Insulin Sensitivity in Thoroughbred Geldings: Effect of Weight Gain, Diet, and Exercise on Insulin Sensitivity in Thoroughbred Geldings

Journal of Equine Veterinary Science

Volumn 28, Issue 12, 2008, Pages 728-738

  Quinn, Rachael W ^a   Burk, Amy O ^a   Hartsock, Thomas G ^a   Petersen, Erin D ^a   Whitley, Niki C ^b   Treiber, Kibby H ^c   Boston, Raymond C ^d  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND EASTERN SHORE   (United States)

^c VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Equine; Glucose dynamics; Insulin sensitivity; Obesity

Indexed keywords

EQUIDAE;

EID: 57049105199     PISSN: 07370806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jevs.2008.10.020     Document Type: Article

References (39)

1. Treiber K.H., Kronfeld D.S., Hess T.M., Byrd B.M., Splan R.K., and Staniar W.B. Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies. J Am Vet Med Assoc 228 (2006) 1538-1545
2. Asplin K.E., Sillence M.N., Pollitt C.C., and McGowan C.M. Induction of laminitis by prolonged hyperinsulinemia in clinically normal ponies. Vet J 174 (2007) 530-535
3. Hoffman R.M., Boston R.C., Stefanovski D., Kronfeld D.S., and Harris P.A. Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings. J Anim Sci 81 (2003) 2333-2342
4. Vick M.M., Adams A.A., Murphy B.A., Sessions D.R., Horohov D.W., Cook R.F., et al. Relationship between inflammatory cytokines, obesity and insulin sensitivity in the horse. J Anim Sci 85 (2007) 1144-1155
5. Kronfeld D.S., Treiber K.H., Hess T.M., and Boston R.C. Insulin resistance in the horse: definition, detection and dietetics. J Anim Sci 83 Suppl (2005) E22-E31
6. Pratt S.E., Geor R.J., and McCutcheon L.J. Effects of dietary energy source and physical conditioning on insulin sensitivity and glucose tolerance in Standardbred horses. Equine Vet J (Suppl) 36 (2006) 579-584
7. Kopp W. High-insulinogenic nutrition: an etiologic factor for obesity and the metabolic syndrome?. Metab Clin Exp 52 (2003) 840-844
8. Treiber K.H., Boston R.C., Kronfeld D.S., Staniar W.B., and Harris P.A. Insulin resistance and compensation in Thoroughbred weanlings adapted to high-glycemic meals. J Anim Sci 83 (2005) 2357-2364
9. Freestone J.F., Shoemaker K., Bessin R., and Wolfsheimer K.J. Insulin and glucose response following oral glucose administration in well-conditioned ponies. Equine Vet J (Suppl) 11 (1992) 13-17
10. Powell D., Reedy S., Sessions D., and Fitzgerald B. Effect of short-term exercise training on insulin sensitivity in obese and lean mares. Equine Vet J 34 (2002) 81-84
11. Henneke D.R., Potter G.D., Kreider J.L., and Yeates B.F. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J 15 (1983) 371-372
12. NRC. Nutrient requirements of horses. 5th rev (1989), National Academies Press, Washington, DC 43-4490-110
13. Heusner G.L. Ad libitum feeding of mature horses to achieve rapid weight gain. Proceedings 8th Equine Nutrition and Physiology Symposium (1983) 86-87
14. Harris P.A., and Kronfeld D.S. Influence of dietary energy sources on health and performance. Curr Ther Equine Nutr 5 (2003) 698-704
15. Geor R., Li R., Waterfall L., Larsen L., Stewart-Hurst L., and McCutcheon J. Repeatability of insulin sensitivity and glucose effectiveness from minimal model analysis of the frequently sampled intravenous tolerance test in horses. J Vet Intern Med 19 (2005) 484
16. Treiber K.H., Hess T.M., and Kronfeld D.S. Insulin resistance and compensation in laminitis-predisposed ponies characterized by the minimal model. Pferdeheilkunde 21 (2005) 91-92
17. Forhead A.J., and Dobson H. Plasma glucose and cortisol responses to exogenous insulin in fasted donkeys. Res Vet Sci 62 (1997) 265-269
18. Freestone J.F., Wolfsheimer K.J., Kamerling S.G., Church G., Hamra J., and Bagwell C. Exercise induced hormonal and metabolic changes in Thoroughbred horses: effects of conditioning and acepromazine. Equine Vet J 23 (1991) 219-223
19. Bergman R.N. The minimal model: yesterday, today and tomorrow. In: Bray G.A., and Ryan G.A. (Eds). The minimal model approach and determinants of glucose tolerance (1997), Louisiana State University Press, Baton Rouge, LA 3-50
20. Johnson P.J. The equine metabolic syndrome Peripheral Cushing's syndrome. Vet Clin North Am: Equine Pract 18 (2002) 271-293
21. Frank N., Elliot S.B., Brandt L.E., and Keisler D.H. Physical characteristics, blood hormone concentrations and plasma lipid concentrations in obese horses with insulin resistance. J Am Vet Med Assoc 228 (2006) 1383-1390
22. Stull C.L., and Rodiek A.V. Responses of blood glucose, insulin and cortisol concentrations to common equine diets. J Nutr 118 (1987) 206-213
23. Pagan J.D., Harris P.A., Kennedy M.A.P., Davidson N., and Hoekstra K.E. Feed type and intake effects glycemic response in Thoroughbred horses. Proceedings 16th Equine Nutrition and Physiology Symposium (1999) 149-152
24. Williams C.A., Kronfeld D.S., Staniar W.B., and Harris P.A. Plasma glucose and insulin responses of Thoroughbred mares fed a meal high in starch and sugar or fat and fiber. J Anim Sci 79 (2001) 2196-2201
25. Sticker L.S., Thompson D.L., Bunting L.D., Fernandez J.M., and DePew C.L. Dietary protein and(or) energy restriction in mares: plasma glucose, insulin, non-esterified fatty acid and urea nitrogen responses to feeding, glucose and epinephrine. J Anim Sci 73 (1995) 136-144
26. Despres J.P., and Lemieux I. Abdominal obesity and metabolic syndrome. Nature 444 (2006) 881-887
27. Vick M.M., Murphy B.A., Sessions D.R., Reedy S.E., Kennedy E.L., and Horohov D.W. Effects of systemic inflammation on insulin sensitivity in horses and inflammatory cytokine expression in adipose tissue. Am J Vet Res 69 (2008) 130-139
28. Wilcox G. Insulin and insulin resistance. Clin Biochem 26 (2005) 19-39
29. Ader M., Ta-Chen N., and Bergman R.N. Glucose effectiveness assessed under dynamic and steady state conditions: comparability of uptake versus production components. J Clin Invest 99 (1997) 1187-1199
30. Araujo-Vilar D., Garcia-Estevez D.A., and Cabezas-Cerrato J. Both a reduced acute insulin response to glucose and lower glucose effectiveness are responsible for the worsening of intravenous glucose tolerance in healthy subjects independently of the degree of obesity. Metab Clin Exp 47 (1998) 313-320
31. Rebrin K., Steil G.M., Mittleman S.D., and Bergman R.N. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest 98 (1996) 741-749
32. Pawlak D.B., Bryson J.M., Denyer G.S., and Brand-Miller J.C. High glycemic index starch promotes hypersecretion of insulin and higher body fat in rats without affecting insulin sensitivity. J Nutr 131 (2001) 99-104
33. Pratt S.E., Geor R.J., Spriet L.L., and McCutcheon L.J. Time course of insulin sensitivity and skeletal muscle glycogen synthase activity after a single bout of exercise in horses. J Appl Physiol 103 (2007) 1063-1069
34. Ye J. Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle. Endocrine Metab Immune Disord Drug Targets 7 (2007) 65-74
35. Finegood D.T., and Tzur D. Reduced glucose effectiveness associated with reduced insulin release: an artifact of the minimal model method. Am J Physiol Endocrinol Metab 34 (1996) E485-E496
36. Holland J.L., Kronfeld D.S., and Meacham T.N. Behavior of horses is affected by soy lecithin and corn oil in the diet. J Anim Sci 74 (1996) 1252-1255
37. Pagan J.D., and Hintz H.F. Equine energetics. II. Energy expenditure in horses during submaximal exercise. J Anim Sci 63 (1989) 822-830
38. Treiber K.H., Hess T.M., Kronfeld D.S., Boston R.C., Geor R.J., Friere M., et al. Glucose dynamics during exercise: dietary energy sources affect minimal model parameters in trained Arabian geldings during endurance exercise. Equine Vet J 36 (2006) 631-636
39. Kronfeld D.S., and Harris P.A. Equine grain-associated disorders. Comp Cont Educ Pract Vet 25 (2003) 974-983