Glucagon Receptor Signaling Is Essential for Control of Murine Hepatocyte Survival

Gastroenterology

Volumn 135, Issue 6, 2008, Pages 2096-2106

  Sinclair, Elaine M ^a   Yusta, Bernardo ^a   Streutker, Catherine ^b   Baggio, Laurie L ^a   Koehler, Jacqueline ^a   Charron, Maureen J ^c   Drucker, Daniel J ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CHOLINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; FAS LIGAND; GLUCAGON; GLUCAGON RECEPTOR; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DIET RESTRICTION; DISEASE COURSE; DISEASE PREDISPOSITION; ENZYME ACTIVATION; EXPERIMENTAL MOUSE; FIBROBLAST; GLUCOSE HOMEOSTASIS; LIVER CELL; LIVER INJURY; MALE; METABOLIC REGULATION; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; WILD TYPE;

EID: 57249104894     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.07.075     Document Type: Article

References (29)

1. Jiang G., and Zhang B.B. Glucagon and regulation of glucose metabolism. Am J Physiol Endocrinol Metab 284 (2003) E671-E678
2. Gelling R.W., Du X.Q., Dichmann D.S., et al. Lower blood glucose, hyperglucagonemia, and pancreatic {alpha} cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci U S A 100 (2003) 1438-1443
3. Sorensen H., Winzell M.S., Brand C.L., et al. Glucagon receptor knockout mice display increased insulin sensitivity and impaired {beta}-cell function. Diabetes 55 (2006) 3463-3469
4. Conarello S.L., Jiang G., Mu J., et al. Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia. Diabetologia 50 (2007) 142-150
5. Riddle M.C., and Drucker D.J. Emerging therapies mimicking the effects of amylin and glucagon-like peptide 1. Diabetes Care 29 (2006) 435-449
6. Liang Y., Osborne M.C., Monia B.P., et al. Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Diabetes 53 (2004) 410-417
7. Sloop K.W., Cao J.X., Siesky A.M., et al. Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors. J Clin Invest 113 (2004) 1571-1581
8. Mayo K.E., Miller L.J., Bataille D., et al. International Union of Pharmacology. XXXV. The Glucagon Receptor Family. Pharmacol Rev 55 (2003) 167-194
9. Armato U., Romano F., Andreis P.G., et al. Growth stimulation and apoptosis induced in cultures of neonatal rat liver cells by repeated exposures to epidermal growth factor/urogastrone with or without associated pancreatic hormones. Cell Tissue Res 245 (1986) 471-480
10. Fladmark K.E., Gjertsen B.T., Doskeland S.O., et al. Fas/APO-1(CD95)-induced apoptosis of primary hepatocytes is inhibited by cAMP. Biochem Biophys Res Commun 232 (1997) 20-25
11. Baggio L.L., Huang Q., Brown T.J., et al. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 127 (2004) 546-558
12. Dickson L.M., Lingohr M.K., McCuaig J., et al. Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem 276 (2001) 21110-21120
13. Lawen A. Apoptosis-an introduction. Bioessays 25 (2003) 888-896
14. Scheuer P.J. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 13 (1991) 372-374
15. Holz G.G. Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 53 (2004) 5-13
16. Nagata S. Fas ligand-induced apoptosis. Annu Rev Genet 33 (1999) 29-55
17. Reinehr R., and Haussinger D. Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95. Gastroenterology 126 (2004) 249-262
18. Koteish A., and Mae Diehl A. Animal models of steatohepatitis. Best Pract Res Clin Gastroenterol 16 (2002) 679-690
19. Yusta B., Boushey R.P., and Drucker D.J. The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway. J Biol Chem 275 (2000) 35345-35352
20. Boushey R.P., Yusta B., and Drucker D.J. Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis. Am J Physiol 277 (1999) E937-E947
21. Brubaker P.L., and Drucker D.J. Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system. Endocrinology 145 (2004) 2653-2659
22. Li Y., Hansotia T., Yusta B., et al. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278 (2003) 471-478
23. Drucker D.J. Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17 (2003) 161-171
24. Cullen K.A., McCool J., Anwer M.S., et al. Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis. Am J Physiol Gastrointest Liver Physiol 287 (2004) G334-G343
25. Graf D., Reinehr R., Kurz A.K., et al. Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms. Arch Biochem Biophys 415 (2003) 34-42
26. Qiao L., Han S.I., Fang Y., et al. Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 23 (2003) 3052-3066
27. Simon M.T., Pauloin A., Normand G., et al. HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway. FASEB J 17 (2003) 1441-1450
28. Rust C., Bauchmuller K., Fickert P., et al. Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers. Am J Physiol Gastrointest Liver Physiol 289 (2005) G88-G94
29. Qureshi S.A., Rios Candelore M., Xie D., et al. A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes 53 (2004) 3267-3273