Enantioselective addition of diethylzinc to aromatic aldehydes catalyzed by Ti(IV) complexes of C2-symmetrical chiral BINOL derivatives

Tetrahedron Letters

Volumn 50, Issue 3, 2009, Pages 281-283

  Gou, Shaohua ^a   Judeh, Zaher M A ^a  

^a Nanyang Technological University   (Singapore)

Author keywords

Aldehyde; Alkylation; BINOL; Chiral C2 symmetric ligand; Chiral core; Diethylzinc; Secondary alcohol; Ti(OiPr)4

Indexed keywords

2,2' DIHYDROXY 1,1' BINAPHTHYL; ALDEHYDE; TITANIUM;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOSELECTIVITY; SYNTHESIS;

EID: 57349123419     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.10.149     Document Type: Article

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28. 4 and evaporated to dryness under vacuum pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate, 10/1, v/v) to afford the secondary alcohol products. The enantioselectivities of the reactions were determined by Chiral GC G-TA using OJ-H or OD-H columns.