilizes the human mediator complex in promoter activation

Journal of Virology

Volumn 82, Issue 24, 2008, Pages 12154-12163

  Yang, Min ^a   Hay, John ^a   Ruyechan, William T ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 8; PROTEIN IE62; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; TRANSACTIVATION; VARICELLA ZOSTER VIRUS; VIRUS REPLICATION;

CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASES; HERPESVIRUS 3, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; MODELS, GENETIC; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN TRANSPORT; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; VIRAL ENVELOPE PROTEINS;

HUMAN HERPESVIRUS 3;

EID: 57349188981     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01693-08     Document Type: Article

References (72)

1. Akoulitchev, S., S. Chuikov, and D. Reinberg. 2000. TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature 407:102-106.
2. Arvin, A. M. 2001. Varicella-zoster virus, p. 2731-2767. In D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman, and S. E. Straus (ed.), Fields virology, 4th ed., vol. 2. Lippincott-Williams and Wilkins, Philadelphia, PA.
3. Arvin, A. M., E. Kinney-Thomas, K. Shriver, C. Grose, C. M. Koropchak, E. Scranton, A. E. Wittek, and P. S. Diaz. 1986. Immunity to varicella-zoster viral glycoproteins, gp I (gp 90/58) and gp III (gp 118), and to a nonglycosylated protein, p 170. J. Immunol. 137:1346-1351.
4. Berk, A. J. 1986. Adenovirus promoters and E1A transactivation. Annu. Rev. Genet. 20:45-79.
5. Besser, J., M. Ikoma, K. Fabel, M. H. Sommer, L. Zerboni, C. Grose, and A. M. Arvin. 2004. Differential requirement for cell fusion and virion formation in the pathogenesis of varicella-zoster virus infection in skin and T cells. J. Virol. 78:13293-13305.
6. Besser, J., M. H. Sommer, L. Zerboni, C. P. Bagowski, H. Ito, J. Moffat, C. C. Ku, and A. M. Arvin. 2003. Differentiation of varicella-zoster virus ORF47 protein kinase and IE62 protein binding domains and their contributions to replication in human skin xenografts in the SCID-hu mouse. J. Virol. 77:5964-5974.
7. Bhoite, L. T., Y. Yu, and D. J. Stillman. 2001. The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II. Genes Dev. 15:2457-2469.
8. Boyer, T. G., M. E. Martin, E. Lees, R. P. Ricciardi, and A. J. Berk. 1999. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. Nature 399:276-279.
9. Bryant, G. O., and M. Ptashne. 2003. Independent recruitment in vivo by Gal4 of two complexes required for transcription. Mol. Cell 11:1301-1309.
10. Burakov, D., C. W. Wong, C. Rachez, B. J. Cheskis, and L. P. Freedman. 2000. Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. J. Biol. Chem. 275:20928-20934.
11. Bushmeyer, S., K. Park, and M. L. Atchison. 1995. Characterization of functional domains within the multifunctional transcription factor, YY1. J. Biol. Chem. 270:30213-30220.
12. Casamassimi, A., and C. Napoli. 2007. Mediator complexes and eukaryotic transcription regulation: an overview. Biochimie 89:1439-1446.
13. Chatterjee, P. K., M. Bruner, S. J. Flint, and M. L. Harter. 1988. DNA-binding properties of an adenovirus 289R E1A protein. EMBO J. 7:835-841.
14. Cohen, J. I., and S. E. Straus. 2001. Varicella-zoster Virus and its replication, p. 2707-2730. In D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman, and S. E. Straus (ed.), Fields virology, 4th ed., vol. 2. Lippincott-Williams and Wilkins, Philadelphia, PA.
15. Cohen, J. I., D. Heffel, and K. Seidel. 1993. The transcriptional activation domain of varicella-zoster virus open reading frame 62 protein is not conserved with its herpes simplex virus homolog. J. Virol. 67:4246-4251.
16. Conaway, R. C., S. Sato, C. Tomomori-Sato, T. Yao, and J. W. Conaway. 2005. The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem. Sci. 30:250-255.
17. Cosma, M. P., S. Panizza, and K. Nasmyth. 2001. Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF. Mol. Cell 7:1213-1220.
18. Davison, A. J., and J. E. Scott. 1986. The complete DNA sequence of varicella-zoster virus. J. Gen. Virol. 67:1759-1816.
19. Eisfeld, A. J., S. E. Turse, S. A. Jackson, E. C. Lerner, and P. R. Kinchington. 2006. Phosphorylation of the varicella-zoster virus (VZV) major transcriptional regulatory protein IE62 by the VZV open reading frame 66 protein kinase. J. Virol. 80:1710-1723.
20. Elmlund, H., V. Baraznenok, M. Lindahl, C. O. Samuelsen, P. J. Koeck, S. Holmberg, H. Hebert, and C. M. Gustafsson. 2006. The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II. Proc. Natl. Acad. Sci. USA 103:15788-15793.
21. Fan, X., D. M. Chou, and K. Struhl. 2006. Activator-specific recruitment of Mediator in vivo. Nat. Struct. Mol. Biol. 13:117-120.
22. Fondell, J. D., H. Ge, and R. G. Roeder. 1996. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc. Natl. Acad. Sci. USA 93:8329-8333.
23. Fryer, C. J., J. B. White, and K. A. Jones. 2004. Mastermind recruits CycC: CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol. Cell 16:509-520.
24. Ge, K., M. Guermah, C. X. Yuan, M. Ito, A. E. Wallberg, B. M. Spiegelman, and R. G. Roeder. 2002. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 417:563-567.
25. Gold, M. O., J. P. Tassan, E. A. Nigg, A. P. Rice, and C. H. Herrmann. 1996. Viral transactivators E1A and VP16 interact with a large complex that is associated with CTD kinase activity and contains CDK8. Nucleic Acids Res. 24:3771-3777.
26. Grose, C., and P. A. Brunel. 1978. Varicella-zoster virus: isolation and propagation in human melanoma cells at 36 and 32 degrees C. Infect. Immun. 19:199-203.
27. Gu, W., S. Malik, M. Ito, C. X. Yuan, J. D. Fondell, X. Zhang, E. Martinez, J. Qin, and R. G. Roeder. 1999. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol. Cell 3:97-108.
28. Gwack, Y., H. J. Baek, H. Nakamura, S. H. Lee, M. Meisterernst, R. G. Roeder, and J. U. Jung. 2003. Principal role of TRAP/mediator and SWI/ SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol. Cell. Biol. 23:2055-2067.
29. Hengartner, C. J., V. E. Myer, S. M. Liao, C. J. Wilson, S. S. Koh, and R. A. Young. 1998. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol. Cell 2:43-53.
30. Ito, M., C. X. Yuan, S. Malik, W. Gu, J. D. Fondell, S. Yamamura, Z. Y. Fu, X. Zhang, J. Qin, and R. G. Roeder. 1999. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol. Cell 3:361-370.
31. Jenkins, H. L., and C. A. Spencer. 2001. RNA polymerase II holoenzyme modifications accompany transcription reprogramming in herpes simplex virus type 1-infected cells. J. Virol. 75:9872-9884.
32. Kato, Y., R. Habas, Y. Katsuyama, A. M. Naar, and X. He. 2002. A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature 418:641-646.
33. Kennedy, P. G. 2002. Varicella-zoster virus latency in human ganglia. Rev. Med. Virol. 12:327-334.
34. Kim, Y. J., S. Bjorklund, Y. Li, M. H. Sayre, and R. D. Kornberg. 1994. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77:599-608.
35. Kinchington, P. R., K. Fite, and S. E. Turse. 2000. Nuclear accumulation of IE62, the varicella-zoster virus (VZV) major transcriptional regulatory protein, is inhibited by phosphorylation mediated by the VZV open reading frame 66 protein kinase. J. Virol. 74:2265-2277.
36. Kinchington, P. R., and S. E. Turse. 1998. Regulated nuclear localization of the varicella-zoster virus major regulatory protein, IE62. J. Infect. Dis. 178(Suppl. 1):S16-S21.
37. Kornberg, R. D. 2005. Mediator and the mechanism of transcriptional activation. Trends Biochem. Sci. 30:235-239.
38. Kuras, L., T. Borggrefe, and R. D. Kornberg. 2003. Association of the Mediator complex with enhancers of active genes. Proc. Natl. Acad. Sci. USA 100:13887-13891.
39. Lau, J. F., I. Nusinzon, D. Burakov, L. P. Freedman, and C. M. Horvath. 2003. Role of metazoan mediator proteins in interferon-responsive transcription. Mol. Cell. Biol. 23:620-628.
40. Lukonis, C. J., and S. K. Weller. 1997. Formation of herpes simplex virus type 1 replication compartments by transfection: requirements and localization to nuclear domain 10. J. Virol. 71:2390-2399.
41. Lynch, J. M., T. K. Kenyon, C. Grose, J. Hay, and W. T. Ruyechan. 2002. Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins. Virology 302:71-82.
42. Malik, S., and R. G. Roeder. 2005. Dynamic regulation of Pol II transcription by the mammalian Mediator complex. Trends Biochem. Sci. 30:256-263.
43. Malik, S., A. E. Wallberg, Y. K. Kang, and R. G. Roeder. 2002. TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol. Cell. Biol. 22:5626-5637.
44. McGeoch, D. J., and A. J. Davison. 1999. The molecular evolutionary history of the herpesviruses, p. 441-466. In E. Domingo, R. G. Webster, and J. J. Holland (ed.), Origin and evolution of viruses. Academic Press, London, England.
45. Meier, J. L., X. Luo, M. Sawadogo, and S. E. Straus. 1994. The cellular transcription factor USF cooperates with varicella-zoster virus immediateearly protein 62 to symmetrically activate a bidirectional viral promoter. Mol. Cell. Biol. 14:6896-6906.
46. Mittler, G., T. Stuhler, L. Santolin, T. Uhlmann, E. Kremmer, F. Lottspeich, L. Berti, and M. Meisterernst. 2003. A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J. 22:6494-6504.
47. Mo, X., E. Kowenz-Leutz, H. Xu, and A. Leutz. 2004. Ras induces mediator complex exchange on C/EBP beta. Mol. Cell 13:241-250.
48. Moffat, J. F., L. Zerboni, M. H. Sommer, T. C. Heineman, J. I. Cohen, H. Kaneshima, and A. M. Arvin. 1998. The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse. Proc. Natl. Acad. Sci. USA 95:11969-11974.
49. Näär, A. M., S. Ryu, and R. Tjian. 1998. Cofactor requirements for transcriptional activation by Sp1. Cold Spring Harb. Symp. Quant. Biol. 63:189-199.
50. Näär, A. M., D. J. Taatjes, W. Zhai, E. Nogales, and R. Tjian. 2002. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev. 16:1339-1344.
51. Pandey, P. K., T. S. Udayakumar, X. Lin, D. Sharma, P. S. Shapiro, and J. D. Fondell. 2005. Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol. Cell. Biol. 25:10695-10710.
52. Peng, H., H. He, J. Hay, and W. T. Ruyechan. 2003. Interaction between the varicella zoster virus IE62 major transactivator and cellular transcription factor Sp1. J. Biol. Chem. 278:38068-38075.
53. Perera, L. P. 2000. The TATA motif specifies the differential activation of minimal promoters by varicella zoster virus immediate-early regulatory protein IE62. J. Biol. Chem. 275:487-496.
54. Perera, L. P., J. D. Mosca, W. T. Ruyechan, G. S. Hayward, S. E. Straus, and J. Hay. 1993. A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain. J. Virol. 67:4474-4483.
55. Perera, L. P., J. D. Mosca, M. Sadeghi-Zadeh, W. T. Ruyechan, and J. Hay. 1992. The varicella-zoster virus immediate early protein, IE62, can positively regulate its cognate promoter. Virology 191:346-354.
56. Rachez, C., B. D. Lemon, Z. Suldan, V. Bromleigh, M. Gamble, A. M. Naar, H. Erdjument-Bromage, P. Tempst, and L. P. Freedman. 1999. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 398:824-828.
57. Rice, S. A., M. C. Long, V. Lam, and C. A. Spencer. 1994. RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection. J. Virol. 68:988-1001.
58. Ruyechan, W. T. 2004. Mechanism(S) of activation of varicella zoster virus promoters by the VZV IE62 protein. Recent Res. Dev. Virol. 6:145-172.
59. Ryu, S., S. Zhou, A. G. Ladurner, and R. Tjian. 1999. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature 397:446-450.
60. Sato, S., C. Tomomori-Sato, T. J. Parmely, L. Florens, B. Zybailov, S. K. Swanson, C. A. Banks, J. Jin, Y. Cai, M. P. Washburn, J. W. Conaway, and R. C. Conaway. 2004. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol. Cell 14:685-691.
61. Schaap, A., J. F. Fortin, M. Sommer, L. Zerboni, S. Stamatis, C. C. Ku, G. P. Nolan, and A. M. Arvin. 2005. T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infection. J. Virol. 79:12921-12933.
62. Spengler, M. L., W. T. Ruyechan, and J. Hay. 2000. Physical interaction between two varicella zoster virus gene regulatory proteins, IE4 and IE62. Virology 272:375-381.
63. Stevens, J. L., G. T. Cantin, G. Wang, A. Shevchenko, A. Shevchenko, and A. J. Berk. 2002. Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science 296:755-758.
64. Triezenberg, S. J., R. C. Kingsbury, and S. L. McKnight. 1988. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev. 2:718-729.
65. Udayakumar, T. S., M. Belakavadi, K. H. Choi, P. K. Pandey, and J. D. Fondell. 2006. Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1. J. Biol. Chem. 281:14691-14699.
66. Uhlmann, T., S. Boeing, M. Lehmbacher, and M. Meisterernst. 2007. The VP16 activation domain establishes an active mediator lacking CDK8 in vivo. J. Biol. Chem. 282:2163-2173.
67. Wang, G., M. A. Balamotis, J. L. Stevens, Y. Yamaguchi, H. Handa, and A. J. Berk. 2005. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol. Cell 17:683-694.
68. Yang, F., R. DeBeaumont, S. Zhou, and A. M. Naar. 2004. The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. Proc. Natl. Acad. Sci. USA 101:2339-2344.
69. Yang, F., B. W. Vought, J. S. Satterlee, A. K. Walker, Z. Y. Jim Sun, J. L. Watts, R. DeBeaumont, R. M. Saito, S. G. Hyberts, S. Yang, C. Macol, L. Iyer, R. Tjian, S. van den Heuvel, A. C. Hart, G. Wagner, and A. M. Naar. 2006. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature 442:700-704.
70. Yang, M., J. Hay, and W. T. Ruyechan. 2004. The DNA element controlling expression of the varicella-zoster virus open reading frame 28 and 29 genes consists of two divergent unidirectional promoters which have a common USF site. J. Virol. 78:10939-10952.
71. Yang, M., H. Peng, J. Hay, and W. T. Ruyechan. 2006. Promoter activation by the varicella-zoster virus major transactivator IE62 and the cellular transcription factor USF. J. Virol. 80:7339-7353.
72. Yuan, C. X., M. Ito, J. D. Fondell, Z. Y. Fu, and R. G. Roeder. 1998. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. USA 95:7939-7944.