Functionality testing of gellan gum, a polymeric excipient material for ophthalmic dosage forms

International Journal of Pharmaceutics

Volumn 153, Issue 2, 1997, Pages 191-198

  Rozier, Annouk ^a   Mazuel, Claude ^a   Grove, Jeffrey ^a   Plazonnet, Bernard ^a  

^a Dohme Chibret Centre de Recherche Riom   (France)

Author keywords

Functionality test; Gel strength; Gellan gum; Gelrite; Ocular bioavailability; Ophthalmics

Indexed keywords

AGENTS ACTING ON THE EYE; EXCIPIENT; GELLAN; GELLING AGENT; POLYMER; TIMOLOL MALEATE;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM; DRUG FORMULATION; EYE; GEL; MEASUREMENT; MOLECULAR WEIGHT; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RABBIT; STRENGTH; TOPICAL DRUG ADMINISTRATION;

EID: 0030757996     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00109-9     Document Type: Article

References (10)

1. Adler's Physiology of the Eye, Moses R.A. (Ed.), C.V. Mosby, St. Louis, Missouri, 1981, p. 74.
2. Greaves, J.L., Wilson, C.G., Rozier, A., Grove, J., Plazonnet, B., 1990. Scintigraphic assessment of an ophthalmic gelling vehicle in man and rabbit. Curr. Eye Res. 9 (5), 415-420.
3. Mazuel, C., Friteyre, M.C. Composition pharmaceutique de type à transition de phase liquide-gel. French Patent Fr 85 14689, 3 October 1985.
4. Robinson, G., Manning, C.E., Morris, E.R., Properties of the bacterial polysaccharides Gellan, Welan and Rhamsan. In: Dickinson E. (Ed.), Food Polymers, Gels and Colloids. The Royal Society of Chemistry, Cambridge, UK, 1991, p. 22-33.
5. Rozier, A., Grove, J., Mazuel, C., Plazonnet, B., Gelrite® solutions: novel ophthalmic vehicles that enhance ocular drug penetration. Proc. Int. Symp. Control. Release Bioact. Mater. (1989a) 109-110.
6. Rozier, A., Mazuel, C., Grove, J., Plazonnet, B., 1989b. Gelrite®: a novel, ion activated, in situ-gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol. Int. J. Pharm. 57, 163-168.
7. Sanderson, G.R., Bell, V.L., Clark, R.C., Onega, D., The texture of gellan gum gels. In: Phillips G.O. et al. (Ed), Gums and Stabilizers for the Food Industry 4. IRL Press Ltd, Oxford, UK, 1988, pp. 219-229.
8. Shedden, A.H., 1994. Timolol maleate in gel forming solution: a novel formulation of timolol maleate. Chibret Int. J. Ophthalmol. 10, 32-36.
9. Szczesniak, A.S., Brandt, M.A., Friedman, H.H., 1963. Development of standard rating scales for mechanical parameters of texture and correlation between the objective and sensory methods of textural evaluation. J. Food Sci. 28, 397.
10. US Pharmacopeia XXIII, 1995. Gel Strength of Gelatin, p. 1922