A motor function for the DEAD-box RNA helicase, Gemin3, in Drosophila

PLoS Genetics

Volumn 4, Issue 11, 2008, Pages

  Cauchi, Ruben J ^a   Davies, Kay E ^a   Liu, Ji Long ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEAD BOX PROTEIN; DEAD BOX PROTEIN 20; RNA HELICASE; SURVIVAL MOTOR NEURON PROTEIN; UNCLASSIFIED DRUG; GEMIN3 PROTEIN, DROSOPHILA; SURVIVAL MOTOR NEURON PROTEIN 1;

ARTICLE; DROSOPHILA MELANOGASTER; GENE EXPRESSION; INSECT; LARVA; LETHALITY; MESODERM; MOTOR PERFORMANCE; MUSCLE ATROPHY; NEUROMUSCULAR SYNAPSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SPINAL MUSCULAR ATROPHY; TRANSGENE; VERTEBRATE; WALKING DIFFICULTY; ANIMAL; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MOTONEURON; MOUSE; MUTATION; PHYSIOLOGY; PRENATAL DEVELOPMENT;

DROSOPHILA MELANOGASTER; VERTEBRATA;

ANIMALS; DEAD BOX PROTEIN 20; DEAD-BOX RNA HELICASES; DROSOPHILA MELANOGASTER; HUMANS; LARVA; MICE; MOTOR NEURONS; MUTATION; SURVIVAL OF MOTOR NEURON 1 PROTEIN; TRANSGENES;

EID: 57149104579     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000265     Document Type: Article

References (55)

1. Briese M, Esmaeili B, Sattelle DB (2005) Is spinal muscular atrophy the result of defects in motor neuron processes? Bioessays 27: 946-957.
2. Monani UR (2005) Spinal Muscular Atrophy: A Deficiency in a Ubiquitous Protein; a Motor Neuron-Specific Disease. Neuron 48: 885-896.
3. Liu Q, Fischer U, Wang F, Dreyfuss G (1997) The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell 90: 1013-1021.
4. Campbell L, Unter KMD, Mohaghegh P, Tinsley JM, Brash MA, et al. (2000) Direct interaction of Smn with dp103, a putative RNA helicase: role for Smn in transcription regulation? Hum Mol Genet 9: 1093-1100.
5. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, et al. (1999) Gemin3: a novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of Gems. J Cell Biol 147: 1181-1193.
6. Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, et al. (2000) Gemin4: a novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol 148: 1177-1186.
7. Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, et al. (2002) Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. J Biol Chem 277: 5631-5636.
8. Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (2002) Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. J Biol Chem 277: 7540-7545.
9. Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002) Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. J Biol Chem 277: 31957-31962.
10. Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, et al. (2006) Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly. J Biol Chem 281: 8126-8134.
11. Battle DJ, Kasim M, Yong J, Lotti F, Lau CK, et al. (2006) The SMN complex: an assembly machine for RNPs. Cold Spring Harb Symp Quant Biol 71: 313-320.
12. Yan X, Mouillet JF, Ou Q, Sadovsky Y (2003) A novel domain within the DEAD-box protein DP103 is essential for transcriptional repression and helicase activity. Mol Cell Biol 23: 414-423.
13. Shpargel KB, Matera G (2005) Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins. Proc Natl Acad USA 102: 17372-17377.
14. Almstead LL, Sarnow P (2007) Inhibition of U snRNP assembly by a virus-encoded proteinase. Genes Dev 21: 1086-1097.
15. Grundhoff AT, Kremmer E, Tureci O, Glieden A, Gindorf C, et al. (1999) Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C. J Biol Chem 274: 19136-19144.
16. Ou Q, Mouillet JF, Yan X, Dorn C, Crawford PA, et al. (2001) The DEAD box protein DP103 is a regulator of steroidogenic factor-1. Mol Endocrinol 15: 69-79.
17. Gillian AL, Svaren J (2004) The Ddx20/DP103 dead box protein represses transcriptional activation by Egr2/Krox-20. J Biol Chem 279: 9056-9063.
18. Lee K, Pisarska MD, Ko JJ, Kang Y, Yoon S, et al. (2005) Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. Biochem Biophys Res Commun 336: 876-881.
19. Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, et al. (2002) An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell 109: 169-180.
20. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, et al. (2002) miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev 16: 720-728.
21. Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G (2003) Numerous microRNPs in neuronal cells containing novel microRNAs. Rna 9: 180-186.
22. Nelson PT, Hatzigeorgiou AG, Mourelatos Z (2004) miRNP:mRNA association in polyribosomes in a human neuronal cell line. Rna 10: 387-394.
23. Kroiss M, Schultz J, Wiesner J, Chari A, Sickmann A, et al. (2008) Evolution of an RNP assembly system: a minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster. Proc Natl Acad Sci U S A 105: 10045-10050.
24. Otter S, Grimmler M, Neuenkirchen N, Chari A, Sickmann A, et al. (2007) A comprehensive interaction map of the human survival of motor neuron (SMN) complex. J Biol Chem 282: 5825-5833.
25. Lyko F, Ramsahoye BH, Kashevsky H, Tudor M, Mastrangelo MA, et al. (1999) Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila. Nat Genet 23: 363-366.
26. Zhang H, Xing L, Rossoll W, Wichterle H, Singer RH, et al. (2006) Multiprotein complexes of the survival of motor neuron protein SMN with gemins traffic to neuronal processes and growth cones of motor neurons. J Neurosci 26: 8622-8632.
27. Boudet N, Aubourg S, Toffano-Nioche C, Kreis M, Lecharny A (2001) Evolution of intron/exon structure of DEAD helicase family genes in Arabidopsis, Caenorhabditis, and Drosophila. Genome Res 11: 2101-2114.
28. Liu JL, Gall JG (2007) U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies. Proc Natl Acad Sci U S A 104: 11655-11659.
29. Mouillet JF, Yan X, Ou Q, Jin L, Muglia LJ, et al. (2008) DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function. Endocrinology 149: 2168-2175.
30. Clark KA, Bland JM, Beckerle MC (2007) The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. J Cell Sci 120: 2066-2077.
31. Bunch TA, Graner MW, Fessler LI, Fessler JH, Schneider KD, et al. (1998) The PS2 integrin ligand tiggrin is required for proper muscle function in Drosophila. Development 125: 1679-1689.
32. Chan YB, Miguel-Aliaga I, Franks C, Thomas N, Trulzsch B, et al. (2003) Neuromuscular defects in a Drosophila survival motor neuron gene mutant. Hum Mol Genet 12: 1367-1376.
33. Miguel-Aliaga I, Chan YB, Davies KE, van den Heuvel M (2000) Disruption of SMN function by ectopic expression of the human SMN gene in Drosophila. FEBS Lett 486: 99-102.
34. Rajendra TK, Gonsalvez GB, Walker MP, Shpargel KB, Salz HK, et al. (2007) A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. J Cell Biol 176: 831-841.
35. Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, et al. (2008) Modeling spinal muscular atrophy in Drosophila. PLoS ONE 3: e3209.
36. Dietzl G, Chen D, Schnorrer F, Su KC, Barinova Y, et al. (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448: 151-156.
37. Benzer S (1973) Genetic dissection of behavior. Sci Am 229: 24-37.
38. Ekengren S, Tryselius Y, Dushay MS, Liu G, Steiner H, et al. (2001) A humoral stress response in Drosophila. Curr Biol 11: 1479.
39. Lin DM, Goodman CS (1994) Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance. Neuron 13: 507-523.
40. Sink H, Rehm EJ, Richstone L, Bulls YM, Goodman CS (2001) sidestep encodes a target-derived attractant essential for motor axon guidance in Drosophila. Cell 105: 57-67.
41. Sun B, Xu P, Salvaterra PM (1999) Dynamic visualization of nervous system in live Drosophila. Proc Natl Acad Sci U S A 96: 10438-10443.
42. Yeh E, Gustafson K, Boulianne GL (1995) Green fluorescent protein as a vital marker and reporter of gene expression in Drosophila. Proc Natl Acad Sci U S A 92: 7036-7040.
43. Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, et al. (2001) Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293: 711-714.
44. Aberle H, Haghighi AP, Fetter RD, McCabe BD, Magalhaes TR, et al. (2002) wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Neuron 33: 545-558.
45. Manseau L, Baradaran A, Brower D, Budhu A, Elefant F, et al. (1997) GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of Drosophila. Dev Dyn 209: 310-322.
46. Schuster CM, Davis GW, Fetter RD, Goodman CS (1996) Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron 17: 641-654.
47. Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
48. Ranganayakulu G, Schulz RA, Olson EN (1996) Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo. Dev Biol 176: 143-148.
49. Haghighi AP, McCabe BD, Fetter RD, Palmer JE, Hom S, et al. (2003) Retrograde control of synaptic transmission by postsynaptic CaMKII at the Drosophila neuromuscular junction. Neuron 39: 255-267.
50. Budnik V, Koh YH, Guan B, Hartmann B, Hough C, et al. (1996) Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg. Neuron 17: 627-640.
51. Renden RB, Broadie K (2003) Mutation and activation of Galpha s similarly alters pre- and postsynaptic mechanisms modulating neurotransmission. J Neurophysiol 89: 2620-2638.
52. Viquez NM, Li CR, Wairkar YP, DiAntonio A (2006) The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction. J Neurosci 26: 9293-9303.
53. Zhang YQ, Bailey AM, Matthies HJ, Renden RB, Smith MA, et al. (2001) Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107: 591-603.
54. Bellen HJ, Levis RW, Liao G, He Y, Carlson JW, et al. (2004) The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167: 761-781.
55. Thibault ST, Singer MA, Miyazaki WY, Milash B, Dompe NA, et al. (2004) A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat Genet 36: 283-287.