Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT

Genes to Cells

Volumn 13, Issue 2, 2008, Pages 159-170

  Hoshino, Tomofumi ^a   Shimizu, Ritsuko ^a   Ohmori, Shinya ^a,b   Nagano, Masumi ^a   Pan, Xiaoqing ^a   Ohneda, Osamu ^a   Khandekar, Melin ^c   Yamamoto, Masayuki ^a,b   Lim, Kim Chew ^c   Engel, James Douglas ^c  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; MESSENGER RNA; TRANSCRIPTION FACTOR GATA 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYONIC STRUCTURES; ERYTHROPOIESIS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEMATOPOIESIS; HETEROZYGOTE; HYDRONEPHROSIS; INTRON; KIDNEY ANOMALY; LETHALITY; MEGAURETER; MOUSE; MOUSE MUTANT; NONHUMAN; PATHOPHYSIOLOGY; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; TRANSGENE; URINARY TRACT MALFORMATION; YEAST ARTIFICIAL CHROMOSOME;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; BONE MORPHOGENETIC PROTEINS; DISEASE MODELS, ANIMAL; DNA PRIMERS; FEMALE; GATA2 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HETEROZYGOTE; HUMANS; INTRONS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MODELS, BIOLOGICAL; PHENOTYPE; PREGNANCY; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; UROGENITAL ABNORMALITIES; UROGENITAL SYSTEM;

ANIMALIA; MUS; WOLFFIA;

EID: 38849149878     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2007.01158.x     Document Type: Article

References (44)

1. Basson, M.A., Albulut, S., Watson-Johnson, J., Simon, R., Carroll, T.J., Shakya, R., Gross, I., Martin, G.R., Lufkin, T., McMahon, A.P., Wilson, P.D., Costantini, F.D., Mason, I.J. & Licht, J.D. (2005) Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev. Cell 8, 229-239.
2. Batourina, E., Choi, C., Paragas, N., Bello, N., Hensle, T., Costantini, F.D., Schuchardt, A., Bacallao, R.L. & Mendelsohn, C.L. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat. Genet. 32, 109-115.
3. Brophy, P.D., Ostrom, L., Lang, K.M. & Dressler, G.R. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128, 4747-4756.
4. Charles, M.A., Saunders, T.L., Wood, W.M., Owens, K., Parlow, A.F., Camper, S.A., Ridgway, A., Ridgway, E.C. & Gordon, D.F. (2006) Pituitary-specific Gata2 knockout: Effects on gonadotrope and thyrotrope function. Mol. Endorinol. 20, 1366-1377.
5. Costantini, F. & Shakya, R. (2006) GDNF/Ret signaling and the development of the kidney. Bioassays 28, 117-127.
6. Dressler, G.R. (2006) The cellular basis of kidney development. Annu. Rev. Cell Dev. Biol. 22, 509-529.
7. Dudley, A.T. & Robertson, E.J. (1997) Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev. Dyn. 208, 349-362.
8. Grieshammer, U., Le, M., Plump, A.S., Wang, F., Tessier-Lavigne, M. & Martin, G.R. (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev. Cell 6, 709-717.
9. Hogan, B.L. (1996) Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes Dev. 10, 1580-1594.
10. Hu, M.C., Piscione, T.D. & Rosenblum, N.D. (2003) Elevated SMAD1/ β-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice. Development 130, 2753-2766.
11. Ichikawa, I., Kuwayama, F., Pope, J.C.4th., Stephens, F.D. & Miyazaki, Y. (2002) Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT. Kidney Int. 61, 889-898.
12. Ingham, P.W. & McMahon, A.P. (2001) Hedgehog signaling in animal development: Paradigms and principles. Genes Dev. 15, 3059-3087.
13. Khandekar, M., Brandt, W., Zhou, Y., Dagenais, S., Glover, T.W., Suzuki, N., Shimizu, R., Yamamoto, M., Lim, K.C. & Engel, J.D. (2007) Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development 134, 1703-1712.
14. Khandekar, M., Suzuki, N., Lewton, J., Yamamoto, M. & Engel, J.D. (2004) Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system. Mol. Cell. Biol. 24, 10263-10276.
15. Ko, L.J. & Engel, J.D. (1993) DNA-binding specificities of the GATA transcription factor family. Mol. Cell. Biol. 13, 4011-4022.
16. Kume, T., Deng, K. & Hogan, B.L. (2000) Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development 127, 1387-1395.
17. Lugus, J.J., Chung, Y.S., Mills, J.C., Kim, S.I., Grass, J.A., Kyba, M., Doherty, J.M., Bresnick, E.H. & Choi, K. (2007) GATA2 functions at multiple steps in hemangioblast development and differentiation. Development 134, 393-405.
18. Maeno, M., Mead, P.E., Kelley, C., Xu, R.H., Kung, H.F., Suzuki, A., Ueno, N. & Zon, L.I. (1996) The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis. Blood 88, 1965-1972.
19. Mendelsohn, C., Batourina, E., Fung, S., Gilbert, T. & Dodd, J. (1999) Stromal cells mediate retinoid-dependent functions essential for renal development. Development 126, 1139-1148.
20. Mendelsohn, C., Lohnes, D., Decimo, D., Lufkin, T., LeMeur, M., Chambon, P. & Mark, M. (1994) Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120, 2749-2771.
21. Merika, M. & Orkin, S.H. (1993) DNA-binding specificity of GATA family transcription factors. Mol. Cell. Biol. 13, 3999-4010.
22. Michos, O., Goncalves, A., Lopes-Rios, J., Tiecke, E., Naillat, F., Beier, K., Galli, A., Vainio, S. & Zeller, R. (2007) Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development 134, 2397-2405.
23. Michos, O., Panman, L., Vintersten, K., Beier, K., Zeller, R. & Zuniga, A. (2004) Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131, 3401-3410.
24. Minegishi, N., Ohta, J., Suwabe, N., Nakauchi, H., Ishihara, H., Hayashi, N. & Yamamoto, M. (1998) Alternative promoters regulate transcription of the mouse GATA-2 gene. J. Biol. Chem. 273, 3625-3634.
25. Miyazaki, Y., Oshima, K., Fogo, A., Hogan, B.L. & Ichikawa, I. (2000) Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J. Clin. Invest. 105, 863-873.
26. Nemer, G. & Nemer, M. (2003) Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Dev. Biol. 254, 131-148.
27. Nony, P., Hannon, R., Gould, H. & Felsenfeld, G. (1998) Alternate promoters and developmental modulation of expression of the chicken GATA-2 gene in hematopoietic progenitor cell. J. Biol. Chem. 273, 32910-32919.
28. Oren, T., Torreqroza, I. & Evans, T. (2005) An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling. Nucleic Acids Res. 33, 4357-4367.
29. Patient, R.K. & McGhee, J.D. (2002) The GATA family (vertebrates and invertebrates). Curr. Opin. Genet. Dev. 12, 416-422.
30. Peterkin, T., Gibson, A. & Patient, R. (2003) GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation. EMBO J. 22, 4260-4273.
31. Peterkin, T., Gibson, A., Loose, M. & Patient, R. (2005) The roles of GATA-4, -5 and -6 in vertebrate heart development. Semin. Cell Dev. Biol. 16, 83-94.
32. Raatikainen-Ahokas, A., Hytonen, M., Tenhunen, A., Sainio, K. & Sariola, H. (2000) BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney. Dev. Dyn. 217, 146-158.
33. Sainio, K., Suvanto, P., Davies, J., Wartiovaara, J., Wartiovaara, K., Saarma, M., Arumae, U., Meng, X., Lindahl, M., Pachnis, V. & Sariola, H. (1997) Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development 124, 4077-4087.
34. Shakya, R., Jho, E.H., Kotka, P., Wu, Z., kholodilov, N, Burke, R., D'Agati, V. & Costantini, F. (2005) The role of GDNF in patterning the excretory system. Dev. Biol. 283, 70-84.
35. Suzuki, N., Ohneda, O., Minegishi, N., Nishikawa, M., Ohta, T., Takahashi, S., Engel, J.D. & Yamamoto, M. (2006) Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche. Proc. Natl. Acad. Sci. USA 103, 2202-2207.
36. Takahashi, S., Onodera, K., Motohashi, H., Suwabe, N., Hayashi, N., Yanai, N., Nabashima, Y. & Yamamoto, M. (1997) Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene. J. Biol. Chem. 272, 12611-12615.
37. Thomas, K.R. & Capecchi, M.R. (1987) Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503-512.
38. Thompson, D.L., Gerlach-Bank, L.M., Barald, K.F. & Koenig, R.J. (2003) Retinoic acid repression of bone morphogenetic protein 4 in inner ear development. Mol. Cell. Biol. 23, 2277-2286.
39. Tsai, F.Y., Keller, G., Kuo, F.C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F.W. & Orkin, S.H. (1994) An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371, 221-226.
40. Wilkinson, D.G. & Nieto, M.A. (1993) Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol. 225, 361-373.
41. Yagi, T., Nada, S., Watanabe, N., Tamemoto, H., Kohmura, N., Ikawa, Y. & Aizawa, S. (1993) A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene. Analy. Biochem. 214, 77-86.
42. Yamamoto, M., Ko, L.J., Leonard, M.W., Beug, H., Orkin, S.H. & Engel, J.D. (1990) Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev. 4, 1650-1662.
43. Zhao, L., Bakke, M., Krimkevich, Y., Cushman, L.J., Parlow, A.F., Camper, S.A. & Paker, K.L. (2001) Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development 128, 147-154.
44. Zhou, Y., Lim, K.C., Onodera, K., Takahashi, S., Ohta, J., Minegishi, N., Tsai, F.Y., Orkin, S.H., Yamamoto, M. & Engel, J.D. (1998) Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J. 17, 6689-6700.