Spectroscopic study of the cobalamin-dependent methionine synthase in the activation conformation: Effects of the Y1139 residue and S-adenosylmethionine on the B12 cofactor

Journal of the American Chemical Society

Volumn 130, Issue 48, 2008, Pages 16374-16381

  Liptak, Matthew D ^a   Datta, Supratim ^b   Matthews, Rowena G ^b   Brunold, Thomas C ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT; CONFORMATIONS; COORDINATION REACTIONS; ELECTRIC INSTRUMENT TRANSFORMERS; ESCHERICHIA COLI; HYDROCARBONS; MOLECULAR ORBITALS; MOLECULES; SPECTROSCOPIC ANALYSIS;

ACTIVE SITES; AXIAL LIGANDS; CATALYTIC CYCLES; COBALAMIN COFACTOR; COFACTOR; COORDINATED WATER MOLECULES; FLAVODOXIN; HOMOCYSTEINE; METHIONINE SYNTHASE; METHYL GROUPS; MODULAR ENZYMES; REACTIVATION PROCESSES; REDUCTION POTENTIALS; SIDE REACTIONS; SPECTROSCOPIC CHARACTERIZATIONS; SPECTROSCOPIC STUDIES; TERMINAL FRAGMENTS; TETRAHYDROFOLATE; TRIPLE MUTANTS;

ENZYMES;

5 METHYLTETRAHYDROFOLIC ACID; COBALAMIN; CYANOCOBALAMIN; FLAVODOXIN; HOMOCYSTEINE; MECOBALAMIN; METHIONINE; METHIONINE SYNTHASE; S ADENOSYLMETHIONINE; TETRAHYDROFOLIC ACID;

ARTICLE; CATALYSIS; CHEMICAL BOND; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ESCHERICHIA COLI; NONHUMAN; REDUCTION; SPECTROSCOPY; THERMODYNAMICS;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; CIRCULAR DICHROISM; COBALT; CRYSTALLOGRAPHY, X-RAY; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVATION; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; S-ADENOSYLMETHIONINE; TYROSINE; VITAMIN B 12;

EID: 57149090919     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja8038129     Document Type: Article

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