Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and β2-integrin surface expression in human neutrophils

American Journal of Physiology - Cell Physiology

Volumn 295, Issue 5, 2008, Pages

  Kaba, Nubia K ^a   Schultz, Joanne ^a   Law, Foon Yee ^a   Lefort, Craig T ^a   Martel Gallegos, Guadalupe ^a   Kim, Minsoo ^a   Waugh, Richard E ^a   Arreola, Jorge ^a,b   Knauf, Philip A ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

Author keywords

Integrins; Ischemia reperfusion; Lactate; Na + H+ exchanger inhibitors; p38 mitogen activated protein kinase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; AMMONIUM CHLORIDE; BETA2 INTEGRIN; CELL ADHESION MOLECULE; L SELECTIN; LACTIC ACID; N1 [2,2 DIMETHYL 1 [(METHYLAMINO)CARBONYL]PROPYL] N4 HYDROXY 2 (2 METHYLPROPYL)BUTANEDIAMIDE; SODIUM PROTON EXCHANGE PROTEIN;

ARTICLE; CELL PH; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; ISCHEMIA; LACTIC ACIDOSIS; NEUTROPHIL; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPERFUSION INJURY;

AMILORIDE; AMMONIUM CHLORIDE; ANTIGENS, CD11B; ANTIGENS, CD18; CELL MEMBRANE; GUANIDINES; HUMANS; HYDROGEN-ION CONCENTRATION; L-SELECTIN; LACTIC ACID; MACROPHAGE-1 ANTIGEN; METALLOPROTEASES; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEASE INHIBITORS; PROTEIN KINASE INHIBITORS; REPERFUSION INJURY; SODIUM-HYDROGEN ANTIPORTER; SULFONES; TIME FACTORS;

EID: 57349184671     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00535.2007     Document Type: Article

References (57)

1. + exchanger in renal microvillus membrane vesicles. J Biol Chem 258: 6767-6771, 1983.
2. Ayoub IM, Kolarova J, Yi Z, Trevedi A, Deshmukh H, Lubell DL, Franz MR, Maldonado FA, Gazmuri RJ. Sodium-hydrogen exchange inhibition during ventricular fibrillation: beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability. Circulation 107: 1804-1809, 2003.
3. Behmanesh S, Kempski O. Mechanisms of endothelial cell swelling from lactacidosis studied in vitro. Am J Physiol Heart Circ Physiol 279: H1512-H1517, 2000.
4. Berg EL, McEvoy LM, Berlin C, Bargatze RF, Butcher EC. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature 366: 695-698, 1993.
5. Blobel CP. ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 6: 32-43, 2005.
6. Buerke M, Rupprecht HJ, vom Dahl J, Terres W, Seyfarth M, Schultheiss HP, Richardt G, Sheehan FH, Drexler H. Sodium-hydrogen exchange inhibition: novel strategy to prevent myocardial injury following ischemia and reperfusion. Am J Cardiol 83: 19G-22G, 1999.
7. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67: 1033-1036, 1991.
8. Cox CS Jr, Sauer H, Allen SJ, Buja LM, Laine GA. Sodium/hydrogen-exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass: an experimental study. J Thorac Cardiovasc Surg 123: 959-966, 2002.
9. Diamond MS, Springer TA. A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J Cell Biol 120: 545-556, 1993.
10. + transporters. Expert Opin Investig Drugs 12: 1123-1142, 2003.
11. Engler RL, Dahlgren MD, Morris DD, Peterson MA, Schmid-Schonbein GW. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Physiol Heart Circ Physiol 251: H314-H323, 1986.
12. Fan H, Derynck R. Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J 18: 6962-6972, 1999.
13. + exchange activity during phagocytosis in human neutrophils: role of Fcgamma receptors and tyrosine kinases. J Cell Biol 132: 1037-1052, 1996.
14. Gechtman Z, Alonso JL, Raab G, Ingber DE, Klagsbrun M. The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading. J Biol Chem 274: 28828-28835, 1999.
15. Gevers W. Generation of protons by metabolic processes in heart cells. J Mol Cell Cardiol 9: 867-874, 1977.
16. + antiporter. Soc Gen Physiol Ser 43: 303-314, 1988.
17. + exchange inhibition-induced cardioprotection in dogs: effects on neutrophils versus cardiomyocytes. Am J Physiol Heart Circ Physiol 279: H1563-H1570, 2000.
18. Heuser D, Guggenberger H. Ionic changes in brain ischaemia and alterations produced by drugs. Br J Anaesth 57: 23-33, 1985.
19. Ichihara K, Haga N, Abiko Y. Is ischemia-induced pH decrease of dog myocardium respiratory or metabolic acidosis? Am J Physiol Heart Circ Physiol 246: H652-H657, 1984.
20. + exchanger and ischemia-reperfusion injury in the myocardium. Am J Physiol Heart Circ Physiol 292: H2237-H2247, 2007.
21. + exchange inhibitor (SM-20550) protects from microvascular deterioration and myocardial injury after reperfusion. Eur J Pharmacol 374: 355-366, 1999.
22. Jacobus WE, Taylor GJ 4th, Hollis DP, Nunnally RL. Phosphorus nuclear magnetic resonance of perfused working rat hearts. Nature 265: 756-758, 1977.
23. Kaba NK, Knauf PA. Hypotonicity induces L-selectin shedding in human neutrophils. Am J Physiol Cell Physiol 281: C1403-C1407, 2001.
24. Kaminski KA, Bonda TA, Korecki J, Musial WJ. Oxidative stress and neutrophil activation-the two keystones of ischemia/reperfusion injury. Int J Cardiol 86: 41-59, 2002.
25. Kansas GS. Structure and function of L-selectin. APMIS 100: 287-293, 1992.
26. + exchange inhibitors against cardiac injury produced by ischemia/reperfusion, hypoxia/reoxygenation, and the calcium paradox. J Cardiovasc Pharmacol 21: 172-178, 1993.
27. Kishimoto TK, Jutila MA, Berg EL, Butcher EC. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245: 1238-1241, 1989.
28. Kitakaze M, Weisfeldt ML, Marban E. Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts. J Clin Invest 82: 920-927, 1988.
29. Knight DR, Smith AH, Flynn DM, MacAndrew JT, Ellery SS, Kong JX, Marala RB, Wester RT, Guzman-Perez A, Hill RJ, Magee WP, Tracey WR. A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J Pharmacol Exp Ther 297: 254-259, 2001.
30. Kutsuna H, Suzuki K, Kamata N, Kato T, Hato F, Mizuno K, Kobayashi H, Ishii M, Kitagawa S. Actin reorganization and morphological changes in human neutrophils stimulated by TNF, GM-CSF, and G-CSF: the role of MAP kinases. Am J Physiol Cell Physiol 286: C55-C64, 2004.
31. Lee D, Schultz JB, Knauf PA, King MR. Mechanical shedding of L-selectin from the neutrophil surface during rolling on sialyl Lewis x under flow. J Biol Chem 282: 4812-4820, 2007.
32. Lozano DD, Kahl EA, Wong HP, Stephenson LL, Zamboni WA. L-selectin and leukocyte function in skeletal muscle reperfusion injury. Arch Surg 134: 1079-1081, 1999.
33. Lucchesi BR, Werns SW, Fantone JC. The role of the neutrophil and free radicals in ischemic myocardial injury. J Mol Cell Cardiol 21: 1241-1251, 1989.
34. + exchanger. Eur J Med Chem 38: 547-554, 2003.
35. Mazzoni MC, Borgstrom P, Intaglietta M, Arfors KE. Lumenal narrowing and endothelial cell swelling in skeletal muscle capillaries during hemorrhagic shock. Circ Shock 29: 27-39, 1989.
36. + pathways in capillary endothelial cell swelling during hemorrhagic shock. J Appl Physiol 73: 1467-1473, 1992.
37. Morgan D, Cherny VV, Murphy R, Katz BZ, DeCoursey TE. The pH dependence of NADPH oxidase in human eosinophils. J Physiol 569: 419-431, 2005.
38. Preece G, Murphy G, Ager A. Metalloproteinase-mediated regulation of L-selectin levels on leucocytes. J Biol Chem 271: 11634-11640, 1996.
39. Redlin M, Werner J, Habazettl H, Griethe W, Kuppe H, Pries AR. Cariporide (HOE 642) attenuates leukocyte activation in ischemia and reperfusion. Anesth Analg 93: 1472-1479, 2001.
40. Rizoli SB, Rotstein OD, Kapus A. Cell volume-dependent regulation of L-selectin shedding in neutrophils. A role for p38 mitogen-activated protein kinase. J Biol Chem 274: 22072-22080, 1999.
41. Romson JL, Hook BG, Kunkel SL, Abrams GD, Schork MA, Lucchesi BR. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 67: 1016-1023, 1983.
42. Rosengren S, Henson PM, Worthen GS. Migration-associated volume changes in neutrophils facilitate the migratory process in vitro. Am J Physiol Cell Physiol 267: C1623-C1632, 1994.
43. Rotstein OD, Nasmith PE, Grinstein S. The bacteroides by-product succinic acid inhibits neutrophil respiratory burst by reducing intracellular pH. Infect Immun 55: 864-870, 1987.
44. + exchange and its inhibition in cardiac ischemia and reperfusion. Basic Res Cardiol 88: 443-455, 1993.
45. Serrano CV Jr, Fraticelli A, Paniccia R, Teti A, Noble B, Corda S, Faraggiana T, Ziegelstein RC, Zweier JL, Capogrossi MC. pH dependence of neutrophil-endothelial cell adhesion and adhesion molecule expression. Am J Physiol Cell Physiol 271: C962-C970, 1996.
46. Sheppard FR, Moore EE, McLaughlin N, Kelher M, Johnson JL, Silliman CC. Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation. J Trauma 58: 752-757, 2005.
47. Siesjo BK. Acid-base homeostasis in the brain: physiology, chemistry, and neurochemical pathology. Prog Brain Res 63: 121-154, 1985.
48. Simchowitz L, Roos A. Regulation of intracellular pH in human neutrophils. J Gen Physiol 85: 443-470, 1985.
49. - cotransport system. J Gen Physiol 100: 341-367, 1992.
50. Springer TA. Adhesion receptors of the immune system. Nature 346: 425-434, 1990.
51. + overload in isolated rat hearts. Am J Physiol Heart Circ Physiol 288: H287-H292, 2005.
52. Theroux P, Chaitman BR, Danchin N, Erhardt L, Meinertz T, Schroeder JS, Tognoni G, White HD, Willerson JT, Jessel A. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial Guard during ischemia against necrosis (GUARDIAN) Investigators. Circulation 102: 3032-3038, 2000.
53. Trevani AS, Andonegui G, Giordano M, Lopez DH, Gamberale R, Minucci F, Geffner JR. Extracellular acidification induces human neutrophil activation. J Immunol 162: 4849-4857, 1999.
54. Warny M, Keates AC, Keates S, Castagliuolo I, Zacks JK, Aboudola S, Qamar A, Pothoulakis C, LaMont JT, Kelly CP. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J Clin Invest 105: 1147-1156, 2000.
55. Wu D, Cederbaum A. Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-kappaB DNA binding activity. Mol Pharmacol 66: 749-760, 2004.
56. + exchange inhibitor, on survival and infarct size in rat myocardial infarction. Pharmacology 64: 176-181, 2002.
57. Zakrzewicz A, Grafe M, Terbeek D, Bongrazio M, Auch-Schwelk W, Walzog B, Graf K, Fleck E, Ley K, Gaehtgens P. L-selectin-dependent leukocyte adhesion to microvascular but not to macrovascular endothelial cells of the human coronary system. Blood 89: 3228-3235, 1997.