Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension

Croatian Medical Journal

Volumn 49, Issue 5, 2008, Pages 586-599

  Bilušić, Marijo ^a   Moreno, Carol ^b   Barreto, Nadia E ^b   Tschannen, Michael R ^b   Harris, Eugenie L ^c   Porteous, William K ^c   Thompson, Caryn M ^d   Grigor, Murray R ^e   Weder, Alan ^f   Boerwinkle, Eric ^g   Hunt, Steven C ^h   Curb, J David ⁱ   Jacob, Howard J ^b   Kwitek, Anne E ^b,j  

^a SETON HALL UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c Childrens Hospital of Wisconsin ^*  (United States)

^d UNIVERSITY OF LOUISVILLE   (United States)

^e UNIVERSITY OF OTAGO   (New Zealand)

^f UNIVERSITY OF MICHIGAN HOSPITALS   (United States)

^g UNIVERSITY OF TEXAS   (United States)

^h UNIVERSITY OF UTAH   (United States)

ⁱ PACIFIC HEALTH RESEARCH INSTITUTE   (United States)

^j UNIVERSITY OF IOWA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ANGIOTENSIN II;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERY CATHETERIZATION; ARTICLE; BIOMETRY; BLOOD PRESSURE MEASUREMENT; BROWN NORWAY RAT; CHROMOSOME 18; CHROMOSOME 2; CHROMOSOME 6; CONGENIC STRAIN; CONTINUOUS INFUSION; CONTROLLED STUDY; CROSS BREEDING; DIASTOLIC BLOOD PRESSURE; FEMALE; FEMORAL ARTERY; GENE MAPPING; GENETIC EPISTASIS; GENETIC MARKER; GENETIC SELECTION; GENETIC TRAIT; GENOME; HEART RATE; HEREDITARY HYPERTENSION; LINKAGE ANALYSIS; MALE; NONHUMAN; PHENOTYPE; PRESSORECEPTOR REFLEX; PROGENY; QUANTITATIVE TRAIT LOCUS; RAT; RECEPTOR SENSITIVITY; SYSTOLIC BLOOD PRESSURE; TELEMETRY; TRANSGENIC ORGANISM;

ANGIOTENSIN II; ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; FEMALE; GENETIC MARKERS; HYPERTENSION; LINKAGE (GENETICS); MALE; PHENOTYPE; PRESSORECEPTORS; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED BN; RISK FACTORS;

EID: 57149093204     PISSN: 03539504     EISSN: 13328166     Source Type: Journal    
DOI: 10.3325/cmj.2008.5.586     Document Type: Article

References (62)

1. James GD, Baker PT. Human population biology and hypertension. In: Laragh JH, Brenner BM, editors. Hypertension: pathophysiology, diagnosis and management. New York (NY): Raven Press Publishers; 1990. p. 137-45.
2. Vasan RS, Beiser A, Seshadri S, Larson MG, Kannel WB, D'Agostino RB, et al. Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. JAMA. 2002;287:1003-10.
3. Cusi D, Barlassina C, Taglietti MV. Genetics of human arterial hypertension. J Nephrol. 2003;16:609-15.
4. Hong Y, de Faire U, Heller DA, McClearn GE, Pedersen N. Genetic and environmental influences on blood pressure in elderly twins. Hypertension. 1994;24:663-70.
5. Hunt SC, Hasstedt SJ, Kuida H, Stults BM, Hopkins PN, Williams RR. Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins. Am J Epidemiol. 1989;129:625-38.
6. Lander ES, Schork NJ. Genetic dissection of complex traits. Science. 1994;265:2037-48.
7. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661-78.
8. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, et al. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell. 1994;79:407-14.
9. Mune T, Rogerson FM, Nikkila H, Agarwal AK, White PC. Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet. 1995;10:394-9.
10. Lifton RP, Dluhy RG, Powers M, Ulick S, Lalouel JM. The molecular basis of glucocorticoid-remediable aldosteronism, a Mendelian cause of human hypertension. Trans Assoc Am Physicians. 1992;105:64-71.
11. Barkley RA, Chakravarti A, Cooper RS, Ellison RC, Hunt SC, Province MA, et al. Positional identification of hypertension susceptibility genes on chromosome 2. Hypertension. 2004;43:477-82.
12. Wong CM, O'Connor DT, Martinez JA, Kailasam MT, Parmer RJ. Diminished renal kallikrein responses to mineralocorticoid stimulation in African Americans: determinants of an intermediate phenotype for hypertension. Am J Hypertens. 2003;16:281-9.
13. Connell JM, Fraser R, MacKenzie S, Davies E. Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension? Hypertension. 2003;41:993-9.
14. Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, et al. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics. 2003;15:243-57.
15. Litchfield WR, Hunt SC, Jeunemaitre X, Fisher ND, Hopkins PN, Williams RR, et al. Increased urinary free cortisol: a potential intermediate phenotype of essential hypertension. Hypertension. 1998;31:569-74.
16. Kailasam MT, O'Connor DT, Parmer RJ. Hereditary intermediate phenotypes in African American hypertension. Ethn Health. 1996;1:117-28.
17. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev. 2000;80:135-72.
18. Simpson FO, Phelan EL, Ledingham JM, Millar JA. Hypertension in the genetically hypertensive (GH) strain. In: Ganten D, de Jong W, editors. Handbook of hypertension - experimental and genetic models of hypertension. Amsterdam: Elsevier; 1994. p. 228-71.
19. Harris EL, Phelan EL, Thompson CM, Millar JA, Grigor MR. Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat. J Hypertens. 1995;13:397-404.
20. Lande R, Thompson R. Efficiency of marker-assisted selection in the improvement of quantitative traits. Genetics. 1990;124:743-56.
21. Markel P, Shu P, Ebeling C, Carlson GA, Nagle DL, Smutko JS, et al. Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet. 1997;17:280-4.
22. Wakeland E, Morel L, Achey K, Yui M, Longmate J. Speed congenics: a classic technique in the fast lane (relatively speaking). Immunol Today. 1997;18:472-7.
23. Laird PW, Zijderveld A, Linders K, Rudnicki MA, Jaenisch R, Berns A. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 1991;19:4293.
24. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, et al. A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet. 1995;9:63-9.
25. Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, et al. A genomic-systems biology map for cardiovascular function. Science. 2001;294:1723-6.
26. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet. 1996;58:1347-63.
27. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995;11:241-7.
28. Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics. 1995;139:1421-8.
29. Lincoln S, Daly M, Lander E. Mapping gene controlling quantitative traits with MAPMAKER/QTL 1.1. Whitehead Institute technical report. 2nd ed. Cambridge: Whitehead Institute; 1992.
30. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, et al. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics. 1987;1:174-81.
31. Broman KW, Wu H, Sen S, Churchill GA. R/qtl: QTL mapping in experimental crosses. Bioinformatics. 2003;19:889-90.
32. Kendziorski CM, Cowley AW Jr, Greene AS, Salgado HC, Jacob HJ, Tonellato PJ. Mapping baroreceptor function to genome: a mathematical modeling approach. Genetics. 2002;160:1687-95.
33. Su DF, Cerutti C, Barr?s C, Vincent M, Sassard J. Blood pressure and baroreflex sensitivity in conscious hypertensive rats of Lyon strain. Am J Physiol. 1986;251:H1111-7.
34. Cowley AW Jr, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, et al. Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats. Physiol Genomics. 2000;2:107-15.
35. Frisbee JC, Lombard JH. Development and reversibility of altered skeletal muscle arteriolar structure and reactivity with high salt diet and reduced renal mass hypertension. Microcirculation. 1999;6:215-25.
36. Drenjancevic-Peric I, Frisbee JC, Lombard JH. Skeletal muscle arteriolar reactivity in SS.BN13 consomic rats and Dahl salt-sensitive rats. Hypertension. 2003;41:1012-5.
37. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, et al. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell. 1991;67:213-24.
38. Brown DM, Matise TC, Koike G, Simon JS, Winer ES, Zangen S, et al. An integrated genetic linkage map of the laboratory rat. Mamm Genome. 1998;9:521-30.
39. Watanabe TK, Ono T, Okuno S, Mizoguchi-Miyakita A, Yamasaki Y, Kanemoto N, et al. Characterization of newly developed SSLP markers for the rat. Mamm Genome. 2000;11:300-5.
40. Chen A, Grigor MR, Thompson CM, Harris EL. Kallikrein binding protein (KBP) maps to rat chromosome 6 but does not cosegregate with blood pressure in a GH x BN cross. Mamm Genome. 1997;8:701-3.
41. Harris EL, Grigor MR, Thompson CM. Cosegregation of the Tnfalpha locus with cardiovascular phenotypes in the F2 generation of a New Zealand genetically hypertensive and Brown Norway cross. Clin Exp Pharmacol Physiol. 1998;25:204-7.
42. Alemayehu A, Breen L, Krenova D, Printz MP. Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL. Physiol Genomics. 2002;10:199-210.
43. Deng AY, Dene H, Rapp JP. Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2. Hypertension. 1997;30:199-202.
44. Jeffs B, Negrin CD, Graham D, Clark JS, Anderson NH, Gauguier D, et al. Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2. Hypertension. 2000;35:179-87.
45. Dutil J, Deng AY. Mapping a blood pressure quantitative trait locus to a 5.7-cM region in Dahl salt-sensitive rats. Mamm Genome. 2001;12:362-5.
46. Dutil J, Deng AY. Further chromosomal mapping of a blood pressure QTL in Dahl rats on chromosome 2 using congenic strains. Physiol Genomics. 2001;6:3-9.
47. Garrett MR, Rapp JP. Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats. Mamm Genome. 2002;13:41-4.
48. Mattson DL, Kunert MP, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ, et al. Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. Physiol Genomics. 2004;16:194-203.
49. Kovacs P, Voigt B, Kloting I. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Biochem Biophys Res Commun. 1997;235:343-8.
50. Frantz SA, Kaiser M, Gardiner SM, Gauguier D, Vincent M, Thompson JR, et al. Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains. Hypertension. 1998;32:639-46.
51. Bianchi G, Tripodi G. Genetics of hypertension: the adducin paradigm. Ann N Y Acad Sci. 2003;986:660-8.
52. Steen RG, Kwitek-Black AE, Glenn C, Gullings-Handley J, Van Etten W, Atkinson OS, et al. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Res. 1999;9:AP1-8.
53. Monti J, Plehm R, Schulz H, Ganten D, Kreutz R, Hubner N. Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. Hum Mol Genet. 2003;12:435-9.
54. Kreutz R, Hubner N, Ganten D, Lindpaintner K. Genetic linkage of the ACE gene to plasma angiotensin-converting enzyme activity but not to blood pressure. A quantitative trait locus confers identical complex phenotypes in human and rat hypertension. Circulation. 1995;92:2381-4.
55. Weinstock M, Gorodetsky E. Comparison of the effects of angiotensin II, losartan, and enalapril on baroreflex control of heart rate in conscious rabbits. J Cardiovasc Pharmacol. 1995;25:501-7.
56. Yamada Y, Miyajima E, Tochikubo O, Matsukawa T, Shionoiri H, Ishii M, et al. Impaired baroreflex changes in muscle sympathetic nerve activity in adolescents who have a family history of essential hypertension. J Hypertens Suppl. 1988;6:S525-8.
57. Tank J, Jordan J, Diedrich A, Stoffels M, Franke G, Faulhaber HD, et al. Genetic influences on baroreflex function in normal twins. Hypertension. 2001;37:907-10.
58. Imai Y, Aihara A, Ohkubo T, Nagai K, Tsuji I, Minami N, et al. Factors that affect blood pressure variability. A community-based study in Ohasama, Japan. Am J Hypertens. 1997;10:1281-9.
59. Parmer RJ, Cervenka JH, Stone RA. Baroreflex sensitivity and heredity in essential hypertension. Circulation. 1992;85:497-503.
60. Ditto B, France C. Carotid baroreflex sensitivity at rest and during psychological stress in offspring of hypertensives and non-twin sibling pairs. Psychosom Med. 1990;52:610-20.
61. Piccirillo G, Viola E, Nocco M, Durante M, Tarantini S, Marigliano V. Autonomic modulation of heart rate and blood pressure in normotensive offspring of hypertensive subjects. J Lab Clin Med. 2000;135:145-52.
62. Robertson D, Hollister AS, Biaggioni I, Netterville JL, Mosqueda-Garcia R, Robertson RM. The diagnosis and treatment of baroreflex failure. N Engl J Med. 1993;329:1449-55.