Non-native R1 substitution in the S4 domain uniquely alters Kv4.3 channel gating

PLoS ONE

Volumn 3, Issue 11, 2008, Pages

  Skerritt, Matthew R ^a   Campbell, Donald L ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; SHAKER POTASSIUM CHANNEL; VALINE; SHAL POTASSIUM CHANNEL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYSICAL SENSITIVITY; SENSITIVITY ANALYSIS; SITE DIRECTED MUTAGENESIS; STEADY STATE; VOLTAGE CLAMP; VOLTAGE SENSITIVITY; AMINO ACID SEQUENCE; ANIMAL; BIOCHEMISTRY; CHEMISTRY; ELECTROPHYSIOLOGY; FERRET; KINETICS; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MUTAGENESIS; MUTATION; OOCYTE; PHENOTYPE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; BIOCHEMISTRY; ELECTROPHYSIOLOGY; FERRETS; ION CHANNEL GATING; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; OOCYTES; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; SHAL POTASSIUM CHANNELS; XENOPUS LAEVIS;

EID: 56849121002     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003773     Document Type: Article

References (40)

1. Tombola F, Pathak MM, Isacoff EY (2006) How does voltage open an ion channel? Ann Rev Cell Dev Biol 22: 23-52.
2. Chanda B, Bezanilla F (2008) A common pathway for charge transport through voltage-sensing domains. Neuron 57: 345-351.
3. Bezanilla F (2008) How membrane proteins sense voltage. Nat Rev Mol Cell Biol 9: 323-332.
4. Bezanilla F (2000) The voltage-sensor in voltage-dependent ion channels. Physiol Rev 80: 555-592.
5. Bezanilla F (2005) Voltage-gated ion channels. IEEE Trans Nanobiosci 1: 34-48.
6. Birnbaum SG, Varga AW, Yuan L-Y, Andersen AE, Sweatt JD, et al. (2004) Structure and function of Kv4-family transient potassium channels. Physiol Rev 84: 803-833.
7. Jerng HH, Pfaffinger PJ, Covarrubias M (2004) Molecular physiology and modulation of somatodendritic A-type potassium channels. Mol Cell Neurosci 27: 343-369.
8. to", phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J Physiol 569: 7-39.
9. Skerritt MR, Campbell DL (2007) Role of S4 positively charged residues in the regulation of Kv4.3 inactivation and recovery. Am J Physiol Cell Physiol 293: 906-914.
10. Skeritt MR, Campbell DL (2008) Contribution of Electrostatic and Structural Properties of Kv4.3 S4 Arginine Residues to the Regulation of Channel Gating. Biochim Biophys Acta (In Press).
11. + channels. Circ Res 20: 739-750.
12. Yellen G (1998) The moving parts of voltage-gated ion channels. Quart Rev Biophys 31: 239-295.
13. Aldrich RW (2001) Fifty years of inactivation. Nature 411: 643-644.
14. Zhou M, Morals-Cabral JH, Mann S, MacKinnon R (2001) Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 411: 657-661.
15. Claydon TW, Kehl SJ, Fedida D (2008) Closed-state inactivation induced in Kv1 channels by extracellular acidification. Channels 2: 139-142.
16. Amadi CC, Brust RD, Skerritt MR, Campbell DL (2007) Regulation of Kv4.3 closed state inactivation and recovery by extracellular potassium and intracellular KChIP2b. Channels 1: 305-314.
17. o dependence. J Physiol 557: 705-712.
18. Sigworth FJ (1994) Voltage gating of ion channels. Quart Rev Biophys 27: 1-40.
19. Hille B (2001) Gating: Voltage sensing and inactivation. In: Ion Channels of Excitable Membranes, 3rd Edition. Sunderland, MA. pp 603-634.
20. Jackson MB (2006) Global transitions in proteins. In: Molecular and Cellular Biophysics. Cambridge, UK: Cambridge University Press. pp 1-24.
21. Zamyatnin AA (1984) Amino acid, peptide, and protein volume in solution. Ann Rev Biophys Bioeng 13: 145-165.
22. Engelman DM, Steitz TA, Goldman A (1986) Identifying nonpolar transmembrane helices in amino acid sequences of membrane proteins. Ann Rev Biophys Biophys Chem 15: 321-353.
23. Wang S, Bondarenko V, Qu Y-J, Bett GC, Morales MJ, et al. (2005) Time- and voltage-dependent components of Kv4.3 inactivation. Biophys J 89: 3026-3041.
24. Smith-Maxwell CJ, Ledwell JL, Aldrich RW (1998) Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation. J Gen Physiol 111: 421-439.
25. Patel SP, Parai R, Parai R, Campbell DL (2004) Regulation of Kv4.3 voltage-dependent gating kinetics by KChIP2 isoforms. J Physiol 557: 19-41.
26. Papazian DM, Timpe LC, Jan YN, Jan LY (1991) Alteration of voltage dependence of Shaker potassium channel by mutations in the S4 sequence. Nature 349: 305-310.
27. Bahring R, Boland LM, Vargese A, Gebauer M, Pongs O (2001) Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels. J Physiol 535: 65-81.
28. Campos FV, Chanda B, Roux B, Bezanilla F (2007) Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel. Proc Nat Acad Sci USA 104: 7904-7909.
29. + channel in a lipid membrane-like environment. Nature 450: 376-383.
30. + channel. Neuron 56: 124-140.
31. + channels. J Gen Physiol 110: 579-590.
32. Tombola F, Pathak MM, Isacoff EY (2005) Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron 45: 379-388.
33. Tombola F, Pathak MM, Gorostiza P, Isacoff EY (2007) The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature 445: 546-549.
34. Asamoah OK, Wuskell JP, Loew LM, Bezanilla F (2003) A fluorometric approach to local electric field measurements in a voltage-gated ion channel. Neuron 37: 85-97.
35. Starace DM, Bezanilla F (2004) A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature 427: 548-553.
36. Ahern CA, Horn R (2005) Focused electric field across the voltage sensor of potassium channels. Neuron 48: 25-29.
37. + channel. Neuron 16: 1169-1177.
38. + channel. Neuron 16: 1159-1167.
39. Patel SP, Campbell DL, Morales MJ, Strauss HC (2002) Heterogeneous expression of KChIP2 isoforms in the ferret heart. J Physiol 539: 649-656.
40. Covarrubias M, Bhattacharji A, De Santiago-Castillo JA, Dougherty K, Kaulin YA, et al. (2008) The neuronal Kv4 channel complex. Neurochem Res 33: 1558-1567.