The antiglucocorticoid action of mifepristone

Pharmacology and Therapeutics

Volumn 70, Issue 3, 1996, Pages 183-213

  Agarwal, M K ^a  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

glucocorticoids; hormones; mifepristone; receptors; RU 38486; steroids

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE;

ANIMAL TISSUE; APOPTOSIS; CUSHING DISEASE; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG RECEPTOR BINDING; HORMONE RELEASE; HUMAN; HUMAN TISSUE; IMMUNITY; INFECTION; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SHOCK; STRESS;

EID: 0029758072     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(96)00016-2     Document Type: Review

References (461)

1. Aboudrar, S., Sempore, B., Koubi, H., Dechaud, H. and Desplanches, D. (1993) Effects of adrenalectomy or RU 486 on rat muscle fibers during hindlimb suspension. J. Appl. Physiol. 75: 2767-2773.
2. Abrass, I. B. and Scarpace, P. J. (1981) Glucocorticoid regulation of myocardial β-adrenergic receptors. Endocrinology 108: 977-980.
3. Acs, Z. and Stark, E. (1975) Effect of cortexolone on the feedback action of dexamethasone. Experientia 31: 1365-1366.
4. Adaikan, P. G. and Kottegoda, S. R. (1984) RU-486. Drugs Future 9: 755-756.
5. Agarwal, M. K. (1972) Corticosteroid enzyme induction and control of specific gene expression in mammalian liver. Subcell. Biochem. 1: 207-215.
6. Agarwal, M. K. (1977) Multiple Molecular Forms of Steroid Hormone Receptors. Elsevier/North Holland, Amsterdam.
7. Agarwal, M. K. (1982) Antagonism of glucocorticoid action in vivo. In: Hormone Antagonists, pp. 381-390, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
8. Agarwal, M. K. (1992) Steroid receptor structure and antihormone drug design. Biochem. Pharmacol. 43: 2299-2306.
9. Agarwal, M. K. (1993) Receptors for mammalian steroid hormones in microbes and plants. FEBS Lett. 322: 207-210.
10. Agarwal, M. K. (1994a) Perspectives in receptor mediated mineral-ocorticoid hormone action. Pharmacol. Rev. 46: 67-87.
11. Agarwal, M. K. (1994b) Analysis of steroid receptor domains with the aid of antihormones. Int. J. Biochem. 26: 341-350.
12. Agarwal, M. K. and Cayanis, E. (1986) Evidence for differences in the steroid binding domains of the glucocorticoid receptor versus the idiotype antibody. Biochem. Biophys. Res. Commun. 136: 470-475.
13. Agarwal, M. K. and Lazar, G. (1977) Metabolic basis of endotoxicosis. Microbios 20: 183-214.
14. Agarwal, M. K. and Lazar, G. (1984) Biological reactions to bacterial endotoxins in the non-responder C3H/HeJ mouse strain. Microbios 39:193-207.
15. Agarwal, M. K. and Lazar, G. (1987) Analysis of the structure and function of steroid receptors with the aid of the antihormone RU 38486. In: Receptor Mediated Antisteroid Action, pp. 43-75, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
16. Agarwal, M. K. and Lazar, G. (1991) Antimineralocorticoids. Renal Physiol. Biochem. 14: 217-223.
17. Agarwal, M. K. and Mirshahi, M. (1992) Rat lung possesses the mineralocorticoid receptor. Biochem. Biophys. Res. Commun. 183: 405-410.
18. Agarwal, M. K. and Philippe, M. (1977) Heterogeneity of steroid hormone receptor in adult rat lung cytosol. Biochim. Biophys. Acta 500: 42-84.
19. Agarwal, M. K. and Philippe, M. (1979) Physicochemical characterization of corticosteroid binders in adult rat heart. J. Mol. Cell. Cardiol. 11: 115-126.
20. Agarwal, M. K., Sekiya, S. and Lazar, G. (1979a) Hormone-hormone antagonism in glucocorticoid action in vivo. In: Antihormones, pp. 51-73, Agarwal, M. K. (ed.) Elsevier/North Holland, Amsterdam.
21. Agarwal, M. K., Sekiya, S. and Lazar, G. (1979b) Search for antiglucocorticoid activity in rat liver in vivo. Res. Exp. Med. 176: 181-192.
22. Agarwal, M. K., Lombarde, G., Eliezer, N. and Moudgil, V. K. (1985) Activation of rat liver glucocorticoid receptor bound to the antiglucocorticoid RU 38486. Biochem. Biophys. Res. Commun. 133: 745-752.
23. Agarwal, M. K., Hainque, B., Moustaid, N. and Lazar, G. (1987) Glucocorticoid antagonists. FEBS Lett. 217: 221-226.
24. Agarwal, M. K., Mirshahi, F., Mirshahi, M. and Rostene, W. (1993) Immunochemical detection of the mineralocorticoid receptor in rat brain. Neuroendocrinology 58: 575-580.
25. Agarwal, M. K., Mirshahi, F., Mirshahi, M., Bracq, S., Chentoufi, J., Hott, M., Jullienne, A. and Marie, P. J. (1996) Evidence for receptor-mediated mineralocorticoid action in rat osteoblastic cells. Am. J. Physiol. (Cell Physiol.) 270: C1088-C1095.
26. Aguilera, G. (1993) Factors controlling streroid biosynthesis in the zona glomerulosa of the adrenal. J. Steroid Biochem. Mol. Biol. 45: 1-3.
27. Ahluwalia, A., Mohamed, R. W. and Flower, R. J. (1994) Induction of lipocortin-1 by topical steroid in rat skin. Biochem. Pharmacol. 48: 1647-1654.
28. Akatsuka, N., Yamaguchi, T. and Matsuda, M. (1974) Long term effect of corticosteroids on cardiac function. Jpn. Heart J. 15: 443-454.
29. AlAshry, D., Onate, S. A., Nordeen, S. K. and Edwards, D. P. (1989) Human progesterone receptor complexed with the antagonist RU 486 binds to hormone response elements in a structurally altered form. Mol. Endocrinol. 3: 1545-1558.
30. Albright, F., Parson, W. and Bloomberg, E. (1942) Cushing's syndrome interpreted as hypercorticism leading to hypergluconeogenesis: results of treatment with testosterone propionate. J. Clin. Endocrinol. 1: 375-384.
31. 3H-dexamethasone for receptotrs in the rat central nervous system. J. Steroid Biochem. 30: 411-415.
32. Anfinsen, B. (1959) The Molecular Basis of Evolution. Wiley, New York.
33. Angeras, M. H., Angeras, U., Zamir, O., Hasselgren, P. O. and Fischer, J. E. (1991) Effect of glucocorticoid receptor antagonist RU 38486 on muscle protein breakdown in sepsis. Surgery 109: 468-473.
34. Antonakis, N., Georgoulias, V., Margioris, A. N., Stournaras, C. and Gravanis, A. (1994) In vitro differential effects of the antiglucocorticoid RU 486 on the release of lymphokines from mitogen-activated normal human lymphocytes. J. Steroid Biochem. Mol. Biol. 51: 67-72.
35. Arai, K., Tsigos, C., Suzuki, Y., Listwak, S., Zachman, K., Zangeneh, F., Rapaport, R., Chanoine, J. P. and Chrousos, P. (1995) No apparent mineralocorticoid receptor defect in a series of sporadic cases of pseudohypoaldosteronism. J. Clin. Endocrinol. Metab. 80: 814-817.
36. Armanini, D., Kuhnle, U., Strasser, T., Helmuth, D., Butenandt, I., Weber, P. C., Stockigt, J. R., Pearce, P. and Funder, J. (1985) Aldosterone-receptor deficiency in pseudohypoaldosteronism. N. Engl. J. Med. 313: 1178-1181.
37. Armanini, D., Wehling, M., DaDalt, L., Zennaro, M., Scali, U., Keller, U., Pratesi, C., Mantero, F. and Kuhnle, U. (1991) Pseudohypoaldosteronism and mineralocorticoid receptor abnormalities. J. Steroid Biochem. Mol. Biol. 40: 363-365.
38. Arzt, E., Sauer, J., Pollmächer, T., Labeur, M., Holsboer, F., Reul, J. M. and Stalla, G. K. (1994) Glucocorticoids suppress interleukin-1 receptor antagonist synthesis following induction by endotoxin. Endocrinology 134: 672-677.
39. Baird, D. T. (1993) Clinical use of Mifepristone (RU 486). Ann. Med. 25: 65-69.
40. Bansal, N., Houle, A. and Melnykovych, G. (1991) Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents. FASEB J. 5: 211-216.
41. Barber, A. E., Coyle, S. M., Marano, M. A., Fischer, E., Calvano, S. E., Fong, Y., Moldawer, L. L. and Lowry, S. F. (1993) Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J. Immunol. 150: 1999-2006.
42. Barnea, A., Cho, G., Hajibeigi, A., Aguila, M. C. and Magni, P. (1991) Dexamethasone-induced accumulation of neuropeptide Y by aggregating fetal brain cells in culture: a process dependent on the developmental age of the aggregates. Endocrinology 129: 931-938.
43. Barrington, E. J. W. (1962) Hormones and vertebrate evolution. Experientia 18: 201-210.
44. Barrington, E. J. W. (1964) Hormones and Evolution. English Universities Press, London.
45. Bartter, F. C. (1960) The Clinical Uses of Aldosterone Antagonists. Charles C. Thomas, Springfield.
46. Bateman, A., Singh, A., Kral, T. and Solomon, S. (1989) The immune-hypothalamic-pituitary-adrenal axis. Endocr. Rev. 10: 92-112.
47. Beaufrère, B., DeParscau, L., Chatelain, P., Morel, Y., Aguercif, M. and François, R. (1987) RU 486 administration in a child with Cushing's syndrome. Lancet ii: 217.
48. Beck, C. A., Estes, P. A., Bona, B. J., Cacho, C. A., Nordeen, S. K. and Edwards, D. P. (1993) The steroid antagonist RU 486 exerts different effects on the glucocorticoid and progesterone receptors. Endocrinology 133: 728-740.
49. Bell, P. A. and Jones, T. R. (1982) Discriminations between glucocorticoid agonists and antagonists by means of receptor binding studies. In: Hormone Antagonists, pp. 391-405, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
50. Bell, P. A. and Weatherhill, P. J. (1986) Physicochemical characterstics of the interaction of the glucocorticoid antagonist RU 38486 with glucocorticoid receptors in vitro and the role of molybdate. J. Steroid Biochem. 25: 473-481.
51. Ben-Ari, E. T. and Garrison, J. C. (1988) Regulation of angioten-sinogen mRNA accumulation in rat hepatocytes. Am. J. Physiol. 255: E70-E79.
52. Ben-Dror, I., Havazelet, N. and Vardimon, L. (1993) Developmental control of glucocorticoid receptor transcriptional activity in embryonic retina. Proc. Natl. Acad. Sci. USA 90: 1117-1121.
53. Benhamou, B., Garcia, T., Lerouge, T., Vergezac, A., Gofflo, D., Bigogne, C., Chambon, P. and Gronemeyer, H. (1992) A single amino acid that determines the sensitivity of progesterone receptor to RU 486. Science 255: 206-209.
54. Benveniste, P. (1986) Sterol biosynthesis. Annu. Rev. Plant Physiol. 37: 275-308.
55. Bertini, R., Bianchi, M. and Ghezzi, P. (1988) Adrenalectomy sensitizes mice to the lethal effects of interleukin-1 and tumor necrosis factor. J. Exp. Med. 167: 1708-1712.
56. Bertoglio, J. H. and Leroux, E. (1988) Differential effects of glucocorticoids on the proliferation of a murine helper and a cytolytic T cell clone in response to IL-2 and IL-4. J. Immunol. 141: 1191-1196.
57. Betito, K., Diorio, J., Meaney, M. J. and Boksa, P. (1992) Adrenal phenylethanolamine N-methyltransferase induction in relation to glucocorticoid receptor dynamics: evidence that acute exposure to high cortisol levels is sufficient to induce the enzyme. J. Neurochem. 58: 1853-1862.
58. Bhattacharya, A. and Holland, L. (1991) Coordinate regulation of fibrinogen subunit messenger RNA levels by glucocorticoids in primary cultures of Xenopus liver parenchymal cells. Mol. Endocrinol. 5: 587-597.
59. Billiau, A. and Vandekerckhove, F. (1991) Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock. Eur. J. Clin. Invest. 21: 559-573.
60. Billings, M. P., Leighton, B., Dimitriadis, G. D., Bond, J. and News-holme, E. A. (1990) Effects of physiological and pathological levels of glucocorticoids on skeletal muscle glutamine metabolism in the rat. Biochem. Pharmacol. 40: 1145-1148.
61. Biol, M. C., Lenoir, D., Hugueny, I. and Louisot, P. (1992) Hormonal regulation of glycosylation process in rat small intestine: responsiveness of fucosyl-transferase activity to hydrocortisone during the suckling period, unresponsiveness after weaning. Biochim. Biophys. Acta 1133: 206-212.
62. Blalock, A. (1940) Experimental hypertension. Physiol. Rev. 20: 159-193.
63. Bocquel, M. T., Ji., J., Ylikomi, T., Benhamou, B., Vergezac, A., Chambon, P. and Gronemeyer, H. (1993) Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization. J. Steroid Biochem. 45: 205-215.
64. Boggaram, V., Smith, M. E. and Mendelson, C. R. (1991) Posttranscriptional regulation of surfactant protein-A messenger RNA in human fetal lung in vitro by glucocorticoids. Mol. Endocrinol. 5: 414-423.
65. Bone, R. C., Fisher, C. J., Clemmer, T. P., Slotman, G. J., Metz, C. A. and Balk, R. A. (1987) A control clinical trial of high-dose methylprednisolone in treatment of severe sepsis and septic shock. N. Engl. J. Med. 317: 653-658.
66. Brandt, A., Giesseler, J., Schmidt, K. and Hirschelmann, R. (1993) Megadose glucocorticoid therapy: investigations in rat anaphylactic shock and experimental allergic encephalomyelitis. Agents Actions 38: C108-C111.
67. Bransome, E. D. (1968) Adrenal cortex. Annu. Rev. Physiol. 30: 171-212.
68. Brasier, A. R., Philippe, J., Campbell, D. J. and Habener, J. F. (1986) Novel expression of the angiotensinogen gene in a rat pancreatic islet cell line. J. Biol. Chem. 261: 16148-16154.
69. Breuninger, L. M., Dempsey, W. L., Uhl, J. and Murasko, D. M. (1993) Hydrocortisone regulation of interleukin-6 protein produced by a purified population of human peripheral blood monocytes. Clin. Immunol. Immunopathol. 69: 205-214.
70. Brilla, C. G., Pick, R., Tan, L. B., Janicki, S. and Weber, K. T. (1990) Remodeling of the rat right and left ventricles in experimental hypertension. Circ. Res. 67: 1355-1364.
71. Briski, K. P. (1995) Effects of peripheral versus central administration of the endogenous glucocorticoid, corticosterone, and the glucocorticoid receptor agonist, RU 28362, on LH release in male rats. Brain Res. 670: 66-74.
72. Briski, K. P., Vogel, K. L. and McIntyre, A. R. (1995) The antiglucocorticoid RU 486 attenuates stress-induced decreases in plasma luteinizing hormone concentrations in male rats. Neuroendocrinology 61: 638-645.
73. Brouckaert, P., Liebert, C., Everaerdt, B., Takahashi, N., Cauwels, A. and Fiers, W. (1993) Tumor necrosis factor, its receptors and the connection with interleukin-1 and interleukin-6. Immunobiology 187: 317-329.
74. Brown, D. H., Sheridan, J., Pearl, D. and Zwilling, B. S. (1993) Regulation of mycobacterial growth by the hypothalamus-pituitaryadrenal axis: differential responses of Mycobacterium bovis BCG-resistant and -susceptible mice. Infec. Immun. 61: 4793-4800.
75. Bryant, H. U., Bernton, E. W., Kenner, J. R. and Holaday, J. W. (1991) Role of adrenocortical activation in the immunosuppressive effects of chronic morphine treatment. Endocrinology 128: 3253-3258.
76. Burollaud, T., Danzé, P. M., Tbarka, N., Formstecher, P. and Dautrevaux, M. (1993) Binding of RU 486 and deacylcortivazol to the glucocorticoid receptor is insensitive to sulfhydryl-modifying agents. J. Steroid Biochem. Mol. Biol. 44: 217-225.
77. Busso, N., Collard, M., Vassalli, J. D. and Belin, D. (1987) Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes. Exp. Cell Res. 173: 425-430.
78. Bygdeman, M., Swahn, M. L., Danielsson, K. and Svalander, P. (1993) Mode of action of RU 486. Ann. Med. 25: 61-64.
79. Cake, M. H., Ho, K. W. and Yeoh, G. C. T. (1982) Antagonism of glucocorticoid action by insulin. In: Hormone Antagonists, pp. 407-418, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
80. Canny, B. J. (1990) Hippocampal glucocorticoid receptors and the regulation of ACTH secretion. Mol. Cell. Endocrinol. 71: C35-C38.
81. Capasso, A., DiGiannuario, A., Loizzo, A., Pieretti, S. and Sorrentino, L. (1992) Central interaction of dexamethasone and RU 38486 on morphine antinociception in mice. Life Sci. 51: 139-143.
82. Cardoso, S. S., Sowell, J. G., Godrum, P. J. and Fuste, G. (1972) Effect of dexamethasone upon circadian mitotic rhythm in rat cornea. Proc. Soc. Exp. Biol. Med. 140: 1235-1239.
83. Casey, M. L. and McDonald, P. C. (1982) Extraadrenal formation of a mineralocorticoid: deoxycorticosterone and deoxycorticosterone sulphate biosynthesis and metabolism. Endocr. Rev. 3: 396-403.
84. Chader, G. J., Meltzer, R. and Silver, J. (1972) A soluble receptor for corticoids in the neural retina of the chick embryo. Biochem. Biophys. Res. Commun. 46: 2026-2033.
85. Champigny, G., Voilley, N., Lingueglia, E., Friend, V., Barbry, P. and Lazdunski, M. (1994) Regulation of expression of the lung amiloride sensitive channel by steroid hormones. EMBO J. 13: 2177-2181.
86. Chang, E. and Perlman, A. J. (1987) Multiple hormones regulate angiotensinogen messenger ribonucleic acid levels in rat hepatoma cell line. Endocrinology 121: 513-519.
87. Cheeks, L. and Green, K. (1986) Distribution of a steroid antagonist in the eye following topical administration. Curr. Eye Res. 5: 705-709.
88. Chen, D., Kohli, K., Zhang, S., Danielsen, M. and Stallcup, M. R. (1994) Phenylalanine-780 near the C-terminus of the mouse glucocorticoid receptor is important for ligand binding affinity and specificity. Mol. Endocrinol. 8: 422-430.
89. Chen, H. L. and Romsos, D. R. (1994) Type II glucocorticoid receptors in the CNS regulate metabolism in ob/ob mice independent of protein synthesis. Am. J. Physiol. 266: E427-E432.
90. Chen, J. D. and Evans, R. M. (1995) A transcriptional corepressor that interacts with nuclear hormone receptors. Nature 377: 454-456.
91. Chen, Y. Z., Hua, S. Y., Wang, C. A., Wu, L. G., Gu, Q. and Xing, B. R. (1991) An electrophysiological study on the membrane receptor-mediated action of glucocorticoids in mammalian neurons. Neuroendocrinology 53 (Suppl. 1): 25-30.
92. Cherfas, J. (1989) The pill of choice. Science 245: 1319-1324.
93. Chobert, M. O., Barouki, R., Finidori, J., Aggerbeck, M., Hanoune, J., Philibert, D. and Dereadt, R. (1983) Antiglucocorticoid properties of RU 38486 in a differentiated hepatoma cell line. Biochem. Pharmacol. 32: 3481-3483.
94. Clark, R. B. (1961) The origin and formation of the heteroneresis. Biol. Rev. 36: 199-236.
95. Clore, J., Schoolwerth, A. and Watlington, C. O. (1992) When is cortisol a mineralocorticoid? Kidney Int. 42: 1297-1308.
96. Compton, M. M., Caron, L. M. and Cidlowski, J. A. (1987) Glucocorticoid action on the immune system. J. Steroid Biochem. 27: 201-208.
97. Concordet, J. P. and Ferry, A. (1993) Physiological programmed cell death in thymocytes is induced by physical stress (exercise). Am. J. Physiol. 265: C626-C629.
98. Conway, E. J. and Hingerty, D. (1953) The effects of cortisone, deoxycorticosterone and other steroids on the active transport of sodium and potassium ions in yeast. Biochem. J. 55: 455-458.
99. Croxtall, J. D. and Flower, R. J. (1992) Lipocortin-1 mediates dexamethasone-induced growth arrest of the A549 adenocarcinoma cell line. Proc. Natl. Acad. Sci. USA 89: 3571-3575.
100. Dabreida, H. and Durand, P. (1987) Glucocorticoid enhancement of adrenocorticotropin-induced 3′,5′-cyclic adenosine monophosphate production by cultured ovine adrenocortical cells. Endocrinology 121: 1051-1055.
101. Dabreida, H. and Durand, P. (1988) Glucocorticoid enhancement of glucocorticoid production by cultured ovine adrenocortical cells. Biochim. Biophys. Acta 972: 200-208.
102. Dasarthy, Y., Lanzillo, J. J. and Fanburg, B. L. (1992) Stimulation of bovine pulmonary artery endothelial cell ACE by dexamethasone: involvement of steroid receptors. Am. J. Physiol. 263: L645-L649.
103. Dausse, J. P., Duval, D., Meyer, P., Gaignault, J. C., Marchandeau, C. and Raynaud, J. P. (1977) The relationship between glucocorticoid structure and effects upon thymocytes. Mol. Pharmacol. 13: 948-945.
104. Dayanithi, G. and Antoni, F. A. (1989) Rapid as well as delayed inhibitory effects of glucocorticoid hormones on pituitary adrenocorticotropic hormone release are mediated by Type II glucocorticoid receptors and require newly synthesized messenger ribonucleic acid as well as protein. Endocrinology 125: 308-313.
105. DeBold, A. J. (1985) Atrial natriuretic factor: a hormone produced by the heart. Science 230: 767-770.
106. DeDuve, C. (1995) The begginings of life on earth. Am. Sci. 83: 428-437.
107. DeKloet, E. R., Kock, S. D., Schild, V. and Veldhuis, H. D. (1988) Antiglucocorticoid RU 38486 attenuates retention of behaviour and disinhibits the hypothalamic-pituitary-adrenal axis at different brain sites. Neuroendocrinology 47: 109-115.
108. Denis, M. G., Chadeneau, C., Pleignet, C. and Lustenberger, P. (1991) A secreted Mr 40,000 glycoprotein specifically induced by glucocorticoids in a rat colon carcinoma cell line. Int. J. Cancer 48: 774-778.
109. Deschepper, C. F. and Flaxman, M. (1990) Glucocorticoid regulation of rat diencephalon angiotensinogen production. Endocrinology 126: 963-970.
110. DiBattista, J. A., Pelletier, J. M., Wosu, L. O., Sandor, T., Antakly, T. and Pelletier, J. P. (1991) Glucocorticoid receptor mediated inhibition of interleukin-1 stimulated neutral metalloprotease synthesis in normal human chondrocytes. J. Clin. Endocrinol. Metab. 72: 316-326.
111. Distelhorst, C. W. and Howard, K. J. (1990) Evidence from pulsechase labelling studies that the antiglucocorticoid hormone RU 486 stabilizes the nonactivated form of the glucocorticoid receptor in mouse lymphoma cells. J. Steroid Biochem. 36: 25-31.
112. Dluhy, R. G. and Lifton, R. P. (1995) Glucocorticoid-remediable aldosteronism (GRA): diagnosis, variability of phenotype and regulation of potassium homeostasis. Steroids 60: 48-51.
113. Dobbs, C. M., Vasquez, M., Glaser, R. and Sheridan, J. F. (1993) Mechanisms of stress-induced modulation of viral pathogenesis and immunity. J. Neuroimmunol. 48: 151-160.
114. Donckier, J. E., Michel, L. A., Berbinschi, A., Decoster, P. M., Deplaen, J. F., Ketelslegers, J. N. and Buysschaert, M. (1989) Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane. Surgery 105: 690-692.
115. Duax, W. L. and Griffin, J. F. (1984) Structural characterstics of antagonists for gluco- and mineralocorticoids. In: Adrenal Steroid Antagonism, pp. 15-41, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
116. Duax, W. L., Griffin, J. F., Rohrer, D. C. and Weeks, C. H. M. (1982) Steroid antagonists: molecular conformation, receptor binding and activity. In: Hormone Antagonists, pp. 3-24, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
117. Dubuc, P. U. and Peterson, C. M. (1990) Ineffectiveness of patenteral fluoxetine or RU 486 to alter long-term food intake, body weight or body composition of genetically obese mice. J. Pharmacol. Exp. Ther. 256: 976-979.
118. Duncan, M. R. and Duncan, G. R. (1979) An in vivo study of the action of antiglucocorticoids on thymus weight ratio, antibody titre and the adrenal-pituitary-hypothalamus axis. J. Steroid Biochem. 10: 245-249.
119. Edgren, R. A. and Calhoun, D. W. (1957) Estrogen antagonism: inhibition of estrone induced uterine growth by testosterone propionate, progesterone and 17-ethyl-19-nortestosterone. Proc. Soc. Exp. Biol. Med. 94: 537-539.
120. Eijgelshoven, M. H. J., DeKloet, E. R., VandenBerg, D. T. W. M. and VanGiersbergen, P. L. M. (1991) Activation of glucocorticoid receptors and the effect of naloxone during hemorrhagic hypotension. Eur. J. Pharmacol. 205: 183-189.
121. Endo, S., Inada, K., Inoue, Y., Kuwata, Y., Suzuki, M., Yamashita, N., Hoshi, S. and Yoshida, M. (1992) Two types of septic shock classified by plasma levels of cytokines and endotoxin. Circ. Shock 38: 264-274.
122. Evans, R. M. (1988) The steroid and thyroid hormone receptor superfamily. Science 240: 889-895.
123. +-ATPase: mechanisms underlying rapid and sustained changes in pump activity. Am. J. Physiol. 269: C295-C311.
124. Ewing, T. M., Murphy, L. J., Ng, M. L., Pang, G. Y., Lee, C. S., Watts, C. K. and Sutherland, R. L. (1989) Regulation of epidermal growth factor receptor by progestins and glucocorticoids in human breast cancer cell lines. Int. J. Cancer 44: 744-752.
125. Fantuzzi, G. and Ghezzi, P. (1993) Glucocorticoids as cytokine inhibitors: role in neuroendocrine control and therapy of inflammatory diseases. Mediators Inflamm. 2: 263-270.
126. Feng, B., Hilt, D. C. and Max, S. R. (1990) Transcriptional regulation of glutamine synthetase gene expression by dexamethasone in L6 muscle cells. J. Biol. Chem. 265: 18702-18706.
127. Feigelson, P., Beato, M., Colman, P., Kalimi, M., Killewich, L. A. and Schutz, G. (1975) Studies on the hepatic glucocorticoid receptor and on the hormonal modulation of specific mRNA levels during enzyme induction. Recent Prog. Horm. Res. 31: 213-239.
128. Fève, B., Antras, J., Lasnier, F., Hilliou, F. and Pairault, J. (1989) The antiglucocorticoid RU 38486 is a potent accelerator of adipose conversion of 3T3-F442A cells. Mol. Cell. Endocrinol. 67: 17-27.
129. Fève, B., Baude, B., Krief, S., Strosberg, A. D., Pairault, J. and Emorine, L. J. (1992) Inhibition by dexamethasone of β3-adrenergic receptor responsiveness in 3T3-F442A adipocytes. J. Biol. Chem. 267: 15909-15915.
130. Fieser, L. F. and Fieser, M. (1959) Steroids. Reinhold Publishing Co., New York.
131. Fraker, P. J. and Garvy, A. (1991) Suppression of the antigenic response of murine bone marrow B cells by physiological concentrations of glucocorticoids. Immunology 74: 519-523.
132. Franckhauser, S., Ferry, J. A., Robin, P., Robin, D. and Forest, C. (1994) Glucocorticoids antagonize retinoic acid stimulation of PEPCK gene transcription in 3T3-F442A adipocytes. Cell. Mol. Biol. 40: 723-729.
133. Fraser, R. and Lantos, C. P. (1978) 18-Hydroxycorticosterone: a review. J. Steroid Biochem. 9: 273-286.
134. Fraslon, C., Masmonteil, T. L., Zupan, V., Heu, B. C. and Bourbon, J. R. (1993) Fetal lung type II cell differentiation in serum free isolated cell culture: modulation and inhibition. Am. J. Physiol. 264: L504-L516.
135. Fuchs, B. A. and Pruett, S. B. (1993) Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glucocorticoid receptors. J. Pharmacol. Exp. Ther. 266: 417-423.
136. Fukumoto, S., Allan, E. H., Zeheb, R., Gelehrter, T. D. and Martin, T. J. (1992) Glucocorticoid regulation of plasminogen activator inhibitor-1 messenger ribonucleic acid and protein in normal and malignant rat osteoblasts. Endocrinology 130: 797-804.
137. Funder, J. D. and Sheppard, K. (1987) Adrenocortical steroids and the brain. Annu. Rev. Physiol. 49: 397-411.
138. Gagnon, J., Kim, M. A. H., Boissonneault, G., Dube, J. Y., Rogers, P. A. and Tremblay, R. R. (1987) The influence of immobilization stress on cardiac protein synthesis. A possible regulatory role for glucocorticoids. J. Recept. Res. 7: 639-652.
139. Galand, G. (1988) Effect of an antiglucocorticoid (RU 38486) on hydrocortisone induction of maltase-glucosamylase, sucraseisomaltase and trehalase in brush border membranes of suckling rats. Experientia 44: 516-517.
140. Ganguly, A. (1992) Atrial natriuretic peptide-induced inhibition of aldosterone secretion: a quest for mediators. Am. J. Physiol. 263: E181-E194.
141. Ganong, W. F., Biglieri, E. G. and Murlow, P. J. (1966) Mechanisms regulating adrenocortical secretion of aldosterone and glucocorticoids. Recent Prog. Horm. Res. 22: 381-430.
142. Gardner, D. G., Gertz, B. J., Deschepper, C. F. and Kim, D. Y. (1988) Gene for the rat atrial natriuretic peptide is regulated by glucocorticoids in vitro. J. Clin. Invest. 82: 1275-1281.
143. Garvy, B. A., Telford, W. G., King, L. E. and Frakerand, L. E. (1993) Glucocorticoids and irradiation-induced apoptosis in normal murine bone marrow B-lineage lymphocytes as determined by flow cytometry. Immunology 79: 270-277.
144. Gaunt, R., Tuthill, C. J., Antonchak, N. and Oppenheimer, E. (1953) Steroids which prevent cortisone from causing atrophy of the adrenal. Arch. Exp. Pathol. Pharmacol. 219: 91-99.
145. Geiger, H., Bahner, U., Palkovits, M., Nicklas, E., Hugo, C. and Heidland, A. (1991) Effects of aldosterone and dexamethasone on atrial natriuretic peptide levels in preoptic and hypothalamic nuclei of adrenalectomized and intact rats. Neuroendocrinology 53: 63-68.
146. Gemma, C., DeLuigi, A. and DeSimoni, M. G. (1994) Permissive role of glucocorticoids on interleukin-1 activation of the hypothalamic serotonergic system. Brain Res. 651: 169-173.
147. 1 MF-2 smooth muscle cells. Mol. Pharmacol. 40: 149-155.
148. Gilmour, D. (1960) The Biochemistry of Insects. Academic Press, New York.
149. Gjerde, H., Morland, J. and Olsen, H. (1985) The antiglucocorticoid RU 486 inhibits the ethanol-induced increase of tryptophan oxygenase. J. Steroid Biochem. 23: 1091-1011.
150. Glenn, E. M. (1963) Metabolic effects of adrenocortical steroids in vivo and in vitro: relationship to anti-inflammatory effects. Recent Prog. Horm. Res. 19: 107-199.
151. Glibetic, M., Larson, D. E., Rothblum, L. I. and Sells, B. H. (1993) Dexamethasone stimulates rRNA gene transcription in rat myoblasts. Mol. Cell. Endocrinol. 94: 243-252.
152. Gonzalo, J. A., Garcia, A. G., Kalland, T., Hedlund, G., Martinez, C. A. and Kroemer, G. (1993) Linomide, a novel immunomodulator that prevents death in four models of septic shock. Eur. J. Immunol. 23: 2372-2374.
153. Gordon, R. D., Stowasser, M., Klemm, S. A. and Tunny, T. J. (1995) Primary aldosteronism-some genetic, morphological, and biochemical aspects of subtypes. Steroids 60: 35-41.
154. Green, K., Cheeks, L., Slagle, T. and Phillips, C. I. (1990) Effects of mifepristone on rabbit intraocular pressure in the presence and absence of dexamethasone. Ophthalmic Res. 22: 247-252.
155. Grimaldi, B., Barre, J. and Tillement, J. P. (1992) Respective role of mifepristone (RU 486) binding to blood and tissue proteins in its quantitative distribution in the body. C. R. Acad. Sci. III 315: 93-99.
156. Gronemeyer, H., Benhamou, B., Berry, M., Bocquel, M. T., Gofflo, D., Garcia, T., Lerouge, T., Metzger, D., Meyer, M. E. and Tora, L. (1992) Mechanisms of antihormone action. J. Steroid Biochem. Mol. Biol. 41: 217-221.
157. Gross, I., Wilson, C. M., Floros, J. and Dynia, D. W. (1989) Initiation of fetal lung phospholipid and surfactant-associated protein A mRNA synthesis. Pediatr. Res. 25: 239-244.
158. Groyer, A., Schweizer, G. G., Cadepond, F., Mariller, M. and Baulieu, E. (1987) Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro. Nature 328: 624-626.
159. Groyer, D. J. and Wolfe, K. A. (1990) Transformation of glucocorticoid receptors bound to the antagonist RU 486: effects of alkaline phosphatase. Biochemistry 29: 7958-7996.
160. Gruber, J., Sgonc, R., Hu, Y. H., Beug, H. and Wick, G. (1994) Thymocyte apoptosis induced by elevated endogenous corticosterone levels. Eur. J. Immunol. 24: 1115-1121.
161. Grünfeld, J. P. (1990) Glucocorticoids in blood pressure regulation. Horm. Res. 34: 111-113.
162. Grünfeld, J. P., Eloy, L., Araujo, A. and Marie, F. R. (1986a) Effects of gluco- and antiglucocorticoids on renal and aortic prostaglandin synthesis. Am. J. Physiol. 251: F810-F816.
163. Grünfeld, J. P., Eloy, L., Moura, A. M., Ganeual, D., Frendo, B. R. and Worcel, M. (1986b) Effects of antiglucocorticoids on glucocorticoid hypertension in the rat. Hypertension 7: 292-299.
164. Gruol, D. J. and Altschmied, J. (1993) Synergistic induction of apoptosis with glucocorticoids and 3′,5′-cyclic adenosine monophosphate reveals agonist activity by RU 486. Mol. Endocrinol. 7: 104-113.
165. Guarneri, P., Guarneri, R., Cascio, C., Pavasant, P., Piccoli, F. and Papadopoulos, V. (1994) Neurosterogenesis in rat retina. J. Neurochem. 63: 86-96.
166. Guettari, N., Marin, L., Bourbon, J., Dufour, M. E., Rieutort, M. and Tordet, C. (1988) Effects of the antiglucocorticoid RU 486 on the maturation of fetal rat lung surfactant. Exp. Lung Res. 15: 151-166.
167. Guo, W. X. and Antakly, T. (1995) AIDS-related Kaposi's sarcoma: evidence for direct stimulatory effect of glucocorticoid on cell proliferation. Am. J. Pathol. 146: 727-734.
168. Guthrie, G. P. and Miller, R. E. (1981) Antiglucocorticoids in man: inability of several candidate steroids to acutely antagonize glucocorticoid actions in humans. Clin. Res. 29: 707A.
169. Haffar, O. K., Vallerga, A. K., Marenda, S. A., Witchel, H. J. and Firestone, G. L. (1987) Glucocorticoid regulated compartmentalization of cell surface associated glycoproteins in rat hepatoma cells: evidence for an independent response that requires receptor function and de novo RNA synthesis. Mol. Cell. Biol. 7: 1508-1517.
170. Han, Y. C., Lin, T. L. and Pruett, S. B. (1993) Thymic atrophy caused by ethanol in a mouse model for binge drinking: involvement of endogenous glucocorticoids. Toxicol. Appl. Pharmacol. 123: 16-25.
171. Hardwick, A. J., Linton, E. A. and Rothwell, N. J. (1989) Thermogenic effects of the antiglucocorticoid RU 486 in the rat: involvement of corticotropin-releasing factor and sympathetic activation of brown adipose tissue. Endocrinology 124: 1684-1688.
172. Hawes, A. S., Rock, C. S., Keogh, C. V., Lowry, S. F. and Calvano, S. E. (1992) In vivo effects of the antiglucocorticoid RU 486 on glucocorticoid and cytokine response to Escherichia coli endotoxin. Infect. Immun. 60: 2641-2647.
173. Hawes, A. S., Richardson, R. P., Antonacci, A. C. and Calvano, S. E. (1995) Chronic pathophysiologic elevation of corticosterone after thermal injury or thermal injury and burn wound infection adversely affects body mass, lymphocyte numbers, and outcome. J. Burn Care Rehabil. 16: 1-15.
174. 3H-dihydropyridine binding in A7r5 vascular smooth muscle cells. Am. J. Physiol. 261: C106-C114.
175. Healy, D. L., Chrousos, G. P., Schulte, H. M., Gold, P. W. and Hodgen, G. D. (1985) Increased adrenocorticotropin, cortisol and arginine vasopressin secretion in primates after the antiglucocorticoid steroid RU 38486: dose response relationships. J. Clin. Endocrinol. Metab. 60: 1-4.
176. Hechtor, O. and Lester, G. (1960) Cell permeability and hormone action. Recent Prog. Horm. Res. 16: 139-186.
177. Hechtor, O. and Pincus, G. (1954) Genesis of adrenocortical secretion. Pharmacol. Rev. 34: 459-496.
178. Heck, S., Kullmann, M., Gast, A., Ponta, H., Rahmsdorf, H. J., Herrlich, P. and Cato, A. C. (1994) A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13: 4087-4095.
179. Heftman, E. (1963) Biochemistry of plant steroids. Annu. Rev. Plant Physiol. 14: 255-248.
180. Heftman, E. (1975) Functions of steroids in plants. Phytochemistry 14: 891-901.
181. Heikinheimo, O. and Kekkonen, R. (1993) Dose-response relationships of RU 486. Ann. Med. 25: 71-76.
182. Henderson, I. W., Jackson, B. A. and Hargreaves, G. (1975) Action and metabolism of corticosteroids in teleost fish. Biochem. Soc. Trans. 3: 1168-1171.
183. Hendry, I. A., Hill, C. E. and McLennan, I. S. (1987) RU 38486 blocks the steroid regulation of transmitter choice in cultured rat sympathetic ganglia. Brain Res. 402: 264-268.
184. Hermann, G., Beck, F. M. and Sheridan, J. F. (1995) Stress-induced glucocorticoid response modulates mononuclear cell trafficking during an experimental influenza viral infection. J. Neuroimmunol. 56: 179-186.
185. Hermus, A. R. M. M., Pieters, G. F. F. M., Pesman, G. J., Smals, A. G., Benraad, T. J. and Kloppenborg, P. W. (1987) Enhancement of ACTH response to human CRF by pretreatment with the antiglucocorticoid RU 486. Eur. J. Clin. Pharmacol. 31: 609-611.
186. Hers, H. G., DeWulf, H. and Stalmans, W. (1970) The control of glycogen metabolism in liver. FEBS Lett. 12: 73-82.
187. Hess, P. and Payvar, F. (1992) Hormone withdrawal triggers a premature and sustained gene activation from delayed secondary glucocorticoid response elements. J. Biol. Chem. 267: 3490-3497.
188. Hidalgo, J., Giralt, M., Garvey, J. S. and Armario, A. (1991) Effect of morphine administration on rat liver metallothionein and zinc metabolism. J. Pharmacol. Exp. Ther. 259: 274-278.
189. Hill, N. C. W., Selinger, M., Ferguson, J. and MacKenzie, I. Z. (1991) Transplacental passage of mifepristone and its influence on maternal and fetal steroid concentrations in the second trimester pregnancy. Hum. Reprod. 6: 458-462.
190. Hirschelmann, R. (1988) Dexamethasone antagonism by RU 38486 in inflammatory reactions of the rat and mouse. Pharmazie 43: 219-220.
191. Hirschelmann, R., Böhm, V. and Funke, T. (1988) Hydrogen peroxide production ex vivo by peritonitis exudate leukocytes of rats and influence of dexamethasone and a glucocorticoid antagonist. Agents Actions 23: 101-102.
192. Hirschelmann, R., Schade, R., Bürger, W. and Bekemeier, H. (1990) Nonspecific action of glucocorticoids after high-dose pulse therapy. Agents Actions 31: 148-151.
193. + by the retinal pigment epithelium during the light response. Experientia 50: 438-441.
194. Hoeck, W., Rusconi, S. and Groner, B. (1989) Down regulation and phosphorylation of glucocorticoid receptors in cultured cells. J. Biol. Chem. 264: 14396-14402.
195. Hong, D. H. and Forsberg, N. E. (1995) Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures. Mol. Cell. Endocrinol. 108: 199-209.
196. Hu, S. B., Tannahill, L. A. and Lightman, S. L. (1992) Dexamethasone and aldosterone modulated corticotropin-releasing factor-41 release from cultured rat fetal hypothalamic cells through type II and type I corticosteroid receptors respectively. Neuroendocrinology 56: 591-596.
197. Hua, S. Y. and Chen, Y. Z. (1989) Membrane receptor-mediated electrophysiological effects of glucocorticoid on mammalian neurons. Endocrinology 124: 687-691.
198. Iannuzzi, D. M., Ertsey, R. and Ballard, P. L. (1993) Biphasic glucocorticoid regulation of pulmonary SP-A: characterization of inhibitory process. Am. J. Physiol. 264: L236-L244.
199. +-ATPase gene expression in adult and neonatal rat cardiocytes. J. Biol. Chem. 266: 12058-12066.
200. Imai, T., Hirata, Y., Iwashina, M. and Marumo, F. (1995) Hormonal regulation of rat adrenomedullin gene in vasculature. Endocrinology 136: 1544-1548.
201. Ishida, T., Matsura, K., Setoguchi, M., Higuchi, Y. and Yamamoto, S. (1994) Enhancement of murine serum amyloid A3 mRNA expression by glucocorticoids and its regulation by cytokines. J. Leukoc. Biol. 56: 797-806.
202. Ismahan, G. and Agarwal, M. K. (1979) Glucocorticoid antagonism by bacterial endotoxins. In: Antihormones, pp. 95-111, Agarwal, M. K. (ed.) Elsevier/North Holland, Amsterdam.
203. Israel, D. I. and Kaufman, R. J. (1993) Dexamethasone negatively regulates the activity of a chimeric dihydrofolate reductase/ glucocorticoid receptor protein. Proc. Natl. Acad. Sci. USA 90: 4290-4294.
204. Jahn, G. A., Moguilewsky, M., Houdebine, L. M. and Djiane, J. (1987) Binding and action of glucocorticoids and mineralocorticoids in rabbit mammary gland. Exclusive participation of glucocorticoid type II receptors for stimulation of casein synthesis. Mol. Cell. Endodcrinol. 52: 205-212.
205. James, V. H. T. (1992) The Adrenal Gland. Raven Press, New York.
206. James, V. H. T. and Few, J. D. (1985) Adrenocorticoids: chemistry, synthesis and disturbance in disease. Clin. Endocrinol. Metab. 14: 867-892.
207. Jamieson, A., Connell, J. M. and Fraser, R. (1993) Glucocorticoid-suppressible hyperaldosteronism: from confusion to conclusion. J. Mol. Endocrinol. 10: 3-5.
208. Jantzen, H. M., Strohle, G., Gloss, B., Stewart, F., Schmid, W., Boshart, M., Miksicek, R. and Schutz, G. (1987) Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell 49: 29-38.
209. Jazayeri, A. and Meyer, W. J. (1989) Mineralocorticoid-induced increase in β-adrenergic receptors of cultured rat arterial smooth muscle cells. J. Steroid Biochem. 5: 987-991.
210. Jellinck, P. H., Newcombe, A. M. and Lyttle, C. R. (1993) Antiandrogenic property of RU 486: enhancement of estrogen-induced uterine peroxidase activity in the rat. J. Steroid Biochem. 45: 303-307.
211. Jensen, E. V. (1995) Steroid hormone antagonists: summary and future challenges. Ann. NY Acad. Sci. 761: 4-20.
212. Jensen, E. V., Greene, G. L., Closs, L. E., DeSombre, E. R. and Nadji, M. (1982) Receptors reconsidered: a 20-year perspective. Recent Prog. Horm. Res. 38: 1-40.
213. Johnson, G. S. and Ralhan, R. (1986) Glucocorticoid agonists as well as antagonists are effective inducers of mouse mammary tumor virus RNA in mouse mammary tumor cells treated with inhibitors of ADP-ribosylation. J. Cell. Physiol. 129: 36-42.
214. Jones, M. T. and Hillhouse, E. W. (1976) Structure-activity relationship and the mode of action of corticosteroid feedback on the secretion of corticotrophin-releasing factor (corticoliberin). J. Steroid Biochem. 7: 1189-1202.
215. Jourdainne, C. F., Garaud, J. C., Emvo, E. N. and Raul, F. (1993) Epidermal growth factor and the maturation of intestinal sucrase in suckling rats. Am. J. Physiol. 265: G459-G466.
216. Kageyama, Y., Suzuki, H. and Saruta, T. (1994) Role of glucocorticoid in the development of glycyrrhizin-induced hypertension. Clin. Exp. Hypertens. 16: 761-778.
217. Kalimi, M. (1989) Role of antiglucocorticoid RU 486 on dexamethasone-induced hypertension in rats. Am. J. Physiol. 256: E682-E685.
218. Kalimi, M. and Agarwal, M. K. (1988) Interaction of antiglucocorticoid RU 486 with rat kidney glucocorticoid receptors. Biochem. Biophys. Res. Commun. 153: 365-371.
219. Kalimi, M., Opoku, J., Agarwal, M. K. and Corley, K. (1990) Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats. Am. J. Physiol. 258: E737-E739.
220. 1 regulates the induction of tyrosine aminotransferase gene transcription in rat hepatocyte cultures. Biochem. Biophys. Res. Commun. 205: 1696-1701.
221. Kanno, K., Hirata, Y., Imai, T. and Marumo, F. (1993) Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells. Hypertension 22: 34-39.
222. Karlson, P. and Sekeris, C. (1966) Ecdysone: an insect hormone and its mode of action. Recent Prog. Horm. Res. 22: 473-494.
223. Kater, C. E., Biglieri, E. G., Brust, N., Chang, B., Hirai, J. and Irony, I. (1989) Stimulation and suppression of the mineralocorticoid hormones in normal subjects and adrenocortical disorders. Endocr. Rev. 10: 149-164.
224. Kennedy, B., Elayan, H. and Ziegler, M. G. (1993) Glucocorticoid elevation of mRNA encoding epinephrine-forming enzyme in lung. Am. J. Physiol. 265: L117-L120.
225. Kim, M. Y., Lee, K. Y. and Lee, S. K. (1994) Inductive effect of ginsenoside-RG1 on tyrosine aminotransferase gene expression in rat primary hepatocyte cultures. Biochem. Mol. Biol. Int. 34: 845-851.
226. King, L. B. and Corley, R. B. (1990) Lipopolysaccharide and dexamethasone induce mouse mammary tumor proviral gene expression and differentiation in B lymphocytes through distinct regulatory pathways. Mol. Cell. Biol. 10: 4211-4220.
227. Kling, M. A., Whitfield, H. J., Brandt, H. A., Demitrack, M. A., Kalogeras, K., Geracioti, T. D., Perini, G. I., Calabrese, J. R., Chrousos, G. P. and Gold, P. W. (1989) Effects of glucocorticoid antagonism with RU 486 on pituitary-adrenal function in patients with major depression: time-dependent enhancement of plasma ACTH secretion. Psychopharmacol. Bull. 25: 466-472.
228. Kling, M. A., Demitrack, M. A., Whitfield, H. J., Kalogeras, K. T., Listwak, S. J., DeBellis, M. D., Chrousos, G. P., Gold, P. W. and Brandt, H. A. (1993) Effects of the glucocorticoid antagonist RU 486 on pituitary-adrenal function in patients with anorexia nervosa and healthy volunteers: enhancement of plasma ACTH and cortisol secretion in underwight patients. Neuroendocrinology 57: 1082-1091.
229. Klyne, W. (1957) The Chemistry of Steroids. Metheun, London.
230. Knox, W. E. (1972) Enzyme Patterns in Fetal, Adult and Neoplastic Rat Tissues. S. Karger, Basel.
231. Kocarek, T. A., Schuetz, E. G. and Guzelian, P. S. (1994) Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel. Biochem. Pharmacol. 48: 1815-1822.
232. Konagaya, M., Bernard, P. A. and Max, S. R. (1986) Blockade of glucocorticoid receptor binding and inhibition of dexamethasone-induced muscle atrophy in the rat by RU 38486, a potent glucocorticoid antagonist. Endocrinology 119: 375-380.
233. Konagaya, M., Konagaya, Y. and Max, S. R. (1987) Evaluation of the endogenous glucocorticoid hypothesis of denervation atrophy. J. Neurol. Sci. 79: 149-154.
234. Konagaya, M., Konagaya, Y., Friedman, J. A. and Max, S. R. (1988) Nuclear glucocorticoid receptor binding in L6 skeletal muscle cells in culture. J. Steroid Biochem. 29: 685-689.
235. Kornel, L., Kanamarlapudi, N., Travers, T., Taff, D. J., Patel, N., Chen, C., Baum, R. M. and Raynor, W. J. (1982) Studies on high affinity binding of mineralo- and glucocorticoids in rabbit aorta cytosol. J. Steroid Biochem. 16: 245-264.
236. Kornel, L., Nelson, W. A., Manisundaram, B., Chigurupati, R. and Hayashi, T. (1993) Mechanism of the effects of glucocorticoids and mineralocorticoids on vascular smooth muscle contractility. Steroids 58: 580-587.
237. Korte, S. M., DeBoer, S. F., DeKloet, E. R. and Bohus, B. (1995) Anxiolytic-like effects of selective mineralocorticoid and glucocorticoid antagonists on fear-induced behavior in the elevated plus maze. Psychoneuroendocrinology 20: 385-394.
238. Kostrouch, Z., Kostrouchova, M. and Rall, J. E. (1995) Steroid/ thyroid hormone receptor genes in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 92: 156-159.
239. Kramlik, S. K., Altemus, M. and Castonguay, T. W. (1993) The effects of the acute administration of RU 486 on dietary fat preference in fasted lean and obese men. Physiol. Behav. 54: 717-724.
240. Krishnan, K. R. R., Reed, D., Wilson, W. H., Saunders, W. C., Ritchie, J. C., Nemeroff, C. B. and Carroll, B. J. (1992) RU 486 in depression. Prog. Neuropsychopharmacol. Biol. Psychiat. 16: 913-920.
241. Kroemer, G. and Martinez, C. A. (1994) Pharmacological inhibition of programmed lymphocyte death. Immunol. Today 15: 235-242.
242. Kurokawa, M., Michelangeli, V. P. and Findlay, D. M. (1991) Induction of calcitonin receptor expression by glucocorticoids in T47D breast cancer cells. J. Endocrinol. 130: 321-326.
243. Kutteh, W. H., Rainey, W. E. and Carr, B. R. (1991) Regulation of interleukin-6 production in human fetal Kupffer cells. Scand. J. Immunol. 33: 607-613.
244. Lähteenmäki, P., Heikenheimo, O., Croxxato, H., Spitz, I., Shoupe, D., Birgerson, L. and Luukkainen, T. (1987) Pharmacokinetics and metabolism of RU 486. J. Steroid Biochem. 27: 859-863.
245. Lakasa, D., Agli, B. and Giudecelli, Y. (1988) Permissive action of glucocorticoids on catecholamine-induced lipolysis: direct "in vitro" effects of the fat β-adrenoreceptor-coupled-adenylate cyclase system. Biochem. Biophys. Res. Commun. 153: 489-497.
246. Lamberts, S. W. J., Bons, E. G. and Uitterlinden, P. (1985a) Studies on the glucocorticoid-receptor blocking action of RU 38486 in cultured ACTH-secreting human pituitary cells and normal rat pituitary cells. Acta Endocrinol. 109: 64-69.
247. Lamberts, S. W. J., Uitterlinden, P., Bons, E. G. and Verleun, T. (1985b) Comparison of the actions of RU 38486 and megestrol acetate in the model of a transplantable adrenocorticotropin and prolactin-secreting rat pituitary tumor. Cancer Res. 45: 1015-1019.
248. Lamberts, S. W. J., DenHolder, F. and Hofland, L. J. (1989) The inter relationship between the effects of insulin-like growth factor I and somatostatin on growth hormone secretion by normal rat pituitary cells: the role of glucocorticoids. Endocrinology 124: 905-911.
249. Lamberts, S. W. J., Koper, J. W. and Dejong, F. H. (1991) The endocrine effects of long term-treatment with mifepristone (RU 486). J. Clin. Invest. Metab. 73: 187-191.
250. Landau, R. L. (1979) Progesterone vs aldosterone. In: Antihormones, pp. 153-166, Agarwal, M. K. (ed.) Elsevier/North Holland, Amsterdam.
251. Landau, R. L. and Lugibihl, K. (1958) Inhibition of sodium retaining influence of aldosterone by progesterone. J. Clin. Endocrinol. Metab. 18: 1237-1245.
252. Langley, S. C. and York, D. A. (1990) Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats. Am. J. Physiol. 259: R539-R544.
253. Lanz, R. B. and Rusconi, S. (1994) A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors. Endocrinology 135: 2183-2195.
254. Laudet, V., Hänni, C., Coll, J., Catzeflis, F. and Stéhélin, D. (1992) Evolution of the nuclear receptor gene superfamily. EMBO J. 11: 1003-1013.
255. Lazar, G. and Agarwal, M. K. (1986a) Physiological action and receptor binding of a newly synthesized and novel antiglucocorticoid. Biochem. Biophys. Res. Commun. 134: 44-50.
256. Lazar, G. and Agarwal, M. K. (1986b) The influence of a novel glucocorticoid antagonist on endotoxin lethality in mice strains. Biochem. Med. Metab. Biol. 36: 70-74.
257. Lazar, G., Lazar, G., Jr. and Agarwal, M. K. (1991) Modification of shock by the antiglucocorticoid RU 38486. In: Antihormones in Health and Disease, pp. 36-44, Agarwal, M. K. (ed.) Karger, Basel.
258. Lazar, G., Lazar, G., Jr., Husztik, E., Duda, E. and Agarwal, M. K. (1995) The influence of antiglucocorticoids on stress and shock. Ann. NY Acad. Sci. 761: 276-295.
259. Lazar, G., Jr., Duda, E. and Lazar, G. (1992a) Effect of RU 38486 on TNF production and toxicity. FEBS Lett. 308: 137-140.
260. Lazar, G., Jr., Lazar, G. and Agarwal, M. K. (1992) Modification of septic shock in mice by the antiglucocorticoid RU 38486. Circ. Shock 36: 180-184.
261. Lee, L. E. and Bols, N. C. (1989) Action of cortisol on the proliferation of rainbow trout fibroblasts. Cell Tissue Kinet. 22: 291-301.
262. Lefebvre, P., Formstecher, P., Richard, C. and Dautrevaux, M. (1988) RU 486 stabilizes a high molecular weight form of the glucocorticoid receptor containing the 90K non-steroid binding protein in intact cells. Biochem. Biophys. Res. Commun. 150: 1221-1229.
263. Leighton, B., Billings, M. P., Dimitriadis, G., Bond, J., Newsholme, E. A., Dacosta, C. and Foot, E. A. (1991) Physiological glucocorticoid levels regulate glutamine and insulin-mediated glucose metabolism in skeletal muscle of the rat. Biochem. J. 274: 187-192.
264. Lemberger, T., Staels, B., Saladin, R., Descergne, B., Auwerx, J. and Wahli, W. (1994) Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. J. Biol. Chem. 269: 24527-24530.
265. Lester, G., Stone, D. and Hechtor, O. (1958) The effects of deoxycorticosterone and other steroids on Neurospora crassa. Arch. Biochem. Biophys. 75: 196-214.
266. Lewis, E. Y., Harrington, E. C. and Chikaraishi, D. M. (1987) Transcriptional regulation of tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. Proc. Natl. Acad. Sci. USA 84: 3550-3554.
267. Lifton, R. P. (1995) Genetic determinants of human hypertension. Proc. Natl. Acad. Sci. USA 92: 8545-8551.
268. Link, H., Dayanithi, G. and Gratzl, M. (1993) Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells without modifying intracellular calcium transients. Endocrinology 132: 873-878.
269. Lu, W., Goncalves, R. S., Yuan, J., Sylvie, D., Han, D. S. and Andrieu, J. M. (1995) Glucocorticoids rescue CD4+ T lymphocytes from activation-induced apoptosis triggered by HIV-1: implications for pathogenesis and therapy. AIDS 9: 35-42.
270. Luisi, B. F., Xu, W. X., Otwinowski, Z., Freeman, L. P., Yamamoto, K. R. and Sigler, P. B. (1991) Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352: 497-505.
271. Maëmpel, J. V. Z. (1974) Corticosteroids in ventricular tachycardia. Isr. J. Med. Sci. 9: 1126-1132.
272. Mahato, S. B., Banerjee, S. and Fodder, S. (1989) Steroid transformations by microorganisms. Phytochemistry 28: 7-40.
273. 2-adrenergic receptor transcription in human lung. Am. J. Physiol. 268: L41-L46.
274. Makrigiannakis, A., Margioris, A., Markogiannakis, E., Stournaras, C. and Gravanis, A. (1992) Steroid hormones regulate the release of immunoreactive β-endorphin from the Ishikawa human endometrial cell line. J. Endocrinol. Metab. 75: 584-589.
275. Mao, J., Regelson, W. and Kalimi, M. (1992) Molecular mechanism of RU 486 action: a review. Mol. Cell. Biochem. 109: 1-8.
276. Max, S. R., Thomas, J. W., Banner, C., Vitkovic, L., Konagaya, M. and Konagaya, Y. (1987) Glucocorticoid-receptor-mediated induction of glutamine synthetase in skeletal muscle cells in vitro. Endocrinology 120: 1179-1183.
277. Mayer, M. and Rosen, F. (1977) Interaction of glucocorticoids and androgens with skeletal muscle. Metabolism 26: 937-962.
278. Mayeux, P., Felix, J. M., Billat, C. and Jacquot, R. (1985) Effect of the antiglucocorticoid agent RU 38486 on the dexamethasone inhibition of Friend cell differentiation. Virology 183: 799-802.
279. McClellan, J. L., Klir, J. J., Morrow, L. E. and Kluger, M. J. (1994) Central effects of glucocorticoid receptor antagonist RU 38486 on lipopolysaccharide and stress-induced fever. Am. J. Physiol. 267: R705-R711.
280. McMillan, V. M., Dennis, G. J., Glimcher, L. H., Finkelman, F. D. and Mond, J. J. (1988) Corticosteroid induction of Ig+Ig-B cells in vitro is mediated via interaction with the glucocorticoid cytoplasmic receptor. J. Immunol. 140: 2549-2555.
281. Melby, J. C. (1989) Clinical review 1: endocrine hypertension. Endocr. Rev. 69: 697-707.
282. Mendelson, C. R. and Boggaram, V. (1989) Regulation of pulmonary surfactant protein synthesis in fetal lung: a major role of glucocorticoids and cAMP. Trends Endocrinol. Metab. 2: 20-25.
283. Mercier, L., Miller, P. A. and Simons, S. S. (1986) Antiglucocorticoid steroids have increased agonist activity in those hepatoma cell lines that are more sensitive to glucocorticoids. J. Steroid Biochem. 25: 11-20.
284. Meyer, M. E., Pornon, A., Ji, J., Bocquel, M. T., Chambon, P. and Gronemeyer, H. (1990) Agonistic and antagonistic activities of RU 486 on the functions of the human progesterone receptor. EMBO J. 9: 3923-3932.
285. Meyer, J. S. (1985) Biochemical effects of corticosteroids on neural tissues. Physiol. Rev. 65: 946-1021.
286. Miller, A. H., Spencer, R. L., Trestman, R. L., Kim, C., McEwen, B. S. and Stein, M. (1991) Adrenal steroid receptor activation in vivo and immune function. Am. J. Physiol. 261: E126-E131.
287. Miller, J. W. and Crapo, L. (1993) The medical treatment of Cushing's syndrome. Endocr. Rev. 14: 443-458.
288. Miller, W. L. (1988) Molecular biology of steroid hormone synthesis. Endocr. Rev. 9: 295-318.
289. Mirshahi, M., Mirshahi, A., Nato, A. and Agarwal, M. K. (1992a) Mineralocorticoid hormone action in plant cells. Biochem. Biophys. Res. Commun. 186: 1102-1107.
290. Mirshahi, M., Mirshahi, A., Nato, A. and Agarwal, M. K. (1992b) Receptor mediated mineralocorticoid action in alga cell mutants. FEBS Lett. 314: 237-240.
291. Mirshahi, M., Pagano, M., Mirshahi, A. and Agarwal, M. K. (1992c) Generation of polyclonal antibodies against the mineralocorticoid receptor and analysis of mineralocortin in rat myocardium by immunophotochemistry. Biochim. Biophys. Acta 1120: 17-23.
292. Mirshahi, M., Nicolas, C., Mirshahi, A., Hecquet, C., d'Hermies, F., Faure, J. P. and Agarwal, M. K. (1996) The mineralocorticoid hormone receptor and action in the eye. Biochem. Biophys. Res. Commun. 219: 150-156.
293. Montminy, M. R., Sevarino, K. A., Wagner, J. A., Mandel, G. and Goodman, R. H. (1986) Identification of a cyclic AMP responsive element within the rat somatostatin gene. Proc. Natl. Acad. Sci. USA 83: 6682-6686.
294. Morrow, L. E., McClellan, J. L., Conn, C. A. and Kluger, M. J. (1993) Glucocorticoids alter fever and IL-6 response to psychological stress and to lipopolysaccharide. Am. J. Physiol. 264: R1010-R1016.
295. Moustaid, N., Hainque, B., Boulange, A. Q. and Agarwal, M. K. (1990) Analysis of the glucocorticoid receptor during differentiation of 3T3-F442A preadipocyte cell line in culture. Biochem. Med. Metab. Biol. 43: 93-100.
296. Müller, J. (1978) Suppression of aldosterone biosynthesis by treatment of rats with adrenocorticotropin: comparison with glucocorticoid effects. Endocrinology 103: 2061-2068.
297. Müller, J. (1994) Aldosterone: the minority hormone of the adrenal cortex. Steroids 60: 2-9.
298. Munck, A., Guyre, P. M. and Holbrook, N. J. (1984) Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 5: 25-44.
299. + mobilization in C6 glioma cells. Neuroendocrinology 57: 322-329.
300. Murasawa, S., Matsubara, H., Kanasaki, M., Kijima, K., Maruyama, K., Nio, Y., Okubo, N., Tsukaguchi, H., Mori, Y. and Inada, M. (1995) Characterization of glucocorticoid response element of rat angiotensin II type 1 receptor gene. Biochem. Biophys. Res. Commun. 209: 832-840.
301. Murlow, P. J., Takagi, M., Takagi, M. and Saenz, R. F. (1987) Inhibitors of aldosterone secretion. J. Steroid Biochem. 27: 941-946.
302. Murphy, B. E., Filipini, D. and Ghadirian, A. M. (1993) Possible use of glucocorticoid receptor antagonists in the treatment of major depression: preliminary results using RU 486. J. Psychiatry Neurosci. 18: 209-213.
303. Naylor, P. H. and Rosen, F. (1982) Antiglucocorticoids: differential antagonism of in vivo responses to dexamethasone. In: Hormone Antagonists, pp. 365-380, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin.
304. Naylor, P. H., Gilani, S. S. H., Milholland, R. J. and Rosen, F. (1980) Antiglucocorticoids: in vivo assay and evaluation of cortexolone, progesterone and 6 β-bromoprogesterone. Endocrinology 107: 117-121.
305. Nebert, D. W. and Gonzalez, F. J. (1987) P450 genes: structure, evolution and regulation. Annu. Rev. Biochem. 56: 945-993.
306. Neef, G., Beier, S., Elger, W., Henderson, D. and Wiechert, R. (1984) New steroids with antiprogestational and antiglucocorticoid activity. Steroids 44: 349-372.
307. Neuberger, T. J., Kalimi, O., Regelson, W., Kalimi, M. and DeVries, G. H. (1994) Glucocorticoids enhance the potency of Schwann cell mitogens. J. Neurosci. Res. 38: 300-313.
308. New, M. I. (1994) The prismatic case of apparent mineralocorticoid excess. J. Clin. Endocrinol. Metab. 79: 1-3.
309. Nichols, N. R., Obert, D. F. and Meyer, W. J. (1985) Comparison of aldosterone binding in aortic cells from Dahl salt-susceptible and salt-resistant rats. Life Sci. 36: 1653-1660.
310. Nieman, L. K. and Loriaux, D. L. (1987) Clinical applications of the glucocorticoid and progestin antagonist RU 486. In: Receptor Mediated Antisteroid Action, pp. 77-98, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
311. Nordeen, S. K., Bona, B. J., Beck, C. A., Edwards, D. P., Borror, K. C. and Defranco, D. B. (1995) The two faces of a steroid antagonist: when an antagonist isn't. Steroids 60: 97-104.
312. Oitzl, M. S., Flüftert, M. and DeKloet, R. R. (1994) The effect of corticosterone on reactivity to spatial novelty is mediated by central mineralocorticoid receptors. Eur. J. Neurosci. 6: 1072-1079.
313. Okada, S., York, D. A. and Bray, G. A. (1992) Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity. Am. J. Physiol. 262: R1106-R1110.
314. Olefsky, J. and Kimmerling, G. (1976) Effects of glucocorticoids on carbohydrate metabolism. Am. J. Med. Sci. 271: 202-210.
315. O'Malley, B. (1990) The steroid receptor superfamily: more excitement predicted for the future. Mol. Endocrinol. 4: 363-369.
316. Ono, S., Hirano, H. and Obara, K. (1972a) Further studies on the cortisol binding proteins in the lens. Ophthalmic Res. 4: 193-198.
317. Ono, S., Hirano, H. and Obara, K. (1972b) Study on the conjugation of cortisol in the lens. Ophthalmic Res. 4: 307-310.
318. Opoku, J. and Kalimi, M. (1992) Role of antiglucocorticoid RU 486 in the prevention of steroid-induced hypertension. Acta Endocrinol. 127: 258-261.
319. Opoku, J., Kalimi, M., Agarwal, M. K. and Qureshi, D. (1991) Effect of a new mineralocorticoid antagonist mespirenone on aldosterone-induced hypertension. Am. J. Physiol. 260: E269-E271.
320. Orti, E., Mendel, D. B., Smith, L. I. and Munck, A. (1989) Agonist-dependent phosphorylation and nuclear dephosphorylation of glucocorticoid receptors in intact cells. J. Biol. Chem. 264: 9728-9731.
321. Ota, K., Kimura, T., Shoji, M., Inoue, M., Sato, K., Ohta, M., Yamamoto, T., Tsunoda, K., Abe, K. and Yoshinaga, K. (1992) Interaction of ANP with endothelin on cardiovascular, renal, and endocrine function. Am. J. Physiol. 262: E135-E141.
322. Ottow, E., Beier, S., Elger, W., Henderson, D. A., Neef, G. and Wiechert, R. (1984) Synthesis of ent-17-(prop-1-ynyl-17β-hydroxy-11β-(4-(N,N-dimethylamino)-pheny 1)-4,9-estradien-3-one, the antipode of RU 38486. Steroids 44: 519-530.
323. Pacha, J., Popp, M. and Capek, K. (1988) Corticosteroid regulation of Na+ and K+ transport in the rat distal colon during postnatal development. J. Dev. Physiol. 10: 531-540.
324. Pagano, M., Mirshahi, M., Mirshahi, F., Monnot, M., Lazar, G., Chassaing, C. G., Fermandjian, S. and Agarwal, M. K. (1994) Properties of the mineralocorticoid receptor immunopurified from bovine kidney. Biochem. Pharmacol. 48: 1163-1169.
325. Pan, C. J., Shelly, L. L., Rabin, D. S. and Chou, J. Y. (1992) Inhibition of tyrosine aminotransferase gene expression by retinoic acid. Mol. Endocrinol. 6: 572-580.
326. Papolos, D. F., Edwards, E., Marmur, R., Lachman, H. M. and Henn, F. A. (1993) Effects of the antiglucocorticoid RU 38486 on the induction of learned helpless behavior in Sprague-Dawley rats. Brain Res. 615: 304-309.
327. Parrillo, J. E. (1993) Pathogenetic mechanisms of septic shock. N. Engl. J. Med. 328: 1471-1477.
328. Pastorino, J. G., Wilhelm, T. J., Glascott, P. A., Kocsis, J. J. and Farber, J. L. (1995) Dexamethasone induces resistance to the lethal consequences of electron transport inhibition in cultured hepatocytes. Arch. Biochem. Biophys. 318: 175-181.
329. Patejunas, G. and Young, A. P. (1990) Constitutive and glucocorticoid-mediated activation of glutamine synthetase gene expression in the developing chicken retina. J. Biol. Chem. 265: 15280-15285.
330. Pater, M. M. and Pater, A. (1991) RU 486 inhibits glucocorticoid hormone-dependent oncogenesis by human papilloma virus type 16 DNA. Virology 183: 799-802.
331. Paul, S. M. and Purdy, R. H. (1992) Neuroactive steroids. FASEB J. 6: 2311-2322.
332. Peers, S. H., Duncan, G. S., Flower, R. J. and Bolton, C. (1995) Endogenous corticosteroids modulate lymphoproliferation and susceptibility to experimental allergic encephalomyelitis in the brown Norway rat. Int. Arch. Allergy Immunol. 106: 20-24.
333. Pekki, A., Ylikomi, T., Syvälä, H. and Touhimaa, P. (1994) Progesterone receptor and hsp90 are not complexed in intact nuclei. J. Steroid Biochem. Mol. Biol. 48: 475-479.
334. Perlstein, R. S., Whitnall, M. H., Abrams, J. S., Mougey, E. H. and Neta, R. (1993) Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinology 132: 946-952.
335. Perretti, M., Duncan, G. S., Flower, R. J. and Peers, S. H. (1993) Serum corticosterone, interleukin-1 and tumor necrosis factor in rat experimental endotoxemia: comparison between Lewis and Wistar strains. Br. J. Pharmacol. 110: 868-874.
336. Pesonen, U., Koulu, M., Heikinheimo, O. and Huupponen, R. (1992a) The glucocorticoid antagonist mifepristone reveals abnormal regulation of the adrenocortical system in obese Zucker rats. J. Endocrinol. 132: 424-431.
337. Pesonen, U., Miettinen, T., Scheinin, M. and Koulu, M. (1992b) α2-Adrenoreceptor density in forebrain areas of Zucker rats: no effect of genetic obesity or antiglucocorticoid treatment. Brain Res. 574: 353-356.
338. Phillips, C. I., Green, K., Gore, S. M., Cullen, R. M. and Campbell, M. (1984) Eye drops of RU 486, a peripheral steroid blocker, lower intraocular pressure in rabbits. Lancet i: 767-768.
339. Phillips, C. I., Peat, K., Gore, S. M., Clark, C. V., Clark, M., Mackintosh, G. I. S. and Green, K. (1989) Topical dexamethasone lowers rabbit ocular tension, as does topical mifepristone (RU 486), a peripheral blocker of dexamethasone and progesterone. Ophthalmic Res. 21: 235-238.
340. Picard, D., Khursheed, B., Garabedian, M. J., Fortin, M. G., Lindquist, S. and Yamamoto, K. (1990) Reduced levels of HSP90 compromise steroid receptor action in vivo. Nature 348: 166-168.
341. Pinto, A., Carnuccio, R., Sorrentino, R. and DiRosa, M. (1993) The inhibition of platelet aggregation by activated macrophages is blocked by dexamethasone. Pharmacol. Res. 27: 165-172.
342. Potvin, W. and Varma, D. R. (1991) Down-regulation of myometrial natriuretic factor receptors by progesterone and pregnancy and up-regulation by oestrogen in rats. J. Endocrinol. 131: 259-266.
343. Potvin, W., Mulay, S. and Varma, D. R. (1991) Inhibition of the tocolytic activity of atrial natriuretic factor by progesterone and potentiation by progesterone receptor antagonist RU 486 in rats. Br. J. Pharmacol. 104: 379-384.
344. Provencher, P. H., Bélanger, A. and Fiet, J. (1991) Effects of RU 486 on adrenal steroidogenesis in the guinea pig. J. Endocrinol. 130: 71-78.
345. Qi, M., Stasenko, L. and Defranco, D. (1990) Recycling and desensitization of glucocorticoid receptor in V-mos transformed cells depend on the ability of nuclear receptors to modulate gene expression. Mol. Endocrinol. 4: 455-464.
346. Ramsay, L. E. (1982) Clinical pharmacology and therapeutic use of aldosterone antagonists. In: Hormone Antagonists, pp. 335-364, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
347. Ratka, A., Sutanto, W., Bloemers, M. and DeKloet, E. R. (1989) On the role of brain mineralocorticoid (Type I) and glucocorticoid (Type II) receptors in neuroendocrine regulation. Neuroendocrinology 50: 117-123.
348. Refaeli, Y., Levy, D. N. and Weiner, D. B. (1995) The glucocorticoid receptor type II complex is a target of the HIV-vpr gene product. Proc. Natl. Acad. Sci. USA 92: 3621-3625.
349. Reid, A. F., Coghlan, J. P., Spence, C. D., Whitworth, J. A. and Scoggins, B. A. (1989) Studies on spirolactone steroid antagonists in ACTH-induced hypertension in sheep. J. Steroid Biochem. 33: 1213-1221.
350. Rey, M., Carlier, E. and Soumireu-Mourat, B. (1989) Effects of RU 486 on hippocampal slice electrophysiology in normal and adrenalectomized BALB/c mice. Neuroendocrinology 49: 120-124.
351. Robles, R. G. and Ruilope, L. M. (1987) Pharmacological influences on aldosterone secretion. J. Steroid Biochem. 27: 947-951.
352. Rosenfeld, P., Sutanto, W., Levine, S. and DeKloet, E. R. (1990) Ontogeny of mineralocorticoid (type 1) receptors in brain and pituitary: an in vivo autoradiographic study. Dev. Brain Res. 52: 57-62.
353. Rosewicz, S. and Logsdon, C. G. (1991) Glucocorticoids stimulate ornithine decarboxylase gene expression in pancreatic AR42J cells. Gastroenterology 101: 1102-1108.
354. Rosewicz, S., Detjen, K., Logsdon, C. D., Chen, L. M., Chao, J. and Riecken, E. O. (1991) Glandular kallikrein gene expression is selectively down-regulated by glucocorticoids in pancreatic AR42J cells. Endocrinology 128: 2216-2222.
355. 3H-RU 486. J. Steroid Biochem. 25: 605-614.
356. Sakiz, E. (1987) Survey on antiglucocorticoids. In: Pharmacology and Clinical Uses of Inhibitors of Hormone Secretion and Action, pp. 213-233, Furr, B. J. A. and Wakeling, A. E. (eds.) Baillière-Tindall, London.
357. Sakly, M., Philibert, D., Bucher, B. L. and Koch, B. (1984) Paradoxical involvment of glucocorticoid receptors in aldosterone-induced impairment of ACTH secretion from perifused pituitary glands. J. Steroid Biochem. 20: 1101-1104.
358. Samuels, L. T. (1960) Metabolism of steroid hormones. In: Metabolic Pathways, Vol. 1, pp. 431-480, Greenberg, D. M. (ed.) Academic Press, New York.
359. Sanchez, P. E., Ryan, M. A., Kridelka, F., Gielen, I., Ren, S. G., Albertson, B., Malozowski, S., Niemann, L. and Cassorla, F. (1989) RU 486 inhibits rat gonadal steroidogenesis. Horm. Metab. Res. 21: 369-371.
360. Sandi, C. and Rose, S. P. R. (1994) Corticosterone enhances long-term retention in one day old chicks trained in a weak passive avoidance learning paradigm. Brain Res. 647: 106-112.
361. Sandor, T. (1969) A comparative survey of steroids and steroidogenic pathways throughout the vertebrates. Gen. Comp. Endocrinol. 2 (Suppl.): 284-298.
362. Sandor, T. and Mehdi, A. Z. (1979) Steroids and evolution. In: Hormones and Evolution, pp. 2-72, Barrington, E. J. W. (ed.) Academic Press, London.
363. Sandor, T., Fazekas, A. G. and Robinson, B. H. (1976) The biosynthesis of corticosteroids throughout the vertebrates. In: General, Comparative and Clinical Endocrinology of Adrenal Cortex, Vol. I, pp. 24-142, Jones, I. C. and Henderson, I. W. (eds.) Academic Press, London.
364. Sapi, E., Flick, M. B., Hebert, M. G., Rodov, S. and Kacinski, B. M. (1995) Transcriptional regulation of the c-fms (CSF-1R) protooncogene in human breast carcinoma cells by glucocorticoids. Oncogene 10: 529-542.
365. Sarantos, P., Abouhamze, A., Chakrabarti, R. and Souba, W. W. (1994) Glucocorticoids regulate intestinal synthetase gene expression in endotoxemia. Arch. Surg. 129: 59-65.
366. Sato, A., Suzuki, H., Iwaita, Y., Nakazato, Y., Kato, H. and Saruta, T. (1992) Dexamethasone potentiates production of inositol triphosphate evoked by endothelin-1 in vascular smooth muscle cells. J. Cardiovasc. Pharmacol. 20: 290-295.
367. Sato, A., Suzuki, H., Murakami, M., Nakazato, Y., Iwaita, Y. and Saruta, T. (1994) Glucocorticoid increases angiotensin II type I receptor and its gene expression. Hypertension 23: 25-30.
368. Sayers, G. and Sayers, M. (1948) The pituitary-adrenal system. Recent Prog. Horm. Res. 2: 81-116.
369. Schelling, J. R., DeLuca, D., Konieczkowski, M., Marzec, R., Sedor, J. R., Dubyak, G. R. and Linas, S. L. (1994) Glucocorticoid uncoupling of angiotensin II-dependent phospholipase C activation in rat vascular smooth muscle cells. Kidney Int. 46: 675-682.
370. Schilling, K., Schmale, H., Oeding, P. and Pilgrim, C. (1991) Regulation of vasopressin expression in cultured diencephalic neurons by glucocorticoids. Neuroendocrinology 53: 528-535.
371. Schimchowitsch, S., Plante, M., Kienlen, P., Felix, J. M., Koch, B. and Stoeckel, M. E. (1994) Glucocorticoids, but not dopamine, negatively regulate the melanotropic activity of the rabbit pituitary intermediate lobe. J. Neuroendocrinol. 6: 385-390.
372. 3H-cortivazol: a unique high affinity ligand for the glucocorticoid receptor. Endocrinology 117: 1355-1362.
373. Scoggins, B. A., Coghlan, J. P., Denton, D. A., Reid, A. F., Spence, C. D. and Whitworth, J. A. (1989) Understanding the mechanism of adrenocortical steroid hypertension. J. Steroid Biochem. 32: 205-208.
374. Scott, B. A., Lawrence, B., Nguyen, H. H. and Meyer, W. J. (1987) Aldosterone and dexamethasone binding in human arterial smooth muscle cells. J. Hypertens. 5: 739-744.
375. Segintz, B. and Gehring, U. (1990) Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells. J. Biol. Chem. 265: 2789-2796.
376. Selye, H. (1947) Textbook of Endocrinology. University of Montreal, Montreal.
377. Selye, H. (1971) Hormones and Resistance. Springer Verlag, New York.
378. Shaw, P. M., Adesnik, M., Weiss, M. C. and Corcos, L. (1993) The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU 486. Mol. Pharmacol. 44: 775-783.
379. Shi, Y. E., Ye, Z. H., He, C. H., Zhang, G. Q., Xu, J. Q., van Look, P. F. and Fotherby, K. (1993) Pharmacokinetic study of RU 486 and its metabolites after oral administration of single doses to pregnant and non-pregnant women. Contraception 48: 133-149.
380. Shields, P. P., Dixon, J. E. and Glembotski, C. C. (1988) The secretion of atrial natriuretic factor (99-126) by cultured cardiac myocytes is regulated by glucocorticoids. J. Biol. Chem. 263: 12619-12628.
381. Shire, J. G. M. and Spickett, S. G. (1967) Genetic variation in adrenal structure, qualitative differences in the zona glomerulosa. J. Endocrinol. 39: 277-284.
382. Simons, S. S. and Miller, P. A. (1986) Affinity-labelling steroids as biologically active probes of antiglucocorticoid hormone action. J. Steroid Biochem. 24: 25-32.
383. Smith, D. F. and Toft, D. O. (1993) Steroid receptors and their associated proteins. Mol. Endocrinol. 7: 4-11.
384. Smith, K. L. C. and Currie, M. G. (1991) Glucocorticoid regulation of atrial natriuretic peptide receptors on cultured endothelial cells. Endocrinology 129: 2311-2317.
385. Snart, R. S., Sanyal, N. N. and Agarwal, M. K. (1970) Binding of corticosterone in rat liver. J. Endocrinol. 47: 149-158.
386. Snart, R. S., Shepherd, R. E. and Agarwal, M. K. (1972) Studies of corticosterone binding in rat liver. Hormones 3: 293-312.
387. Sonino, N. (1982) Inhibition of adrenal steroid biosynthesis by metyrapone. In: Hormone Antagonists, pp. 419-429, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
388. Southern, A. L., Gordon, G. G., Yeh, H. S., Dunn, M. W. and Weinstein B. I. (1978) Receptors for glucocorticoids in the lens epithelium of the calf. Science 200: 1177-1178.
389. Speiser, P. W., Riddick, L. M., Martin, K. and New, M. I. (1993) Investigation of the mechanism of hypertension in apparent mineralocorticoid excess. Metabolism 42: 843-845.
390. Spitz, I. M. and Bardin, C. W. (1993) Clinical pharmacology of RU 486-an antiprogestin and antiglucocorticoid. Contraception 48: 403-444.
391. Steiner, A., Locher, R., Sachinidis, A. and Vetter, W. (1989) Cortisol-stimulated phosphoinositide metabolism in vascular smooth muscle cells: a role for glucocorticoids in blood pressure control. J. Hypertens. 7 (Suppl. 6): S140-S141.
392. Steingold, K. A., Matt, D. W., Dua, L., Anderson, T. L. and Hodgen, G. D. (1990) Orosomucoid in human pregnancy serum diminishes bioavailability of the progesterone antagonist RU 486 in rats. Am. J. Obstet. Gynecol. 162: 523-524.
393. Sternberg, E. M., Hill, J. M., Chrousos, G. P., Kamilaris, T., Listwak, S. J., Gold, P. W. and Wilder, R. L. (1989) Inflammatory mediatorinduced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis susceptible Lewis rats. Proc. Nad Acad. Sci. USA 86: 2374-2378.
394. Stokes, P. E. and Sikes, C. R. (1988) The hypothalamic-pituitary-adrenocortical axis in major depression. Neurol. Clin. 6: 1-19.
395. Suarez, F., Rothhut, B., Comera, C., Touqui, L., Marie, F. R. and Silve, C. (1993) Expression of annexin, I, II, V and VI by rat osteoblasts in primary culture: stimulation of annexin 1 expression by dexamethasone. J. Bone Miner. Res. 8: 1201-1210.
396. Sumners, C., Gault, T. R. and Fregly, M. J. (1991) Potentiation of angiotensin II-induced drinking by glucocorticoids is a specific glucocorticoid type II receptor (GR) mediated event. Brain Res. 552: 283-290.
397. Sutanto, W. and DeKloet, E. R. (1991) Mineralocorticoid receptor ligands: biochemical, pharmacological and clinical aspects. Med. Res. Rev. 11: 617-639.
398. Swahn, M. L., Wang, G., Aedo, A. R., Cekan, S. Z. and Bygdeman, M. (1986) Plasma levels of antiprogestin RU 486 following oral administration to non-pregnant and early pregnant women. Contraception 34: 469-481.
399. Swann, H. G. (1940) The pituitary-adrenocortical relationship. Physiol. Rev. 20: 493-521.
400. Szabo, C., Thiemermann, C., Wu, C. C., Perretti, M. and Vane, J. R. (1994) Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proc. Natl. Acad. Sci. USA 91: 271-275.
401. Takeda, R., Hatakeyama, H., Takeda, Y., Iki, K., Miyamori, I., Sheng, W. P., Yamamoto, H. and Blair, I. A. (1995) Aldosterone biosynthesis and action in vascular cells. Steroids 60: 120-124.
402. Talmi, M., Carlier, E., Rey, M. and Soumireu-Mourat, B. (1992) Modulation of the in vitro electrophysiological effect of corticosterone by extracellular calcium in the hippocampus. Neuroendocrinology 55: 257-263.
403. Tempel, D. L. and Leibowitz, S. F. (1993) Glucocorticoid receptors in PVN: interaction with NE, NPY, and Gal in relation to feeding. Am. J. Physiol. 265: E794-E800.
404. Thomas, D. H. and Philips, J. G. (1975) Studies on adrenal function. IV. Adrenalectomy and response of domestic duck to hypertonic salt loading. Gen. Comp. Endocrinol. 26: 427-439.
405. Tischler, M. E. (1994) Effect of the antiglucocorticoid RU 38486 on protein metabolism in unweighted soleus muscle. Metabolism 43: 1451-1455.
406. Toft, D. D. and Smith, D. F. (1993) Steroid receptors and their associated proteins. Mol. Endocrinol. 7: 4-11.
407. Tsukahara, S., Sasaki, T., Phillips, C. I. and Gore, S. M. (1986) Subconjunctival suspension of RU 486 lowers intraocular pressure in normal rabbits. Br. J. Ophthalmol. 70: 451-455.
408. Turnbow, M. A., Keller, S. R., Rice, K. M. and Garner, C. W. (1994) Dexamethasone down-regulation of insulin-receptor substrate-1 in 3T3-L1 adipocytes. J. Biol. Chem. 269: 2516-2520.
409. Udelsman, R., Blake, M. J., Stagg, C. A. and Holbrook, N. J. (1994) Endocrine control of stress-induced heat shock protein 70 expression in vivo. Surgery 115: 611-616.
410. Ulick, S., Tedde, R. and Mantero, F. (1990) Pathogenesis of the type 2 variant of the syndrome of apparent mineralocorticoid excess. J. Clin. Endocrinol. Metab. 70: 200-206.
411. Ulick, S., Wand, J. Z., Blumenfeld, J. D. and Pickering, T. G. (1992) Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome. J. Clin. Endocrinol. Metab. 74: 963-967.
412. Vacchio, M. S., Papadopoulos, V. and Ashwell, J. D. (1994) Steroid production in the thymus: implications for thymocyte selection. J. Exp. Med. 179: 1835-1846.
413. Vallee, S. M., Grillo, C. A., Gonzalez, S., Binker, L. C., DeKloet, E. R., McEwen, B. S. and DeNicola, A. F. (1995) Further studies in deoxycorticosterone acetate treated rats: brain content of mineralocorticoid and glucocorticoid receptors and effect of steroid antagonists on salt intake. Neuroendocrinology 61: 117-124.
414. VandenBerg, D. T. W. M., DeKloet, E. R., VanDjiken, H. H. and DeJong, W. (1990) Differential central effects of mineralocorticoid and glucocorticoid agonists and antagonists on blood pressure. Endocrinology 126: 118-124.
415. VanEekelen, J. A. M., Kiss, J. S., Westphal, H. M. and DeKloet, E. R. (1987) Immunocytochemical study on the intracellular localization of the type 2 glucocorticoid receptor in the rat brain. Brain Res. 436: 120-128.
416. Vargish, T., Shircliffe, A. and James, P. M. (1974) Effects of steroids on cardiac function. Am. Surg. 71: 688-696.
417. Varloot, L. L., Ojasoo, T., Mornon, J. P. and Raynaud, J. P. (1992) A model for the determination of the 3D-spatial distribution of the functions of the hormone binding domain of receptors that bind 3-keto-4-ene steroids. J. Steroid Biochem. 41: 369-388.
418. Vecsei, P., Haack, D. and Gless, K. H. (1982) Antagonism of steroid hormone action by specific antibodies. In: Hormone Antagonists, pp. 39-59, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin, New York.
419. Vegeto, E., Allan, G. F., Schrader, W. T., Tsai, M. J., McDonnell, D. P. and O'Malley, B. (1992) Mechanisms of RU 486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell 69: 703-713.
420. Veyries, M. L., Sinet, M., Desforges, B. and Rouveix, B. (1995) Effects of morphine on the pathogenesis of murine friend retrovirus infection. J. Pharmacol. Exp. Ther. 272: 498-504.
421. Viguerie, N., Estève, J. P., Susini, C., Logsdon, C. D., Vaysse, N. and Ribet, A. (1987) Dexamethasone effects on somatostatin receptors in pancreatic acinar AR4-2J cells. Biochem. Biophys. Res. Commun. 147: 942-948.
422. Vijayan, M. M., Reddy, P. K., Leatherland, J. F. and Moon, T. W. (1994) The effects of cortisol on hepatocyte metabolism in rainbow trout: a study using the steroid analogue RU 486. Gen. Comp. Endocrinol. 96: 75-84.
423. Vintermyr, O. K. and Doskeland, S. O. (1989) Characterization of the inhibitory effect of glucocorticoids on the DNA replication of adult rat hepatocytes growing at various cell densities. J. Cell. Physiol. 138: 29-37.
424. Waage, A., Brandtzaeg, P., Espevik, T. and Halstensen, A. (1991) Current understanding of the pathogenesis of gram-negative shock. Infect. Dis. Clin. North Am. 5: 781-791.
425. Wada, S., Akatsu, T., Tamura, T., Takahashi, N., Suda, T. and Nagata, N. (1994) Glucocorticoid regulation of calcitonin receptor in mouse osteoclast-like multinucleated cells. J. Bone Miner. Res. 9: 1705-1712.
426. Wade, C. E., Spitz, I. M., Lähteenmäki, P., Heikinheimo, O., Krieger, D. T. and Bardin, C. W. (1988) Effects of the antiglucocorticoid RU 486 on adrenal function in dogs. J. Clin. Endocrinol. Metab. 66: 473-479.
427. Wambach, G. and Helber, A. (1982) Structure-activity relationship of antimineralocorticoid active steroids. In: Hormone Antagonists, pp. 293-306, Agarwal, M. K. (ed.) Walter de Gruyter, Berlin.
428. Wambach, G. and Higgins, J. R. (1979) Antimineralocorticoid action of progesterone. In: Antihormones, pp. 167-180, Agarwal M. K. (ed.) Elsevier/North Holland, Amsterdam.
429. Wan, D. C. C. and Livett, B. G. (1989) Induction of phenylethonalmine N-methyltransferase mRNA expression by glucocorticoids in cultured bovine adrenal chromaffin cells. Eur. J. Pharmacol. 172: 107-115.
430. Wang, G., Aedo, A. R. and Cekan, S. Z. (1986) Pharmacokinetics of the progesterone antagonist. Arzncimittelforschung/Drug Res. 36: 936-938.
431. Warriar, N., Yu, C. and Govindan, M. V. (1994) Hormone binding domain of human glucocorticoid receptor. J. Biol. Chem. 269: 29010-29015.
432. Webster, M. K., Guthrie, J. and Firestone, G. L. (1990) Suppression of rat mammary tumor cell growth in vitro by glucocorticoids requires serum proteins. J. Biol. Chem. 265: 4831-4838.
433. Weidenfeld, J. and Feldman, S. (1993) Glucocorticoid feedback regulation of adrenocortical responses to neural stimuli: role of CRF-41 and corticosteroid type I and type II receptors. Neuroendocrinology 58: 49-56.
434. Weidenfeld, J., Amir, I. and Shohami, E. (1993) Role of glucocorticoids in the regulation of brain prostaglandin biosynthesis under basal conditions and in response to endotoxin. Endocrinology 132: 941-945.
435. Weidmann, P., Saxenhofer, H., Shaw, S. G. and Ferrier, C. (1989) Atrial natriuretic peptide in man. J. Steroid Biochem. 32: 229-241.
436. West, J. R. B., Coghlan, J. P., Denton, D. A., Goding, J. R., Wintour, M. and Wright, R. D. (1963) The control of aldosterone secretion. Recent Prog. Horm. Res. 19: 311-383.
437. White, B. D., Dean, R. G., Edwards, G. L. and Martin, R. J. (1994) Type II corticosteroid receptor stimulation increases NPY gene expression in basomedial hypothalamus of rats. Am. J. Physiol. 266: R1523-R1529.
438. Wichterman, K. A., Baue, A. E. and Chaudry, I. H. (1980) Sepsis and septic shock-review of laboratory models and proposals. J. Surg. Res. 29: 189-201.
439. Wickens, T. (1995) Glucocorticoids and immune function: physiological relevance and pathogenic potential of hormonal dysfunction. Trends Pharmacol. Sci. 16: 193-197.
440. Wiegers, G. J., Croiset, G., Reul, J. M. H. M., Holsboer, F. and DeKloet, E. R. (1993) Differential effects of corticosteroids on rat peripheral blood T-lymphocyte mitogenesis in vivo and in vitro. Am. J. Physiol. 265: E825-E830.
441. Winguth, S. D. and Firestone, G. L. (1987) Dual regulation of protein maturation in viral infected rat HTC hepatoma cells by glucocorticoids and progesterone. Mol. Endocrinol. 1: 823-833.
442. Winter, J., Shackleton, C. H. L., O'Rourke, S. and Bokkenheuser, V. D. (1984) Bacterial formation of aldosterone metabolites. J. Steroid Biochem. 21: 563-569.
443. Wolf, J. P., Chillik, C. F., Itskovitz, J., Weyman, D, Anderson, T. L., Ulmann, A., Baulieu, E. E. and Hodgen, G. D. (1988) Transplacental passage of progesterone antagonist in monkeys. Am. J. Obstet. Gynecol. 159: 238-242.
444. Worcel, M. and Moura, A. M. (1987) Arterial effects of aldosterone and antimineralocorticoid compounds: mechanism of action. J. Steroid Biochem. 27: 4-6.
445. Wu, C. W., Wang, S. R., Chien, S. L., Yen, T. H., Lian, S. L., Shimizu, N., Lui, W. Y., Peng, F. K. and Chi, C. W. (1992) Regulation of arginase production by glucocorticoid in three human gastric cancer cell lines. Life Sci. 51: 1355-1361.
446. Xu, X. and Björntrop, P. (1990) Effects of dexamethasone on multiplication and differentiation of rat adipose precursor cells. Exp. Cell Res. 189: 247-252.
447. Yagi, A., Ichikawa, S., Sakamaki, T., Ono, Z., Sato, K., Nakamura, T., Sakamoto, H. and Murata, K. (1994) Aldosterone response to adrenocorticotrophin and furosemide in primary aldosteronism after prolonged spironolactone treatment. Eur. J. Endocrinol. 131: 215-220.
448. Yamamoto, K. R. and Alberts, B. M. (1976) Steroid receptors: elements for modulation of eukaryotic transcription. Annu. Rev. Biochem. 45: 722-746.
449. Yang, Z., Lee, D., Huang, W., Copolov, D. L. and Lim, A. T. (1994) Glucocorticoids potentiate the adenyl cyclase-cAMP system mediated immunoreactive β-endorphin production and secretion from hypothalamic neurons in culture. Brain Res. 648: 99-108.
450. Yasunari, K., Kohno, M., Murakawa, K. I., Yokokawa, K. and Takeda, T. (1990) Glucocorticoids and atrial natriuretic factor receptors on vascular smooth muscles. Hypertension 16: 581-586.
451. 1 receptors on vascular smooth muscle cells are regulated by glucocorticoid and sodium chloride. Am. J. Physiol. 267: R628-R634.
452. Yi, S. J., Masters, J. N. and Baram, T. Z. (1993) Effects of a specific glucocorticoid receptor antagonist on corticotropin releasing hormone gene expression in the paraventricular nucleus of the neonatal rat. Dev. Brain Res. 73: 253-259.
453. Young, M. (1995) Adrenal steroids and cardiac fibrosis. Steroids 60: 133-136.
454. Zach, T. L., Hill, L. D., Herrman, V. A., Leuschen, M. P. and Hostetter, M. K. (1992) Effect of glucocorticoids on C3 gene expression by the A549 human pulmonary epithelial cell line. J. Immunol. 148: 3964-3969.
455. Zach, T. L., Herrman, V. A., Hill, D. and Leuschen, M. P. (1993) Effect of steroids on the synthesis of complement C3 in a human alveolar epithelial cell line. Exp. Lung Res. 19: 603-616.
456. Zacharchuk, C. M., Mercep, M., Chakraborti, P. K., Simons, S. S. and Ashwell, J. D. (1990) Programmed T lymphocyte death. Cell-activation and steroid-induced pathways are mutually antagonistic. J. Immunol. 145: 4037-4045.
457. Zakar, T., Hirst, J. J., Mijovic, J. E. and Olson, D. M. (1995) Glucocorticoids stimulate the expression of prostaglandin endoperoxidase H synthase-2 in amnion cells. Endocrinology 136: 1610-1619.
458. Zamir, O., Hasselgren, P. O., VonAllmen, D and Fischer, J. E. (1991) The effect of interleukin-1α and the glucocorticoid receptor blocker RU 38486 on total and myofibrillar protein breakdown in skeletal muscle. J. Surg. Res. 50: 579-583.
459. Zamir, O., James, J. H., Hasselgren, P. O. and Fischer, J. E. (1993) Evidence that inhibition of muscle amino acid uptake during endotoxemia is not mediated by glucocorticoids. Metabolism 42: 1190-1194.
460. Zembovicz, A. and Vane, J. R. (1992) Induction of nitric oxide synthase activity by toxic shock syndrome toxin 1 in a macrophagemonocyte line. Proc. Natl. Acad. Sci. USA 89: 2051-2055.
461. Zhang, J. J., Jacob, T. J. C., Valverde, M. A., Hardy, S. P., Mintenig, G. M., Sepulvada, F. V., Gill, D. R., Hyde, S. C., Trezise, A. E. O. and Higgins, C. F. (1994) Tamoxifen blocks chloride channels. A possible mechanism for cataract formation. J. Clin. Invest. 94: 1690-1697.