The role of integrins in pulmonary fibrosis

European Respiratory Review

Volumn 17, Issue 109, 2008, Pages 157-162

  Sheppard, D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

V 6; Epithelial to mesenchymal transition; Transforming growth factor

Indexed keywords

3 G9; BLOCKING ANTIBODY; INTEGRIN; INTEGRIN ALPHA V BETA 6; MONOCLONAL ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG;

CELL ADHESION; DISEASE ACTIVITY; DISEASE COURSE; DISEASE MODEL; DRUG MEGADOSE; EPITHELIUM CELL; HUMAN; LOW DRUG DOSE; LUNG FIBROSIS; MESENCHYME; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; TISSUE STRUCTURE;

EID: 57149096493     PISSN: 09059180     EISSN: None     Source Type: Journal    
DOI: 10.1183/09059180.00010909     Document Type: Review

References (30)

1. Cepek KL, Shaw SK, Parker CM, et al. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin. Nature 1994; 372: 190-193.
2. Munger JS, Huang X, Kawakatsu H, et al. The integrin αvβ 6 binds and activates latent TGF-β1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999; 96: 319-328.
3. Brooks PC, Strromblad S, Sanders LC, et al. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3. Cell 1996; 85: 683-693.
4. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110: 673-687.
5. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor-β in human disease. N Engl J Med 2000; 342: 1350-1358.
6. Kulkarni AB, Huh CG, Becker D, et al. Transforming growth factor-β1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993; 90: 770-774.
7. Kaartinen V, Voncken JW, Shuler C, et al. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 1995; 11: 415-421.
8. Sanford LP, Ormsby I, Gittenberger-de Groot AC, et al. TGF-β2 knockout mice have multiple developmental defects that are non-overlapping with other TGF-β knockout phenotypes. Development 1997; 124: 2659-2670.
9. Sheppard D. Transforming growth factor-β: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 2006; 3: 413-417.
10. Rifkin DB. Latent transforming growth factor-β (TGF-β) binding proteins: orchestrators of TGF-β availability. J Biol Chem 2005; 280: 7409-7412.
11. Nunes I, Gleizes PE, Metz CN, Rifkin DB. Latent transforming growth factor-β binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-β. J Cell Biol 1997; 136: 1151-1163.
12. Ruoslahti E, Pierschbacher MD. New perspectives in cell adhesion: RGD and integrins. Science 1987; 238: 491-497.
13. Busk M, Pytela R, Sheppard D. Characterization of the integrin αvβ6 as a fibronectin-binding protein. J Biol Chem 1992; 267: 5790-5796.
14. Prieto AL, Edelman GM, Crossin KL. Multiple integrins mediate cell attachment to cytotactin/tenascin. Proc Natl Acad Sci USA 1993; 90: 10154-10158.
15. Huang XZ, Wu JF, Cass D, et al. Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol 1996; 133: 921-928.
16. Mu D, Cambier S, Fjellbirkeland L, et al. The integrin αVβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-β1. J Cell Biol 2002; 157: 493-507.
17. Zhu J, Motejlek K, Wang D, Zang K, Schmidt A, Reichardt LF. β8 integrins are required for vascular morphogenesis in mouse embryos. Development 2002; 129: 2891-2903.
18. Travis MA, Reizis B, Melton AC, et al. Loss of integrin αVβ8 on dendritic cells causes autoimmunity and colitis in mice. Nature 2007; 449: 361-365.
19. Puthawala K, Hadjiangelis N, Jacoby SC, et al. Inhibition of integrin αVβ6, an activator of latent transforming growth factor-β, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med 2008; 177: 82-90.
20. Wang B, Dolinski BM, Kikuchi N, et al. Role of αvβ6 integrin in acute biliary fibrosis. Hepatology 2007; 46: 1404-1412.
21. Giri SN, Hyde DM, Hollinger MA. Effect of antibody to transforming growth factor-β on bleomycin induced accumulation of lung collagen in mice. Thorax 1993; 48: 959-966.
22. Abe M, Harpel JG, Metz CN, Nunes I, Loskutoff DJ, Rifkin DB. An assay for transforming growth factor-β using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem 1994; 216: 276-284.
23. Sheppard D. Integrin-mediated activation of transforming growth factor-β1 in pulmonary fibrosis. Chest 2001; 120: Suppl. 1, 49S-53S.
24. Jenkins RG, Su X, Su G, et al. Ligation of protease-activated receptor 1 enhances αVβ6 integrin-dependent TGF-β activation and promotes acute lung injury. J Clin Invest 2006; 116: 1606-1614.
25. Horan GS, Wood S, Ona V, et al. Partial inhibition of integrin αVβ6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med 2008; 177: 56-65.
26. McCartney-Francis NL, Frazier-Jessen M, Wahl SM. TGF-β: a balancing act. Int Rev Immunol 1998; 16: 553-580.
27. Shull MM, Ormsby I, Kier AB, et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 1992; 359: 693-699.
28. Mallat Z, Gojova A, Marchiol-Fournigault C, et al. Inhibition of transforming growth factor-β signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ Res 2001; 89: 930-934.
29. Robertson AK, Rudling M, Zhou X, Gorelik L, Flavell RA, Hansson GK. Disruption of TGF-β signaling in T cells accelerates atherosclerosis. J Clin Invest 2003; 112: 1342-1350.
30. Kim KK, Kugler MC, Wolters PJ, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 2006; 103: 13180-13185.