Serum from children with polyarticular juvenile idiopathic arthritis (pJIA) inhibits differentiation, mineralization and may increase apoptosis of human osteoblasts "in vitro"

Clinical Rheumatology

Volumn 28, Issue 1, 2009, Pages 71-77

  Caparbo, Valéria F ^a   Prada, Flávia ^a   Silva, Clóvis A A ^a   Regio, Paula L ^a   Pereira, Rosa M R ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Apoptosis; Bone; Differentiation; Juvenile idiopathic arthritis; Mineralization; Osteoblast

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CASPASE 3; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; OSTEOCALCIN; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; BLOOD ANALYSIS; BONE DEFECT; BONE METABOLISM; BONE MINERALIZATION; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA FRAGMENTATION; DNA SYNTHESIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; JUVENILE RHEUMATOID ARTHRITIS; MALE; OSTEOBLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD;

ALKALINE PHOSPHATASE; APOPTOSIS; ARTHRITIS, JUVENILE RHEUMATOID; CALCIFICATION, PHYSIOLOGIC; CALCIUM; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHILD; CYTOKINES; DNA; DNA FRAGMENTATION; FEMALE; HUMANS; MALE; OSTEOBLASTS; OSTEOCALCIN; SERUM;

EID: 57049164837     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-008-0985-y     Document Type: Article

References (41)

1. Juvenile rheumatoid arthritis. In: Cassidy JT, Petty RE (1995) Textbook of pediatric rheumatology. Philadelphia WB, pp 133-223
2. Pepmueller PH, Cassidy JT, Allen SH et al (1996) Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis. Arthritis Rheum 39:746-757
3. Pereira RMR, Corrente JE, Chahade WH et al (1998) Evaluation by dual X-ray absorptiometry (DXA) of bone mineral density in children with juvenile chronic arthritis. Clin Exp Rheumatol 16:495-501
4. Hopp RJ, Degan JA, Gallagher JC et al (1991) Estimation of bone mineral density in children with juvenile rheumatoid arthritis. J Rheumatol 218:1235-1239
5. Elsasser U, Wilkins B, Hesp R et al (1982) Bone rarefaction and crush fractures in juvenile chronic arthritis. Arch Dis Child 57:377-380
6. Varonos S, Ansell BM, Reeve J (1987) Vertebral collapse in juvenile chronic arthritis: Its relationship with glucocorticoid therapy. Calcif Tissue Int 41:75-78
7. Cassidy JT (1999) Osteopenia and osteoporosis in children. Clin Exp Rheumatol 17:245-250
8. Bianchi ML (2002) Glucocorticoids and bone: Some general remarks and some special observations in pediatric patients. Calcif Tissue Int 70:384-390
9. Yilmaz M, Kendirli SG, Altintas D et al (2001) Cytokine levels in serum of patients with juvenile rheumatoid arthritis. Clin Rheumatol 20:30-35
10. Walsh NC, Crotti TN, Goldring SR et al (2005) Rheumatic diseases: The effects of inflammation on bone. Immunol Rev 208:228-251
11. Horowitz J, Lorenzo J (2002) Local regulators of bone: IL-1, TNF and lymphotoxin, interferon gamma, IL-8, IL-10, IL-4, the LIF/IL-6 family and additional cytokines. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. Academic, San Diego, pp 961-977
12. Manolagas SC, Jilka RL (1995) Bone marrow, cytokines and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 232:305-311
13. Grcevic D, Katavic V, Lukic IK et al (2001) Cellular and molecular interactions between immune system and bone. Croat Med J 42:384-391
14. Pereira RMR, Corrente JE, Chahade WH et al (1999) Abnormalities in biochemical markers of bone turnover in children with juvenile chronic arthritis. Clin Exp Rheumatol 17:251-255
15. Falcini F, Ermini M, Bagnoli F (1998) Bone turnover is reduced in children with juvenile rheumatoid arthritis. J Endocrinol Invest 21:31-36
16. Reed A, Haugen M, Pachman LM et al (1990) Abnormalities in serum osteocalcin values in children with chronic rheumatic diseases. J Pediatr 116:574-580
17. Aubin JE, Triffit JT (2002) Mesenchymal stem cells and osteoblast differentiation. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. Academic, San Diego, pp 59-81
18. Jilka RL, Weinstein RS, Bellido T et al (1998) Osteoblast programmed cell death (apoptosis): Modulation by growth factors and cytokines. J Bone Miner Res 13:793-802
19. Petty RE, Southwood TR, Baum J et al (1997) Revision of the proposed classification criteria for juvenile idiopathic arthritis. J Rheumatol 25:1991-1994
20. Tanner JM (1962) Growth at adolescence, 2nd edn. Blackwell Scientific, Oxford
21. Human osteoblast culture. In: Helfrich MH, Ralston SH (2003) Bone research protocols. Humana, Totowa, New Jersey pp 3-18
22. Pereira RM, Delany AM, Canalis E (2001) Cortisol inhibits the differentiation and apoptosis of osteoblasts in cultures. Bone 28:484-490
23. Varghese S, Wyzga N, Griffiths AM et al (2002) Effects of serum from children with newly diagnosed Crohn disease on primary cultures of rat osteoblasts. J Pedriatr Gastroenterol Nutr 35:641-648
24. Fromigué O, Marie PJ, Lomri A (1997) Differential effects of transforming growth factor-b2, dexamethasone and 1,25-dihydroxyvitamin D on human bone marrow stromal cells. Cytokine 9:613-623
25. Morgan E, Varro R, Sepulveda H et al (2004) Cytomertric bed array: A multiplexed assay platform with applications in various areas of biology. Clin Immunol 110:252-266
26. Taylor AK, Lueken SA, Libanati C et al (1994) Biochemical markers of bone turnover for the clinical assessment of bone metabolism. Rheum Dis Clin North Am 20:589-607
27. Ducy P, Desbois C, Boyce B et al (1996) Increased bone formation in osteocalcin-deficient mice. Nature 382:448-452
28. Stein GS, Lian JB (1993) Molecular mechanism mediating proliferation/ differentiation interrelationship during progressive development of osteoblast phenotype. Endocr Rev 14:424-442
29. Tsuboi M, Kawakami A, Nakashima T et al (1999) Tumor necrosis factor-alpha and interleukin-1beta increase the Fas-mediated apoptosis of human osteoblasts. J Lab Clin Med 134:222-231
30. Kallio A, Guo T, Lamminen E et al (2008) Estrogen and the selective estrogen receptor modulator (SERM) protection against cell death in estrogen receptor alpha and beta expressing U2OS cells. Mol Cell Endocrinol 289:38-48
31. Goldring SR (2003) Inflammatory mediators as essential elements in bone remodeling. Calcif Tissue Int 73:97-100
32. Roodman GD (1992) Interleukin-6: An osteotropic factor? J Bone Miner Res 7:475-478
33. Rusinska A, Chlebna-Sokol D (2005) Evaluation of interleukin-1 and -6 in the etiopathogenesis of idiopathic osteoporosis and osteopenia in children. Arch Immunol Ther Exp (Warsz) 53:257-265
34. Franchimont N, Wertz S, Malaise M (2005) Interleukin-6: An osteotropic factor influencing bone formation? Bone 37:601-606
35. Littlewood AJ, Aarden LA, Evans DB et al (1991) Human osteoblast like cells do not respond to interleukin-6. J Bone Miner Res 6:141-148
36. Kim C-H, Cheng S-L, Him GS (1997) Lack of autocrine effects of IL-6 on human bone marrow stromal osteoprogenitor cells. Endocr Res 23:181-90
37. Hughes FJ, Howells GL (1993) Interleukin-6 inhibits bone formation in vitro. Bone Miner 21:21-28
38. Kitamura H, Kawata H, Takahashi F et al (1995) Bone marrow neutrophilia and suppressed bone turnover in human interleukin-6 transgenic mice. Am J Pathol 147:1682-1692
39. Baker PJ, Dixon M, Evans RT et al (1999) CD4+ T cells and proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun 67:2804-2809
40. Alonzi T, Fattori E, Lazzaro D et al (1998) Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med 187:461-468
41. Sylvester FA, Wyzga N, Hyams JS et al (2002) Effect of Crohn's disease on bone metabolism in vitro: A role for interleukin-6. J B Min Res 17:695-702