Probing Peptide Fragment Ion Structures by Combining Sustained Off-Resonance Collision-Induced Dissociation and Gas-Phase H/D Exchange (SORI-HDX) in Fourier Transform Ion-Cyclotron Resonance (FT-ICR) Instruments

Journal of the American Society for Mass Spectrometry

Volumn 19, Issue 12, 2008, Pages 1771-1775

  Somogyi, Árpád ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; DISSOCIATION; FOURIER TRANSFORMS; IONS; MOLECULAR STRUCTURE; RATE CONSTANTS; REACTION RATES; RESONANCE;

EXPERIMENTAL CONDITIONS; FRAGMENT IONS; H/D EXCHANGES; INDUCED DISSOCIATIONS; ISOMERIC IONS; KINETIC RATES; PARENT IONS; PEPTIDE FRAGMENTATIONS; PEPTIDE FRAGMENTS; PRECURSOR IONS; PROTONATED; REACTION TIMES;

ION EXCHANGE;

PEPTIDE FRAGMENT;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COLLISIONALLY ACTIVATED DISSOCIATION; CYCLIZATION; FRAGMENTATION REACTION; GAS EXCHANGE; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; ISOMERISM; PROTON TRANSPORT;

CYCLOTRONS; DEUTERIUM; FOURIER ANALYSIS; HYDROGEN; IONS; MOLECULAR STRUCTURE; PEPTIDE FRAGMENTS; TANDEM MASS SPECTROMETRY;

EID: 56949102633     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2008.08.012     Document Type: Article

References (18)

1. Dongré A.R., Jones J.L., Somogyi Á., and Wysocki V.H. Influence of Peptide Composition, Gas-Phase Basicity, and Chemical Modification on Fragmentation Efficiency: Evidence for the Mobile Proton Model. J. Am. Chem. Soc 118 (1996) 8365-8374
2. Wysocki V.H., Tsaprailis G., Smith L.L., and Breci L.A. Mobile and Localized Protons: A Framework for Understanding Peptide Dissociation. J. Mass Spectrom 35 (2000) 1399-1406
3. Paizs B., and Suhai S. Fragmentation Pathways of Protonated Peptides. Mass Spectrom. Rev 24 (2005) 508-548
4. 2D, and ND3. J. Am. Chem. Soc 116 (1994) 9765-9766
5. Herrmann K.A., Wysocki V.H., and Vorpagel E.R. Computational Investigation and H/D Exchange of the Fixed Charged Derivative Tris (2,4,6-trimethoxyphenyl) phosphonium. Implications for the Aspartic Acid Cleavage Mechanism. J. Am. Soc. Mass Spectrom 16 (2005) 1067-1080
6. Somogyi Á., Pasilis S.P., and Pemberton J.E. Electrospray Ionization of Uranyl-Citrate Complexes: Adduct Formation and Ion-Molecule Reactions in 3D Ion Trap and Ion Cyclotron Resonance Trapping Instruments. Int. J. Mass Spectrom 265 (2007) 281-294
7. Reid G.E., Simpson R.J., and O'Hair R.A.J. Probing the Fragmentation Reactions of Protonated Glycine Oligomers via Multistage Mass Spectrometry and Gas Phase Ion-Molecule Hydrogen/Deuterium Exchange. Int. J. Mass Spectrom 190-191 (1999) 209-230
8. Herrmann K.A., Somogyi Á., Wysocki V.H., Drahos L., and Vékey K. Combination of Sustained Off-Resonance Irradiation and On-Resonance Excitation in FT-ICR for the Enhancement of Higher Energy Fragmentation Pathways. Anal. Chem 77 (2005) 7626-7638
9. Polfer N.C., Oomens J., Suhai S., and Paizs B. Spectroscopic and Theoretical Evidence for Oxazolone Ring Formation in Collision Induced Dissociation of Peptides. J. Am. Chem. Soc 127 (2005) 17154-17155
10. Polfer N.C., Oomens J., Suhai S., and Paizs B. Infrared Spectroscopy and Theoretical Studies on Gas-Phase Protonated Leu-enkephalin and Its Fragments: Direct Experimental Evidence for the Mobile Proton. J. Am. Chem. Soc 129 (2007) 5887-5897
11. Polfer N.C., Bohrer B.C., Plasencia M.D., Paizs B., and Clemmer D.E. On the Dynamics of Fragment Isomerization in Collision-Induced Dissociation of Peptides. J. Phys. Chem. A 112 (2008) 1286-1293
12. Riba-Garcia I., Giles K., Bateman R.H., and Gaskell S.J. Evidence for Structural Variants of a- and b-Type Peptide Fragment Ions Using Combined Ion Mobility/Mass Spectrometry. J. Am. Soc. Mass Spectrom 19 (2008) 609-613
13. Jiao C.Q., Ranatunga D.R.A., Vaughn W.E., and Freiser B.S.J. A Pulsed Leak Valve for Use with Ion Trapping Mass Spectrometers. Am. Soc. Mass Spectrom 7 (1996) 118-122
14. + Ions in the Gas Phase. J. Am. Soc. Mass Spectrom 4 (1993) 477-481
15. Vachet R.W., Bishop B.M., Erickson B.W., and Glish G.L. Novel Peptide Dissociation: Gas-Phase Intramolecular Rearrangement of Internal Amino Acid Residues. J. Am. Chem. Soc 119 (1997) 5481-5488
16. 3* Ions from Protonated Tetraglycine J. Am. Soc. Mass Spectrom 17 (2006) 1654-1664
17. Harrison A.G., Young A.B., Bleiholder C., Suhai S., and Paizs B. Scrambling of Sequence Information in Collision-Induced Dissociation of Peptides. J. Am. Chem. Soc 128 (2006) 10364-10365
18. Galhena, A.; Perkins, B.; Somogyi, A.; Wysocki, V. H. Gas-phase Intramolecular Rearrangement of Peptides and Their Fragments, unpublished.