TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 295, Issue 4, 2008, Pages

  Lynn, P A ^a   Chen, B N ^a   Zagorodnyuk, V P ^a   Costa, M ^a   Brookes, S J H ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

Hypersensitivity; Pelvic afferents; Rectal nerves; Trinitrobenzene sulfonic acid

Indexed keywords

BRADYKININ; CAPSAICIN; TRINITROBENZENESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANUS SPHINCTER; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; GUINEA PIG; IN VITRO STUDY; INFLAMMATION; MECHANORECEPTOR; MUSCLE CONTRACTILITY; MYOTATIC REFLEX; NONHUMAN; PHYSICAL SENSITIVITY; PRIORITY JOURNAL; RECTUM; STIMULUS RESPONSE; ULCER;

ANIMALS; BRADYKININ; CAPSAICIN; ELECTRIC STIMULATION; FEMALE; GUINEA PIGS; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MECHANORECEPTORS; MUSCLE CONTRACTION; RECTUM; TRINITROBENZENESULFONIC ACID;

EID: 57349097610     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00585.2007     Document Type: Article

References (34)

1. + currents in mouse colonic dorsal root ganglia neurons and their role in colitis-induced hyperexcitability. Am J Physiol Gastrointest Liver Physiol 287: G845-G855, 2004.
2. Brierley SM, Jones RC 3rd, Gebhart GF, Blackshaw LA. Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice. Gastroenterology 127: 166-178, 2004.
3. Brunsden AM, Grundy D. Sensitization of visceral afferents to bradykinin in rat jejunum in vitro. J Physiol 521: 517-527, 1999.
4. Bueno L, Fioramonti J. Visceral perception: inflammatory and non-inflammatory mediators. Gut 51, Suppl 1: i19 -i23, 2002.
5. Cervero F, Laird JM. Visceral pain. Lancet 353: 2145-2148, 1999.
6. Coldwell JR, Phillis BD, Sutherland K, Howarth GS, Blackshaw LA. Increased responsiveness of rat colonic splanchnic afferents to 5-HT after inflammation and recovery. J Physiol 579: 203-213, 2007.
7. Delafoy L, Gelot A, Ardid D, Eschalier A, Bertrand C, Doherty AM, Diop L. Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat. Gut 55: 940-945, 2006.
8. Delafoy L, Raymond F, Doherty AM, Eschalier A, Diop L. Role of nerve growth factor in the trinitrobenzene sulfonic acid-induced colonic hypersensitivity. Pain 105: 489-497, 2003.
9. Grossi L, McHugh K, Collins SM. On the specificity of altered muscle function in experimental colitis in rats. Gastroenterology 104: 1049-1056, 1993.
10. Grundy D, Al-Chaer ED, Aziz Q, Collins SM, Ke M, Tache Y, Wood JD. Fundamentals of neurogastroenterology: basic science. Gastroenterology 130: 1391-1411, 2006.
11. Habler HJ, Janig W, Koltzenburg M. Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol 425: 545-562, 1990.
12. Ishizawa M. Contractile effects of 16-methyl analogues of PGE2 on the circular and longitudinal muscles of the guinea-pig isolated colon. Prostaglandins 42: 579-586, 1991.
13. Linden DR, Sharkey KA, Mawe GM. Enhanced excitability of myenteric AH neurones in the inflamed guinea-pig distal colon. J Physiol 547: 589-601, 2003.
14. Linhart O, Obreja O, Kress M. The inflammatory mediators serotonin, prostaglandin E2 and bradykinin evoke calcium influx in rat sensory neurons. Neuroscience 118: 69-74, 2003.
15. Longhurst JC, Dittman LE. Hypoxia, bradykinin, and prostaglandins stimulate ischemically sensitive visceral afferents. Am J Physiol Heart Circ Physiol 253: H556-H567, 1987.
16. Longhurst JC, Kaufman MP, Ordway GA, Musch TI. Effects of bradykinin and capsaicin on endings of afferent fibers from abdominal visceral organs. Am J Physiol Regul Integr Comp Physiol 247: R552-R559, 1984.
17. Lynn P, Zagorodnyuk V, Hennig G, Costa M, Brookes S. Mechanical activation of rectal intraganglionic laminar endings in the guinea pig distal gut. J Physiol 564: 589-601, 2005.
18. Lynn PA, Blackshaw LA. In vitro recordings of afferent fibres with receptive fields in the serosa, muscle and mucosa of rat colon. J Physiol 518: 271-282, 1999.
19. Lynn PA, Olsson C, Zagorodnyuk V, Costa M, Brookes SJ. Rectal intraganglionic laminar endings are transduction sites of extrinsic mechanoreceptors in the guinea pig rectum. Gastroenterology 125: 786-794, 2003.
20. Moore BA, Stewart TM, Hill C, Vanner SJ. TNBS ileitis evokes hyperexcitability and changes in ionic membrane properties of nociceptive DRG neurons. Am J Physiol Gastrointest Liver Physiol 282: G1045-G1051, 2002.
21. Moreels TG, De Man JG, Dick JM, Nieuwendijk RJ, De Winter BY, Lefebvre RA, Herman AG, Pelckmans PA. Effect of TNBS-induced morphological changes on pharmacological contractility of the rat ileum. Eur J Pharmacol 423: 211-222, 2001.
22. Nagy I, Santha P, Jancso G, Urban L. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. Eur J Pharmacol 500: 351-369, 2004.
23. Ness TJ, Gebhart GF. Acute inflammation differentially alters the activity of two classes of rat spinal visceral nociceptive neurons. Neurosci Lett 281: 131-134, 2000.
24. Olsson C, Costa M, Brookes SJ. Neurochemical characterization of extrinsic innervation of the guinea pig rectum. J Comp Neurol 470: 357-371, 2004.
25. Pons L, Droy-Lefaix MT, Bueno L. Leukotriene D4 participates in colonic transit disturbances induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. Gastroenterology 102: 149-156, 1992.
26. Sengupta JN, Snider A, Su X, Gebhart GF. Effects of kappa opioids in the inflamed rat colon. Pain 79: 175-185, 1999.
27. Shin JB, Martinez-Salgado C, Heppenstall PA, Lewin GR. A T-type calcium channel required for normal function of a mammalian mechanoreceptor. Nat Neurosci 6: 724-730, 2003.
28. Stewart T, Beyak MJ, Vanner S. Ileitis modulates potassium and sodium currents in guinea pig dorsal root ganglia sensory neurons. J Physiol 552: 797-807, 2003.
29. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol 20: 495-549, 2002.
30. Su X, Gebhart GF. Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. J Neurophysiol 80: 2632-2644, 1998.
31. Su X, Wachtel RE, Gebhart GF. Capsaicin sensitivity and voltage-gated sodium currents in colon sensory neurons from rat dorsal root ganglia. Am J Physiol Gastrointest Liver Physiol 277: G1180-G1188, 1999.
32. Wells RW, Blennerhassett MG. Persistent and selective effects of inflammation on smooth muscle cell contractility in rat colitis. Pflügers Arch 448: 515-524, 2004.
33. Wynn G, Ma B, Ruan HZ, Burnstock G. Purinergic component of mechanosensory transduction is increased in a rat model of colitis. Am J Physiol Gastrointest Liver Physiol 287: G647-G657, 2004.
34. Zagorodnyuk VP, Lynn P, Costa M, Brookes SJ. Mechanisms of mechanotransduction by specialized low-threshold mechanoreceptors in the guinea pig rectum. Am J Physiol Gastrointest Liver Physiol 289: G397-G406, 2005.