Cutaneous biotransformation of N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane and its product, 4-bromobenzamide, leading to percutaneous penetration enhancement of drugs: Initial evidence using hydrocortisone

Journal of Controlled Release

Volumn 133, Issue 1, 2009, Pages 44-51

  Sintov, Amnon C ^a,c   Zhang, Peter Ji ^a   Michniak Kohn, Bozena B ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

4 Bromobenzamide; Chemical penetration enhancer; Hydrocortisone; Iminosulfurane; Percutaneous penetration; Skin metabolism

Indexed keywords

ANIMAL CELL CULTURE; BIOCHEMISTRY; CAPILLARY FLOW; DRUG PRODUCTS; IODINE; NEEDLES; SKIN;

4-BROMOBENZAMIDE; CHEMICAL PENETRATION ENHANCER; HYDROCORTISONE; IMINOSULFURANE; PERCUTANEOUS PENETRATION;

METABOLISM;

4 BROMOBENZAMIDE; BENZAMIDE DERIVATIVE; DITHIOTHREITOL; HYDROCORTISONE; IODINE; IODOACETIC ACID; N (4 BROMOBENZOYL) S,S DIMETHYLIMINOSULFURANE; SULFUR DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DIFFUSION; DRUG METABOLISM; DRUG STABILITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN PENETRATION;

ADJUVANTS, PHARMACEUTIC; ALKYLATING AGENTS; ANIMALS; BENZAMIDES; BIOTRANSFORMATION; EPIDERMIS; HUMANS; HYDROCORTISONE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IODINE; KINETICS; MALE; MICE; MICE, HAIRLESS; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; SULFUR COMPOUNDS; SWINE;

EID: 57049083441     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.09.084     Document Type: Article

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