Hydroxypropyl Methylcellulose Acetate Succinate: Potential Drug - Excipient Incompatibility

AAPS PharmSciTech

Volumn 9, Issue 3, 2008, Pages 991-997

  Dong, Zedong ^a   Choi, Duk Soon ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Drug excipient incompatibility; Hot melt extrusion; Hydroxypropyl methylcellulose acetate succinate (HPMC AS); Solid dispersion; Succinic acid

Indexed keywords

ACETIC ACID; DIPROPHYLLINE; ESTER; EXCIPIENT; HYDROXYL GROUP; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; SUCCINIC ACID;

ARTICLE; CHEMICAL BOND; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG FORMULATION; DRUG RESEARCH; DRUG STRUCTURE; EXCIPIENT COMPATIBILITY; HEATING; HYDROLYSIS;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, LIQUID; DRUG INCOMPATIBILITY; DYPHYLLINE; ESTERIFICATION; EXCIPIENTS; HYDROLYSIS; METHYLCELLULOSE; TANDEM MASS SPECTROMETRY;

EID: 57149143582     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9138-5     Document Type: Article

References (13)

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