Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 4, 2008, Pages

  Houck, Kristy L ^a   Fox, Todd E ^a   Sandirasegarane, Lakshman ^a   Kester, Mark ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Bioactive lipids; Cell migration; Mitogen activated protein kinase; Phosphatidylinositol 3 kinase; Proliferation

Indexed keywords

CYTOKINE; DIACYLGLYCEROL; ETHER; GROWTH FACTOR; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; PROTEIN KINASE C; TENSIN;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CHROMOSOME 10; GROWTH DISORDER; HUMAN; HUMAN CELL; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; RAT; SECOND MESSENGER; SMOOTH MUSCLE FIBER; SPECIES; THROMBOCYTE; VASCULAR SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DIGLYCERIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCERYL ETHERS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE C-EPSILON; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION;

EID: 57049141078     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00141.2008     Document Type: Article

References (44)

1. Allen TR, Krueger KD, Hunter WJ 3rd, Agrawal DK. Evidence that insulin-like growth factor-1 requires protein kinase C-epsilon, PI3-kinase and mitogen-activated protein kinase pathways to protect human vascular smooth muscle cells from apoptosis. Immunol Cell Biol 83: 651-667, 2005.
2. Araki S, Tsuna I, Kaji K, Hayashi H. Programmed cell death in response to alkyllysophospholipids in endothelial cells. J Biochem (Tokyo) 115: 245-247, 1994.
3. Barber DF, Alvarado-Kristensson M, Gonzalez-Garcia A, Pulido R, Carrera AC. PTEN regulation, a novel function for the p85 subunit of phosphoinositide 3-kinase. Sci STKE 2006: pe49, 2006.
4. Bourbon NA, Sandirasegarane L, Kester M. Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. J Biol Chem 277: 3286-3292, 2002.
5. Bourbon NA, Yun J, Berkey D, Wang Y, Kester M. Inhibitory actions of ceramide upon PKC-ε/ERK interactions. Am J Physiol Cell Physiol 280: C1403-C1411, 2001.
6. Brites P, Waterham HR, Wanders RJ. Functions and biosynthesis of plasmalogens in health and disease. Biochim Biophys Acta 1636: 219-231, 2004.
7. Cabot MC, Jaken S. Structural and chemical specificity of diacylglycerols for protein kinase C activation. Biochem Biophys Res Commun 125: 163-169, 1984.
8. Cacace AM, Guadagno SN, Krauss RS, Fabbro D, Weinstein IB. The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene 8: 2095-2104, 1993.
9. Chamberlain MD, Berry TR, Pastor MC, Anderson DH. The p85alpha subunit of phosphatidylinositol 3 -kinase binds to and stimulates the GTPase activity of Rab proteins. J Biol Chem 279: 48607-48614, 2004.
10. Charles R, Sandirasegarane L, Yun J, Bourbon N, Wilson R, Rothstein RP, Levison SW, Kester M. Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries. Circ Res 87: 282-288, 2000.
11. Flanagan CA, Schnieders EA, Emerick AW, Kunisawa R, Admon A, Thorner J. Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Science 262: 1444-1448, 1993.
12. Ford DA, Miyake R, Glaser PE, Gross RW. Activation of protein kinase C by naturally occurring ether-linked diglycerides. J Biol Chem 264: 13818-13824, 1989.
13. Foukas LC, Beeton CA, Jensen J, Phillips WA, Shepherd PR. Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo. Mol Cell Biol 24: 966-975, 2004.
14. Fox TE, Houck KL, O'Neill SM, Nagarajan M, Stover TC, Pomianowski PT, Unal O, Yun JK, Naides SJ, Kester M. Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains. J Biol Chem 282: 12450-12457, 2007.
15. Fromm M, Berdel WE, Schick HD, Fink U, Pahlke W, Bicker U, Reichert A, Rastetter J. Antineoplastic activity of the thioether lysophospholipid derivative BM 41.440 in vitro. Lipids 22: 916-918, 1987.
16. Ganong BR, Loomis CR, Hannun YA, Bell RM. Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci USA 83: 1184-1188, 1986.
17. Gorgas K, Teigler A, Komljenovic D, Just WW. The ether lipiddeficient mouse: tracking down plasmalogen functions. Biochim Biophys Acta 1763: 1511-1526, 2006.
18. Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev 19: 2054-2065, 2005.
19. Harpur AG, Layton MJ, Das P, Bottomley MJ, Panayotou G, Driscoll PC, Waterfield MD. Intermolecular interactions of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase. J Biol Chem 274: 12323-12332, 1999.
20. Hermans SW, Engelmann B, Reinhardt U, Bartholomeus-Van Nooij IG, De Pont JJ, Willems PH. Diradylglycerol formation in cholecystokinin-stimulated rabbit pancreatic acini. Assessment of precursor phospholipids by means of molecular species analysis. Eur J Biochem 235: 73-81, 1996.
21. Heymans F, Da Silva C, Marrec N, Godfroid JJ, Castagna M. Alkyl analogs of diacylglycerol as activators of protein kinase C. FEBS Lett 218: 35-40, 1987.
22. Ivaska J, Nissinen L, Immonen N, Eriksson JE, Kahari VM, Heino J. Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. Mol Cell Biol 22: 1352-1359, 2002.
23. Jones DR, Pettitt TR, Sanjuan MA, Merida I, Wakelam MJ. Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol. J Biol Chem 274: 16846-16852, 1999.
24. Kang H, Schneider H, Rudd CE. Phosphatidylinositol 3-kinase p85 adaptor function in T-cells. Co-stimulation and regulation of cytokine transcription independent of associated p110. J Biol Chem 277: 912-921, 2002.
25. Leli U, Hauser G, Froimowitz M. Requirements for the activation of protein kinase C: comparison of the molecular geometries of phorbol and diacylglycerol. Mol Pharmacol 37: 286-295, 1990.
26. -ΔΔCT method. Methods 25: 402-408, 2001.
27. Mandal A, Wang Y, Ernsberger P, Kester M. Interleukin-1-induced ether-linked diglycerides inhibit calcium-insensitive protein kinase C isotypes. Implications for growth senescence. J Biol Chem 272: 20306-20311, 1997.
28. Menice CB, Hulvershorn J, Adam LP, Wang CA, Morgan KG. Calponin and mitogen-activated protein kinase signaling in differentiated vascular smooth muscle. J Biol Chem 272: 25157-25161, 1997.
29. Mischak H, Goodnight JA, Kolch W, Martiny-Baron G, Schaechtle C, Kazanietz MG, Blumberg PM, Pierce JH, Mushinski JF. Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 268: 6090-6096, 1993.
30. Moser HW. Molecular genetics of peroxisomal disorders. Front Biosci 5: D298-D306, 2000.
31. Mosior M, Epand RM. Mechanism of activation of protein kinase C: roles of diolein and phosphatidylserine. Biochemistry 32: 66-75, 1993.
32. Musial A, Mandal A, Coroneos E, Kester M. Interleukin-1 and endothelin stimulate distinct species of diglycerides that differentially regulate protein kinase C in mesangial cells. J Biol Chem 270: 21632-21638, 1995.
33. Newton AC. The ins and outs of protein kinase C. Methods Mol Biol 233: 3-7, 2003.
34. Rando RR, Kishi Y. Structural basis of protein kinase C activation by diacylglycerols and tumor promoters. Biochemistry 31: 2211-2218, 1992.
35. Salamanca DA, Khalil RA. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol 70: 1537-1547, 2005.
36. Sasaguri T, Kosaka C, Hirata M, Masuda J, Shimokado K, Fujishima M, Ogata J. Protein kinase C-mediated inhibition of vascular smooth muscle cell proliferation: the isoforms that may mediate G1/S inhibition. Exp Cell Res 208: 311-320, 1993.
37. Sato S, Fujita N, Tsuruo T. Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci USA 97: 10832-10837, 2000.
38. Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky JM. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol 24: 8778-8789, 2004.
39. Walker VG, Ammer A, Cao Z, Clump AC, Jiang BH, Kelley LC, Weed SA, Zot H, Flynn DC. PI3K activation is required for PMAdirected activation of cSrc by AFAP-110. Am J Physiol Cell Physiol 293: C119-C132, 2007.
40. Wanders RJ, Waterham HR. Peroxisomal disorders I: biochemistry and genetics of peroxisome biogenesis disorders. Clin Genet 67: 107-133, 2005.
41. Wang LP, Summers SA. Measuring insulin-stimulated phosphatidylinositol 3-kinase activity. Methods Mol Med 83: 127-136, 2003.
42. Warne TR, Buchanan FG, Robinson M. Growth-dependent accumulation of monoalkylglycerol in Madin-Darby canine kidney cells. Evidence for a role in the regulation of protein kinase C. J Biol Chem 270: 11147-11154, 1995.
43. Wieder T, Haase A, Geilen CC, Orfanos CE. The effect of two synthetic phospholipids on cell proliferation and phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells. Lipids 30: 389-393, 1995.
44. Wymann MP, Pirola L. Structure and function of phosphoinositide 3-kinases. Biochim Biophys Acta 1436: 127-150, 1998.