Validated quantitative structure-activity relationship analysis of a series of 2-aminothiazole based p56Lck inhibitors

Analytica Chimica Acta

Volumn 631, Issue 1, 2009, Pages 29-39

  Li, Jiazhong ^a   Du, Juan ^a   Xi, Lili ^a   Liu, Huanxiang ^a   Yao, Xiaojun ^a   Liu, Mancang ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Genetic algorithm (GA); Lymphocyte specific kinase (LCK); Multiple linear regression (MLR); Quantitative structure activity relationship (QSAR)

Indexed keywords

ALGORITHMS; MOLECULAR GRAPHICS; SULFUR COMPOUNDS;

AMINOTHIAZOLE; DESCRIPTORS; INHIBITION ACTIVITIES; LYMPHOCYTE-SPECIFIC KINASE (LCK); MULTIPLE LINEAR REGRESSION (MLR); QSAR MODELS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR); QUANTITATIVE STRUCTURES; STRUCTURAL FEATURES;

GENETIC ALGORITHMS;

2 AMINOTHIAZOLE DERIVATIVE; PROTEIN KINASE LCK; PROTEIN KINASE LCK INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DRUG ACTIVITY; GENETIC ALGORITHM; MULTIPLE LINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL MODEL; VALIDATION PROCESS;

ALGORITHMS; ARTIFICIAL INTELLIGENCE; ENZYME INHIBITORS; GENETICS; LINEAR MODELS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; THIAZOLES;

EID: 56949099063     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2008.10.026     Document Type: Article

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