Brief communication: Latent toxoplasmosis and salivary testosterone concentration - Important confounding factors in second to fourth digit ratio studies

American Journal of Physical Anthropology

Volumn 137, Issue 4, 2008, Pages 479-484

  Flegr, Jaroslav ^a   Lindová, Jitka ^a   Pivoñková, Věra ^a   Havlíček, Jan ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

2D:4D; Androgens; Infection; Postnatal changes; Toxoplasma

Indexed keywords

ANDROGEN; SEX HORMONE; TESTOSTERONE;

ADULT; ANTHROPOMETRY; ARTICLE; BIOLOGICAL TRAIT; CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; FINGER; HAND; HUMAN; HUMAN EXPERIMENT; LIFE HISTORY; MALE; NORMAL HUMAN; PERINATAL PERIOD; PERSONALITY; PREDICTION; PRENATAL PERIOD; PREVALENCE; RADIOIMMUNOASSAY; SALIVA LEVEL; SEX DIFFERENCE; TOXOPLASMA; TOXOPLASMOSIS;

ADOLESCENT; ADULT; ANIMALS; ANTIBODIES, PROTOZOAN; CHILD; CHILD, PRESCHOOL; FEMALE; FINGERS; FUNCTIONAL LATERALITY; GONADAL STEROID HORMONES; HUMANS; MALE; SALIVA; SEX CHARACTERISTICS; TESTOSTERONE; TOXOPLASMA; TOXOPLASMOSIS; YOUNG ADULT;

EID: 57149087310     PISSN: 00029483     EISSN: 10968644     Source Type: Journal    
DOI: 10.1002/ajpa.20888     Document Type: Article

References (47)

1. Ankarberg C, Norjavaara E. 1999. Diurnal rhythm of testosterone secretion before and throughout puberty in healthy girls: correlation with 17 beta-estradiol and dehydroepiandrosterone sulfate. J Clin Endocrin Metab 84:975-984.
2. Bailey AA, Hurd PL. 2005. Finger length ratio (2D:4D) correlates with physical aggression in men but not in women. Biol Psychol 68:215-222.
3. Bernhardt PC, Dabbs JM, Fielden JA, Lutter CD. 1998. Testosterone changes during vicarious experiences of winning and losing among fans at sporting events. Physiol Behav 65:59-62.
4. Brown WM, Finn CJ, Breedlove SM. 2002a. Sexual dimorphism in digit-length ratios of laboratory mice. Anat Rec 267:231-234.
5. Brown WM, Hines M, Fane BA, Breedlove SM. 2002b. Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia. Horm Behav 42:380-386.
6. Dabbs JM. 1990a. Age and seasonal-variation in serum testosterone concentration among men. Chronobiol Int 7:245-249.
7. Dabbs JM. 1990b. Salivary testosterone measurements-reliability across hours, days, and weeks. Physiol Behav 48:83-86.
8. Fink B, Brookes H, Neave N, Manning JT, Geary DC. 2006a. Second to fourth digit ratio and numerical competence in children. Brain Cogn 61:211-218.
9. Fink B, Manning JT, Neave N. 2004. Second to fourth digit ratio and the 'Big Five' personality factors. Pers Individ Dif 37:495-503.
10. Fink B, Neave N, Laughton K, Manning JT. 2006b. Second to fourth digit ratio and sensation seeking. Pers Individ Dif 41:1253-1262.
11. Flegr J. 2007. Effects of Toxoplasma on human behavior. Schizophr Bull 33:757-760.
12. Flegr J, Hrušková M, Hodný Z, Novotná M, Hanušová J. 2005. Body height, body mass index, waist-hip ratio, fluctuating asymmetry and second to fourth digit ratio in subjects with latent toxoplasmosis. Parasitology 130:621-628.
13. Flegr J, Lindová J, Kodym P. 2008. Sex-dependent toxoplasmosis-associated differences in testosterone concentration in humans. Parasitology 135:427-431.
14. Hall LS, Love CT. 2003. Finger-length ratios in female monozygotic twins discordant for sexual orientation. Arch Sex Behav 32:23-28.
15. Handa K, Ishii H, Kono S, Shinchi K, Imanishi K, Mihara H, Tanaka K. 1997. Behavioral correlates of plasma sex hormones and their relationships with plasma lipids and lipoproteins in Japanese men. Atherosclerosis 130:37-44.
16. Hodková H, Kolbeková P, Skallová A, Lindová J, Flegr J. 2007. Higher perceived dominance in Toxoplasma infected men - the new evidence for role of increased level of testosterone in toxoplasmosis-associated changes in human behavior. Neuro Endocrinol Lett 28:101-105.
17. Kaňková Š, Kodym P, Frynta D, Vavrinová R, Kubena A, Flegr J. 2007b. Influence of latent toxoplasmosis on the secondary sex ratio in mice. Parasitology 134:1709-1718.
18. Kaňková Š, Šulc J, Nouzová K, Fajfrlík K, Frynta D, Flegr J. 2007a. Women infected with parasite Toxoplasma have more sons. Naturwissenschaften 94:122-127.
19. Kirchengast S. 1993. Anthropometric-hormonal correlation patterns in fertile and postmenopausal women from Austria. Ann Hum Biol 20:47-65.
20. Lindová J, Novotná M, Havlíček J, Jozífková E, Skallová A, Kolbeková P, Hodný Z, Kodym P, Flegr J. 2006. Gender differences in behavioural changes induced by latent toxoplasmosis. Int J Parasitol 36:1485-1492.
21. Lippa RA. 2003. Are 2D:4D finger-length ratios related to sexual orientation? Yes for men, no for women. J Pers Soc Psychol 85:179-188.
22. Lutchmaya S, Baron-Cohen S, Raggatt P, Knickmeyer R, Manning JT. 2004. 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Hum Dev 77:23-28.
23. Luxen MF, Buunk BP. 2005. Second-to-fourth digit ratio related to verbal and numerical intelligence and the big five. Pers Individ Dif 39:959-966.
24. Manning JT. 2002. Digit ratio: a pointer to fertility, behavior, and health. New Jersey: Rutgers University Press.
25. Manning JT, Barley L, Walton J, Lewis-Jones DI, Trivers RL, Singh D, Thornhill R, Rohde P, Bereczkei T, Henzi P, Soler M, Szwed A. 2000a. The 2nd:4th digit ratio, sexual dimorphism, population differences, and reproductive success. Evidence for sexually antagonistic genes? Evol Hum Behav 21:163-183.
26. nd to 4th digit ratio and autism. Dev Med Child Neurol 43:160-164.
27. Manning JT, Scutt D, Wilson J, Lewis-Jones DI. 1998. The ratio of 2nd to 4th digit length: a predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen. Hum Reprod 13:3000-3004.
28. Manning JT, Stewart A, Bundred PE, Trivers RL. 2004. Sex and ethnic differences in 2nd to 4th digit ratio of children. Early Hum Dev 80:161-168.
29. Manning JT, Trivers RL, Thornhill R, Singh D. 2000b. The 2nd:4th digit ratio and asymmetry of hand performance in Jamaican children. Laterality 5:121-132.
30. McIntyre MH, Ellison PT, Lieberman DE, Demerath E, Tone B. 2005. The development of sex differences in digital formula from infancy in the Fels Longitudinal Study. Proc R Soc Lond B Biol Sci 272:1473-1479.
31. Millet K, Dewitte S. 2006. Second to fourth digit ratio and cooperative behavior. Biol Psychol 71:111-115.
32. Neave N, Laing S, Fink B, Manning JT. 2003. Second to fourth digit ratio, testosterone and perceived male dominance. Proc R Soc Lond B Biol Sci 270:2167-2172.
33. Okten A, Kalyoncu M, Yaris N. 2002. The ratio of second- and fourth-digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Early Hum Dev 70:47-54.
34. Paul SN, Kato BS, Cherkas LF, Andrew T, Spector TD. 2006. Heritability of the second to fourth digit ratio (2d:4d): a twin study. Twin Res Hum Genet 9:215-219.
35. Pokorny J, Fruhbauer Z, Polednakova S, Sykora J, Zastera M, Fialova D. 1989. Stanoveni antitoxoplasmickych protilatek IgG metodou ELISA (Assessment of antitoxoplasmatic IgG antibodies with the ELISA method). Cs Epidem 38:355-361.
36. Roberts CW, Walker W, Alexander J. 2001. Sex-associated hormones and immunity to protozoan parasites. Clin Microbiol Rev 14:476-488.
37. Roney JR, Whitham JC, Leoni M, Bellem A, Wielebnowski N, Maestripieri D. 2004. Relative digit lengths and testosterone levels in Guinea baboons. Horm Behav 45:285-290.
38. Rubolini D, Pupin F, Sacchi R, Gentilli A, Zuffi MAL, Galeotti P, Saino N. 2006. Sexual dimorphism in digit length ratios in two lizard species. Anat Rec A Discov Mol Cell Evol Biol 288:491-497.
39. Saino N, Leoni B, Romano M. 2006. Human digit ratios depend on birth order and sex of older siblings and predict maternal fecundity. Behav Ecol Sociobiol 60:34-45.
40. Schuster JP, Schaub GA. 2001. Experimental Chagas disease: the influence of sex and psychoneuroimmunological factors. Parasitol Res 87:994-1000.
41. Sheskin DJ. 2003. Handbook of parametric and nonparametric statistical procedures. Boca Raton: Chapman and Hall.
42. Shirtcliff EA, Granger DA, Likos A. 2002. Gender differences in the validity of testosterone measured in saliva by immunoassay. Horm Behav 42:62-69.
43. Trivers R, Manning JT, Jacobson A. 2006. A longitudinal study of digit ratio (2D:4D) and other finger ratios in Jamaican children. Horm Behav 49:150-156.
44. Troisi R, Potischman N, Roberts JM, Harger G, Markovic N, Cole B, Lykins D, Siiteri P, Hoover RN. 2003. Correlation of serum hormone concentrations in maternal and umbilical cord samples. Cancer Epidemiol Biomarkers Prev 12:452-456.
45. Warren J, Sabin AB. 1942. The complement fixation reaction in toxoplasmic infection. Proc Soc Exp Biol Med 51:11-16.
46. Williams JH, Greenhalgh KD, Manning JT. 2003. Second to fourth finger ratio and possible precursors of developmental psychopathology in preschool children. Early Hum Dev 72:57-65.
47. Wood S, Vang E, Manning JT, Walton J, Troup S, Kingsland C, Lewis-Jones ID. 2003. The ratio of second to fourth digit length in azoospermic males undergoing surgical sperm retrieval: predictive value for sperm retrieval and on subsequent fertilization and pregnancy rates in IVF/ICSI cycles. J Androl 24:871-877.