"Chiral amnesia" as a driving force for solid-phase homochirality

Chemistry - A European Journal

Volumn 13, Issue 12, 2007, Pages 3290-3295

  Blackmond, Donna G ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Chiral resolution; Chirality; Crystal growth; Crystallization; Eutectic; Phase rule

Indexed keywords

CHIRALITY; CRYSTAL GROWTH; CRYSTALLIZATION; ENANTIOMERS;

CHIRAL RESOLUTION; PHASE RULES;

EUTECTICS;

EID: 34250370143     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200601463     Document Type: Article

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23. Homochiral and heterochiral interactions were discussed in reference [11] in terms of the Frank model for absolute asymmetric synthesis (see reference [2]). The authors state that the Frank autocatalytic model includes the assumption that the heterochiral state is more stable than the homochiral state. Such an assumption is not in fact necessary in the Frank model to obtain simplification of ee. Indeed, experimental kinetic studies of the Soai autocatalytic reaction have been shown to follow the Frank model in the case where heterochiral and homochiral dimers are formed with equal stability. Asymmetric amplification of product ee is not dependent on differing stability of homochiral and heterochiral interactions. See reference [4] for a detailed explanation.