Effects of systemic inflammation on insulin sensitivity in horses and inflammatory cytokine expression in adipose tissue

American Journal of Veterinary Research

Volumn 69, Issue 1, 2008, Pages 130-139

  Vick, Mandi M ^a,b   Murphy, Barbara A ^a   Sessions, Dawn R ^a   Reedy, Stephanie E ^a   Kennedy, Erin L ^a   Horohov, David W ^a   Cook, R Frank ^a   Fitzgerald, Barry P ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Center for Research and Conservation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INSULIN; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; FEMALE; HORSE; HYPERINSULINEMIA; INFLAMMATION; INSULIN SENSITIVITY; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOSE TISSUE; ANIMALS; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HORSE DISEASES; HORSES; INFLAMMATION; INSULIN RESISTANCE; TIME FACTORS;

ANIMALIA; EQUIDAE;

EID: 38749126783     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.69.1.130     Document Type: Article

References (58)

1. Hoffman RM, Boston RC, Stefanovski D, et al. Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings. J Anim Sci 2003;81:2333-2342.
2. Powell DM, Reedy SE, Sessions DR, et al. Effect of short-term exercise training on insulin sensitivity in obese and lean mares. Equine Vet J Suppl 2002;34:81-84.
3. Treiber KH, Kronfeld DS, Geor RJ. Insulin resistance in equids: possible role in laminitis. J Nutr 2006;136:2094S-2098S.
4. Vick MM, Sessions DR, Murphy BA, et al. Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity Reprod Fertil Dev 2006;18:609-617.
5. Hotamisligil GS. The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med 1999;245:621-625.
6. Rajala MW, Scherer PE. Minireview: the adipocyte - at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003;144:3765-3773.
7. Ramos EJ, Xu Y, Romanova I, et al. Is obesity an inflammatory disease? Surgery 2003;134:329-335.
8. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821-1830.
9. Yuan M, Konstantopoulos N, Lee J, et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001;293:1673-1677.
10. Agwunobi AO, Reid C, Maycock P, et al. Insulin resistance and substrate utilization in human endotoxemia. J Clin Endocrinol Metab 2000;85:3770-3778.
11. Ruan H, Lodish HF. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. Cytokine Growth Factor Rev 2003;14:447-455.
12. Fernandez-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 2003;24:278-301.
13. Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005;96:939-949.
14. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006;6:772-783.
15. Vick MM, Adams AA, Murphy BA, et al. Relationship between inflammatory cytokines, obesity, and insulin sensitivity in the horse. J Anim Sci 2007;85:1144-1155.
16. Leininger MT, Portocarrero CP, Schinckel AP, et al. Physiological response to acute endotoxemia in swine: effect of genotype on energy metabolites and leptin. Domest Anim Endocrinol 2000;18:71-82.
17. MacKay RJ, Merritt AM, Zertuche JM, et al. Tumor necrosis factor activity in the circulation of horses given endotoxin. Am J Vet Res 1991;52:533-538.
18. Moeniralam HS, Sprangers F, Endert E, et al. Role of nitric oxide in the regulation of glucose kinetics in response to endotoxin in dogs. J Appl Physiol 2001;91:130-136.
19. Freestone JF, Wolfsheimer KJ, Kamerling SG, et al. Exercise induced hormonal and metabolic changes in Thoroughbred horses: effects of conditioning and acepromazine. Equine Vet J 1991;23:219-223.
20. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223.
21. Sessions DR, Reedy SE, Vick MM, et al. Development of a model for inducing transient insulin resistance in the mare: preliminary implications regarding the estrous cycle. J Anim Sci 2004;82:2321-2328.
22. Breathnach CC, Sturgill-Wright T, Stiltner JL, et al. Foals are interferon gamma-deficient at birth. Vet Immunol Immunopathol 2006;112:199-209.
23. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
24. Reedy SE, Powell DM, Williams NM, et al. Thoughts on the source of tissue on subsequent cell culture success. Methods Cell Sci 2000;22:29-32.
25. Fried SK, Moustaid-Moussa N. Culture of adipose tissue and isolated adipocytes. In: Adipose tissue protocols. Totowa, NJ: Humana Press Inc, 2001;204-208.
26. Malide D. Confocal microscopy of adipocytes. In: Adipose tissue protocols. Totowa, NJ: Humana Press Inc, 2001;55-62.
27. Cargile JL, MacKay RJ, Dankert JR, et al. Effect of treatment with a monoclonal antibody against equine tumor necrosis factor (TNF) on clinical, hematologic, and circulating TNF responses of miniature horses given endotoxin. Am J Vet Res 1995;56:1451-1459.
28. Maitra SR, Wojner MM, Lang CH. Alterations in tissue glucose uptake during hyperglycemic and hypoglycemic phases of sepsis. Shock 2000;13:379-385.
29. White RH, Frayn KN, Little RA, et al. Hormonal and metabolic responses to glucose infusion in sepsis studied by the hyper-insulinemic glucose clamp technique. JPEN J Parenter Enteral Nutr 1987;11:345-353.
30. Virkamaki A, Yki-Jarvinen H. Mechanisms of insulin resistance during acute endotoxemia. Endocrinology 1994;134:2072-2078.
31. Lang CH, Dobrescu C. Gram-negative infection increases noninsulin-mediated glucose disposal. Endocrinology 1991;128:645-653.
32. Lang CH, Dobrescu C, Bagby GJ. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 1992;130:43-52.
33. Bedard S, Marcotte B, Marette A. Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase. Biochem J 1997;325:487-493.
34. Marntell S, Nyman G, Funkquist P, et al. Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses. Vet Anaesth Analg 2005;32:83-93.
35. Parry BW, Anderson GA, Gay CC. Hypotension in the horse induced by acepromazine maleate. Aust Vet J 1982;59:148-152.
36. Chung S, Lapoint K, Martinez K, et al. Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 2006;147:5340-5351.
37. Charriere G, Cousin B, Arnaud E, et al. Preadipocyte conversion to macrophage. Evidence of plasticity. J Biol Chem 2003; 278:9850-9855.
38. Ling PR, Bistrian BR, Mendez B, et al. Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral glucose uptake. Metabolism 1994;43:279-284.
39. Klover PJ, Zimmers TA, Koniaris LG, et al. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 2003;52:2784-2789.
40. Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808.
41. Suganami T, Nishida J, Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 2005;25:2062-2068.
42. Martinez-Riquelme AE, Allison SP. Insulin revisited. Clin Nutr 2003;22:7-15.
43. Thorell A, Nygren J, Hirshman MF, et al. Surgery-induced insulin resistance in human patients: relation to glucose transport and utilization. Am J Physiol 1999;276:E754-E761.
44. Nygren J, Thorell A, Efendic S, et al. Site of insulin resistance after surgery: the contribution of hypocaloric nutrition and bed rest. Clin Sci (Lond) 1997;93:137-146.
45. Thorell A, Loftenius A, Andersson B, et al. Postoperative insulin resistance and circulating concentrations of stress hormones and cytokines. Clin Nutr 1996;15:75-79.
46. Thorell A, Efendic S, Gutniak M, et al. Development of post-operative insulin resistance is associated with the magnitude of operation. Eur J Surg 1993;159:593-599.
47. Das UN. Insulin in sepsis and septic shock. J Assoc Physicians India 2003;51:695-700.
48. Jeschke MG, Klein D, Bolder U, et al. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology 2004;145:4084-4093.
49. Ljungqvist O, Nygren J, Thorell A. Modulation of post-operative insulin resistance by pre-operative carbohydrate loading. Proc Nutr Soc 2002;61:329-336.
50. Ljungqvist O, Nygren J, Soop M, et al. Metabolic perioperative management: novel concepts. Curr Opin Crit Care 2005;11:295-299.
51. Brandi LS, Frediani M, Oleggini M, et al. Insulin resistance after surgery: normalization by insulin treatment. Clin Sci (Lond) 1990;79:443-450.
52. Noblett SE, Watson DS, Huong H, et al. Pre-operative oral carbohydrate loading in colorectal surgery: a randomized controlled trial. Colorectal Dis 2006;8:563-569.
53. Van den Berghe G, Wouters PJ, Bouillon R, et al. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 2003;31:359-366.
54. Rhoads WS, Barton MH, Parks AH. Comparison of medical and surgical treatment for impaction of the small colon in horses: 84 cases (1986-1996). J Am Vet Med Assoc 1999;214:1042-1047.
55. Parks AH, Doran RE, White NA, et al. Ileal impaction in the horse: 75 cases. Cornell Vet 1989;79:83-91.
56. Treiber KH, Kronfeld DS, Hess TM, et al. Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies. J Am Vet Med Assoc 2006;228:1538-1545.
57. Pollitt CC. Equine laminitis: a revised pathophysiology in Proceedings. Annu Conv Am Assoc Equine Pract 1999;45:188-192.
58. Pass MA, Pollitt S, Pollitt CC. Decreased glucose metabolism causes separation of hoof lamellae in vitro: a trigger for laminitis? Equine Vet J Suppl 1998;26:133-138.