Lack of autocrine effects of IL-6 on human bone marrow stromal osteoprogenitor cells

Endocrine Research

Volumn 23, Issue 3, 1997, Pages 181-190

  Kim, Chul Hee ^a   Cheng, Su Li ^b   Kim, Ghi Su ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b BARNES JEWISH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM 45; CELL PROTEIN; COLLAGEN; DECORIN; MESSENGER RNA; OSTEOPONTIN; RECOMBINANT INTERLEUKIN 6; THYMIDINE; TRITIUM;

ARTICLE; AUTOCRINE EFFECT; BONE MARROW CELL; BONE REMODELING; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; OSTEOBLAST; PRIORITY JOURNAL; STROMA CELL;

EID: 0030923590     PISSN: 07435800     EISSN: None     Source Type: Journal    
DOI: 10.3109/07435809709031852     Document Type: Article

References (15)

1. Suda T, Udagawa N, Nakamura, I, Miyaura C, Takahashi N. 1995 Modulation of osteoclast differentiation by local factors. Bone 17:87S-91S.
2. Canalis E, McCarthy T, Centrella M. 1988 Growth factors and the regulation of bone remodelling. J Clin Invest 81:277-281.
3. Littlewood AJ, Aarden LA, Evans DB, Russell RGG, Gowen M. 1991 Human osteoblastlike cells do not respond to interleukin-6. J Bone Miner Res 6:141-148.
4. Littlewood AJ, Russell J, Harvey GR, Hughes DE, Russell RGG, Gowen M. 1991 The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro. Endocrinology 129:1513-1520.
5. Udagawa N, Takahashi N, Katagiri T, Tamura T, Wada S, Findlay DM, Martin TJ, Hirota H, Taga T, Kishimoto T, Suda T. 1995 Interleukin(IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med 182: 1461-1468.
6. Fang MA, Hahn TJ. 1991 Effect of interleukin-6 on cellular function in UMR-106-01 osteoblastlike cells. J Bone Miner Res 6:133-139.
7. Hughes FJ, Howells GL. 1993 Interleukin-6 inhibits bone formation in vitro. Bone Miner 21:21-28.
8. Kuroki T, Shingu M, Koshihara Y, Nobunaga M. 1994 Effects of cytokines on alkaline phosphatase and osteocalcin production, calcification and calcium release by human osteoblastic cells. Br J Rheumatol 33:224-230.
9. Green J, Schotland S, Sella Z, Kleeman CR. 1994 Interleukin-6 attenuates agonist-mediated calcium mobilization in murine osteoblastic cells. J Clin Invest 93:2340-2350.
10. Maniatopoulos C, Sodek J, Melcher AH. 1988 Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 254:317-330.
11. Benz EW Jr, Getz MJ, Wells DJ, Moses HL. 1977 Nuclear RNA polymerase activities and poly(A)-containing mRNA accumulation in cultured AKR mouse embryo cells stimulated to proliferate. Exp Cell Res 108:157-165.
12. Puzas JE, Brand JS. 1985 Bone cell phosphotyrosine phosphatase: Characterization and regulation by calcitropic hormones. Endocrinology 116:2463-2468.
13. Cheng S-L, Zhang S-F, Nelson TL, Warlow PM, Civitelli R. 1994 Stimulation of human osteoblast differentiation and function by ipriflavone and its metabolites. Calcif Tissue Int 55:356-362.
14. Rodan GA, Noda M. 1991 Gene expression in osteoblastic cells. Critical Reviews in Eukaryotic Gene Expression 1:85-98.
15. Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Yamada Y, Koishihara Y, Ohsugi Y, Kumaki K, Taga T, Suda T. 1993 Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6. Proc Natl Acad Sci USA 90:11924-11928.