Impaired initiation of contact hypersensitivity by FTY720

Journal of Investigative Dermatology

Volumn 128, Issue 12, 2008, Pages 2833-2841

  Nakashima, Daiki ^a   Kabashima, Kenji ^a   Sakabe, Jun Ichi ^a   Sugita, Kazunari ^a   Kobayashi, Takashi ^b   Yoshiki, Ryutaro ^a   Tokura, Yoshiki ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; FINGOLIMOD; HERMES ANTIGEN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOTAXIS; CONTACT ALLERGY; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; IMMUNE RESPONSE; IMMUNIZATION; LYMPH NODE CELL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION;

ANIMALS; ANTIGENS, CD44; CHEMOTAXIS; DERMATITIS, CONTACT; FEMALE; IMMUNOLOGIC MEMORY; L-SELECTIN; LYMPH NODES; LYMPHOCYTES; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C57BL; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; T-LYMPHOCYTES;

EID: 57349125902     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.174     Document Type: Article

References (47)

1. Allende ML, Dreier JL, Mandala S, Proia RL (2004) Expression of the sphingosine-1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J Biol Chem 279:15396-401
2. Allende ML, Yamashita T, Proia RL (2003) G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood 102:3665-7
3. Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R et al. (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277:21453-7
4. Budde K, Schmouder RL, Brunkhorst R, Nashan B, Lucker PW, Mayer T et al. (2002) First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. J Am Soc Nephrol 13:1073-83
5. Bursch LS, Wang L, Igyarto B, Kissenpfennig A, Malissen B, Kaplan DH et al. (2007) Identification of a novel population of Langerin+ dendritic cells. J Exp Med 204:3147-56
6. Chiba K, Yanagawa Y, Masubuchi Y, Kataoka H, Kawaguchi T, Ohtsuki M et al. (1998) FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol 160:5037-44
7. Cyster JG (2005) Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol 23:127-59
8. Czeloth N, Bernhardt G, Hofmann F, Genth H, Forster R (2005) Sphingosine-1-phosphate mediates migration of mature dendritic cells. J Immunol 175:2960-7
9. Dev KK, Mullershausen F, Mattes H, Kuhn RR, Bilbe G, Hoyer D et al. (2008) Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis. Pharmacol Ther 117:77-93
10. Fujii R, Kanai T, Nemoto Y, Makita S, Oshima S, Okamoto R et al. (2006) FTY720 suppresses CD4+CD44highCD62L-effector memory T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol 291:G267-74
11. Fujita T, Hirose R, Yoneta M, Sasaki S, Inoue K, Kiuchi M et al. (1996) Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols. J Med Chem 39:4451-9
12. Ginhoux F, Collin MP, Bogunovic M, Abel M, Leboeuf M, Helft J et al. (2007) Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J Exp Med 204:3133-46
13. Grabbe S, Schwarz T (1998) Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today 19:37-44
14. Graler MH, Goetzl EJ (2004) The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J 18:551-3
15. Hofmann M, Brinkmann V, Zerwes HG (2006) FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs. Int Immunopharmacol 6:1902-10
16. Idzko M, Hammad H, van Nimwegen M, Kool M, Muller T, Soullie T et al. (2006) Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. J Clin Invest 116:2935-44
17. Idzko M, Panther E, Corinti S, Morelli A, Ferrari D, Herouy Y et al. (2002) Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. FASEB J 16:625-7
18. Ishii I, Fukushima N, Ye X, Chun J (2004) Lysophospholipid receptors: signaling and biology. Annu Rev Biochem 73:321-54
19. Kabashima K, Haynes NM, Xu Y, Nutt SL, Allende ML, Proia RL et al. (2006) Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J Exp Med 203:2683-90
20. Kabashima K, Miyachi Y (2004) Prostanoids in the cutaneous immune response. J Dermatol Sci 34:177-84
21. Kabashima K, Murata T, Tanaka H, Matsuoka T, Sakata D, Yoshida N et al. (2003a) Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity. Nat Immunol 4:694-701
22. Kabashima K, Sakata D, Nagamachi M, Miyachi Y, Inaba K, Narumiya S (2003b) Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nat Med 9:744-9
23. Kabashima K, Shiraishi N, Sugita K, Mori T, Onoue A, Kobayashi M et al. (2007) CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol 171:1249-57
24. Kissenpfennig A, Malissen B (2006) Langerhans cells-revisiting the paradigm using genetically engineered mice. Trends Immunol 27:132-9
25. Kiuchi M, Adachi K, Kohara T, Minoguchi M, Hanano T, Aoki Y et al. (2000) Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols. J Med Chem 43:2946-61
26. Kohno T, Tsuji T, Hirayama K, Watabe K, Matsumoto A, Kohno T et al. (2004) A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice. Biol Pharm Bull 27:1392-6
27. Kunisawa J, Kurashima Y, Higuchi M, Gohda M, Ishikawa I, Ogahara I et al. (2007) Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med 204:2335-48
28. Ledgerwood LG, Lal G, Zhang N, Garin A, Esses SJ, Ginhoux F et al. (2008) The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat Immunol 9:42-53
29. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-8
30. Luo ZJ, Tanaka T, Kimura F, Miyasaka M (1999) Analysis of the mode of action of a novel immunosuppressant FTY720 in mice. Immunopharmacology 41:199-207
31. Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J et al. (2002) Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296:346-9
32. Masopust D, Vezys V, Marzo AL, Lefrancois L (2001) Preferential localization of effector memory cells in nonlymphoid tissue. Science 291:2413-7
33. Mathers AR, Larregina AT (2006) Professional antigen-presenting cells of the skin. Immunol Res 36:127-36
34. Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V et al. (2004) Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427:355-60
35. Poulin LF, Henri S, de Bovis B, Devilard E, Kissenpfennig A, Malissen B (2007) The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med 204:3119-31
36. Reinhardt RL, Khoruts A, Merica R, Zell T, Jenkins MK (2001) Visualizing the generation of memory CD4 T cells in the whole body. Nature 410:101-5
37. Renkl A, Berod L, Mockenhaupt M, Idzko M, Panther E, Termeer C et al. (2004) Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells. Int J Mol Med 13:203-9
38. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708-12
39. Sanchez T, Hla T (2004) Structural and functional characteristics of S1P receptors. J Cell Biochem 92:913-22
40. Sawicka E, Zuany-Amorim C, Manlius C, Trifilieff A, Brinkmann V, Kemeny DM et al. (2003) Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720. J Immunol 171:6206-14
41. Schroder JM, Reich K, Kabashima K, Liu FT, Romani N, Metz M et al. (2006) Who is really in control of skin immunity under physiological circumstances - lymphocytes, dendritic cells or keratinocytes? Exp Dermatol 15:913-29
42. Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG (2005) Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309:1735-9
43. Spiegel S, Milstien S (2003) Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 4:397-407
44. Suzuki S, Enosawa S, Kakefuda T, Shinomiya T, Amari M, Naoe S et al. (1996) A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation 61:200-5
45. Wherry EJ, Teichgraber V, Becker TC, Masopust D, Kaech SM, Antia R et al. (2003) Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 4:225-34
46. Yanagawa Y, Hoshino Y, Kataoka H, Kawaguchi T, Ohtsuki M, Sugahara K et al. (1999) FTY720, a novel immunosuppressant, prolongs rat skin allograft survival by decreasing T-cell infiltration into grafts. Transplant Proc 31:1227-9
47. Yanagawa Y, Sugahara K, Kataoka H, Kawaguchi T, Masubuchi Y, Chiba K (1998) FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. J Immunol 160:5493-9