Indistinguishable landscapes of meiotic DNA breaks in rad50+ and rad50S strains of fission yeast revealed by a novel rad50+ recombination intermediate

PLoS Genetics

Volumn 4, Issue 11, 2008, Pages

  Hyppa, Randy W ^a   Cromie, Gareth A ^a   Smith, Gerald R ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAD50 PROTEIN; SPACER DNA; FUNGAL DNA; RAD50 PROTEIN, S POMBE; REC12 PROTEIN, S POMBE; SCHIZOSACCHAROMYCES POMBE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BUDDING; DNA RECOMBINATION; DNA REPAIR; DNA STRAND BREAKAGE; FUNGAL STRAIN; GENETIC ANALYSIS; GENOME; MEIOSIS; NONHUMAN; WILD TYPE; YEAST; CHEMISTRY; COMPARATIVE STUDY; DOUBLE STRANDED DNA BREAK; GENETIC RECOMBINATION; GENETICS; METABOLISM; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

DNA BREAKS, DOUBLE-STRANDED; DNA, FUNGAL; MEIOSIS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EID: 57149112521     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000267     Document Type: Article

References (34)

1. Roeder GS (1997) Meiotic chromosomes: it takes two to tango. Genes Dev 11: 2600-2621.
2. Keeney S (2001) Mechanism and control of meiotic recombination initiation. Curr Top Dev Biol 52: 1-53.
3. Terasawa M, Ogawa H, Tsukamoto Y, Shinohara M, Shirahige K, et al. (2007) Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation. Proc Natl Acad Sci U S A 104: 5965-5970.
4. Keeney S, Giroux CN, Kleckner N (1997) Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88: 375-384.
5. Cromie GA, Hyppa RW, Cam HE, Farah JA, Grewal SHIS, Smith GR (2007) A discrete class of intergenic DNA dictates meiotic DNA break hotspots in fission yeast. PLoS Genetics 3: e141.
6. Neale MJ, Pan J, Keeney S (2005) Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature 436: 1053-1057.
7. Gerton JL, DeRisi J, Shroff R, Lichten M, Brown PO, et al. (2000) Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 97: 11383-11390.
8. Buhler C, Borde V, Lichten M (2007) Mapping meiotic single-strand DNA reveals a new landscape of DNA double-strand breaks in Saccharomyces cerevisiae. PLoS Biol 5: e324.
9. Blitzblau HG, Bell GW, Rodriguez J, Bell SP, Hochwagen A (2007) Mapping of meiotic single-stranded DNA reveals double-stranded-break hotspots near centromeres and telomeres. Curr Biol 17: 2003-2012.
10. Dresser ME, Ewing DJ, Conrad MN, Dominguez AM, Barstead R, et al. (1997) DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway. Genetics 147: 533-544.
11. Baudat F, Nicolas A (1997) Clustering of meiotic double-strand breaks on yeast chromosome III. Proc Natl Acad Sci U S A 94: 5213-5218.
12. Young JA, Schreckhise RW, Steiner WW, Smith GR (2002) Meiotic recombination remote from prominent DNA break sites in S. pombe. Molecular Cell 9: 253-263.
13. Borde V, Lin W, Novikov E, Petrini JH, Lichten M, et al. (2004) Association of Mre11p with double-strand break sites during yeast meiosis. Mol Cell 13: 389-401.
14. Prieler S, Penkner A, Borde V, Klein F (2005) The control of Spo11's interaction with meiotic recombination hotspots. Genes Dev 19: 255-269.
15. Cromie GA, Rubio CA, Hyppa RW, Smith GR (2005) A natural meiotic DNA break site in Schizosaccharomyces pombe is a hotspot of gene conversion, highly associated with crossing over. Genetics 169: 595-605.
16. Ellermeier C, Schmidt H, Smith GR (2004) Swi5 acts in meiotic DNA joint molecule formation in Schizosaccharomyces pombe. Genetics 168: 1891-1898.
17. Akamatsu Y, Dziadkowiec D, Ikeguchi M, Shinagawa H, Iwasaki H (2003) Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast. Proc Natl Acad Sci U S A 100: 15770-15775.
18. Farah JA, Hartsuiker E, Mizuno K-I, Ohta K, Smith GR (2002) A 160-bp palindrome is a Rad50NRad32-dependent mitotic recombination hotspot in Schizosacchromyces. pombe. Genetics 161: 461-468.
19. Steiner WW, Smith GR (2005) Optimizing the nucleotide sequence of a meiotic recombination hotspot in Schizosaccharomyces pombe. Genetics 169: 1973-1983.
20. Keeney S, Kleckner N (1995) Covalent protein-DNA complexes at the 59 strand termini ofmeiosis-specific double-strand breaks in yeast. Proc Natl Acad Sci U S A 92: 11274-11278.
21. Buck MJ, Nobel AB, Lieb JD (2005) ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data. Genome Biol 6: R97.
22. Cromie GA, Hyppa RW, Taylor AF, Zakharyevich K, Hunter N, et al. (2006) Single Holliday junctions are intermediates of meiotic recombination. Cell 127: 1167-1178.
23. Hunter N, Kleckner N (2001) The single-end invasion: an asymmetric intermediate at the double-strand break to double-Holliday junction transition of meiotic recombination. Cell 106: 59-70.
24. Cao L, Alani E, Kleckner N (1990) A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae. Cell 61: 1089-1101.
25. Johzuka K, Ogawa H (1995) Interaction of Mre11 and Rad50: Two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Genetics 139: 1521-1532.
26. Young JA, Hyppa RW, Smith GR (2004) Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts. Genetics 167: 593-605.
27. Alani E, Padmore R, Kleckner N (1990) Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell 61: 419-436.
28. Davis L, Smith GR (2003) Non-random homolog segregation at meiosis I in Schizosacchharomyces pombe mutants lacking recombination. Genetics 163: 857-874.
29. Ludin K, Mata J, Watt S, Lehmann E, Bahler J, et al. (2008) Sites of strong Rec12/Spo11 binding in the fission yeast genome are associated with meiotic recombination and with centromeres. Chromosoma.
30. Puizina J, Siroky J, Mokros P, Schweizer D, Riha K (2004) Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosis. Plant Cell 16: 1968-1978.
31. Mehrotra S, McKim KS (2006) Temporal analysis of meiotic DNA double-strand break formation and repair in Drosophila females. PLoS Genet 2: e200.
32. Hayashi M, Chin GM, Villeneuve AM (2007) C. elegans Germ cells switch between distinct modes of double-strand break repair during meiotic prophase progression. PLoS Genet 3: e191.
33. Iino Y, Yamamoto M (1985) Negative control for the initiation of meiosis in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A 82: 2447-2451.
34. Hyppa RW, Smith GR (in press) Using Schizosaccharomyces pombe meiosis to analyze DNA recombination intermediates. In: Keeney S, ed. Meiosis. Totowa, NJ: Humana Press.