Role of Bone in Osteoarthritis Pathogenesis

Medical Clinics of North America

Volumn 93, Issue 1, 2009, Pages 25-35

  Goldring, Steven R ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Biomechanics; Bone; Cartilage; Osteoarthritis; Remodeling

Indexed keywords

BIOMECHANICS; BONE CYST; BONE MARROW EDEMA; BONE MINERAL; BONE STRUCTURE; DISEASE COURSE; EDEMA; HISTOPATHOLOGY; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOARTHRITIS; OSTEOPHYTE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; TRABECULAR BONE;

BONE AND BONES; BONE REMODELING; CARTILAGE, ARTICULAR; HUMANS; JOINTS; OSTEOARTHRITIS; OSTEOPHYTE;

EID: 57049093938     PISSN: 00257125     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcna.2008.09.006     Document Type: Review

References (64)

1. Buckland-Wright C. Subchondral bone changes in hand and knee osteoarthritis detected by radiography. Osteoarthr Cartil 12 Suppl A (2004) S10-S19
2. Bullough P.G. The role of joint architecture in the etiology of arthritis. Osteoarthr Cartil 12 Suppl A (2004) S2-S9
3. Burr D.B. Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthrosis. Osteoarthr Cartil 12 Suppl A (2004) S20-S30
4. Frost H.M. Perspective: genetic and hormonal roles in bone disorders: insights of an updated bone physiology. J Musculoskelet Neuronal Interact 3 2 (2003) 118-135
5. Burr D.B., and Schaffler M.B. The involvement of subchondral mineralized tissues in osteoarthrosis: quantitative microscopic evidence. Microsc Res Tech 37 4 (1997) 343-357
6. Teitelbaum S.L. Osteoclasts: what do they do and how do they do it?. Am J Pathol 170 2 (2007) 427-435
7. Teitelbaum S.L., and Ross F.P. Genetic regulation of osteoclast development and function. Nat Rev Genet 4 8 (2003) 638-649
8. Martin R.B. Targeted bone remodeling involves BMU steering as well as activation. Bone 40 6 (2007) 1574-1580
9. Scharstuhl A., Glansbeek H.L., van Beuningen H.M., et al. Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair. J Immunol 169 1 (2002) 507-514
10. Scharstuhl A., Vitters E.L., and van der Kraan P.M. Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis. Arthritis Rheum 48 12 (2003) 3442-3451
11. van der Kraan P.M., and van den Berg W.B. Osteophytes: relevance and biology. Osteoarthr Cartil 15 3 (2007) 237-244
12. Messent E.A., Ward R.J., Tonkin C.J., et al. Osteophytes, juxta-articular radiolucencies and cancellous bone changes in the proximal tibia of patients with knee osteoarthritis. Osteoarthr Cartil 15 2 (2007) 179-186
13. Muir P., McCarthy J., Radtke C.L., et al. Role of endochondral ossification of articular cartilage and functional adaptation of the subchondral plate in the development of fatigue microcracking of joints. Bone 38 3 (2006) 342-349
14. Patel N., and Buckland-Wright C. Advancement in the zone of calcified cartilage in osteoarthritic hands of patients detected by high definition macroradiography. Osteoarthr Cartil 7 6 (1999) 520-525
15. Lane L.B., Villacin A., and Bullough P.G. The vascularity and remodelling of subchondrial bone and calcified cartilage in adult human femoral and humeral heads. An age- and stress-related phenomenon. J Bone Joint Surg Br 59 3 (1977) 272-278
16. Day J.S., Ding M., van der Linden J.C., et al. A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res 19 5 (2001) 914-918
17. Faibish D., Ott S.M., and Boskey A.L. Mineral changes in osteoporosis: a review. Clin Orthop Relat Res 443 (2006) 28-38
18. Meunier P.J., and Boivin G. Bonse mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implications. Bone 21 5 (1997) 373-377
19. Li B., and Aspden R.M. Mechanical and material properties of the subchondral bone plate from the femoral head of patients with osteoarthritis or osteoporosis. Ann Rheum Dis 56 4 (1997) 247-254
20. Day J.S., Van Der Linden J.C., Bank R.A., et al. Adaptation of subchondral bone in osteoarthritis. Biorheology 41 3-4 (2004) 359-368
21. Messent E.A., Ward R.J., Tonkin C.J., et al. Differences in trabecular structure between knees with and without osteoarthritis quantified by macro and standard radiography, respectively. Osteoarthr Cartil 14 12 (2006) 1302-1305
22. Radin E.L., and Rose R.M. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res 213 (1986) 34-40
23. Goldring S.R., and Goldring M.B. The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop 427 Suppl (2004) S27-S36
24. Hunziker E.B. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartil 10 6 (2002) 432-463
25. Maroudas A., Bayliss M.T., Uchitel-Kaushansky N., et al. Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age. Arch Biochem Biophys 350 1 (1998) 61-71
26. Plaas A., Osborn B., Yoshihara Y., et al. Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages. Osteoarthr Cartil 15 7 (2007) 719-734
27. Sandell L.J., and Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 3 2 (2001) 107-113
28. Goldring M.B., and Goldring S.R. Osteoarthritis. J Cell Physiol 213 3 (2007) 626-634
29. Goodwin J.L., Farley M.L., Swaim B., et al. Dual proline labeling protocol for individual "baseline" and "response" biosynthesis measurements in human articular cartilage. Osteoarthr Cartil 16 (2008) 1263-1266
30. Buckland-Wright J.C., Macfarlane D.G., Fogelman I., et al. Technetium 99m methylene diphosphonate bone scanning in osteoarthritic hands. Eur J Nucl Med 18 1 (1991) 12-16
31. Hutton C.W., Higgs E.R., Jackson P.C., et al. 99mTc HMDP bone scanning in generalised nodal osteoarthritis. I. Comparison of the standard radiograph and four hour bone scan image of the hand. Ann Rheum Dis 45 8 (1986) 617-621
32. Hutton C.W., Higgs E.R., Jackson P.C., et al. 99mTc HMDP bone scanning in generalised nodal osteoarthritis. II. The four hour bone scan image predicts radiographic change. Ann Rheum Dis 45 8 (1986) 622-626
33. Macfarlane D.G., Buckland-Wright J.C., Emery P., et al. Comparison of clinical, radionuclide, and radiographic features of osteoarthritis of the hands. Ann Rheum Dis 50 9 (1991) 623-626
34. Dieppe P., Cushnaghan J., Young P., et al. Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis 52 8 (1993) 557-563
35. McCrae F., Shouls J., Dieppe P., et al. Scintigraphic assessment of osteoarthritis of the knee joint. Ann Rheum Dis 51 8 (1992) 938-942
36. Buckland-Wright J.C., Lynch J.A., and Dave B. Early radiographic features in patients with anterior cruciate ligament rupture. Ann Rheum Dis 59 8 (2000) 641-646
37. Buckland-Wright J.C., Lynch J.A., and Macfarlane D.G. Fractal signature analysis measures cancellous bone organisation in macroradiographs of patients with knee osteoarthritis. Ann Rheum Dis 55 10 (1996) 749-755
38. Buckland-Wright J.C., Macfarlane D.G., Jasani M.K., et al. Quantitative microfocal radiographic assessment of osteoarthritis of the knee from weight bearing tunnel and semiflexed standing views. J Rheumatol 21 9 (1994) 1734-1741
39. Buckland-Wright J.C., MacFarlane D.G., and Lynch J.A. Relationship between joint space width and subchondral sclerosis in the osteoarthritic hand: a quantitative microfocal radiographic study. J Rheumatol 19 5 (1992) 788-795
40. Bingham III C.O., Buckland-Wright J.C., Garnero P., et al. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum 54 11 (2006) 3494-3507
41. Buckland-Wright J.C., Messent E.A., Bingham III C.O., et al. A 2 yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients. Rheumatology (Oxford) 46 2 (2007) 257-264
42. Karvonen R.L., Miller P.R., Nelson D.A., et al. Periarticular osteoporosis in osteoarthritis of the knee. J Rheumatol 25 11 (1998) 2187-2194
43. Messent E.A., Buckland-Wright J.C., and Blake G.M. Fractal analysis of trabecular bone in knee osteoarthritis (OA) is a more sensitive marker of disease status than bone mineral density (BMD). Calcif Tissue Int 76 6 (2005) 419-425
44. Messent E.A., Ward R.J., Tonkin C.J., et al. Cancellous bone differences between knees with early, definite and advanced joint space loss; a comparative quantitative macroradiographic study. Osteoarthr Cartil 13 1 (2005) 39-47
45. Messent E.A., Ward R.J., Tonkin C.J., et al. Tibial cancellous bone changes in patients with knee osteoarthritis. A short-term longitudinal study using Fractal Signature Analysis. Osteoarthr Cartil 13 6 (2005) 463-470
46. Aigner T., Bartnik E., Sohler F., et al. Functional genomics of osteoarthritis: on the way to evaluate disease hypotheses. Clin Orthop Relat Res 427 Suppl (2004) S138-S143
47. Aigner T., Fundel K., Saas J., et al. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 54 11 (2006) 3533-3544
48. Wilson A.J., Murphy W.A., Hardy D.C., et al. Transient osteoporosis: transient bone marrow edema?. Radiology 167 3 (1988) 757-760
49. Felson D.T., Niu J., Guermazi A., et al. Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging. Arthritis Rheum 56 9 (2007) 2986-2992
50. Hernandez-Molina G., Guermazi A., Niu J., et al. Central bone marrow lesions in symptomatic knee osteoarthritis and their relationship to anterior cruciate ligament tears and cartilage loss. Arthritis Rheum 58 1 (2008) 130-136
51. Hunter D.J., Zhang Y., Niu J., et al. Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis. Arthritis Rheum 54 5 (2006) 1529-1535
52. Lo G.H., Hunter D.J., Zhang Y., et al. Bone marrow lesions in the knee are associated with increased local bone density. Arthritis Rheum 52 9 (2005) 2814-2821
53. Reichenbach S., Guermazi A., Niu J., et al. Prevalence of bone attrition on knee radiographs and MRI in a community-based cohort. Osteoarthr Cartil 16 (2008) 1005-1010
54. Taljanovic M.S., Graham A.R., Benjamin J.B., et al. Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology. Skeletal Radiol 37 5 (2008) 423-431
55. Bancroft L.W., Peterson J.J., and Kransdorf M.J. Cysts, geodes, and erosions. Radiol Clin North Am 42 1 (2004) 73-87
56. Carrino J.A., Blum J., Parellada J.A., et al. MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts. Osteoarthr Cartil 14 10 (2006) 1081-1085
57. Hofmann S., Engel A., Neuhold A., et al. Bone-marrow oedema syndrome and transient osteoporosis of the hip. An MRI-controlled study of treatment by core decompression. J Bone Joint Surg Br 75 2 (1993) 210-216
58. Zanetti M., Bruder E., Romero J., et al. Bone marrow edema pattern in osteoarthritic knees: correlation between MR imaging and histologic findings. Radiology 215 3 (2000) 835-840
59. Zoricic S., Maric I., Bobinac D., et al. Expression of bone morphogenetic proteins and cartilage-derived morphogenetic proteins during osteophyte formation in humans. J Anat 202 Pt 3 (2003) 269-277
60. Blaney Davidson E.N., van der Kraan P.M., and van den Berg W.B. TGF-beta and osteoarthritis. Osteoarthr Cartil 15 6 (2007) 597-604
61. van Beuningen H.M., Glansbeek H.L., van der Kraan P.M., et al. Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. Osteoarthr Cartil 6 5 (1998) 306-317
62. van Beuningen H.M., Glansbeek H.L., van der Kraan P.M., et al. Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections. Osteoarthr Cartil 8 1 (2000) 25-33
63. van Beuningen H.M., van der Kraan P.M., Arntz O.J., et al. Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. Lab Invest 71 2 (1994) 279-290
64. Pottenger L.A., Phillips F.M., and Draganich L.F. The effect of marginal osteophytes on reduction of varus-valgus instability in osteoarthritic knees. Arthritis Rheum 33 6 (1990) 853-858