Nanomolar inhibition of the enterobactin biosynthesis enzyme, EntE: Synthesis, substituent effects, and additivity

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 14, 2006, Pages 3802-3805

  Callahan, Brian P ^a   Lomino, Joseph V ^a   Wolfenden, Richard ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Additivity; Adenylate analog; Adenylate forming; Binding energy; Bisubstrate; EntE; Enterobactin; Inhibition; Inhibitor; Iron; Siderophore

Indexed keywords

2,3 DIHYDROXYBENZOHYDROXAMOYL ADENYLATE; 2,3 DIHYDROXYBENZOIC ACID; ACETOHYDROXAMOYL ADENYLATE; ADENOSINE PHOSPHATE; ENTEROCHELIN; HYDROGEN; SIDEROPHORE; UNCLASSIFIED DRUG;

ADDITION REACTION; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; ENERGY; ENZYME INHIBITION; ENZYME SYNTHESIS; ESCHERICHIA COLI; REDUCTION; SUBSTITUTION REACTION;

ADENOSINE MONOPHOSPHATE; BINDING, COMPETITIVE; CATECHOLS; ENTEROBACTIN; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN; HYDROXAMIC ACIDS; HYDROXYBENZOIC ACIDS; IMIDAZOLES; LIGASES; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI;

EID: 33746547862     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.024     Document Type: Article

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