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Volumn 119, Issue 24, 1997, Pages 5481-5488

Novel peptide dissociation: Gas-phase intramolecular rearrangement of internal amino acid residues

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; AMINO ACID; ION; NITROGEN; PEPTIDE; PROTON;

EID: 0030861687     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9640758     Document Type: Article
Times cited : (114)

References (35)
  • 22
    • 1842349492 scopus 로고    scopus 로고
    • note
    • The structure of the 34 ion is formally presumed to be an immonium ion in which the leucine residue on the C-terminus and the carbonyl group on the phenylalanine residue have been lost. The charge can formally be assigned to the nitrogen in the phenylalanine residue having four covalent bonds (pept-CO-NH=CHR).
  • 31
    • 1842267778 scopus 로고    scopus 로고
    • note
    • At the pressures used in these experiments the ion at m/z 380 is expected to undergo on average about 0.01 collisions during one rf cycle. As a result it is unlikely that the ion at m/z 380 would dissociate to form m/z 323 as a result of collisional activation during the time when it is being resonantly ejected. It is also possible that m/z 380 could be formed from m/z 397 with sufficient excess internal energy to dissociate further to the ion at m/z 323 before it could be resonantly ejected. From a simple RRKM calculation, assuming a tight transition state and a critical energy of 1.2 eV, at least 5 eV of internal energy would be required to observe the dissociation of m/z 380 to m/z 323 in less than 1 μs. This amount of excess internal energy seems unlikely; therefore, it is reasonable to conclude that the double resonance experiments in this case are able to distinguish between a concerted reaction and two rapid consecutive reactions.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.