메뉴 건너뛰기




Volumn 460, Issue , 2008, Pages 89-112

Predictive toxicogenomics in preclinical discovery

Author keywords

Classification rule; In vitro; In vivo; Machine learning; Stochastic gradient boosting; Toxicity; Toxicogenomics

Indexed keywords

RATTUS;

EID: 84934441733     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-48-9_5     Document Type: Article
Times cited : (13)

References (22)
  • 1
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, I. and Landis, J. (2004) Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3, 711-715.
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 2
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi, J., Hansen, R., and Grabowski, H. (2003) The price of innovation: new estimates of drug development costs. J. Health Econ. 22, 151-185.
    • (2003) J. Health Econ , vol.22 , pp. 151-185
    • DiMasi, J.1    Hansen, R.2    Grabowski, H.3
  • 3
    • 13444284018 scopus 로고    scopus 로고
    • New technologies and screening strategies for hepatotoxicity: Use of in vitro models
    • Dambach, D.M., Andrews, B.A., and Moulin, F. (2005) New technologies and screening strategies for hepatotoxicity: use of in vitro models. Toxicol. Pathol. 33, 17-26.
    • (2005) Toxicol. Pathol , vol.33 , pp. 17-26
    • Dambach, D.M.1    Andrews, B.A.2    Moulin, F.3
  • 4
    • 20844444779 scopus 로고    scopus 로고
    • Idiosyncratic drug hepatotoxicity
    • Kaplowitz, N. (2005) Idiosyncratic drug hepatotoxicity. Nat. Rev. Drug Discov. 4, 489-499.
    • (2005) Nat. Rev. Drug Discov , vol.4 , pp. 489-499
    • Kaplowitz, N.1
  • 6
    • 21144462902 scopus 로고    scopus 로고
    • Classification of a large microarray data set: Algorithm comparison and analysis of drug signatures
    • Natsoulis, G., Ghaoui, L., Lanckriet, G., Tolley, A., Leroy, F., Dunlea, S., et al. (2005) Classification of a large microarray data set: algorithm comparison and analysis of drug signatures. Genome Res. 15, 724-736.
    • (2005) Genome Res , vol.15 , pp. 724-736
    • Natsoulis, G.1    Ghaoui, L.2    Lanckriet, G.3    Tolley, A.4    Leroy, F.5    Dunlea, S.6
  • 7
    • 0000245743 scopus 로고    scopus 로고
    • Statistical modeling: The two cultures
    • Breiman, L. (2001) Statistical modeling: the two cultures. Stat. Sci. 16, 199-231.
    • (2001) Stat. Sci , vol.16 , pp. 199-231
    • Breiman, L.1
  • 8
    • 0031536511 scopus 로고    scopus 로고
    • Improvements on cross-validation: The .632+ bootstrap method
    • Efron, B. and Tibshirani, R. (1997) Improvements on cross-validation: the .632+ bootstrap method. JASA 92, 548-560.
    • (1997) JASA , vol.92 , pp. 548-560
    • Efron, B.1    Tibshirani, R.2
  • 10
    • 84950461478 scopus 로고
    • Estimating the error rate of a prediction rule
    • Efron, B. (1983): Estimating the error rate of a prediction rule. JASA 78, 316-331.
    • (1983) JASA , vol.78 , pp. 316-331
    • Efron, B.1
  • 11
    • 33745147888 scopus 로고    scopus 로고
    • Assessing performance of prediction rules in maching learning
    • Martin, R. and Yu, K. (2006) Assessing performance of prediction rules in maching learning. Pharmacogenomics 7(4), 543-550.
    • (2006) Pharmacogenomics , vol.7 , Issue.4 , pp. 543-550
    • Martin, R.1    Yu, K.2
  • 12
    • 0027569924 scopus 로고
    • Dual-attribute continuous monitoring of cells proliferation/cytotoxicity
    • Fields, R.D. and Lancaster, M.V. (1993) Dual-attribute continuous monitoring of cells proliferation/cytotoxicity. Am. Biotechnol. Lab. 11, 48-50.
    • (1993) Am. Biotechnol. Lab , vol.11 , pp. 48-50
    • Fields, R.D.1    Lancaster, M.V.2
  • 14
  • 15
    • 0035470889 scopus 로고    scopus 로고
    • Greedy function approximation: A gradient boosting machine
    • Friedman, J. (1996). Greedy function approximation: a gradient boosting machine. Ann. Stat. 29, 1189-1232.
    • (1996) Ann. Stat , vol.29 , pp. 1189-1232
    • Friedman, J.1
  • 17
    • 85069250926 scopus 로고    scopus 로고
    • home page. Available at
    • Metrigenix. Corporate home page. Available at www.metrigenix.com.
    • Corporate
  • 19
    • 0003516711 scopus 로고    scopus 로고
    • An introduction to recursive partitioning using the rpart routines
    • Therneau, T. and Atkinson, E. (1997) An introduction to recursive partitioning using the rpart routines. Mayo Clinic Technical Report.
    • (1997) Mayo Clinic Technical Report
    • Therneau, T.1    Atkinson, E.2
  • 20
  • 21
    • 0030070103 scopus 로고    scopus 로고
    • Culture matrix configuration and composition in the maintenance of hepatocyte polarity and function
    • Morghe, P., Berthiaume, F., Ezzell, R., Toner, M., Tompkins, R., and Yarmush, M. (1996) Culture matrix configuration and composition in the maintenance of hepatocyte polarity and function. Biomaterials 17, 373-385.
    • (1996) Biomaterials , vol.17 , pp. 373-385
    • Morghe, P.1    Berthiaume, F.2    Ezzell, R.3    Toner, M.4    Tompkins, R.5    Yarmush, M.6
  • 22
    • 15444362827 scopus 로고    scopus 로고
    • In vitro methods to study chemicallyinduced hepatotoxicity: A literature review
    • Farkas, D. and Tannenbaum, S. (2005) In vitro methods to study chemicallyinduced hepatotoxicity: a literature review. Curr. Drug Metab. 6, 111-125.
    • (2005) Curr. Drug Metab , vol.6 , pp. 111-125
    • Farkas, D.1    Tannenbaum, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.